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Chinese Che.ical Letters 2024年第10期35卷 32-34页

作者： Rong-Nan Yi Wei-Min he Key Laboratory of Food & Environment & Drug Monitoring and Testing of Universities in Hunan Province Hunan Police Academy School of Che.istry and Che.ical Engineering University of South China

Bioisosteres play an important role in pharmaceutical and agri cultural compound design that has been developed to enhance the.properties of *** a sp3-rich small ring cage hydro carbons,bicyclo[1.1.1]pentanes （BCPs） were commonly considered as a bioisostere of the.para-substituted arenes,internal alkynes and tert–butyl groups,and its introduction can significantly im prove pharmacokinetic properties,including passive permeability aqueous solubility,metabolic stability[1].Over the.past decades numerous pharmaceutically relevant molecules with biaryl frame works were improved by the.approach of bioisosteric replacement Conventional strategies for the.synthe.is of such BCP-aryls deriva tives mostly depend on the.stepwise C–C formation via the.di rect addition to bridgehe.d C–C bond of[1.1.1]propellane to pro vide active BCP-intermediates and followed by a second transition metal cross-coupling ***,the.e pioneer works were limited by the.low step economy,the.use of unstable reagents and harsh conditions in industrial ***,radical mediated one-step,multi-component reactions[2-6]for synthe.sizing various BCP-aryl derivatives have made progress,although the.e strategies were limited to the.prefunctionalized （he.）arene and tertiary alkyl radicals[7].The.efore,it is of great significance to develop a method for diverse BCP-aryls that can be compatible with primary,secondary,tertiary radicals and direct C–H function alization of （he.）arenes.

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Vagus nerve stimulation in cerebral stroke:biological mechanisms,the.apeutic modalities,clinical applications,and future directions

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Neural Regeneration Research 2024年第8期19卷 1707-1717页

作者： Li Du Xuan he.Xiaoxing Xiong Xu Zhang Zhihong Jian Zhe.xing Yang Department of Anesthe.iology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Stroke is a major disorder of the.central nervous system that poses a serious threat to human life and quality of *** stro ke victims are left with long-term neurological dysfunction,which adversely affects the.well-being of the.individual and the.broader socioeconomic ***,poststroke brain dysfunction is a major and difficult area of *** nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autis m,refractory depression,epilepsy,and Alzhe.mer’s *** is expected to be a novel the.apeutic technique for the.treatment of stroke owing to its association with multiple mechanisms such as alte ring neurotransmitters and the.plasticity of central neuro *** animal models of acute ische.ic stroke,vagus nerve stimulation has been shown to reduce infarct size,reduce post-stroke neurological damage,and improve learning and memory capacity in rats with stroke by reducing the.inflammatory response,regulating bloodbrain barrier permeability,and promoting angiogenesis and *** present,vagus nerve stimulation includes both invasive and non-invasive vagus nerve *** studies have found that invasive vagus nerve stimulation combined with rehabilitation the.apy is effective in im proving upper limb motor and cognitive abilities in stroke *** clinical studies have shown that non-invasive vagus nerve stimulation,including ear/ce rvical vagus nerve stimulation,can stimulate vagal projections to the.central nervous system similarly to invasive vagus nerve stimulation and can have the.same *** this paper,we first describe the.multiple effects of vagus nerve stimulation in stroke,and the. discuss in depth its neuroprotective mechanisms in ische.ic *** go on to outline the.res ults of the.current major clinical applications of invasive and non-invasive vagus nerve ***,we provide a more comprehe.sive evaluation of the.advantages and disadvantages of di

关键词： cerebral stroke neuroplasticity non-invasive vagus nerve stimulation rehabilitation vagus nerve stimulation

Incidence,Risk Factors,and Prognosis of Patients with he.atocellular Carcinoma and Brain Metastases

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Current Medical Science 2024年第1期44卷 180-186页

作者： Jin-che.g FENG Ying he.Georgios Polychronidis Jian XIN She. YOU Jun XIONG Department of Liver Transplantation Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Transplant Engineering and immunology Laboratory of Liver TransplantationFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of General Visceral and Transplant SurgeryUniversity of HeidelbergIm Neuenheimer Feld 110Heidelberg 69120Germany Department of he.atobiliary and Pancreatic Surgery Fujian Provincial HospitalFuzhou 350001China

Objective Brain metastases significantly impact the.clinical course of patients with he.atocellular carcinoma(HCC).This study aimed to examine the.age-related incidence,demographics,and survival of patients with HCC and brain *** Data of HCC patients from 2010 to 2015 in the.Surveillance,Epidemiology,and End Results(SEER)Registry were screened for the.presence of brain *** were stratified by age and *** logistic and Cox regression analyses were used to identify factors associated with brain metastases and those with overall survival(OS)and liver cancer-specific survival(CSS),*** A total of 141 HCC patients presenting with brain metastases were identified,accounting for 0.35% of all HCC patients and 2.37% of patients with metastatic *** all HCC patients,the.incidence rate was the.highe.t among patients aged 30-49 years old(0.47%).Ethnicity was not associated with the.presence of brain metastases at the.time of HCC ***,African-American patients presented with a significantly lower disease-specific survival[median time:1 month;interquartile range(IQR):0-3.0 months].Initial lung or bone metastasis was independently associated with an increased risk of the.presence of brain metastases[odds ratio(OR):12.62,95% confidence interval(CI):8.40-18.97]but was not associated with a worse OS or CSS among those with brain *** This study identified the.age-related incidence and risk factors of brain metastases in HCC *** results may contribute to the.consideration of brain screening among patients with initial metastatic HCC with lung or bone metastases,and influence the.counseling of this patient population regarding the.r prognosis.

关键词： brain metastases he.atocellular carcinoma age-related incidence cancer-specific survival overall survival

Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with he.atocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： Jia-Li Che. Lu Guo Zhe.-Ying Wu Kun he.Han Li Chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the.prognosis of he.atocellular carcinoma(HCC).Aim To investigate the.prognostic value of combining the.e two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune the.apy combined with targeted the.apy at the.Department of Oncology,the.Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The.relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(Phe.CTC-NLR(2)group showed a significant decrease in mPFS and *** regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of *** time-dependent receiver operating characteristic curve showed that the.area under the.curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunothe.apy combined with targeted the.apy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio he.atocellular carcinoma Prognosis Survival Marker

Olfactory Response of Trichogramma ostriniae (Hymenoptera: Trichogrammatidae) to Volatiles Emitted by Mungbean Plants

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Agricultural Sciences in China 2011年第4期10卷 560-565页

作者： BAI Shu-xiong WANG Zhe.-ying he.Kang-lai im Dae-joon State Key Laboratory of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China National Crop Experiment Station Rural Development Administration Suwon 441-100 Republic of Korea

Intercropping maize with the.prostrate variety of mungbean, Vigna radiata （L.） Wilczek which grows flat along the.ground can increase parasitism of the.eggs of the.Asian corn borer, Ostrinia furnacalis （Guenée）, a crucial insect pest of maize in China, by Trichogramma ostriniae Pang Che.. This study investigated the.behavioural responses of T. ostriniae to plant volatiles emitted from whole plants, leaves, and flowers of prostrate and erect varieties of mungbean in a 4-armed olfactometer. Female parasitiods were significantly attracted to the.odours from some varieties of prostrate mungbean whe. the.visit duration and the.number of visits were considered, but were not attracted to the.odours from any erect varieties. The.attractive odours were shown to emanate from the.leaves, rathe. than from the.flowers of prostrate mungbean plants. The.e results have implications for the.augmentation of Trichogramma parasitoids in bio-control of O. furnacalis and othe. crop pests.

关键词： Trichogramma ostriniae olfactory response Vigna radiata plant volatile

Proxitome profiling reveals a conserved SGT1- NSL1 signaling module that activates NLRmediated immunity

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Molecular Plant 2024年第9期17卷 1369-1391页

作者： Dingliang Zhang Xinxin Yang Zhiyan Wen Zhe. Li Xinyu Zhang Che.che. Zhong Jiajie She.Qianshe. Zhang he.Zhang Wenli Li Xiaoyun Zhao Mingliang Xu Zhe. Su Dawei Li Savithramma P.Dinesh-Kumar Yongliang Zhang State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBejing 100193China Department of Plant Biology and The.Genome Center College of Biological SciencesUniversity of CaliforniaDavisDavisCA 95616USA State Key Laboratory of Plant Environmental Resilience College of Agronomy and BiotechnologyChina Agricultural UniversityBejing 100193China

Suppressor of G2 allele of skp1(SGT1)is a highly conserved eukaryotic protein that plays a vital role in growth,development,and immunity in both animals and *** some SGT1 interactors have been identified,the.molecular regulatory network of SGT1 remains ***1 serves as a co-chaperone to stabilize protein complexes such as the.nucleotide-binding leucine-rich repeat(NLR)class of immune receptors,the.eby positively regulating plant ***1 has also been found to be asso-ciated with the.SKP1-Cullin-F-box(SCF)E3 ubiquitin ligase ***,whe.he. SGT1 targets im-mune repressors to coordinate plant immune activation remains *** this study,we constructed a toolbox for TurbolD-and split-TurbolD-based proximity labeling(PL)assays in Nicotiana benthamiana and used the.PL toolbox to explore the.SGT1 interactome during pre-and post-immune *** comprehe.sive SGT1 interactome network we identified highlights a dynamic shift from proteins associ-ated with plant development to those linked with plant immune *** found that SGT1 interacts with Necrotic Spotted Lesion1(NSL1),which negatively regulates salicylic acid-mediated defenseby inter-fering with the.nucleocytoplasmic trafficking of non-expressor of pathogenesis-related genes 1(NPR1)during N NLR-mediated response to tobacco mosaic ***1 promotes the.SCF-dependent degrada-tion of NSL1 to facilitate immune activation,while salicylate-induced protein kinase-mediated phosphory-lation of SGT1furthe. potentiates this *** NNLR,NSL1also functions in several othe. NLR-mediated ***,our study unveils the.regulatory landscape of SGT1 and reveals a novel SGT1-NSL1 signaling module that orche.trates plant innate immunity.

关键词： suppressor of G2 allele of skp1 SGT1 proximity labeling N NLR immune receptor Necrotic Spotted Lesion 1 NSL1 salicylic acid ubiquitination

高校青年科研人员学术产出的组态路径研究——基于社会生态系统理论视角

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科学学研究 2024年第6期42卷 1238-1245页

作者：张征谢佳贺伟山西财经大学工商管理学院山西太原030006 西安交通大学管理学院陕西西安710049

科研人员的发展受到所处的整个社会生态系统的影响,然而现有独立效应的研究无法解释其学术产出路径的复杂性。基于社会生态系统理论,本研究从微观、中观、宏观3个系统中识别出6个前因条件,构建了高校青年科研人员学术产出的多重并发机... 详细信息

科研人员的发展受到所处的整个社会生态系统的影响,然而现有独立效应的研究无法解释其学术产出路径的复杂性。基于社会生态系统理论,本研究从微观、中观、宏观3个系统中识别出6个前因条件,构建了高校青年科研人员学术产出的多重并发机制模型,并运用fsQCA方法分析影响青年科研人员学术产出的组态路径。结果发现:不存在引致高校青年科研人员高学术产出的单个必要条件;存在6条可以引发青年科研人员高学术产出的组态路径,根据核心条件的分布特征,可将其归纳为四种类型:自我发展型、团队合作型、环境支持型、要素聚合型。研究成果从社会生态系统视角探讨了多维前因条件对高校青年科研人员学术产出的组态效应,为提升科研人员学术产出提供实践启示。

关键词：学术产出社会生态系统理论 fsQCA 青年科研人员

一种16位电流舵DAC的高精度前台校准方法

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固体电子学研究与进展 2024年第2期44卷 143-148页

作者：张妍蒲佳何善亮何浩江曹文涛西安电子科技大学西安710126 成都振芯科技股份有限公司成都610041

基于28 nm CMOS工艺,采用一种高精度的前台校准技术设计了一款16 bit电流舵数模转换器(Digitalto-analog converter,DAC)电路。该前台校准算法对16 bit数据对应的所有电流源进行校准,并且使用的电流源只有两种大小,降低校准难度的同时... 详细信息

基于28 nm CMOS工艺,采用一种高精度的前台校准技术设计了一款16 bit电流舵数模转换器(Digitalto-analog converter,DAC)电路。该前台校准算法对16 bit数据对应的所有电流源进行校准,并且使用的电流源只有两种大小,降低校准难度的同时也提升了校准的精度。该校准电路引入了两种校准补充电流,分别用于温度和输出电流变化引起电流源失配的补偿,进一步减小了DAC电流源的失配,有效提高了DAC的整体性能。采用校准后,在-40~85℃温度范围内,微分非线性≤0.8 LSB,积分非线性≤2.0 LSB,200 MHz输出信号下无杂散动态范围≥75.3 dB。该校准方法提高了DAC的温度稳定性。

关键词：高精度校准前台校准电流源失配电流舵DAC

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论美育在儿童读物插图设计中的重要性

包装工程 2024年第4期45卷 280-287页

作者：蒋苏平何忠北京工业大学艺术设计学院北京100124

目的儿童读物中的插图设计作为一种特殊的插画种类,可以将美育思想以生动有趣的叙事画面传递给儿童,丰富少儿认知,助其树立良好的情感态度与价值观,从而塑造完整的人格。近年来,由于国内儿童读物市场的崛起和教育界对儿童美育的重视,使... 详细信息

目的儿童读物中的插图设计作为一种特殊的插画种类,可以将美育思想以生动有趣的叙事画面传递给儿童,丰富少儿认知,助其树立良好的情感态度与价值观,从而塑造完整的人格。近年来,由于国内儿童读物市场的崛起和教育界对儿童美育的重视,使得美育观念在儿童读物插图设计中发挥着愈加重要的作用。文章从教育学、儿童审美心理学及设计学交叉学科的角度出发,探讨美育在儿童读物插图设计创意及表现中的重要性。方法通过跨学科研究法、文献研究法、案例分析法等研究方法,结合罗伯特·皮亚杰的认知发展阶段论和霍华德·加德纳儿童审美认知发展阶段论的横向对比分析,导出不同阶段儿童的插图偏好,在了解不同阶段儿童审美心理发展特征的基础上,探讨美育在儿童读物插图中的重要作用。结论希望美术创作者给予儿童审美教育以更多关注,正确引导儿童读物插图设计的方向,加强对儿童审美能力的培养,更好地从设计学领域出发,传递中国文化,讲好中国故事。

关键词：美育儿童读物插图设计创意表现

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双模三维索引调制差分混沌移位键控系统的设计及性能分析

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通信学报 2024年第6期45卷 176-186页

作者：贺利芳武兴根薛岩松重庆邮电大学通信与信息工程学院重庆400065 重庆邮电大学光电工程学院重庆400065

针对传统差分混沌移位键控系统速率低、误码性能差的问题,提出了一种双模三维索引调制差分混沌移位键控系统。该系统利用时隙、正交码和顺序索引,在选中与未选中的时隙上均传输信息比特。在接收端,通过采用降噪技术,减小了噪声的方差,... 详细信息

针对传统差分混沌移位键控系统速率低、误码性能差的问题,提出了一种双模三维索引调制差分混沌移位键控系统。该系统利用时隙、正交码和顺序索引,在选中与未选中的时隙上均传输信息比特。在接收端,通过采用降噪技术,减小了噪声的方差,提升了系统误码性能。推导了在加性白高斯噪声信道和多径瑞利衰落信道下的比特差错率公式。仿真结果显示,与相似的混沌键控系统相比,所提系统具备更高的数据速率和更为优越的误码性能。

关键词：混沌通信差分混沌移位键控索引调制联合解调算法