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Gravitational wave footprints from Higgs-portal scalegenesis with multiple dark chiral scalars

Chinese Physics C 2024年第4期48卷 209-221页

作者： he-xu zhang Shinya Matsuzaki Hiroyuki Ishida Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Center for Liberal Arts and Sciences Toyama Prefectural UniversityToyama 939-0398Japan

We discuss the gravitational wave(GW)spectra predicted from the electroweak scalegenesis of the Higgs portal type with a large number of dark chiral flavors,which many flavor QCD would underlie and give the dynamical explanation of the negative Higgs portal coupling required to trigger the electroweak symmetry *** employ the linear-sigma model as the low-energy description of dark many flavor QCD and show that the model undergoes ultra-supercooling due to the produced strong first-order thermal phase transition along the(approximately realized)flat direction based on the Gildener-Weinberg *** through evaluation of the bubble nucleation/percolation,we address the reheating and relaxation processes,which are generically non-thermal and *** the reheating epoch in terms of the e-folding number,we propose proper formulae for the redshift effects on the GW frequencies and signal *** then turns out that the ultra-supercooling predicted from the Higgs-portal scalegenesis generically yields none of GW signals with the frequencies as low as nano Hz,unless the released latent heat is transported into another sector other than reheating the ***,models of this class prefer to give the higher frequency signals and still keeps the future prospected detection sensitivity,like at LISA,BBO,and DECIGO,*** also find that with large flavors in the dark sector,the GW signals are made further smaller and the peak frequencies *** phenomenological consequences related to the multiple chiral scalars include the prediction of dark pions with the mass much less than TeV scale,which is also briefly addressed.

关键词： gravitational wave electroweak scalegenesis many flavor QCD

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嘌呤衍生物的设计合成及抗肿瘤活性评价

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化学研究与应用 2024年第4期36卷 803-815页

作者：侯学会郭俊何张旭马志伟耿广威张荷丽杨静张京玉河南牧业经济学院理学部河南郑州450046 河南中医药大学药学院河南郑州450046 军事医学研究院生物信息中心北京100850

本文设计合成了22个新型嘌呤类衍生物,其中化合物25显示出最高效的抗增殖活性,其对肿瘤细胞hepG2,A549和MCF-7的ICso值分别为15.4,13.7,7.9μM,与阳性对照Roscovitine相比表现出相当或更高效的活性。此外,化合物25对正常细胞BHK-21的毒... 详细信息

本文设计合成了22个新型嘌呤类衍生物,其中化合物25显示出最高效的抗增殖活性,其对肿瘤细胞hepG2,A549和MCF-7的ICso值分别为15.4,13.7,7.9μM,与阳性对照Roscovitine相比表现出相当或更高效的活性。此外,化合物25对正常细胞BHK-21的毒性较低,ICso值为211μM。构效关系研究表明R,位置取代基的体积对活性影响很大,其中R位置为乙基时活性最优;R²位置为(R)-(-)-2-氨基-1-丁醇取代时比乙醇胺更利于活性;R,位置为合适取代的苄基时对活性有益,苄基上取代基位置对活性影响较大(3位>4位>2位)。进一步评价显示化合物25可有效诱导肿瘤细胞hepG2,A549和MCF-7调亡,调亡率分别为56.56%,38.20%,38.20%。综上,新型嘌呤衍生物25是一个高效低毒的抗肿瘤先导化合物,仍需进一步优化和开发。

关键词：癌症嘌呤抗肿瘤构效关系调亡

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Improving lipid production by Rhodotorula glutinis for renewable fuel production based on machine learning

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 23-35页

作者： Lihe zhang Changwei zhang Xi Zhao Changliu he xu zhang National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China Collage of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Bioprocess Beijing University of Chemical TechnologyBeijing 10029China

Microbial lipid fermentation encompasses intricate complex cell growth processes and heavily relies on expert experience for optimal *** modeling of the fermentation process assists researchers in making intelligent decisions,employing logical reasoning and strategic planning to optimize lipid *** this study,the effects of medium components and concen-trations on lipid fermentation were investigated,*** then,leveraging the collated data,a variety of machine learning algorithms were used to model and optimize the lipid fermentation *** models,based on artificial neural networks and support vector machines,achieved R?values all higher than 0.93,ensuring accurate predictions of the fermentation *** linear regression was used to evaluate the respective target parameter,which were affected by the medium components of lipid ***,single and multi-objective optimiza-tion were conducted for lipid fermentation using the genetic *** results demonstrated the maximum biomass of 50.3 g·L^(-1) and maximum lipid concentration of 14.1 g:L^(-1) with the error between the experimental and predicted values less than 5%.The results of the multi-objective optimization reveal the synergistic and competitive relationship between biomass,lipid concentration,and conversion rate,which lay a basis for in-depth optimization and amplification.

关键词： microbial lipid machine learning artificial neural network support vector machine genetic algorithm

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Experimental distillation of tripartite quantum steering with an optimal local filtering operation

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Photonics Research 2024年第3期12卷 552-562页

作者： QIAN-XI zhang XIAO-xu FANG he LU School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518057China

Multipartite Einstein-Podolsky-Rosen(EPR)steering admits multipartite entanglement in the presence of uncharacterized verifiers,enabling practical applications in semi-device-independent *** applications generally require stronger steerability,while the unavoidable noise weakens steerability and consequently degrades the performance of quantum information ***,we propose the local filtering operation that can maximally distill genuine tripartite EPR steering from N copies of three-qubit generalized Greenberger-Horne-Zeilinger states,in the context of two semi-device-independent *** optimal filtering operation is determined by the maximization of assemblage *** and numerical results indicate the advantage of the proposed filtering operation when N is finite and the steerability of initial assemblages is ***,a proof-of-principle demonstration of two-copy distillation is realized with the optical *** advantage of the optimal local filtering operation is confirmed by the distilled assemblage in terms of higher assemblage fidelity with perfectly genuine tripartite steerable assemblages,as well as the greater violation of the inequality to witness genuine tripartite steerable *** results benefit the distillation of multipartite EPR steering in practice,where the number of copies of initial assemblages is generally finite.

关键词： filtering distillation optimal

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Energy absorption behaviors of a novel buffer lander-leg with Yoshimura core

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Chinese Journal of Aeronautics 2024年第4期37卷 333-342页

作者： Yan xu he HUANG Chao zhang Rongji FU School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310027China School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical UniversityXi’an 710072China

In the current soft-landing system,the lander-leg and the buffer are two independent parts which may cause weight *** traditional mechanical buffers also have their own shortcomings such as small buffer stroke and being non-reusable.A Novel Buffer Lander-leg with Yoshimura core (NBLY) is proposed in this paper,inspired by the Buckling Restrained Brace(BRB).The design details of NBLY and parameter definitions of the core are *** finite element analysis modes have been employed to analyze the nonlinear mechanical behaviors of NBLY subjected to the cyclic *** with four different core styles of hexagon,octagon,dodecagon and hexadecagon are analyzed and *** restraining ratio and cumulative dissipation energy ratio have been obtained to evaluate the energy absorption *** results show that the origami pattern has significant influences on the deformation ductility,plastic energy absorbing and axial load transferring to the *** NBLY with octagon core has outstanding properties,especially the hysteretic energy dissipation and enhancement of compression *** interaction mechanism between the core and encasing member constrains the deformation extensions and contributes to the frictional energy dissipation of the *** paper provides a new conceptual design of buffer lander-leg for soft-landing *** can realize the reuse function as a buffer lander-leg with better loading-bearing and energy absorption behaviors.

关键词： Lander-leg structure Origami Energy absorption Cyclic loading Finite element analysis

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Underwater four-quadrant dual-beam circumferential scanning laser fuze using nonlinear adaptive backscatter filter based on pauseable SAF-LMS algorithm

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Defence Technology（防务技术） 2024年第7期37卷 1-13页

作者： Guangbo xu Bingting Zha Hailu Yuan Zhen Zheng he zhang Ministerial Key Laboratory of ZNDY Nanjing University of Science and TechnologyNanjing 210094China Science and Technology on Electromechanical Dynamic Control Laboratory Beijing 100081China Shanghai Radio Equipment Research Institute Shanghai 201109China

The phenomenon of a target echo peak overlapping with the backscattered echo peak significantly undermines the detection range and precision of underwater laser *** overcome this issue,we propose a four-quadrant dual-beam circumferential scanning laser fuze to distinguish various interference signals and provide more real-time data for the backscatter filtering *** enhances the algorithm loading capability of the *** order to address the problem of insufficient filtering capacity in existing linear backscatter filtering algorithms,we develop a nonlinear backscattering adaptive filter based on the spline adaptive filter least mean square(SAF-LMS)*** also designed an algorithm pause module to retain the original trend of the target echo peak,improving the time discrimination accuracy and anti-interference capability of the ***,experiments are conducted with varying signal-to-noise ratios of the original underwater target echo *** experimental results show that the average signal-to-noise ratio before and after filtering can be improved by more than31 d B,with an increase of up to 76%in extreme detection distance.

关键词： Laser fuze Underwater laser detection Backscatter adaptive filter Spline least mean square algorithm Nonlinear filtering algorithm

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Functional prediction of tomato PLATZ family members and functional verification of Sl PLATZ17

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Journal of Integrative Agriculture 2024年第1期23卷 141-154页

作者： Min xu Zhao Gao Dalong Li Chen zhang Yuqi zhang Qian he Yingbin Qi he zhang Jingbin Jiang Xiangyang xu Tingting Zhao College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region) Ministry of Agriculture and Rural AffairsHarbin 150030China

PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic ***,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource ***,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene *** this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were *** prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern *** genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene ***17 was selected for functional verification by experiment-based *** results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato *** plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was *** study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening.

关键词： tomato PLATZ family abiotic stresses plant development

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In-situ isothermal aging TEM analysis of a micro Cu/ENIG/Sn solder joint for flexible interconnects

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Journal of Materials Science & Technology 2024年第2期169卷 42-52页

作者： Jinhong Liu Jianhao xu Kyung-Wook Paik Peng he Shuye zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China Department of materials science and engineering KAIST291 Daehak-roYuseong-guDaejeon305-338Republic of Korea

Sn/ENIG has recently been used in flexible interconnects to form a more stable micron-sized metallurgical joint,due to high power capability which causes solder joints to heat up to 200℃.However,Cu_(6)Sn_(5)which is critical for a microelectronic interconnection,will go through a phase transition at temperatures between 186 and 189℃.This research conducted an in-situ TEM study of a micro Cu/ENIG/Sn solder joint under isothermal aging test and proposed a model to illustrate the mechanism of the microstructural *** results showed that part of the Sn solder reacted with Cu diffused from the electrode to formη´-Cu_(6)Sn_(5)during the ultrasonic bonding process,while the rest of Sn was left and enriched in a region in the solder *** the enriched Sn quickly diffused to both sides when the temperature reached 100℃,reacting with the ENIG coating and Cu to form(Ni_(x)Cu_(1-x))_(3)Sn_(4),AuSn_(4),and Cu_(6)Sn_(5)*** entering the heat preservation process,the diffusion of Cu from the electrode to the joint became more intense,resulting in the formation of Cu_(3)*** scallop-type Cu_(6)Sn_(5)and the seahorse-type Cu_(3)Sn constituted a typical two-layered structure in the solder *** importantly,the transition betweenηandη’was captured near the phase transition temperature for Cu_(6)Sn_(5)during both the heating and cooling process,which was accompanied by a volume shifting,and the transition process was further *** research is expected to serve as a reference for the service of micro Cu/ENIG/Sn solder joints in the electronic industry.

关键词： In-situ TEM observation Isothermal aging Micro Cu/ENIG/Sn solder joint Cu_(6)Sn_(5)phase transition

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Comparative evaluation of SPE methods for biotoxicity assessment of water and wastewater:Linkage between chemical extracting efficiency and biotoxicity outcome

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Journal of Environmental Sciences 2024年第8期142卷 33-42页

作者： Jiawei Zhou Shihao Wang Xiwei he Hongqiang Ren xu-Xiang zhang State Key Laboratory of Pollution Control and Resource Reuse School of EnvironmentNanjing UniversityNanjing 210023China

Biotoxicity assessment results of environmental waters largely depend on the sample extraction protocols that enrich pollutants to meet the effect-trigger thresholds of ***,more chemical mixture does not necessarily translate to higher combined ***,there is a need to establish the link between chemical extracting efficiency and biotoxicity outcome to standardize extraction methods for biotoxicity assessment of environmental *** study compares the performance of five different extraction phases in solid phase extraction(SPE),namely HLB,HLB+Coconut,C18 cartridge,C18 disk and Strata-X,and evaluated their chemical extracting efficiencies and biotoxicity *** quantitatively assessed cytotoxicity,acute toxicity,genotoxicity,estrogenic activity,and neurotoxicity of the extracts using in vitro bioassays and characterized the chemical extracting efficiencies of the SPE methods through chemical recoveries of 23 model compounds with different polarities and total organic *** Pareto ranking,we identified HLB+Coconut as the optimal SPE method,which exhibited the highest level of water sample biotoxicity and recovered the most chemicals in water *** found that the biotoxicity outcomes of the extracted water samples significantly and positively correlated with the chemical extracting efficiencies of the SPE ***,we observed synchronous changing patterns in biotoxicity outcome and chemical extracting efficiencies in response to increasing sample volumes per cartridge(SVPC)during *** findings underscore that higher chemical extracting efficiency of SPE corresponds to higher biotoxicity outcome of environmental water samples,providing a scientific basis for standardization of SPE methods for adequate assessment of biotoxicities of environmental waters.

关键词： Biotoxicity Chemical recovery Solid phase extraction Surface water Wastewater

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Dynamic responses of cable-stayed bridges to vehicular loading including the effects of the local vibration of cables

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第8期12卷 593-604页

作者： he zhang xu XIE Department of Civil Engineering Zhejiang University Hangzhou 310058 China

Stay cables, the primary load carrying components of cable-stayed bridges (CSBs), are characterised by high flexi-bility which increases with the span of the bridge. This makes stay cables vulnerable to local vibrations which may have significant effects on the dynamic responses of long-span CSBs. hence, it is essential to account for these effects in the assessment of the dynamics CSBs. In this paper, the dynamic responses of CSBs under vehicular loads are studied using the finite element method (FEM), while the local vibration of stay cables is analyzed using the substructure method. A case study of a cable-stayed steel bridge with a center span of 448 m demonstrates that stay cables undergo large displacements in the primary mode of the whole bridge although, in general, a cable’s local vibrations are not obvious. The road surface roughness has significant effects on the interaction force between the deck and vehicle but little effect on the global response of the bridge. Load impact factors of the main girder and tower are small, and the impact factors of the tension of cables are larger than those of the displacements of girders and towers.

关键词： Cable-stayed bridge(CSB) Vehicular load Local vibration of cable Impact effect

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