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Synthesis,characterization,and tunable wettability of poly (ionic liquid) brushes via nitroxide-mediated radical polymerization (NMP)

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Chinese Science Bulletin 2010年第31期55卷 3562-3568页

作者： YAG Wu he XiaoJing GAO JinZhang GUO Hao he XiaoYan WAN fei zhao XiuLi YU Yan PEI Ben College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou 730070 China

Well-defined poly(ionic liquid) brushes with tunable wettability are successfully synthesized via nitroxide-mediated radical polymerization.X-ray photoelectron spectroscopy,attenuated total reflection infrared spectroscopy and static water contact angle measurements are used to monitor each ***,nuclear magnetic resonance(1H and 13C) spectra and gel permeation chromatographic measurements reveal that there is a linear increase in polymer film thickness with polymerization time,indicating that chain growth from the surface is a controlled/"living" *** surface morphology was measured by atomic force ***,the surfaces of the poly(ionic liquid) brushes with tunable wettability and reversible switching between hydrophilicity and hydrophobicity can be easily achieved by counteranion exchange.

关键词：自由基聚合离子液体润湿性可调谐合成 NMP 表面形貌测量 X射线光电子能谱

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei zhao Ruoxuan Zheng Hongqiang Li Wei Chen Yu-fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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Multifunctional Nacre-Like Nanocomposite Papers for Electromagnetic Interference Shielding via heterocyclic Aramid/MXene Template-Assisted In-Situ Polypyrrole Assembly

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Xiong, Jinhua zhao, Xu Liu, Zonglin Chen, he Yan, Qian Lian, Huanxin Chen, Yunxiang Peng, Qingyu he, Xiaodong Harbin Inst Technol Ctr Composite Mat & Struct Natl Key Lab Sci & Technol Adv Composites Special Harbin 150080 Peoples R China

The large-scale, high-strength, super-tough, and multifunctional nacre-like heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite papers were fabricated using the in-situ assembly of PPy onto the HA/MXene hydrogel *** "brick-and-mortar" layered structure and abundant hydrogen-bonding interactions among MXene, PPy, and HA respond cooperatively to external stress and effectively increase the mechanical properties of HMP nanocomposite *** templating effect from HA/MXene was utilized to guide the assembly of conducting polymers, leading to high electrical conductivity and outstanding electromagnetic interference shielding performance. Robust, ultra-flexible, and multifunctional MXene-based electromagnetic interference (EMI) shielding nanocomposite films exhibit enormous potential for applications in artificial intelligence, wireless telecommunication, and portable/wearable electronic equipment. In this work, a nacre-inspired multifunctional heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper with large-scale, high strength, super toughness, and excellent tolerance to complex conditions is fabricated through the strategy of HA/MXene hydrogel template-assisted in-situ assembly of PPy. Benefiting from the "brick-and-mortar" layered structure and the strong hydrogen-bonding interactions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa), outstanding toughness (57.6 MJ m-3), exceptional foldability, and structural stability against ultrasonication. By using the template effect of HA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly, the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dB at an ultra-thin thickness (25.4 mu m) and a high specific EMI SE of 17,204.7 dB cm2 g-1. In addit

关键词： MXene Remarkable mechanical properties heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan fei Hao Wen zhao Yudan Gao zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong he Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

基于Web的高校教学工程项目管理平台的研究与实现

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电脑知识与技术 2017年第3期13卷 93-94,22页

作者：黄和飞赵榆琴大理大学教育评估中心云南大理671003 大理大学数学与计算机学院云南大理671003

为提高高校教学工程项目的管理水平和工作效率,依据大理大学的探索与实践,通过对教学工程项目管理的用户需求和业务流程进行详细分析的基础上,设计实现了基于Web的教学工程项目管理平台,实现了项目的信息化管理。有效地促进了项目管理... 详细信息

为提高高校教学工程项目的管理水平和工作效率,依据大理大学的探索与实践,通过对教学工程项目管理的用户需求和业务流程进行详细分析的基础上,设计实现了基于Web的教学工程项目管理平台,实现了项目的信息化管理。有效地促进了项目管理工作规范化、系统化,提高了工作效率,推动了高校教学管理的信息化建设。

关键词： Web 教学工程项目管理平台信息技术设计开发

乙醇对大鼠胃不同区域环行肌M受体和5-HT受体介导收缩反应的选择性抑制作用

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中国药理学通报 2016年第9期32卷 1242-1248页

作者：许文琪张贺飞都倩赵静夏红月任雷鸣河北医科大学中西医结合学院河北石家庄050017

目的利用大鼠胃不同区域环行肌标本,研究乙醇对M受体和5-HT受体介导的收缩反应是否具有选择性抑制作用。方法制备大鼠离体胃底、胃体、贲门和幽门环行肌标本,观察卡巴胆碱（carbachol,CCh）或5-羟色胺（5-hydroxytryptamine,5-HT）诱发... 详细信息

目的利用大鼠胃不同区域环行肌标本,研究乙醇对M受体和5-HT受体介导的收缩反应是否具有选择性抑制作用。方法制备大鼠离体胃底、胃体、贲门和幽门环行肌标本,观察卡巴胆碱（carbachol,CCh）或5-羟色胺（5-hydroxytryptamine,5-HT）诱发的收缩反应及乙醇的作用。结果体积分数为0.000 05~0.000 5的乙醇不影响CCh诱发的胃底和贲门环行肌收缩反应以及5-HT诱发的胃底和胃体环行肌收缩反应（P〉0.05）。但是0.000 1和0.000 5乙醇明显抑制了CCh诱发的胃体环行肌收缩,Emax值（g）由对照组的12.18±0.33降至10.88±0.41,-lg EC_（50）值由对照组的6.33±0.05降至6.12±0.06（P〈0.05）。同浓度乙醇明显抑制了CCh诱发的幽门环行肌收缩,Emax值（g）由对照组的2.87±0.15降至2.2±0.13,-lg EC_（50）值由对照组的6.49±0.10降至6.05±0.09（P〈0.01）。乙醇预处理贲门环行肌前,5-HT诱发贲门环行肌收缩的E_（max）值（g）是2.93±0.35,-lg EC_（50）值是6.17±0.21;体积分数为0.000 1和0.000 5的乙醇明显抑制了5-HT诱发的贲门环行肌收缩（P〈0.05）,其Emax值（g）降至2.1±0.30（P〈0.05）,-lg EC_（50）值未发生明显改变。结论乙醇对大鼠胃不同区域环行肌收缩功能的抑制强度是：乙醇仅抑制5-HT诱发的贲门收缩,对CCh诱发收缩的抑制强度为幽门大于胃体。在受体激动剂诱发环行肌收缩反应的抑制特点方面,乙醇对CCh的活性及其与受体的亲和力均有抑制作用,但是乙醇仅抑制5-HT的活性。

关键词：乙醇 M受体 5-HT受体胃体幽门贲门大鼠

经尿道等离子电切联合吡柔比星膀胱灌注治疗高龄高危非肌层浸润性膀胱癌

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国际泌尿系统杂志 2013年第4期33卷 453-455页

作者：何兆飞张君俊施东辉苏州市吴中人民医院泌尿外科江苏215128

目的探讨经尿道膀胱癌等离子电切术（PKRBT）联合吡柔比星（THP）治疗高龄高危非肌层浸润性膀胱癌的效果。方法对2008年9月至2012年2月本院17例高龄高危非肌层浸润性膀胱癌患者行经尿道膀胱肿瘤电切联合吡柔比星膀胱灌注治疗的综合措施... 详细信息

目的探讨经尿道膀胱癌等离子电切术（PKRBT）联合吡柔比星（THP）治疗高龄高危非肌层浸润性膀胱癌的效果。方法对2008年9月至2012年2月本院17例高龄高危非肌层浸润性膀胱癌患者行经尿道膀胱肿瘤电切联合吡柔比星膀胱灌注治疗的综合措施进行分析。结果全部患者治疗的短期效果好，能改善患者的生活质量，延长患者的生命。结论经PKRBT联合THP膀胱灌注治疗对高龄高危非肌层浸润性膀胱癌有较好的治疗效果，有望降低瘤荷，可作为高龄高危非肌层浸润性膀胱癌的较好的治疗方法。

关键词：膀胱肿瘤膀胱切除术表柔比星

基于等效质量计算方法的高压断路器传动系统理论研究

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电气开关 2017年第5期55卷 50-52页

作者：周文刘冬初胡标杨和赵斐库柏(宁波)电气有限公司浙江宁波315336

应用等效质量归算的理论方法,对不同运动类型的零部件的等效质量计算方法进行了阐述,介绍了不同运动类型零部件的转动惯量以及节点质量的计算方法,结合速度比,给出了运动部件等效质量的计算结果。在此基础上,以高压断路器的传动系统[1]... 详细信息

应用等效质量归算的理论方法,对不同运动类型的零部件的等效质量计算方法进行了阐述,介绍了不同运动类型零部件的转动惯量以及节点质量的计算方法,结合速度比,给出了运动部件等效质量的计算结果。在此基础上,以高压断路器的传动系统[1]为研究对象,建立了高压断路器传动系统的二维模型,对传动系统分闸过程中的质量变化情况进行了研究,给出了计算高压真空断路器传动系统的等效质量的理论方法。

关键词：运动等效质量转动惯量断路器传动