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Comparison of prognosis and postoperative morbidities between standard pancreaticoduodenectomy and the TRIANGLE technique for resectable pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 689-699页

作者： he-xing hang Zheng-Hua Cai Yi-Fei Yang Xu Fu Yu-Dong Qiu Hao Cheng Division of Pancreatic Surgery Department of General SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND Radical surgery combined with systemic chemotherapy offers the possibility of long-term survival or even cure for patients with pancreatic ductal adenocar-cinoma(PDAC),although tumor recurrence,especially locally,still inhibits the treatment *** TRIANGLE technique was introduced as an extended dissection procedure to improve the R0 resection rate of borderline resectable or locally advanced ***,there was a lack of studies concerning postoperative complications and long-term outcomes of this procedure on patients with resectable *** Patients with resectable PDAC eligible for PD from our hospital between June 2018 and December 2021 were enrolled in this retrospective cohort *** the patients were divided into PDstandard and PDTRIANGLE groups according to the surgical *** characteristics,surgical data,and postoperative morbidities were *** of the patients were followed up,and the date and location of tumor recurrence,and death were *** Kaplan-Meier method and log-rank test were used for the survival *** There were 93 patients included in the study and 37 underwent the TRIANGLE *** of operation was longer in the PDTRIANGLE group compared with the PDstandard group[440(410-480)min vs 320(265-427)min](P=0.001).Intraoperative blood loss[700(500-1200)mL vs 500(300-800)mL](P=0.009)and blood transfusion[975(0-1250)mL vs 400(0-800)mL](P=0.009)were higher in the PDTRIANGLE *** was a higher incidence of surgical site infection(43.2%vs 12.5%)(P=0.001)and postoperative diarrhea(54.1%vs 12.5%)(P=0.001)in the PDTRIANGLE *** rates of R0 resection and local recurrence,overall survival,and disease-free survival did not differ significantly between the two *** The TRIANGLE technique is safe,with acceptable postoperative morbidities compared with standardized PD,but it does not improve prognosis for patients with resectable PDAC.

关键词： Pancreatic ductal adenocarcinoma TRIANGLE technique Pancreaticoduodenectomy Prognosis Postoperative morbidities

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Nrf2-mediated ferroptosis of spermatogenic cells involved in male reproductive toxicity induced by polystyrene nanoplastics in mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 307-323页

作者： Xufeng FU hang HAN Hong YANG Bo XU Wenjie DAI Ling LIU Tiantian he xing DU Xiuying PEI Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education School of Basic Medical SciencesNingxia Medical UniversityYinchuan 750004China Key Laboratory of Reproduction and Genetics in Ningxia Ningxia Medical UniversityYinchuan 750004China

Microplastics(MPs)and nanoplastics(NPs)have become hazardous materials due to the massive amount of plastic waste and disposable masks,but their specific health effects remain *** this study,fluorescence-labeled polystyrene NPs(PS-NPs)were injected into the circulatory systems of mice to determine the distribution and potential toxic effects of NPs in ***,whole-body imaging found that PS-NPs accumulated in the testes of ***,the toxic effects of PS-NPs on the reproduction systems and the spermatocytes cell line of male mice,and their mechanisms,were *** oral exposure to PS-NPs,their spermatogenesis was affected and the spermatogenic cells were *** spermatocyte cell line GC-2 was exposed to PS-NPs and analyzed using RNA sequencing(RNA-seq)to determine the toxic mechanisms;a ferroptosis pathway was found after PS-NP *** phenomena and indicators of ferroptosis were then determined and verified by ferroptosis inhibitor ferrostatin-1(Fer-1),and it was also found that nuclear factor erythroid 2-related factor 2(Nrf2)played an important role in spermatogenic cell ferroptosis induced by ***,it was confirmed in vivo that this mechanism of Nrf2 played a protective role in PS-NPs-induced male reproductive *** study demonstrated that PS-NPs induce male reproductive dysfunction in mice by causing spermatogenic cell ferroptosis dependent on Nrf2.

关键词： Polvstyrene nanoplastics(PS-NPs) Reproductive toxicity Ferroptosis Nuclear factor ervthroid 2-related factor 2(Nrf2)

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Image Segmentation-P300 Selector: A Brain–Computer Interface System for Target Selection

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Computers, Materials & Continua 2024年第5期79卷 2505-2522页

作者： hang Sun Changsheng Li he Zhang Mechanical Engineering Nanjing University of Science and TechnologyNanjing210018China

Brain–computer interface (BCI) systems, such as the P300 speller, enable patients to express intentions withoutnecessitating extensive ***, the complexity of operational instructions and the slow pace of characterspelling pose challenges for some patients. In this paper, an image segmentation P300 selector based on YOLOv7-mask and DeepSORT is proposed. The proposed system utilizes a camera to capture real-world objects forclassification and tracking. By applying predefined stimulation rules and object-specificmasks, the proposed systemtriggers stimuli associated with the objects displayed on the screen, inducing the generation of P300 signals in thepatient’s brain. Its video processing mechanism enables the system to identify the target the patient is focusing oneven if the object is partially obscured, overlapped, moving, or changing in number. The system alters the target’scolor display, thereby conveying the patient’s intentions to caregivers. The data analysis revealed that the selfrecognitionaccuracy of the subjects using this method was between 92% and 100%, and the cross-subject P300recognition precision was 81.9%–92.1%. This means that simple instructions such as “Do not worry, just focuson what you desire” effectively discerned the patient’s intentions using the Image Segmentation-P300 selector. Thisapproach provides cost-effective support and allows patients with communication difficulties to easily express theirneeds.

关键词： Brain-computer interface deep learning electroencephalogram P300 YOLOv7-mask

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Capacitor Voltage Imbalance Mechanism and Balancing Control of MMC When Riding Through PTG Fault

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 778-785页

作者： Zhen he Maozeng Lu Lijun hang Pingliang Zeng Yanhua Liu hangzhou Dianzi University Hangzhou 310018China Shandong University of Technology Zibo 255000China State Grid hangzhou Power Supply Company State GridHangzhou 310000China

Modular multilevel converter (MMC) based fault ride through (FRT) control is a promising solution to deal with the pole-to-ground (PTG) fault in high voltage direct current (HVDC) system. However, when MMC switches to the FRT control, capacitor voltage imbalance between upper and lower arms will occur, resulting in the deterioration of FRT performance. This letter provides a comprehensive analysis for the imbalance issue from the perspective of fundamental frequency circulating current (FFCC). It is found the imbalance during FRT stage will not expand continuously, but converge to a certain value gradually. The specific imbalance degree is closely associated with the amplitude of FFCC. In order to solve the imbalance issue, an open-loop balancing control is proposed. By introducing a fundamental frequency feedforward item to the inherent circulating current control, the proposed method can not only balance the capacitor voltages, but also minimize the amplitude of FFCC, and consequently the power loss of MMC during FRT process can be reduced. Finally, simulation results of PSCAD/ EMTDC verify the validity of theoretical analysis.

关键词： Balancing control capacitor voltage imbalance FFCC FRT control HVDC system PTG fault

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Nitrogen-doped titanium dioxide/schwertmannite nanocomposites as heterogeneous photo-Fenton catalysts with enhanced efficiency for the degradation of bisphenol A

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Journal of Environmental Sciences 2024年第9期143卷 1-11页

作者： xing-xing Qiao Yu-hang Xu Xiang-Ji Liu Sai-Le Chen Zhou Zhong Ya-Feng Li Jian Lü Fujian Provincial Key Laboratory of Soil Environmental health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

Potential health risks related to environmental endocrine disruptors(EEDs)have aroused research hotspots at the forefront of water treatment ***,nitrogen-doped titanium dioxide/schwertmannite nanocomposites(N-TiO_(2)/SCH)have been successfully developed as heterogeneous catalysts for the degradation of typical EEDs via photo-Fenton *** to the sustainable Fe(Ⅲ)/Fe(Ⅱ)conversion induced by photoelectrons,as-prepared N-TiO_(2)/SCH nanocomposites exhibit much enhanced efficiency for the degradation of bisphenol A(BPA;ca.100% within 60 min under visible irradiation)in a wide pH range of 3.0-7.8,which is significantly higher than that of the pristine schwertmannite(ca.74.5%)or N-TiO_(2)(ca.10.8%).In this photo-Fenton system,the efficient degradation of BPA is mainly attributed to the oxidation by hydroxyl radical(·OH)and singlet oxygen(^(1)O_(2)).Moreover,the possible catalytic mechanisms and reaction pathway of BPA degradation are systematically investigated based on analytical and photoelectrochemical *** work not only provides a feasible means for the development of novel heterogeneous photo-Fenton catalysts,but also lays a theoretical foundation for the potential application of mineral-based materials in wastewater treatment.

关键词： Titanium dioxide Schwertmannite Fenton reaction Environmental endocrine disruptors Photocatalysis

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Fractional order distance regularized level set method with bias correction

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 64-82页

作者： Cai Xiumei he Ningning Wu Chengmao Liu Xiao Liu hang School of Automation Xi'an University of Posts and TelecommunicationsXi'an 710121China School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

The existing level set segmentation methods have drawbacks such as poor convergence,poor noise resistance,and long iteration *** this paper,a fractional order distance regularized level set segmentation method with bias correction is *** method firstly introduces fractional order distance regularized term to punish the deviation between the level set function(LSF)and the signed distance *** a series of covering template is constructed to calculate fractional derivative and its conjugate of image *** introducing the offset correction term and fully using the local clustering property of image intensity,the local clustering criterion of image intensity is defined and integrated with the neighborhood center to obtain the global criterion of image ***,the fractional distance regularization,offset correction,and external energy constraints are combined,and the energy optimization segmentation method for noisy image is established by level *** results show that the proposed method can accurately segment the image,and effectively improve the efficiency and robustness of exiting state of the art level set related algorithms.

关键词： image segmentation fractional order distance regularization level set function fractional derivative bias correction

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Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

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Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su Le Chang Guanzhong Jiao Yang Ou Mei Yang Chao Xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming he xing Wang Deng hang he School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain *** reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related *** interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in *** compartment domain(CD)boundaries,the distal interactions were more in hybrids than their *** the hybrids of CURLY LEAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower ***-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance *** addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop *** findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

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Super-resolution diffractive neural network for alloptical direction of arrival estimation beyond diffraction limits

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Light(Science & Applications) 2024年第8期13卷 1602-1614页

作者： Sheng Gao hang Chen Yichen Wang Zhengyang Duan Haiou Zhang Zhi Sun Yuan Shen xing Lin Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China

Wireless sensing of the wave propagation direction from radio sources lays the foundation for communication,radar,navigation,***,the existing signal processing paradigm for the direction of arrival estimation requires the radio frequency electronic circuit to demodulate and sample the multichannel baseband signals followed by a complicated computing process,which places the fundamental limit on its sensing speed and energy ***,we propose the super-resolution diffractive neural networks(S-DNN)to process electromagnetic(EM)waves directly for the DOA estimation at the speed of *** multilayer meta-structures of S-DNN generate super-oscillatory angular responses in local angular regions that can perform the all-optical DOA estimation with angular resolutions beyond the diffraction *** spatial-temporal multiplexing of passive and reconfigurable S-DNNs is utilized to achieve high-resolution DOA estimation over a wide field of *** S-DNN is validated for the DOA estimation of multiple radio sources over 5 GHz frequency bandwidth with estimation latency over two to four orders of magnitude lower than the state-of-the-art commercial devices in *** results achieve the angular resolution over an order of magnitude,experimentally demonstrated with four times,higher than diffraction-limited *** also apply S-DNN’s edge computing capability,assisted by reconfigurable intelligent surfaces,for extremely low-latency integrated sensing and communication with low power *** work is a significant step towards utilizing photonic computing processors to facilitate various wireless sensing and communication tasks with advantages in both computing paradigms and performance over electronic computing.

关键词： beyond optical network

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Fabricating functionally graded Fe-Cr-Co permanent magnetic alloys via laser powder bed fusion

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Journal of Iron and Steel Research International 2024年第3期31卷 729-737页

作者： Ya-zhou he Ya-qing Hou Peng Shen Hao Zhang Dong Zhou hang Su Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Material Digital R&D Center China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-situ alloying technology offers the possibility to construct gradient materials with varied structures and *** graded Fe-Cr-Co permanent magnetic alloys were fabricated by LPBF and in-situ alloying mixed powders of Fe,Cr,and Co *** effects of different Fe,Cr and Co contents on the microstructure,magnetic properties and hardness of Fe-Cr-Co alloys prepared by LPBF were *** as-built Fe-Cr-Co alloys present a single body-centered-cubic phase and have a homogeneous distribution of *** mechanical properties and magnetic properties of the compositionally graded sample show a gradient *** the increase in Cr content,the Vickers hardness of the sample increases,and the saturation magnetization of the sample *** optimal magnetic properties in an isotropic state are given as coercivity HcB=21.65 kA/m,remanence Br=0.70 T and energy product(BH)_(max)=5.35 kJ/m^(3),which are comparable to or higher than the reported magnetic properties in an isotropic state prepared by traditional powder *** in-situ alloying technology has the potential to further explore Fe-Cr-Co magnetic materials,such as those consisting of multiple or more constituent elements,and to maximize the compositional flexibility of magnetic materials.

关键词： Fe-Cr-Co alloy Laser powder bed fusion In-situ alloying Functional material Magnetic property

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Seabed structures and foundations related to deep-sea resource development:A review based on design and research

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Deep Underground Science and Engineering 2024年第2期3卷 131-148页

作者： Shengjie Rui Haojie Zhang hang Xu xing Zha Mengtao Xu Kanmin Shen Key Laboratory of Offshore Geotechnics and Material of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhouChina Advanced Modelling Offshore EnergyNorwegian Geotechnical InstituteOsloNorway Geotechnical Technology Center(Overseas Engineering Center) PowerChina Huadong Engineering Corporation LimitedHangzhouChina

The deep‐sea ground contains a huge amount of energy and mineral resources,for example,oil,gas,and *** infrastructures such as floating structures,seabed structures,and foundations have been developed to exploit these *** seabed structures and foundations can be mainly classified into three types:subsea production structures,offshore pipelines,and *** study reviewed the development,installation,and operation of these infrastructures,including their structures,design,installation,marine environment loads,and *** this basis,the research gaps and further research directions were explored through this literature ***,different floating structures were briefly analyzed and reviewed to introduce the design requirements of the seabed structures and ***,the subsea production structures,including subsea manifolds and their foundations,were reviewed and ***,the basic characteristics and design methods of deep‐sea pipelines,including subsea pipelines and risers,were analyzed and ***,the installation and bearing capacity of deep‐sea subsea anchors and seabed trench influence on the anchor were *** the review,it was found that marine environment conditions are the key inputs for any offshore structure *** fabrication,installation,and operation of infrastructures should carefully consider the marine loads and geological *** structures have their own mechanical *** fatigue and stability of pipelines mainly depend on the soil‐structure *** selection should consider soil types and possible trench *** focuses and research gaps can provide a helpful guide on further research,installation,and operation of deep‐sea structures and foundations.

关键词： anchors floating structures pipelines risers subsea foundations

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