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Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-Yue Tang Xue Shen Run-Sheng Yuan Hui-Yuan Li xin-Wei Li Yi-Ming Jing Yue Zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-Chuan Yang he-xin wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy hepatocellular carcinoma

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Protective efficacy of an H5/H7 trivalent inactivated vaccine(H5-Re13,H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses

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Journal of Integrative Agriculture 2022年第7期21卷 2086-2094页

作者： ZENG Xian-ying he xin-wen MENG Fei MA Qi WANG Yan BAO Hong-mei LIU Yan-jing DENG Guo-hua SHI Jian-zhong LI Yan-bing TIAN Guo-bin CheN Hua-lan State Key Laboratory of Veterinary Biotechnology National Poultry Laboratory Animal Resource CenterHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Some H5 viruses isolated in poultry or wild birds between 2020 and 2021 were found to be antigenically different from the vaccine strains(H5-Re11 and H5-Re12) used in China. In this study, we generated three new recombinant vaccine seed viruses by using reverse genetics and used them for vaccine production. The vaccine strain H5-Re13 contains the hemagglutinin(HA) and neuraminidase(NA) genes of an H5 N6 virus that bears the clade 2.***.4.4 h HA gene, H5-Re14 contains the HA and NA genes of an H5 N8 virus that bears the clade 2.***.4.4 b HA gene, and H7-Re4 contains the HA and NA genes of H7 N9 virus detected in 2021. We evaluated the protective efficacy of the novel H5/H7 trivalent inactivated vaccine in chickens, ducks, and geese. The inactivated vaccine was immunogenic and induced substantial antibody responses in the birds tested. Three weeks after vaccination, chickens were challenged with five different viruses detected in 2020 and 2021: three viruses(an H5 N1 virus, an H5 N6 virus, and an H5 N8 virus) bearing the clade 2.***.4.4 b HA gene, an H5 N6 virus bearing the clade 2.***.4.4 h HA gene, and an H7 N9 virus. All of the control birds shed high titers of virus and died within 4 days post-challenge, whereas the vaccinated chickens were completely protected from these viruses. Similar protective efficacy against H5 viruses bearing the clade 2.***.4.4 h or 2.***.4.4 b HA gene was observed in ducks and geese. Our study indicates that the newly updated H5/H7 vaccine can provide solid protection against the H5 and H7 N9 viruses that are currently circulating in nature.

关键词： avian influenza H5/H7 trivalent vaccine H5-Re13 H5-Re14 H7-Re4 strains protective efficacy chickens ducks and geese

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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清谈与赋谈——从《世说新语》看两晋士人的辞赋评论

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湖北大学学报(哲学社会科学版) 2009年第5期36卷 33-38页

作者：何新文湖北大学文学院

《世说新语》所载两晋名士清谈,既谈玄理,也谈辞赋。谈赋的形式有赋家自评、作者与读者间的论辩,还有读赋会式的研讨;赋谈内容包括赋的思想艺术、人物品藻、模拟与创新及言意之辨等命题。两晋士人赋谈关注"当代"赋的创作,影响了社会重... 详细信息

《世说新语》所载两晋名士清谈,既谈玄理,也谈辞赋。谈赋的形式有赋家自评、作者与读者间的论辩,还有读赋会式的研讨;赋谈内容包括赋的思想艺术、人物品藻、模拟与创新及言意之辨等命题。两晋士人赋谈关注"当代"赋的创作,影响了社会重赋风气的形成,促进了赋的创作和传播;同时,因其充满玄理意蕴,注重赋篇的整体风貌,给读者留有充分的接受空间,具有明显的时代特征和审美意味。

关键词：《世说新语》两晋士人清谈赋谈

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电子商务环境下我国林业企业管理创新研究

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生态经济 2007年第7期23卷 125-127页

作者：贺新闻西南林学院教务处昆明650224

伴随着全球信息化浪潮,人们在共享与交流信息方面摆脱了时空的束缚,传统林业企业管理模式受到极大的冲击与挑战,林业企业必须加快各方面的改革创新,以便在网络经济时代的电子商务环境下掌握市场的主动权,提高企业的竞争优势。本文在简... 详细信息

伴随着全球信息化浪潮,人们在共享与交流信息方面摆脱了时空的束缚,传统林业企业管理模式受到极大的冲击与挑战,林业企业必须加快各方面的改革创新,以便在网络经济时代的电子商务环境下掌握市场的主动权,提高企业的竞争优势。本文在简析电子商务内涵及特征的基础上,强调了我国林业企业管理创新的紧迫性,并从组织结构、交易流程、市场营销三方面对电子商务环境下的我国林业企业管理创新进行了深入探讨和研究。

关键词：电子商务林业企业管理创新

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槽波地震勘探在煤层构造探测中的应用

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煤炭技术 2017年第2期36卷 99-102页

作者：何文欣中国矿业大学资源与地球科学学院江苏徐州221116 中煤科工集团西安研究院有限公司西安710077

以槽波形成机理及传播规律为基础,进行透射槽波能量分析,探讨了槽波衰减规律,并得出槽波透射与断层断距的关系。在透射能量能穿透工作面的基础之上,采用透射槽波能量层析成像方法对工作面煤层进行成像,得出工作面槽波能量成像构造解释图... 详细信息

以槽波形成机理及传播规律为基础,进行透射槽波能量分析,探讨了槽波衰减规律,并得出槽波透射与断层断距的关系。在透射能量能穿透工作面的基础之上,采用透射槽波能量层析成像方法对工作面煤层进行成像,得出工作面槽波能量成像构造解释图;根据槽波在煤层中传播的槽波频率变化规律,得到煤层厚度的变化平面图。结果与实际地质资料吻合较好。

关键词：槽波煤层衰减系数层析成像断层

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Outcomes of Chinese Patients with End-stage Pulmonary Disease while Awaiting Lung Transplantation： A Single-center Study

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Chinese Medical Journal 2016年第1期129卷 3-7页

作者： wen-xin he Yu-Ling Yang Yan Xia Nan Song Ming Liu Peng Zhang Jiang Fan Ge-Ning Jiang Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 China Department of heart and Thoracic Surgery Zhangzhou Affiliated Hospital of Fujian Medical University Zhangzhou Fujian 363000 China

Background： The factors affecting the outcome of patients referred for lung transplantation （LTx） still have not been investigated extensively. The aim of this study was to characterize the patient outcomes and identify the prognostic factors for death while awaiting the LTx. Methods： From January 2003 to November 2013, the clinical data of 103 patients with end-stage lung disease that had been referred for LTx to Department of Thoracic Surgery, Shanghai Pulmonary Hospital were analyzed retrospectively. The relationship between predictors and survival was evaluated using the Kaplan-Meier method and the Cox proportional hazards model. Results： Twenty-five patients （24.3%） died while awaiting the LTx. Fifty patients （48.5%） underwent LTx, and 28 patients （27.2%） were still on the waitlist. Compared to the candidates with chronic obstructive puhnonary disease （COPD）, patients with idiopathic pulmonary fibrosis （IPF） had a higher mortality while awaiting the LTx （40.0% vs. 12.3%, P= 0.003）. Patients requiring mechanical ventilation （MV） had a higher mortality while waiting than others （50.0% vs. 20.2%, P = 0.038）. Two variables, using MV and IPF but not COPD as primary disease, emerged as significant independent risk factors for death on the waitlist （hazard ratio [HR] 56.048, 95% confidence interval [CI]： 3.935-798.263, P= 0.003 and MR = 14.859, 95% CI： 2.695 81.932, P= 0.002, respectively）. Conclusion： The type of end-stage lung disease, pulmonary hypertension, and MV may be distinctive prognostic factors for death while awaiting the LTx.

关键词： End-stage Lung Disease: Lung Transplantation Prognosis: Waitlist

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建设性争辩、真实型领导对工作重塑与创新的影响

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软科学 2021年第4期35卷 99-105页

作者：何文心刘新梅西安交通大学管理学院西安710049 西安交通大学过程控制与效率工程教育部重点实验室西安710049

基于人—环境匹配理论和主动行为动机理论,从社会互动视角探讨了员工工作重塑的驱动因素及其对员工创新的影响。通过对435名员工样本数据的实证研究,结果表明:建设性争辩能够激发工作重塑;工作重塑正向影响创新行为;工作重塑可以中介建... 详细信息

基于人—环境匹配理论和主动行为动机理论,从社会互动视角探讨了员工工作重塑的驱动因素及其对员工创新的影响。通过对435名员工样本数据的实证研究,结果表明:建设性争辩能够激发工作重塑;工作重塑正向影响创新行为;工作重塑可以中介建设性争辩与员工创新行为之间的关系;员工感知的真实型领导力对建设性争辩与工作重塑的关系以及工作重塑的中介作用具有正向调节作用。

关键词：工作重塑建设性争辩真实型领导员工创新行为

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Lung transplantation in a Chinese single center： 7 years of experience

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Chinese Medical Journal 2011年第7期124卷 978-982页

作者： he wen-xin JIANG Ge-ning DING Jia-an GAO wen ZHU Yu-ming ZHOU Xiao CheN Chang WANG Hao FAN Jiang ZHANG Peng LIU Ming Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of Medicine Shanghai Key Laboratoryof Organ Transplantation Shanghai 200433 China

Background Lung transplantation （LT） is a viable option for patients with end-stage lung diseases, but in China, the supply is limited, and the experience with LT is rare too. This study aimed to evaluate the surviv... 详细信息

关键词： lung transplantation China survival complications

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元明两代赋论述略

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湖北大学学报(哲学社会科学版) 2006年第6期33卷 710-714页

作者：何新文湖北大学文学院湖北武汉430062

元明两代,以祝尧、刘埙、王世贞、胡应麟、陈山毓、张溥等人为代表的赋论十分活跃。元明两代赋论,以“祖骚宗汉”的复古理论倾向为主流,而与当时的学术及文学思潮相联系,表现出承前启后的历史风貌,在古代赋论史上具有重要的地位。

关键词：元明赋论复古倾向成就特点

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