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Frontiers of Medicine 2010年第2期4卷 204-207页

作者： Fu-Rong WEI Shan LV he-xiang liu Ling HU Yi ZHANG Department of Vector Control National Institute of Parasitic DiseaseChinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector Biology of the Ministry of HealthShanghai 200025China

Poolingﬁeld specimens could reduce the number of assay and thus increase the efﬁciency in detecting and screening pathogen infections by polymerase chain reaction(PCR)-based *** investigated a pooling strategy in diagnosis of Angiostrongylus canto-nensis in Pomacea *** settings of speci-mens were prepared,divided into portions and detected by multiplex *** A was 0.4490 g positive lung tissue of 28 larval nodes from four snails mixed with 1.310 g negative lung tissue from six snails and divided into 32 *** B was 0.5448 g positive lung tissue with 26 larval nodes from two snails mixed with 1.092 g negative lung tissue from seven snails and divided into 48 *** sampling was performed and sample size-accumulated positive rate curves were *** to the sample size-accumulated positive rate curves,the appropriate sample size of the two specimens were 18 and 15,respectively,which is 0.36–0.58 to the total sample *** test characteristics and the relevant factors to the sample size would need to be determined in much larger studies and more appropriately inﬁeld *** result indicates that the number of larval node is not the most important,nor the only factor to the sample *** also implies the feasibility to detect *** in *** by pooling strategies.

关键词： Angiostrongylus cantonensis Pomacea cana-liculata multiplex polymerase chain reaction diagnosis pooling

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu xiang Renrui Niu Xiaodong he Wenqi Luo Wanguo liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Design and experiment of a laser ionization source for ion mobility spectrometer

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Optoelectronics Letters 2006年第5期2卷 399-402页

作者： JI .Ren-dong KONG xiang-he liu Xian-yun ZHANG Shu-dong College of Physics and Engineering Qufu Normal University Qufu 273165. China

The fabrication and characterization of a laser ionization source for ion mobility spectrometer （IMS） is described with the calculated parameter of the drift tube. Ions are created in air at ambient pressure using laser ionization （ A = 248 nm） with air as the drift gas. Mobility spectra for positive ions at different electric fields are obtained with the length of drift tube of 25 and 50 mm, respectively. The distribution of the electric field in the drift tube （50 mm） has also been investigated by SIMION simulation with the ion shutter closed and open respectively.

关键词：激光电离源离子运动迁移率分光计

Small-scale spatial analysis of intermediate and definitive hosts of Angiostrongylus cantonensis

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Infectious Diseases of Poverty 2018年第1期7卷 1053-1063页

作者： Qiu-An Hu Yi Zhang Yun-Hai Guo Shan Lv Shang Xia he-xiang liu Yuan Fang Qin liu Dan Zhu Qi-Ming Zhang Chun-Li Yang Guang-Yi Lin National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchShanghai 200025China WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical DiseasesMinistry of Science and TechnologyShanghai 200025China Key Laboratory of Parasite and Vector Biology Ministry of HealthShanghai 200025China Centre for Disease Control and Prevention of Guangdong Province Guangzhou 510300China Shanghai Medical College Fudan UniversityShanghai 200032China

Background:Angiostrongyliasis is a food-borne parasitic *** infection is caused by infection with the third-stage larvae of Angiostrongylus *** life cycle of *** involves rodents as definitive hosts and molluscs as intermediate *** study aims to investigate on the infection status and characteristics of spatial distribution of these hosts,which are key components in the strategy for the prevention and control of ***:Three villages from Nanao Island,Guangdong Province,China,were chosen as study area by stratified random *** density and natural infection of Pomacea canaliculata and various rat species were surveyed every three months from December 2015 to September 2016,with spatial correlations of the positive *** and the infection rates analysed by ArcGIS,scan statistics,ordinary least squares(OLS)and geographically weighted regression(GWR)***:A total of 2192 *** specimens were collected from the field,of which 1190 were randomly chosen to be examined for third-stage larvae of ***-two Angiostrongylus-infected snails were found,which represents a larval infection rate of 6.1%(72/1190).In total,110 rats including 85 Rattus norvegicus,10 ***,one *** and 14 Suncus murinus were captured,and 32 individuals were positive(for adult worms),representing an infection rate of 29.1%of the definitive hosts(32/110).Worms were only found in *** and ***,representing a prevalence of 36.5%(31/85)and 10%(1/10),respectively in these species,but none in *** and ***,despite testing as many as 32 of the latter ***,spatial correlation and spatial clusters in the spatial distribution of positive *** and positive rats *** of the spatial variability of the host infection rates came from spatial *** spatial clusters with respect to positive *** were identified,but on

关键词： Angiostrongylus cantonensis Snail intermediate host Pomacea canaliculata Rat definitive host Spatial analysis

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu xiang Li Shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui Chang xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

High-resolution imaging through dynamic scattering media: Iterative optimization based on polarimetric characteristics

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Science China Technological Sciences 2025年第1期 82-84页

作者： Meng xiang Kai DENG Tianyu WANG Jinpeng liu Xue DONG Teli XI Fei liu Xiaopeng SHAO School of Optoelectronic Engineering Xidian University Xi'an Key Laboratory of Computational Imaging National Key Laboratory of Infrared Detection Technologies

High-resolution imaging through randomly dynamic scattered fields and highly scattered walls is an extensively sought-after capability with potential applications in various fields such as underwater imaging, biomedical imaging, and seeing through fog. Numerous methods have been proposed to unscramble object information from degraded scattered images, resulting in considerable improvements in image contrast in degraded scenarios [1].

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质子泵抑制剂预防老年脑出血患者应激性溃疡管理与干预效果的回顾性研究

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中国新药与临床杂志 2016年第9期35卷 669-673页

作者：雷海波郭小兰龙靓李伟贺湘萍刘湘湘潭市中心医院药学部湖南湘潭411100

目的研究质子泵抑制剂(PPIs)预防老年脑出血患者应激性溃疡的合理化管理与干预效果。方法收集本院PPIs管理与干预前(2013年)神经内科老年脑出血患者预防使用PPIs病历119份,及PPIs管理与干预后(2014年)老年脑出血患者预防使用PPIs病历133... 详细信息

目的研究质子泵抑制剂(PPIs)预防老年脑出血患者应激性溃疡的合理化管理与干预效果。方法收集本院PPIs管理与干预前(2013年)神经内科老年脑出血患者预防使用PPIs病历119份,及PPIs管理与干预后(2014年)老年脑出血患者预防使用PPIs病历133份,比较干预前后PPIs使用与应激性溃疡发生情况。结果老年脑出血患者平均预防使用PPIs的时间由干预前的(9.6±5.6)d下降到(5.2±3.5)d,差异有显著意义(P0.05)。结论通过对PPIs的使用进行管理与干预后,PPIs预防老年脑出血患者应激性溃疡的用药情况明显改善。

关键词：质子泵抑制剂老年人脑出血回顾性研究

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng liu Changyu Zhang Zipeng Li Wanying Ma Jia liu xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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