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Evaluation of the therapeutic significance of Glehniae Radix polysaccharides on the ulcerative colitis through DSS-induced rat model

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Food Science and Human Wellness 2025年

作者： Jie Liu Xufang geng Yuxin Yang Jiao Xu Haoran Feng Tianshuo Zhang Guangzhao Zhou Man Wang Changshun Wang Dongsheng Jia Yuting Chen Bin Cong Ding Zhao The Postdoctoral Mobile Station of Basic Medicine， hebei Medical University The Department of Pharmacognosy， School of Pharmacy， hebei Medical University hebei Key Laboratory of Forensic Medicine， College of Forensic Medicine， hebei Medical University

Glehniae Radix has a wide range of pharmaceutical applications， and research on its main components has mainly focused on coumarins， alkaloids， lignans， and flavonoids， while neglecting the research on polysaccharides. Literature reports and our previous studies have shown that polysaccharides have certain therapeutic significance in immune regulation， antioxidant， anti-inflammatory and other aspects. herein， the rat model of ulcerative colitis (UC) was established to evaluate the anti-inflammatory efficacy of the prepared Glehniae Radix polysaccharide (GLP) from the perspectives of inflammatory factors， intestinal tissue morphology， and microflora changes. The polysaccharides are mainly composed of galacturonic acid， rhamnose， glucose， galactose， and arabinose in molar ratios of 1.4:9.2:33.3:2.5:2.9， and GLP could downregulate the expression pro-inflammatory factors (interleukin-6， tumor necrosis factor-α， and interferon-γ) and significantly upregulate the expression of anti-inflammatory factor (interleukin-10). In addition， Glehniae Radix aqueous extract (GLA)， GLP with low dosage (GLPL) and GLP with high dosage (GLPH) could increase the number of goblet cells， enhance the integrity of crypt structure， and reverse the status of inflammatory infiltrating cells. Moreover， GLA and GLPH could upregulate Lactobacillus and Lachnoclostridium in UC rats， and appropriately downregulate Lachnospiraceae＿NK4A136＿group， thereby optimizing the proportion of bacterial flora and improving the intestinal microbial environment. Our findings not only be valuable as theoretical materials for the further clinical applications of GLP， but the identified biomarkers and metabolic pathways also provide new clues for the diagnosis of UC.

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Grammian Determinant Solution and Pfaffianization for a (3+1)-Dimensional Soliton Equation

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Communications in Theoretical Physics 2009年第11期52卷 791-794页

作者： WU Jian-ping geng Xian-Guo2 Institute of Electronic Technology Information Engineering University Zhengzhou 450004 China Department of Mathematics Zhengzhou University Zhengzhou 450052 China

Based on the Pfaffian derivative formulae,a Grammian determinant solution for a(3+1)-dimensionalsoliton equation is ***,the Pfaffianization procedure is applied for the equation to generate a newcoupled *** last,a Gra... 详细信息

关键词： (3+1)-dimensional soliton equation Grammian determinant solution Pfaffianization Gram-type Pfaffian solution

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A newly designed big cup nitinol stent for gastric outlet obstruction

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World Journal of Gastroenterology 2010年第33期16卷 4206-4209页

作者： Ding Shi Sheng-Hui Liao Jian-ping geng Department of Gastroenterology the First People’s Hospital of Yuhang District Hangzhou 311100 Zhejiang Province China School of Information Science and Engineering Central South University Changsha 410083 Hunan Province China Institute for Biomedical Engineering Nanjing University of Technology Nanjing 210009 Jiangsu Province China

AIM:To find out whether a newly designed big cup nitinol stent is suitable for treatment of patients with gastric outlet obstruction resulting from gastric ***:The new stent is composed of a proximal big cup segment(20 mm in length and 48-55 mm in diameter),a middle part(60 mm in length and 20 mm in diameter)covered by a polyethylene membrane and a distal sphericity(20 mm in length and 28 mm in diameter).Half of the proximal big cup segment is also covered by a polyethlene membrane,which is adjacent to the middle part of the *** stent is preloaded in a 6.0-mm-diameter introducer *** patients with gastric outlet obstruction resulting from gastric cancer received the new stents under endoscopic and fluoroscopic ***:Technical success was achieved in 12 of 13(92.3%)*** the 12 patients in whom endoscopic stent was placed successfully,the clinical success rate was 91.7%during a follow-up of average 6.5 *** the first month follow-up,the migration rate was 0%,recurrent obstruction 0%and gastric bleeding 8.3%.During the follow-up between 2-12 mo,no migration,recurrent obstruction and gastric bleeding ***:The proximal big cup segment seems to be effective and promising for technical efficacy,clinical outcome,and preventing migration and tumor ingrowth and increasing the emptying rate of sinus ventriculi.

关键词： Endoscopic Gastric outlet Stenosis Ob- struction Stents

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Tomlinson-Harashima precoding minimizing total MSE with transmitter spatial correlation

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The Journal of China Universities of Posts and Telecommunications 2012年第6期19卷 19-24页

作者： geng Xuan he Chen SUN Zuo-lei LIU Kun College of Information Engineering Shanghai Maritime University School of Electronic Information and Electrical EngineeringShanghai Jiaotong University

This paper proposes a Tomlinson-Harashima precoding （THP） transceiver for multiple-input multiple-output （MIMO） system, where the spatial correlation information at the transmitter is included in the channel state information （CSI） model. It derives the total mean square error （MSE） and its lower bound as a function of precoding matrix. Then, a precoding matrix and the closed-form expression of minimum MSE lower bound are obtained by use of optimization and matrix theory. By right-multiplying a proper unitary matrix to the above precoding matrix, the paper develops the optimal precoding matrix, thus the optimal transceiver matrices are achieved. Simulation results show that the total MSE performance of the proposed method outperforms the existing linear method and the naive THP method.

关键词： MIMO THP transceiver total MSE transmitter spatial correlation

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Circumferential Propagation of Tip Leakage Flow Unsteadiness for a Low-Speed Axial Compressor

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Journal of Thermal Science 2009年第3期18卷 202-206页

作者： Shaojuan geng Feng Lin Jingyi Chen Hongwu Zhang Lei he Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics Chinese Academy of Sciences P. O. Box 2706 Beijing 100190 China Shanghai Electric Power Generation Equipment Co. Ltd.

Full-annulus three-dimensional unsteady numerical simulations were conducted for a low-speed isolated axialcompressor rotor, intending to identify the behavior of self-induced unsteady tip leakage flow within multi-bladepassages. There is a critical mass flow rate near stall point, below it, the self-induced unsteadiness of tip leakageflow can propagate circumferentially and thus initiates two circumferential waves. Otherwise, the self-inducedunsteady tip leakage flow oscillates synchronously in each single blade passage. The major findings are: 1) whilethe self-induced unsteadiness of tip leakage flow is a single-passage phenomenon, there exist phase shifts amongblade passages in multi-passage environments then evolving into the first short length wave propagating at abouttwo times of rotor rotation speed after the transient period ends; and 2) the time traces of the pseudo sensors locatedon the rotor blade tips reveal another much longer length-scale wave modulated with the first wave due tophase shift propagating at about half of rotor rotation speed. Features of the short and long length-scale circumferentialwaves are similar to those of rotating instability and modal wave, respectively.

关键词： unsteady tip leakage flow phase shift circumferential wave axial compressor

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Synthesis and Characterization of Ferrocenyl Substituted Styryl Octasilsesquioxane

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Chinese Chemical Letters 2006年第4期17卷 427-430页

作者： Xiao Yan SONG Hai ping geng Qi Fang LI College of material science and engineering Beijing University of Chemical Technology Beijing 100029

4-（2-Ferrocenylethenyl）-phenyl-POSS Fc-CH=CH-C6H6-（C5H9）7Si8O12 （FEPS, Fc： ferrocene）, containing metal and C=C double bond, was firstly synthesized as a mixture of E/Z isomers by the Wittig reaction. The chemi... 详细信息

关键词： Polyhedral silsesquioxane ferrocene Wittig reaction synthesis.

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Study on the dynamic mechanical properties of winding-block axial structure considering short circuit strain rate effect

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High Voltage 2024年第2期9卷 380-390页

作者： Xinyu Wang ping Wang Jianghai geng Zikang Zhang Fangcheng Lü Shuguo Gao hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina State Grid hebei Electric Power Research Institute ShijiazhuangChina

Transformers may suffer multiple short-circuit impacts during long-term operation,and axial instability is one of the typical types of serious accidents caused by short-circuit *** axial instability form of the winding-block structure is analysed,and the dynamic solution of the winding short-circuit electromagnetic force is obtained by estab-lishing the three-dimensional magnetic-circuit-force multi-physical field coupling simulation *** influence of strain rate on the cushion block constitutive equation is corrected,and the modified model is verified by short-circuit impact test and quasi-static *** research results show that for 110 kV 31.5 MVA transformers,the maximum electromagnetic axial resultant force of winding is 363.16 kN,and the ultimate tilt force is 1214.2 *** pre-tightening force configuration is accordingly recom-mended to range from 363.16 to 608.28 kN,which is narrowed by 18.49%compared with the static calculation method;Meanwhile,adding a logarithmic strain rate correction term to the classical constitutive equation of the cushion block can achieve a good correction of the stress-strain relationship with the coefficient of determination above 0.99,and the cushion block has a larger elastic modulus under high strain rate *** research results provide an important theoretical reference for the axial stability structure of transformers.

关键词： axial correction structure

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Influences of top clearance and liquid throughput on the performances of an external loop airlift slurry reactor integrated mixing and separation

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1514-1521页

作者： Hongyan Liu Zhuo Li Shujun geng Fei Gao Taobo he Qingshan Huang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess Technology(QIBEBT)Chinese Academy of Sciences(CAS)Qingdao 266101China Dalian National Laboratory for Clean Energy(DNL) Dalian 116023China Petrochemical Research Institute China National Petroleum Corporation(CNPC)Beijing 100083China

A new developed external loop airlift slurry reactor, which was integrated with gas–liquid–solid three-phase mixing, mass transfer, and liquid–solid separation simultaneously, was deemed to be a promising slurry reactor due to its prominent advantages such as achieving continuous separation of clear liquid from slurry and cyclic utilization of solid particles without any extra energy, energy-saving, and intrinsic safety design. The principal operating parameters, including gas separator volume, handling capacity, and superficial gas velocity, are systematically investigated here to promote the capabilities of mixing, mass transfer, and yield in the pilot external loop airlift slurry reactor. The influences of top clearance and throughput of the clear liquid on flow regime and gas holdup in the riser, liquid circulating velocity, and volumetric mass transfer coefficient with a typical high solid holdup and free of particles are examined experimentally. It was found that increasing the gas separator volume could promote the liquid circulating velocity by about 14.0% at most. Increasing the handling capacity of the clear liquid from 0.9 m3·h-1 to 3.0 m3·h-1 not only could increase the output without any adverse consequences, but also could enhance the liquid circulating velocity as much as 97.3%. Typical operating conditions investigated here can provide some necessary data and guidelines for this new external loop airlift slurry reactor to upgrade its performances.

关键词： External loop airlift reactor Mixing Separation Hydrocyclone Hydrodynamics Mass transfer

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Mechanical response of a tunnel subjected to strike-slip faulting processes,based on a multi-scale modeling method

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1281-1295页

作者： Guoguo LIU ping geng Tianqiang WANG Xiangyu GUO Jiaxiang WANG Ti DING Key Laboratory of Transportation Tunnel Engineering Ministry of EducationChengdu 610031China College of Civil Engineering Huaqiao UniversityXiamen 361021China China Railway Design Corporation Tianjin 300308China

The stick-slip action of strike-slip faults poses a significant threat to the safety and stability of underground *** this study,the north-east area of the Longmenshan fault,Sichuan,provides the geological background;the rheological characteristics of the crustal lithosphere and the nonlinear interactions between plates are described by Burger’s viscoelastic constitutive model and the friction constitutive model,respectively.A large-scale global numerical model for plate squeezing analysis is established,and the seemingly periodic stick-slip action of faults at different crust depths is *** a second model at a smaller scale,a local finite element model(sub-model),the time history of displacement at a ground level location on the Longmenshan fault plane in a stick-slip action is considered as the displacement *** integration of these models,creating a multi-scale modeling method,is used to evaluate the crack propagation and mechanical response of a tunnel subjected to strike-slip *** determinations of the recurrence interval of stick-slip action and the cracking characteristics of the tunnel are in substantial agreement with the previous field investigation and experimental results,validating the multi-scale modeling *** can be concluded that,regardless of stratum stiffness,initial cracks first occur at the inverted arch of the tunnel in the footwall,on the squeezed side under strike-slip *** smaller the stratum stiffness is,the smaller the included angle between the crack expansion and longitudinal direction of the tunnel,and the more extensive the crack expansion *** the tunnel in a high stiffness stratum,both shear and bending failures occur on the lining under strike-slip faulting,while for that in the low stiffness stratum,only bending failure occurs on the lining.

关键词： stick-slip action plate squeezing analysis multi-scale modeling method lining cracking mechanical response

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盾构隧道实用抗震计算方法研究

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中国公路学报 2020年第12期33卷 15-25页

作者：何川耿萍西南交通大学交通隧道工程教育部重点实验室

首先分析了各国盾构隧道抗震计算的现状,总结了常用的盾构隧道抗震计算方法,分析了这些方法的优缺点及适用性。在此基础上介绍了在盾构隧道抗震分析方法方面笔者带领的研究团队近年来取得的部分进展,主要有:在盾构隧道横向抗震计算中提... 详细信息

首先分析了各国盾构隧道抗震计算的现状,总结了常用的盾构隧道抗震计算方法,分析了这些方法的优缺点及适用性。在此基础上介绍了在盾构隧道抗震分析方法方面笔者带领的研究团队近年来取得的部分进展,主要有:在盾构隧道横向抗震计算中提出修正静力法,解决了静力法的计算合理性问题;提出考虑环间接头非线性刚度的纵向迭代计算方法,进一步发展了纵向广义反应位移法的适用性,以期解决大型复杂结构在非均匀地层中的高精度计算问题;并介绍了上述研究进展在中国相关抗震规范中的采纳应用情况。最后对隧道实用抗震计算方法进行了展望:在管片结构劣化对盾构隧道抗震的影响、拟静力计算方法如何考虑地层非线性、近场地震动对隧道的影响等方面有待进一步研究。

关键词：隧道工程盾构隧道综述抗震计算方法研究进展

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