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Everolimus in de novo liver transplant recipients: a systematic review

hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 461-469页

作者： Cheng-Yong Tang Ai Shen Xu-Fu Wei Qing-Dong Li Rui Liu he-jun deng Yong-Zhong Wu Zhong-jun Wu Department of Pharmacy First Affiliated Hospital of Chongqing Medical University Department of hepatobiliary Surgery Chongqing Cancer Institute Department of hepatobiliary Surgery First Affiliated Hospital of Chongqing Medical University Department of Radiotherapy Chongqing Cancer Institute

BACKGROUND： Everolimus has no nephrotoxicity and is used to treat patients with post-liver transplant chronic renal insufficiency. The present systematic review was to evaluate the efficacy and safety of everolimus in de novo liver transplant *** SOURCES： Randomized controlled trials comparing everolimus for de novo liver transplant in Pub Med, the Cochrane Library, and Science Direct published up to March 31, 2014 were searched by two independent reviewers. Mean differences and 95% confidence interval（95% CI） for renal function, relative risk（RR） and 95% CI for treated biopsy-proven acute rejection（t BPAR）, graft loss, death, neoplasms/tumor recurrence, and adverse events were collected. Meta-analyses were performed with Rev Man version ***： A total of four randomized controlled trials covering 1119 cases were included. The meta-analyses revealed that compared with standard exposure of calcineurin inhibitors（CNIs）, everolimus combined with reduced CNIs improved creatinine clearance（calculated with the Cockcroft-Gault formula） by 5.13 m L/min at one year（95% CI： 0.42-9.84; P=0.03）, and decreased t BPAR（RR： 0.56; 95% CI： 0.35-0.90; P=0.02）. Everolimus initiation with CNIs elimination improved glomerular filtration rate（GFR, measured with the modification of diet in renal disease formula） of 10.42 m L/min/1.73 m2（95% CI： 3.44-17.41; P〈0.01） one year after treatment, but in-creased t BPAR（RR： 1.71; 95% CI： 1.15-2.53; P〈0.01）. Everolimus decreased the risk of neoplasms/tumor recurrence after liver transplant（RR： 0.60; 95% CI： 0.34-1.03; P=0.06）, but was associated with greater risk of adverse events which resulted in drug discontinuation（RR： 1.98; 95% CI： 1.49-2.64; P〈0.01）. CONCLUSIONS： Early introduction of everolimus combined with low-dose or no CNI in de novo liver transplant significantly improves renal function one year post treatment. Everolimus combined with low-dose CNI decreases the risk of t BPAR one year after liver transplant, but everoli

关键词： everolimus calcineurin inhibitors liver transplantation systematic review

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Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells

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Science China Life Sciences 2025年

作者： Shi Chen Yuanyuan he Lejun Lv Bei Liu Cheng Li Hongkui deng jun Xu Department of Cell Biology School of Basic Medical Sciences Peking University Stem Cell Research Center Peking University Health Science Center Peking University Academy of Advanced Interdisciplinary Studies Peking University BeiCell Therapeutics School of Life Sciences Center for Bioinformatics Center for Statistical Science Peking University MOE Engineering Research Center of Regenerative Medicine School of Basic Medical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

Human primed pluripotent stem cells are capable of generating all the embryonic ***,their extraembryonic trophectoderm potentials are *** remains unclear how to expand their developmental potential to trophectoderm *** we show that transient treatment with a cocktail of small molecule epigenetic modulators imparts trophectoderm lineage potentials to human primed pluripotent stem cells while preserving their embryonic *** chemically treated cells can generate trophectoderm-like cells and downstream trophoblast stem cells,diverging into syncytiotrophoblast and extravillous trophoblast *** and CUT&Tag analyses reveal that these induced cells share transcriptional profiles with in vivo trophectoderm and cytotrophoblast,and exhibit reduced H3K27me3 modification at gene loci specific to trophoblast lineages compared with primed pluripotent *** exploration highlighted the critical roles of epigenetic modulators HDAC2,EZH1/2,and KDM5s in the activation of trophoblast lineage *** findings demonstrate that transient epigenetic resetting activates unrestricted lineage potential in human primed pluripotent stem cells,and offer new mechanistic insights into human trophoblast lineage specification and in vitro models for studying placental development and related disorders.

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铝冰固体推进剂燃速特性研究

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固体火箭技术 2016年第3期39卷 358-363页

作者：王革何登军刘平安哈尔滨工程大学航天与建筑工程学院哈尔滨150001 中国航天科工集团公司六院41所呼和浩特010000

通过建立铝冰固体推进剂燃烧模型,研究铝冰固体推进剂的燃速特性。将铝冰固体推进剂的燃烧过程分成铝水固相区、铝水液相区、铝水气相区和铝水反应区4个区域。结合各个区域的守恒方程和边界条件,利用牛顿迭代法求解出铝冰固体推进剂燃... 详细信息

通过建立铝冰固体推进剂燃烧模型,研究铝冰固体推进剂的燃速特性。将铝冰固体推进剂的燃烧过程分成铝水固相区、铝水液相区、铝水气相区和铝水反应区4个区域。结合各个区域的守恒方程和边界条件,利用牛顿迭代法求解出铝冰固体推进剂燃速的精确解。分析了铝颗粒钝化程度、铝粉粒径及水燃比3种因素变化对铝冰固体推进剂燃速的影响。结果表明,随铝颗粒钝化程度、铝粉粒径和水燃比的增大,铝冰固体推进剂的燃速减小;随铝粉粒径的增大,燃速压强指数减小,铝颗粒钝化程度和水燃比的变化不会引起压强指数的改变。

关键词：铝冰固体推进剂燃烧模型燃速

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A Cross-Multi-Domain Trust Assessment Authority Delegation Method Based on Automotive Industry Chain

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Computers, Materials & Continua 2025年第1期82卷 407-426页

作者： Binyong Li Liangming deng Jie Zhang Xianhui deng School of Cybersecurity(Xin Gu Industrial College) Chengdu University of Information TechnologyChengdu610225China Advanced Cryptography and System Security Key Laboratory of Sichuan Province Chengdu610225China SUGON Industrial Control and Security Center Chengdu610225China

To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply relationships in the automotive market,improving data sharing and interactions across various platforms,and achieving more detailed integration of data and *** propose a trust evaluation permission delegation method based on the automotive industry *** proposed method combines smart contracts with trust evaluation mechanisms,dynamically calculating the trust value of users based on the historical behavior of the delegated entity,network environment,and other factors to avoid malicious node attacks during the permission delegation *** also introduce strict control over the cross-domain permission granting and revocation mechanisms to manage the delegation path,prevent information leakage caused by malicious node interception,and effectively protect data integrity and *** analysis shows that this method meets the realtime requirements of collaborative interaction in the automotive industry chain and provides a feasible solution to permission delegation issues in the automotive industry chain,offering dynamic flexibility in authorization and scalability compared to most existing solutions.

关键词： Automotive industry chain cross-domain access block chain delegate authority trust assessment

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染料废水处理技术研究

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化工管理 2021年第26期 17-18页

作者：何登俊成都大学机械工程学院四川成都610106

染料废水由于其成分复杂,处理过程中生化性较差,如果没有经过专业技术处理,排放后会对生态环境造成极大破坏。文章阐述了有关染料废水的处理方法,包括物理法、生物法、化学法3种处理方式,并对各种处理技术的优缺点进行了总结。

关键词：染料废水处理技术研究展望

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Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng Yi Haihan Zou Gao deng Ming Fang junzhe he Xin Sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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Bi_2O_3对Bi_2O_3-ZnO-B_2O_3玻璃润湿性能的研究

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武汉理工大学学报 2009年第22期31卷 33-35,39页

作者：何峰王俊邓大伟武汉理工大学硅酸盐研究中心武汉430070

利用高温显微镜拍照观察粉末压片后Bi2O3-ZnO-B2O3系统低熔点玻璃的形态随温度升高的变化特征;使用卧式石英膨胀仪测定各组成玻璃的软化点。得到压片试样形态随温度升高的变化规律以及Bi2O3对该系统玻璃热性能及润湿性能的影响。结果表... 详细信息

利用高温显微镜拍照观察粉末压片后Bi2O3-ZnO-B2O3系统低熔点玻璃的形态随温度升高的变化特征;使用卧式石英膨胀仪测定各组成玻璃的软化点。得到压片试样形态随温度升高的变化规律以及Bi2O3对该系统玻璃热性能及润湿性能的影响。结果表明:随着温度的升高,粉末压片圆柱体试样会产生烧结、软化、润湿不锈钢基体表面等过程;一定范围内Bi2O3含量的提高使软化过程提前,降低了Bi2O3-ZnO-B2O3系统低熔点玻璃的软化点,使其在较低温度就能润湿不锈钢。

关键词： Bi2O3-ZnO-B2O3系统低熔点玻璃热性能润湿

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2015年四川省常住居民骨质疏松现状调查

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职业卫生与病伤 2018年第1期33卷 25-27页

作者：马霞何君邓颖四川省疾病预防控制中心成都610041

目的通过对四川省8个市22个区5 756名40岁以上常住居民进行问卷调查,了解四川省骨质疏松的患病及人群防治现状,为四川省进行骨质疏松症的宣传教育和防提供依据。方法采用自行设计的调查问卷调查2015-01-09/12-31对调查地点常住居民进行... 详细信息

目的通过对四川省8个市22个区5 756名40岁以上常住居民进行问卷调查,了解四川省骨质疏松的患病及人群防治现状,为四川省进行骨质疏松症的宣传教育和防提供依据。方法采用自行设计的调查问卷调查2015-01-09/12-31对调查地点常住居民进行调查。结果调查5 756人,患病率为12.94%,检出率为13.57%,骨量减少检出率为59.95%;随着年龄的增加骨质疏松症患者、检出患者增多,换病例。结论随着年龄的增加骨质疏松症患病率、检出率增加。

关键词：骨质疏松患病率慢性病防治

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong he Jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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