检索结果-南通市图书馆

Design and Synthesis of poiyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor

在线全文

学校读者我要写书评

暂无评论

Design and Synthesis of poiyhydroxylated aromatics having am...

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

2011年全国药物化学学术会议——药物的源头创新

作者： Sulei Zhang,Zaigang Luo,Xianzhuo he,jie hu,Bin Zhang,Liming hu~* The College of Life Science and Bio-engineering,Beijing University of Technology,Beijing,100124

＜正＞The viral enzyme integrase（IN） is an attractive target for the development of new anti-HIV-1 inhibitors.S-1360,aβ-diketo bioisostere,which showed potent antiviral activity against HIV-1 integrase,was the firs...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong he jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao huang Zhencheng huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie Zhu Xiao-Jia Yang Qian-Ru he Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing Femoropopliteal Arterial Endovascular Interventions： Preliminary Results

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第12期128卷 1563-1566页

作者： Yue-Xin Chen Wen-Da Wang Xiao-Jun Song Yong-Quan Gu Hong-Yan Tian he-jie hu Ji-Chun Zhao Xiao-Qiang Li Chang-Wei Liu Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100068 China Department of Vascular Surgery Peking XuanWu Hospital Beijing 100053 China Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Vascular Surgery Anhui Provincial Hospital Hefei Anhui 230001 China Department of Vascular Surgery West China Hospital Chengdu Sichuan 510100 China Department of Vascular Surgery The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background：Sarpogrelate is a selective 5-hydroxytryptamine （5-HT） receptor subtype 2A antagonist which blocks 5-HT induced platelet aggregation and proliferation of vascular smooth muscle *** compared the efficacy of sarpogrelate-based dual antiplatelet therapies for the prevention of restenosis and target lesion revascularization （TLR） rates comparing with that of clopidogrel after percutaneous endovascular interventions （EVIs） of femoropopliteal （FP） arterial ***：This prospective,multicenter,randomized clinical trial recruited a total of 120 patients with successful EVI of FP lesions at seven centers across China between January 2011 and June *** were randomized to receive either sarpogrelate （100 mg trice daily for 6 months,n =63） or clopidogrel （75 mg once daily for 6 months,n =57）.All patients also received oral aspirin （100 mg once daily for 12 months）.Clinical follow-up was conducted up to 12 months ***：There was no significant difference between the two groups in basic demographic *** restenosis rate was higher in the clopidogrel group （22.80%） than in sarpogrelate group （17.50%）,but there was no significant difference between these two groups （P =0.465）.The TLR rate,ipsilateral amputation rate,mortality in all-cause and bleeding rate were also similar in the two groups （P 〉 0.05）.Conclusions：Aspirin plus sarpogrelate is a comparable antithrombotic regimen to aspirin plus clopidogrel after EVI of FP arterial *** antiplatelet therapies might play an important role in preventing restenosis after successful EVI of FP lesions.

关键词： Clopidogrel Femoropopliteal Artery Percutaneous Endovascular Interventions Restenosis Sarpogrelate

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang jie Wu Kouer Zhang Wenzhi Li Yunxia hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts heterointerface Oxygen evolution reaction Zn-air batteries

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing he Jue Shi Zihe hu Yanyan Zhou Zhijian Xie Yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

An Enhanced Dual-Layer Ensemble Framework for Porosity Prediction Utilizing Conventional Well Logging Data

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2025年

作者： Lu Qiao Shengyu Yang Qinhong hu huijun Wang Taohua he National Key Laboratory of Deep Oil and Gas， China University of Petroleum (East China) Laboratory for Marine Mineral Resources， Qingdao National Laboratory for Marine Science and Technology hubei Key Laboratory of Petroleum Geochemistry and Environment (Yangtze University)， Yangtze University

Porosity is the one of the most fundamental and critical parameters for reservoir characterization and is closely related to the hydrocarbon storage capacity. The interpretation methods of conventional well logs have poor generalization capabilities to achieve the desired accuracy in porosity prediction. The increasing adoption of machine learning has ameliorated this predicament to some extent， but it remains difficult to reconstruct the complex and nonlinear relationship between logging responses and porosity by relying on individual machine learning models alone. This work proposes a two-layer model ensemble framework to predicte porosity， which includes base regressors in the first layer and meta regressor in the second layer. The results indicate that the Light Gradient Boosting Machine (LightGBM) - Categorical-Features Gradient Boosting (CatBoost) ensemble model provides the highest prediction accuracy for the given dataset and is applied for porosity evaluation at other logged depths. This work also points out that the base regressor should be accurate and complex， while the structure of the meta-regressor should be simple in order to achieve the desired performance. Furthermore， the proposed model ensemble framework is versatile and applicable to reservoir evaluation， engineering development， and other potential fields due to its effectiveness and convenience.

关键词：

临时下腔静脉滤器防护下经小隐静脉置管溶栓与足背静脉溶栓在急性髂-股静脉血栓形成治疗中的疗效对比

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国现代医学杂志 2016年第20期26卷 82-86页

作者：方灿军胡何节潘力生安徽医科大学附属安徽省立医院血管外科安徽合肥230001 安徽医科大学附属安庆市立医院血管外科安徽安庆246003

目的比较急性髂一股静脉血栓形成患者经患肢置管溶栓与经足背溶栓的治疗效果，以指导临床治疗。方法通过回顾性分析安徽医科大学附属安庆市立医院2013年9月-2015年6月期间收治的共52例急性髂一股静脉血栓形成患者的临床资料，按照治疗... 详细信息

目的比较急性髂一股静脉血栓形成患者经患肢置管溶栓与经足背溶栓的治疗效果，以指导临床治疗。方法通过回顾性分析安徽医科大学附属安庆市立医院2013年9月-2015年6月期间收治的共52例急性髂一股静脉血栓形成患者的临床资料，按照治疗方法不同分为置管溶栓组（A组）和经足背溶栓组（B组）。其中置管溶栓组28例，术前均置入临时下腔静脉滤器；经足背溶栓组24例，置入临时下腔静脉滤器10例。通过监测患者临床症状、测量下肢周径变化、溶栓并发症、远期通畅率及瓣膜功能情况比较两组治疗效果。结果置管溶栓组术后24h患者肢体肿胀开始减轻，3～5d后下肢疼痛、肿胀等症状均得到明显改善，溶栓治疗后7d症状基本消退。经足背溶栓组一般48～72h后开始起效，7d后症状明显改善。置管溶栓组应用尿激酶总量为（320±100）×10^4u，总疗程为4～7d；经足背溶栓组应用尿激酶总量为（460±120）×10^4u，总疗程为6～10d。置管溶栓组治疗后大、小腿的肢体消肿率分别为（90．12±6．15）％和（86．74±7．24）％，经足背静脉溶栓组治疗后大、小腿的肢体消肿率分别为（85．71±5．54）％和（85．16±6．57）％，置管溶栓组治疗后Ⅲ级血栓溶解率患者达82．1‰经足背静脉溶栓组治疗后Ⅲ级血栓溶解率患者为50％，两组间比较有差异有统计学意义（P〈0．05）。结论经小隐静脉置管溶栓具备疗程短、起效快、并发症少及PTS发生率低等优点，置管溶栓治疗方法优于经足背溶栓治疗，值得临床推广应用。

关键词：深静脉血栓形成腔静脉滤器导管溶栓小隐静脉

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian he Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding Yue hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory