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Chinese Journal of Polymer Science 2023年第6期41卷 933-941,I0009页

作者： Ao Wang Shu-Ren Shao he-cheng wu Chen-Xu Tian Feng Luo Jie-Hua Li Zhen Li Hong Tan College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Fluorinated diols(FDO)with dangling chain were introduced into polyether urethanes(PEUs)as chain extender in order to achieve internal *** on temperature dependent Fourier transform infrared(FTIR)spectroscopy results,the fluorinated polyether urethanes(FPEUs)exhibited weaker hydrogen bonding between C=O and N―H groups with addition of *** crystallinity of hard domain was destroyed determined by thermal *** with the results of dynamic mechanical analysis(DMA)and dissipative particle dynamics(DPD)simulation,it was proved that more loosely aggregated hard domains with weakened interaction separated from soft segment were *** analysis indicated that FDO reduced the complex viscosity and viscous flow activation energy which endowed the polymer with more *** the loss of hydrogen bonds,there was no significant decline in mechanical property resulting from the decrease of hard segment dissolved in soft segment *** presence of fluorinated carbon side chain could function as internal plasticizer and contribute to the processability of polyurethane.

关键词： carbon bonds destroyed

Implantable Polyurethane Scaffolds Loading with PEG-Paclitaxel Conjugates for the Treatment of Glioblastoma Multiforme

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Chinese Journal of Polymer Science 2022年第5期40卷 491-503页

作者： he-cheng wu Yuan Feng Xing-Ying Song Chun-Yang Song Jin-Lin Chen Yan-Chao Wang Xue-Ling he Rui-Chao Liang Jie-Hua Li Hong Tan College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Laboratory Animal Center of Sichuan University Chengdu 610041China

Improvement of the treatment for Glioblastoma multiforme(GBM)especially the development of in situ controllable drug release is still a major *** this study,we developed waterborne biodegradable polyurethane(WBPU)scaffolds incorporated with redox-sensitive and RGD-decorated paclitaxel(PTX)polymer-drug conjugates(PDCs)for targeted GBM therapy in *** drug scaffolds could be implanted at residual GBM site ***-targeting PTX-PDCs were obtained through step-by-step conjugation of disulfide linked PTX,poly(ethylene glycol)(PEG),and arginine-glycine-aspartic acid(RGD).The RGD-modified PTX-PDCs were spherical nanoparticles(NPs)that would be released from scaffolds and identified GBM cells *** redox-sensitive PTX-PDCs would be decomposed and release PTX inside GBM cells under the circumstances of glutathione(GSH).The release profiles of PTX from the scaffolds with/without GSH were *** vitro cytotoxicity assay revealed that the dual-targeting PTX-PDCs from scaffolds could specifically kill GBM cells and protect normal cells,suggesting that dual-targeting PTX-PDC-loaded scaffolds may have the potential to repair tumor-induced brain *** vivo anti-recurrence assay indicated that the PTX-PDC-scaffolds could deliver PTX-PDCs to the GBM cells followed by inhibiting tumor growth and inducing *** general,the PTX prodrug-loaded devices exhibited significant anti-GBM effects and normal tissue protection simultaneously,indicating that the WBPU scaffolds incorporated with dual-targeting PTX-PDCs may be a promising strategy for local therapy of GBM.

关键词： GBM PDCs WBPU Scaffolds Controlled release

New feature extraction in gene expression data for tumor classification

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Progress in Natural Science:Materials International 2005年第9期15卷 861-864页

作者： he Renya, cheng Qiansheng**, wu Lianwen and YUAN Kehong(LMAM, School of Mathematical Sciences, Institute of Molecular Medicine, Peking University, Beijing 100871, China) LMAM School of Mathematical Sciences Institute of Molecular Medicine Beijing 100871 Peking University China

Using gene expression data to discriminate tumor from the normal ones is a powerful method. However, it is sometimes difficult because the gene expression data are in high dimension and the object number of the data sets is very small. The key technique is to find a new gene expression profiling that can provide understanding and insight into tumor related cellular processes. In this paper, we propose a new feature extraction method based on variance to the center of the class and employ the support vector machine to recognize the gene data either normal or tumor. Two tumor data sets are used to demonstrate the effectiveness of our methods. The results show that the performance has been significantly improved.

关键词： Bioinformatics Feature extraction Gene expression Support vector machine (SVM) Tumor classification

Influence of Hydrogen Bonding on the Temperature-Accelerated Hydrolysis of Silicone Based Polyetherurethane

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Chinese Journal of Polymer Science 2023年第8期41卷 1230-1237,I0007页

作者： he-cheng wu Shu-Ren Shao Shuo-Hong Dong Ao Wang Zhen Li Xiang-Long Han Feng Luo Jie-Hua Li Dai-Guo Zhao Wan-Ling Lan Hong Tan College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringMed-X Center for MaterialsSichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Sichuan Institute for Food and Drug Control Chengdu 611731China

Temperature-accelerated in vitro degradation was established to estimate the longevity of polyurethane applied for long-term ***,the prediction did not correlate well with the data from clinical explants and the rationality of accelerated in vitro test is still in a controversial due to the *** improve the accuracy of the in vitro prediction,the influence of hydrogen bonding(HB)on the accelerated hydrolysis of silicone based polyetherurethans(SPEUs)extended with three side *** the temperature-controlled FTIR and the physical properties after temperature-accelerated in vitro degradation,it was demonstrated that side chain could increase the degree of hydrogen bond dissociation at higher temperature,resulting in the decrease of the calculated activation energy(E_(a))of *** low temperatures,changes in surface morphology and molar mass of PEUs are minimal and HB are less easily dissociated,which had barely impact on the hydrolysis *** was proposed that the E_(a) will not be impacted and that the accuracy of prediction will be increased if the acceleration temperature is lower than 70℃ and HB change is less than 15%.

关键词： Polyether urethane Polydimethylsiloxane Activation energy Hydrogen bonding Hydrolysis resistance

Studies on the heredity of the Traits Related to the Photoperiod-Sensitive Phenomenon Among the Temperate ×Tropical Crosses in Maize

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Agricultural Sciences in China 2003年第2期2卷 119-126页

作者： CheN Yan-hui, ZHANG Xiang-qian, CHANG Sheng-he, wu Lian-cheng,wu Jian-yu and XI Zhang-yingAgronomy College , henan Agricultural University , Zhengzhou 450002 , P. R. China Agronomy College Henan Agricultural University Zhengzhou 450002 P. R. China

The genetic study of characters concerning photoperiod sensitivity of the growth and development stages, plant and ear height was carried out from 5 temperate tropical combinations by using P1 , P2, F1, F2, BC1, BC2 generations mean analysis. The results showed that the square sums of additive, of dominance and of epistatic gene effects contributed to total genetic variance were 11. 3 -53. 6%, 36.0 -78. 6% and 5.5 -27.0% respectively for five traits of the insensitive×insensitive combination to photoperiod, which suggested dominance gene effect was the most important among various gene effects. In insensitive X sensitive combination to photoperiod, the square sums of additive gene effect with 66. 9 - 84. 5 %, of dominance gene effect with 11. 6 30. 7% and of epistatic gene effect with 1.4-5. 2% were found for five tested traits, which showed additive gene effect held a dominant position, and dominance and epistatic gene effects were reduced compared with insensitive×insensitive combination. The differences existed among different insensitive×sensitive combinations. The proportion of the genetic component among the insensitive×sensitive crossbreed offspring in the temperate zone had a certain dosage effect on fading photoperiod sensitivity reaction. The sensitivity of BC1 , with 25 % of the tropical genetic component, is extremely weak, but with high application value.

关键词： Maize Photoperiod sensitivity characters Gene effect Generation analysis

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： Feng he Sitong Chen Ruili Zhou Hanyu Diao Yangyang Han Xiaodong wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

A Hybrid Approach for Pavement Crack Detection Using Mask R-CNN and Vision Transformer Model

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Computers, Materials & Continua 2025年第1期82卷 561-577页

作者： Shorouq Alshawabkeh Li wu Daojun Dong Yao cheng Liping Li Faculty of Engineering China University of GeosciencesWuhan430074China

Detecting pavement cracks is critical for road safety and infrastructure *** methods,relying on manual inspection and basic image processing,are time-consuming and prone to *** deep-learning(DL)methods automate crack detection,but many still struggle with variable crack patterns and environmental *** study aims to address these limitations by introducing the Masker Transformer,a novel hybrid deep learning model that integrates the precise localization capabilities of Mask Region-based Convolutional Neural Network(Mask R-CNN)with the global contextual awareness of Vision Transformer(ViT).The research focuses on leveraging the strengths of both architectures to enhance segmentation accuracy and adaptability across different pavement *** evaluated the performance of theMaskerTransformer against other state-of-theartmodels such asU-Net,TransformerU-Net(TransUNet),U-NetTransformer(UNETr),SwinU-NetTransformer(Swin-UNETr),You Only Look Once version 8(YoloV8),and Mask R-CNN using two benchmark datasets:Crack500 and *** findings reveal that the MaskerTransformer significantly outperforms the existing models,achieving the highest Dice SimilarityCoefficient(DSC),precision,recall,and F1-Score across both ***,the model attained a DSC of 80.04%on Crack500 and 91.37%on DeepCrack,demonstrating superior segmentation accuracy and *** high precision and recall rates further substantiate its effectiveness in real-world applications,suggesting that the Masker Transformer can serve as a robust tool for automated pavement crack detection,potentially replacing more traditional methods.

关键词： Pavement crack segmentation transportation deep learning vision transformer Mask R-CNN image segmentation

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng Chuankai Fu Geping Yin Liguang Wang Yongmin wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

When AI meets sustainable 6G

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Science China(Information Sciences) 2025年第1期68卷 4-22页

作者： Xiaohu YOU Yongming HUANG cheng ZHANG Jiaheng WANG Hao YIN hequan wu National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Chinese Academy of Military Science China Information Communication Technologies Group

Sixth-generation(6G) networks are anticipated to achieve transformative advancements, characterized by extreme connectivity, deep integration with artificial intelligence(AI) and sensing, and airground integration. The evolution of 6G exhibits two major trends: ubiquitous intelligence and sustainability. The former aims to embed state-of-the-art AI technology into the 6G network, from the physical layers to applications, while the latter emphasizes reducing energy consumption while enhancing network performance to address environmental concerns. Despite the amazing progress in recent years, AI advancements come with substantial increases in data and computational overhead, posing critical challenges for integrating AI into sustainable 6G networks. First, high energy consumption from large datasets and heavyweight AI models contradicts6G's green goals. Second, the precise collection of large datasets, message delivery latency, and inference delays in AI models pose challenges for real-time tasks in 6G. Third, the uninterpretability and unpredictability of AI models complicate meeting the stringent requirements for controllable transmission in dynamic wireless environments. Addressing these challenges and achieving sustainable 6G with ubiquitous intelligence calls for a revolutionary design of 6G architecture and AI frameworks. To this end, this paper introduces a novel and practical methodology for green, real-time, and controllable 6G native intelligence,starting with knowledge graph(KG) analysis to extract small but critical datasets, followed by the development of distributed lightweight AI models, and the use of digital twins(DTs) to create precise replicas of physical 6G networks. This leads to a pervasive multi-level(PML)-AI framework supported by a task-centric, three-layer 6G architecture. The AI framework operates through non-real-time and real-time cycles, leveraging three key technologies: wireless data KGs for efficient data management,lightweight AI mode

关键词： artificial intelligence sustainable 6G green real-time controllable

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改良垂直曲治疗唇侧近中阻生尖牙的效果评价

上海口腔医学 2016年第2期25卷 242-244页

作者：何武成焉钰西宁市第一人民医院口腔正畸科青海西宁810099

目的 :评价改良垂直曲矫治唇侧近中阻生尖牙的效果。方法 :选取2011—2014年就诊于西宁市第一人民医院口腔正畸科的单侧唇侧近中尖牙阻生患者5例,采用改良垂直曲进行正畸矫治。结果:5颗唇侧近中阻生尖牙平均牵引时间13.6个月,均成功纳... 详细信息

目的 :评价改良垂直曲矫治唇侧近中阻生尖牙的效果。方法 :选取2011—2014年就诊于西宁市第一人民医院口腔正畸科的单侧唇侧近中尖牙阻生患者5例,采用改良垂直曲进行正畸矫治。结果:5颗唇侧近中阻生尖牙平均牵引时间13.6个月,均成功纳入牙弓并建。结论:采用改良垂直曲治疗唇侧近中阻生尖牙,可取得良好的效果。

关键词：阻生尖牙改良垂直曲正畸矫治