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Microstructures of Sintered Mo-Cu Alloys with Mechanically Activated Powder

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Rare Metals 2001年第2期20卷 112-116页

作者： Chengchang Jia, Zhong he, Xuekuan su, Ziqin Yang, Jun Zhao, Zizhang Xie (School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China Beliing Polytechnic University, Beijing 100022, Beijing) 北京科技大学北京 100083 北京工业大学北京 100022

Mechanical activation and liquid phase sintering were used to manufacture high performance Mo-Cu alloy and develop new processes. The microstructures and properties of the alloy were investigated. The experimental results showed that: (1) the ball milled Mo/Cu powder has lamellar structure, (2) the microstructures of the sintered Mo-Cu alloy were homogenous compound structures of adhesive phase Cu linking Mo grains, (3) Mo grains frequently strung or gathered in Cu phase, and (4) the full densities of Mo-Cu alloy was achieved through sintering and special densification process. As a result, the properties of the alloy are good enough to satisfy various requirements.

关键词： Mo-Cu alloy powder metallurgy mechanical activation microstructure

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内蒙古草原火灾概述

中国草地 1999年第4期21卷 76-78页

作者：刘桂香苏和李石磊中国农业科学院草原研究所

通过对内蒙古草原火灾的遥感监测资料和火灾发生区地面信息的综合分析，阐述了内蒙古草原火灾的起因、特点及其危害，并对影响草原火灾的主要因素进行了探讨。

关键词：草原火灾起因特点危害

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分级旋流火焰的燃烧不稳定性及火焰动力学

航空动力学报 2021年第4期36卷 806-815页

作者：苏贺郭志辉北京航空航天大学能源与动力工程学院航空发动机气动热力国家级重点实验室北京100191

实验研究了贫燃预混分级火焰的燃烧不稳定性和火焰动力学特性。实验是在一个常温常压实验台上进行的,燃料为甲烷。通过对动态压力、热释放速率的快速傅里叶变换(FFT)分析,火焰图像的Abel逆变换、热释放积分、本征正交分解(POD)分析等方... 详细信息

实验研究了贫燃预混分级火焰的燃烧不稳定性和火焰动力学特性。实验是在一个常温常压实验台上进行的,燃料为甲烷。通过对动态压力、热释放速率的快速傅里叶变换(FFT)分析,火焰图像的Abel逆变换、热释放积分、本征正交分解(POD)分析等方法,重点研究了分级比对燃烧不稳定性的影响。实验表明:预燃级燃料比例,对火焰的稳焰机制、热释放分布以及火焰的稳定性有至关重要的作用。随着分级比的提高,火焰由不稳定的脱体火焰或者蘑菇形火焰,变成稳定而紧凑的Ⅴ形火焰,火焰的热释放中心向喷嘴方向前移。POD分析表明,分级比较大时,预燃级火焰通过改善火焰根部的稳焰特性,进而削弱了火焰面周期性的膨胀和收缩,最终抑制了燃烧不稳定性。

关键词：分级旋流火焰燃烧不稳定性火焰动力学压力脉动本征正交分解

Enhanced optical nonlinearity in a silicon–organic hybrid slot waveguide for all-optical signal processing

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Photonics Research 2022年第1期10卷 50-58页

作者： YONGHUA WANG su he XIAOYAN GAO PIAOPIAO YE LEI LEI WENCHAN DONG XINLIANG ZHANG PING XU College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Silicon photonic integrated devices used for nonlinear optical signal processing play a key role in ultrafast switching,computing,and modern optical ***,current devices suffer from limited operation speeds and low conversion efficiencies due to the intrinsically low nonlinear index of *** this paper,we experimentally demonstrate enhanced optical nonlinearity in a silicon–organic hybrid slot waveguide consisting of an ultranarrow slot waveguide coated with a highly nonlinear organic *** fabricated slot area is as narrow as 45 nm,which is,to the best of our knowledge,the narrowest slot width that has been experimentally reported in silicon slot *** nonlinear coefficient of the proposed device with a length of 3 mm is measured to be up to 1.43×10^(6) W^(-1)km^(-1).Based on the nanostructure design,the conversion efficiencies of degenerate four-wave mixing showed enhancements of more than 12 dB and 5 dB compared to those measured for an identical device without the organic material and a silicon strip waveguide,*** a proof of concept,all-optical canonical logic units based on the prepared device with two inputs at 40 Gb/s are *** obtained logic results showed clear temporal waveforms and wide-open eye diagrams with error-free performance,illustrating that our device has great potential for use in high-speed all-optical signal processing and high-performance computing in the nodes and terminals of optical networks.

关键词： waveguide optical slot

INFLUENCE OF OPERATION UNDER EPIDURAL ANESTheSIA ON PERIPheRAL T LYMPHOCYTE suBSETS

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中华医学杂志(英文版) 1991年第3期104卷 194-197页

作者： Chen Jin-e Zheng Zhi-xiong Wang su-he Chen Qiu-hong Department of Anesthesiology Union Hospital Fujian Medical College Fuzhou 350004 Department of Anesthesiology Tianjin 2nd Central Hospital Tianjin 300120 Department of Pathophysiology Fujian Medical College Fuzhou 350004

This paper reports the variation of peripheral T lymphocyte subsets in patients before and after operation under epidural anesthesia using OKT monoclonal antibodies (McAb). The results show that TH and TS after anesthesia and during surgery were lower than before anesthesia and in normal controls (Phe ratio of TH/TS after anesthesia and during operation were lower than before anesthesia (Phere was no significant difference with normal controls (P>0.05). Therefore, we consider that the decrease in TH cells was one of the reasons for decrease in patient immune function during anesthesia and surgery. Five to seven days after surgery, patient TH cell levels tended to normalize. This showed that this abnormality was transient and reversible. The results also indicated that emphasising prevention of infection in post-operational case. should be done during the first 5-7 days after surgery.

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基因导向的精准肿瘤学研究现状与抗肿瘤中药研发思路

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中国中药杂志 2023年第6期48卷 1421-1430页

作者：何俗非王邈天津中医药大学现代中药省部共建协同创新中心天津301617 天津中医药大学中医学院天津301617

基因导向的肿瘤治疗(genome-guided oncology)是指超越了组织学病种分类和病理分型,根据肿瘤基因特征用药的一种治疗新理念,基于该理念的新药研发技术与临床试验设计新方法为精准肿瘤学在临床应用提供了新思路。中药多成分、多靶点的特... 详细信息

基因导向的肿瘤治疗(genome-guided oncology)是指超越了组织学病种分类和病理分型,根据肿瘤基因特征用药的一种治疗新理念,基于该理念的新药研发技术与临床试验设计新方法为精准肿瘤学在临床应用提供了新思路。中药多成分、多靶点的特性为天然产物肿瘤靶向药物研发提供了丰富资源,针对精准肿瘤学特性的主方案试验设计为实现临床快速筛选有效的肿瘤靶向药物提供了可能性。合成致死策略的出现突破了以往只能针对癌基因用药,而对发生功能缺失型突变的抑癌基因无能为力的瓶颈。随着高通量测序技术的快速发展,测序的成本也在不断降低,肿瘤靶向药物的研发如何跟上靶点信息的更新速度是目前关注的难题。通过整合精准肿瘤学、网络药理学、合成致死策略等创新理念与方法,进行针对合成致死互作网络的中药抗肿瘤配伍组方设计,并结合主方案试验、篮式试验、伞式试验等创新临床试验方法的改进,有可能在抗体靶向药物、小分子靶向药物之外发挥中药的独特优势,研制出相应的靶向药物应用于临床。

关键词：基因导向精准肿瘤学主方案合成致死

论精神损害行政赔偿制度的构建——让阳光温暖受伤的心灵

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安阳师范学院学报 2009年第1期 32-34,46页

作者：苏贺峰宋慧勇西华师范大学政治与行政学院四川南充637002

国家赔偿法修正案草案前不久终于迎来了全国人大的首次审议,从草案可见,将精神损害纳入赔偿范围是这次国家赔偿法修改的核心内容之一。建立和完善我国精神损害行政赔偿制度正是当务之急。本文应用案例分析方法,分析了现阶段我国立法中... 详细信息

国家赔偿法修正案草案前不久终于迎来了全国人大的首次审议,从草案可见,将精神损害纳入赔偿范围是这次国家赔偿法修改的核心内容之一。建立和完善我国精神损害行政赔偿制度正是当务之急。本文应用案例分析方法,分析了现阶段我国立法中精神损害行政赔偿制度缺失给行政相对人带来的救济缺失,论证了我国构建精神损害行政赔偿制度的必要性,提出了建立和完善我国精神损害行政赔偿制度的几点设想。

关键词：行政赔偿精神损害法律责任

Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang Lu-Fan Shen Xin Yang he su Tao Wu Peng-Xian Tao Hong-Ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** suMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report

HCV replication in PBMC and its influence on interferon therapy

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World Journal of Gastroenterology 2003年第2期9卷 291-294页

作者： Guo-Zhong Gong Li-Ying Lai Yong-Fang Jiang Yan he Xian-Shi su Center for Liver Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China Center for Liver Diseases Second Xiangya Hospital Xiangya Medical School Central South University 86 Middle Renmin Street Changsha 410011 Hunan Province China. guozhong_gong@***

AIM: To study hepatic virus C (HCV) RNA and HCV proteinexpression in peripheral blood mononuclear cells (PBMCs)of patients with HCV infection, and explore the relationshipbetween the HCV RNA in the PBMCs and response tointerferon (IFN) ***: Type-specific primers were designed and RT-nested PCR was used to detect the plus- and minus- strandsof HCV RNA in PBMCs of 54 patients with HCV infection;Indirect immunofluorescence assay was applied to identifyHCVNS5 protein expression in PBMCs; 6 month-, 3 MU-IFNregiment was administrated to observe the responses toIFN in 35 chronic hepatitis C patients with different HCVRNA status in ***: HCV plus strand RNA was found in 10 of 19(52.6 %) acute hepatitis C patients and 22 of 35 (62.9 %)chronic hepatitis C patients. HCV minus strand RNA wasdetected in 14 of 35 (40.0 %) chronic hepatitis C patients,but only one patient (5.3 %) with acute HCV infection wasfound to be minus HCV RNA positive. Though no HCV NS5protein expression was found in the examined 10 cases ofacute HCV infection, it was positive in 17 of 20 (85.0 %)chronic hepatitis C patients by indirect immunofluoresenceassay. There are significant differences of positive rate of theminus-strand and HCVNS5 protein between acute and chronichepatitis C groups(u=2.07, P＜0.05and u=4.43, P＜0.01respectively). The patients with minus-strand HCV RNAshowed a significantly lower 6-month sustained response (SR-6) to IFN compared to those without minus-strand HCVRNAin PBMCs (biologically 14.3 % vs 42.8 %, X2=4.12, P＜0.05and virologically 7.1% vs23.9 %, X2=4.24, P＜0.05).CONCLUSION: HCV is capable of infecting and replicatingin PBMCs, and HCVNS5 protein was expressed in *** patients with minus strand HCV RNA in PBMCs showeda significantly lower 6-month sustained response to IFN,suggesting that minus-strand HCV RNA in PBMCs may beone of the factors influencing response to IFN therapy.

关键词：外周血单核细胞丙型肝炎病毒病毒复制干扰素免疫疗法