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From traditional Chinese medicine formulations to effective anticancer agents:Insights from Calculus bovis

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World Journal of Gastroenterology 2024年第35期30卷 4011-4013页

作者： he-tong Zhao Department of Traditional Chinese Medicine Navy No.905 HospitalShanghai 200050China

This editorial examines the therapeutic potential of traditional Chinese medicine(TCM)for aggressive cancers,particularly liver *** highlights the study by Huang et al,which shows how Calculus bovis,a component of the TCM Pien Tze Huang,suppresses liver cancer by inhibiting M2 macrophage polarization via the Wnt/β-catenin *** research emphasizes the importance of transitioning from effective TCM formulations to isolating active components and understanding their *** the study provides valuable insights,it primarily focuses on the Wnt/β-catenin pathway and does not delve deeply into the mechanisms of individual *** research should aim to comprehensively study these components,explore their interactions,and validate findings through clinical *** approach will integrate traditional wisdom with modern scientific validation,advancing the development of innovative cancer treatments based on TCM formulations.

关键词： Calculus bovis Traditional Chinese medicine Liver cancer Tumor microenvironment M2 tumor-associated macrophages Wnt/β-catenin pathway

Texture Evolution, Formability and Ridging Resistance of a Sn-bearing Ferritic Stainless Steel Under Different Hot Band Annealing Temperatures

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Acta Metallurgica Sinica(English Letters) 2019年第11期32卷 1362-1372页

作者： tong he-Dan Guo Yang Bai tong he Dan Guo Xiu-Ting Liu Fang-Yuan Shao Yan-Dong Liu Key Laboratory for Anisotropy and Texture of Materials of Ministry of Education Northeastern UniversityShenyang 110819China Research Academy Northeastern UniversityShenyang 110819China

The microstructure, texture evolution and spatial orientation distribution during cold rolling and the subsequent annealing as well as formability and ridging of a Sn-bearing ferritic stainless steel under different hot band annealing temperatures were investigated. The four hot bands with annealing temperatures of 900, 950, 1000 and 1050 °C were all cold-rolled to 80% reductions and then were annealed at the same temperature of 900 °C. The results show that optimizing hot band annealing process is benefi cial to reduce the amount of {001} grains and weaken the texture intensity, and thus, to reduce ridging and improve formability. In the present study, the fi nal sheets with hot band annealing temperature of 900 °C possess small and inhomogeneous grains with a large amount of {001} orientations, which deteriorates the formability and increases the ridging. In comparison, the fi nal sheets with hot band annealing temperature of 950 °C are comprised of uniform and equiaxed //ND(ND: normal direction) recrystallized grains with a high texture intensity favorable for the improvement in r value and surface quality. However, when hot band annealing temperature further increases to 1000 and 1050 °C, it shows a sharp decrease in r value and a remarkable increase in ridging as a result of a reduction in γ-fi ber texture intensity and an increase in grain size in the fi nal sheets. Suitable controlling and optimizing hot band annealing process is essential to improve the formability and reduce the ridging.

关键词： Ferritic stainless steel Texture Formability Ridging

白细胞介素-17C在自身免疫性皮肤病中的研究进展

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中国麻风皮肤病杂志 2025年第1期41卷 69-72页

作者：姚心怡贺彤杨欣雅胥明成张峻岭天津中医药大学研究生院天津300000 天津市中医药研究院附属医院皮肤科天津300120

白细胞介素17家族(interleukin-17s,IL-17s)具有促炎效应,参与各种自身免疫性疾病的发生发展。IL-17C是IL-17细胞因子家族中的重要成员之一,不同于广泛来源于各种免疫细胞的IL-17A,IL-17C主要由上皮细胞分泌并通过IL-17RE/A受体复合物... 详细信息

白细胞介素17家族(interleukin-17s,IL-17s)具有促炎效应,参与各种自身免疫性疾病的发生发展。IL-17C是IL-17细胞因子家族中的重要成员之一,不同于广泛来源于各种免疫细胞的IL-17A,IL-17C主要由上皮细胞分泌并通过IL-17RE/A受体复合物发挥作用,在银屑病、特应性皮炎等自身免疫性皮肤病中均存在表达异常。本文综述了IL-17C与自身免疫性皮肤病之间关系的研究进展。

关键词：白细胞介素-17C 细胞因子自身免疫性皮肤病银屑病特应性皮炎

Research on Multi-Objective Real-Time Optimization of Automatic Train Operation(ATO) in Urban Rail Transit

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Journal of Shanghai Jiaotong university(Science) 2018年第2期23卷 327-335页

作者： he tong XIONG Ruiqi School of Traffic and Transportation Lanzhou Jiaotong University Lanzhou 730070 China

The determination and optimization of Automatic Train Operation(ATO) control strategy is one of the most critical technologies for urban rail train operation. The practical ATO optimal control strategy must consider many goals of the train operation, such as safety, accuracy, comfort, energy saving and so on. This paper designs a set of efficient and universal multi-objective control strategy. Firstly, based on the analysis of urban rail transit and its operating environment, the multi-objective optimization model considering all the indexes of train operation is established by using multi-objective optimization theory. Secondly, Non-dominated Sorting Genetic Algorithm II(NSGA-II) is used to solve the model, and the optimal speed curve of train running is ***, the intelligent controller is designed by the combination of fuzzy controller algorithm and the predictive control algorithm, which can control and optimize the train operation in real time. Then the robustness of the control system can ensure and the requirements for multi-objective in train operation can be satisfied.

关键词： urban rail transit multi-objective Automatic Train Operation(ATO) Non-dominated Sorting Genetic Algorithm II(NSGA-II) fuzzy predictive controller

Relationship between dispersibility of ZrO2 nanoparticles in Ni-ZrO2 electroplated nanocomposite coatings and mechanical properties of nanocomposite coatings

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中国有色金属学会会刊：英文版 2004年第z1期14卷 186-189页

作者： WANG Wei HOU Feng-yan GUO he-tong School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Ni-ZrO2 nanocomposite coatings with monodispersed ZrO2 nanoparticles were prepared from the composite plating bath containing dispersant under DC electrodeposition condition. It is found that the morphology, orientation and hardness of the composite coating with monodispersed ZrO2 nanoparticles have lots of difference from the composite coating with agglomerated ZrO2 nanoparticles and pure nickel coating. Especially, the result of hardness shows that only a very low volume fraction (less than 1%) of monodispered ZrO2 nanoparticles in Ni-ZrO2 composite coatings will result in higher hardness of the coating. The hardness of Ni-ZrO2 nanocomposite coatings with monodispersed and agglomerated ZrO2 nanoparticles are HV 529 and HV 393, respectively. The hardness value of the former composite coatings is over 1.3 times higher than that of the later. All these composite coatings are 2 - 3 times higher than that of pure nickel plating (HV 207) prepared under the same conditions.

关键词： Nanocomposites electroplating coating metal matrix composites Ni-ZrO2

Evacuation simulation considering action of guard in artificial attack

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Chinese Physics B 2019年第1期28卷 275-282页

作者： Chang-Kun Chen Yun-he tong Institute of Disaster Prevention Science&Safety Technology Central South UniversityChangsha 410075China

To investigate the evacuation behaviors of pedestrians considering the action of guards and to develop an effective evacuation strategy in an artificial attack, an extended floor field model is proposed. In this model, the artificial attacker's assault on pedestrians, the death of pedestrians, and the guard's capture are involved simultaneously. An alternative evacuation strategy which can largely reduce the number of casualties is developed and the effects of several key parameters such as the deterrence radius and capture distance on evacuation dynamics are studied. The results show that congestion near the exit has dual effects. More specifically, the guard can catch all attackers in a short time because the artificial attackers have a more concentrated distribution, but more casualties can occur because it is hard for pedestrians to escape the assault due to congestion. In contrast, when pedestrians have more preference of approaching the guard, although the guard will take more time to capture the attackers resulting from the dispersion of the attackers, the death toll will decrease. One of the reasons is the dispersal of the crowd, and the decrease in congestion is beneficial for escape. The other is that the attackers will be caught before launching the attack on the people who are around the guard, in other words, the guard protects a large number of pedestrians from being killed. Moreover, increasing capture distance of the guard can effectively reduce the casualties and the catch time. As the deterrence radius reflecting the tendency of escaping from the guard for attackers rises, it becomes more difficult for the guard to catch the attackers and more casualties are caused. However, when the deterrence radius reaches a certain level, the number of deaths is reduced because the attackers prefer to stay as far away as possible from the guard rather than occupy a position where they could assault more people.

关键词： evacuation behavior artificial attack floor field model

Influence of Shear Banding on the Formation of Brass-type Textures in Polycrystalline fcc Metals with Low Stacking Fault Energy

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Journal of Materials Science & Technology 2014年第4期30卷 408-416页

作者： Haile Yan Xiang Zhao Nan Jia Yiran Zheng tong he Key Laboratory for Anisotropy and Texture of Materials(MOE) Northeastern University Northeastern University Research Academy

Texture evolution in nickel, copper and α-brass that are representative of face-centered-cubic （fcc） materials with different stacking fault energy （SFE） during cold rolling was systematically investigated. X-ray diffraction, scanning electron microscopy and electron backscatter diffraction techniques were employed to characterize microstructures and local orientation distributions of specimens at different thickness reductions. Besides, Taylor and Schmid factors of the {111} 〈110〉 slip systems and {111} 〈112〉 twin systems for some typical orientations were utilized to explore the relationship between texture evolution and deformation microstructures. It was found that in fcc metals with low SFE at large deformations, the copper-oriented grains rotated around the 〈110〉 crystallographic axis through the brass-R orientation to the Goss orientation, and finally toward the brass orientation. The initiation of shear banding was the dominant mechanism for the above-mentioned texture transition.

关键词： Face-centered-cubic ahoy Texture Rolling Shear band

Individual Grain Orientation and heterogeneous Deformation in Cold-deformed Interstitial-Free Sheet Steel

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Journal of Materials Science & Technology 2007年第5期23卷 689-692页

作者： Yandong LIU Chungang WANG Qiwu JIANG tong he Liang ZUO School of Materials and Metallurgy Northeastern University Shenyang 110004 China Production Manufacture Department Angang Steel Company Limited Anshan 114001 China Factory of Cold Rolling Silicon Steel Angang Steel Company Limited Anshan 114001 China

The cold rolling deformation textural evolution of an interstitial-free （IF） steel sheet is investigated by experiment and simulation. The microstructure of the IF steel is observed by transmission electron microscopy （TEM）. The relationship between the deformation behavior of individual grain and the grain orientation are connected by Taylor factor M. The results show that the grains with higher Taylor factor are deformed slighter than those with lower ones. By considering the heterogeneous deformation, the texture simulation result can be greatly improved.

关键词： IF steel Texture heterogeneous deformation Taylor factor

Formation of Nuclei With {111}<110> and {111}<112> Orientations of IF Steel at Early Stage of Recrystallization Using EBSD Analysis

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Journal of Iron and Steel Research International 2013年第9期20卷 61-66页

作者： he tong LIU Yan-dong SUN Wei ZUO Liang Research Academy Northeastern University Key Laboratory for Anisotropy and Texture of Materials of Ministry of Education

The excellent deep drawability of interstitial free steel （IF steel） is closely related to its texture formed during recrystallization. The nucleation process of cold rolled IF steel at the early stage of recrystallization was inves-tigated by electron back scattered diffraction （EBSD）. The characteristics of the microstructure after deformation and the orientation of nucleation were observed. The results show that the deformed microstructure with 80% reduction could be subdivided into two groups. These two types of microstructure were characterized by their orientation and internal local misorientations. The nuclei with γ-orientation preferred to form in deformed bands with γ-orientation and at the boundaries between deformed grains with different orientations. The recrystallized grains with { 111 } 〈 110〉 orientation appeared firstly in deformed matrix with {111} 〈112〉 orientation and consumed the matrix with {111 } 〈112〉 to grow up, while the recrystallized grains with {111} 〈112〉 orientation were observed secondly in de-formed matrix with { 111 }〈110〉 orientation and consumed matrix with { 111} 〈110〉 to grow up.

关键词： IF steel texture recrystallization EBSD