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“Inner GPS”, a far-reaching influence in brain research—For the Nobel Prize in Physiology or Medicine 2014

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Science China(Life Sciences) 2014年第12期57卷 1243-1244页

作者： he Rong qiao State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences

On the day of Oct.6,2014,John O’Keefe and a Norwegian couple May-Britt Moser and Edvard Moser won the Nobel Prize in Physiology or Medicine for discovering the"inner GPS"that functions in the brain when the animals navigate through the *** prize was awarded for their work in identifying the cells that make up the positioning system in the mammalian brain.

关键词：诺贝尔生理学或医学奖大脑功能 GPS 内蒙古哺乳动物定位系统脑细胞

Design of thiol-containing amino acids for native chemical ligation at non-Cys sites

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Chinese Chemical Letters 2013年第4期24卷 265-269页

作者： qiao-qiao he Ge-Min Fang Lei Liu Tsinghua-Peking Center for Life Sciences Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education)Department of ChemistryTsinghua University High Magnetic Field Laboratory Chinese Academy of Sciences

Protein chemical synthesis usually relies on the use of native chemical ligation that couples peptide thioester with a Cys-peptide. A limitation of this method is the difficulty of finding an appropriate Cys ligation site in many synthetic targets. To overcome this problem, the ligation-desulfurization approach has been developed. This approach involves the use of a thiol-containing amino acid as the ligation partner. After the sequence assembly is completed, the thiol group is removed through a desulfurization reaction to generate the standard amino acids. Currently this strategy has been applied to the ligations at a number of amino acids including Ala, Phe, Val, Lys, Thr, Leu, Pro and Gin. The present article reviews the design and svnthesis of these thiol-containing amino acids for native chemical libation at non-Cys sites.

关键词： Protein chemical synthesisNative chemical ligationDesulfurization

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铂修饰氮化铝纳米管对CO的吸附性能研究

原子与分子物理学报 2025年第1期42卷 88-94页

作者：任舒宁何建桥黄海深沈光先吴波贵州师范大学物理与电子科学学院贵阳550025 遵义师范学院物理与电子科学学院遵义563006

本文采用基于密度泛函理论的第一性原理研究了铂修饰的(5,5)氮化铝纳米管的几何结构、电子性质以及与一氧化碳(CO)之间的相互作用.结果表明:铂原子吸附于氮化铝纳米管表面氮原子的顶位时能量最低.铂原子附近可以吸附四个CO分子,平均吸... 详细信息

本文采用基于密度泛函理论的第一性原理研究了铂修饰的(5,5)氮化铝纳米管的几何结构、电子性质以及与一氧化碳(CO)之间的相互作用.结果表明:铂原子吸附于氮化铝纳米管表面氮原子的顶位时能量最低.铂原子附近可以吸附四个CO分子,平均吸附能在1.189-2.940 eV之间,铂原子的修饰有效提高了氮化铝纳米管对CO分子的吸附能力.本研究为实验上开发制备性能更加优良的CO气体传感器提供理论指导.

关键词：氮化铝纳米管第一性原理密度泛函理论

Response of snow hydrological processes to a changing climate during 1961 to 2016 in the headwater of Irtysh River Basin, Chinese Altai Mountains

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Journal of Mountain Science 2017年第11期14卷 2295-2310页

作者： ZHANG Wei KANG Shi-chang SheN Yong-ping he Jian-qiao CheN An-an State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences University of Chinese Academy of Sciences

With changing climatic conditions and snow cover regime, regional hydrological cycle for a snowy basin will change and further available surface water resources will be redistributed. Assessing snow meltwater effect on runoff is the key to water safety, under climate warming and fast social-economic developing status. In this study, stable isotopic technology was utilized to analyze the snow meltwater effect on regional hydrological processes, and to declare the response of snow hydrology to climate change and snow cover regime, together with longterm meteorological and hydrological observations, in the headwater of Irtysh River, Chinese Altai Mountains during 1961-2015. The average δ^(18) O values of rainfall, snowfall, meltwater, groundwater and river water for 2014–2015 hydrological year were-10.9‰,-22.3‰,-21.7‰,-15.7‰ and-16.0‰, *** results from stable isotopes, snow melting observation and remote sensing indicated that the meltwater effect on hydrological processes in Kayiertesi River Basin mainly occurred during snowmelt supplying period from April to June. The contribution of meltwater to runoff reached 58.1% during this period, but rainfall, meltwater and groundwater supplied 49.1%, 36.9% and 14.0% of water resource to annual runoff, respectively. With rising air temperature and increasing snowfall in cold season, the snow water equivalent(SWE) had an increasing trend but the snow cover duration declined by about one month including 13-day delay of the first day and 17-day advancement of the end day during 1961–2016. Increase in SWE provided more available water resource. However, variations in snow cover timing had resulted in redistribution of surface water resource, represented by an increase of discharge percentage in April and May, and a decline in Juneand July. This trend of snow hydrology will render a deficit of water resource in June and July when the water resource demand is high for agricultural irrigation and industrial manufacture.

关键词： Irtysh River Basin Chinese AltaiMountains Snow hydrology Isotope Climate change

Investigations of the dynamical behaviors of a millimeter-scale cavitation bubble near the rigid wall

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Journal of Hydrodynamics 2023年第6期35卷 1064-1076页

作者： Dan Zi Dong-qiao he Zhi-feng Yao Fu-jun Wang Qiang Zhong Pin Lyu College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System Beijing100083China Yichang Testing Technology Research Institute Yichang443000China

The collapse of the cavitation bubble near the rigid wall emits shock waves and creates micro-jet,causing cavitation damage and operation instability of the hydraulic *** this paper,the millimeter-scale bubble near the rigid wall was investigated experimentally and numerically with the help of a laser photogrammetry system with nanosecond-micron space-time resolution and the open source package *** morphological characteristics of the bubble during its growth phase,collapse phase and rebound phase were observed by experiment and numerical simulation,and characteristics of the accompanying phenomena including the shock wave propagation and micro-jet evolution were well *** numerical results agree well with the experimental *** bubble starts from a tiny small size with high internal pressure and expands into a sphere with a radius of 1.07 mm forγ=d/R_(max)=*** bubble collapses into a heart shape and moves towards to the rigid wall during its collapse phase,resulting in a higher pressure load for the rigid wall in the second *** maximum pressure of the shock wave of the first bubble collapse phase reaches 5.4 MPa,and the velocity of the micro-jet reaches approximately 100 m/*** study enriches the existing experimental and numerical results of the dynamics of the near-wall cavitation bubble.

关键词： Cavitation bubble collapse shock wave micro jet the rigid wall

Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys

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Zoological Research 2020年第4期41卷 444-448页

作者： Zhen-Hui Li Xia-Ping he Hao Li Rong-qiao he Xin-Tian Hu Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingVt/nnan 650204China School of Basic Medical Sciences Dali UniversityDaliYunnan 671000China CAS Center for Excellence in Brain Science Chinese Academy of SciencesShanghai 200031China Kunming Primate Research Center and National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) Chinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of ScienceBeijing 100101China

DEAR EDITOR,Rhesus monkeys(Macaca mulatta)are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans(Zhang et al.,2014).Rhesus monkeys also display similar hallmarks of aging and neurodegeneration as humans,including formation of senile plaques in the brain(Beckman et al.,2019;Paspalas et al.,2018).

关键词： al. senile amyloid

Synthesis and evaluation of bio-based elastomer based on diethyl itaconate for oil-resistance applications

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Science China Chemistry 2016年第11期59卷 1376-1383页

作者： Weiwei Lei he qiao Xinxin Zhou Wencai Wang Liqun Zhang Runguo Wang Kuo-Chih Hua State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical Technology Engineering Center of Ministry of Education on Elastomer Materials Energy Saving and Resource Utilization Beijing University of Chemical Technology Goodyear Innovation Center Goodyear Tire & Rubber Co.

Bio-based elastomer poly(diethyl itaconate-co-isoprene)(PDEII) was designed and synthesized by redox-initiated emulsion polymerization from diethyl itaconate and isoprene with mass ratio of 20:80, 40:60, 60:40 and 80:20. The number-average molecular weights of PDEII exceeded 140000 with relatively high yields. The physical properties of PDEII, such as glass transition temperatures and thermostability, were comparable with conventional synthetic elastomers and can be readily tuned by varying the ratio of diethyl itaconate to isoprene. The interaction between silica and PDEII macromolecules was effectively enhanced with the increase of diethyl itaconate content by endowing high polarity. The oil-resistance relevant properties of silica/PDEII80(80% diethyl itaconate, 20% isoprene) such as retention of tensile strength, retention of elongation at break and change in volume even surpass those of silica/NBR 240 S after soaked in ASTM 3# oil at different temperatures.

关键词： bio-based elastomer synthesis oil-resistance

Reactive carbonyl compounds(RCCs) cause aggregation and dysfunction of fibrinogen

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Protein & Cell 2012年第8期3卷 627-640页

作者： Ya-Jie Xu Min Qiang Jin-Ling Zhang Ying Liu Rong-qiao he State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Mental health Institute of PsychologyChinese Academy of SciencesBeijing 100101China

Fibrinogen is a key protein involved in coagulation and its deposition on blood vessel walls plays an important role in the pathology of *** the causes of fibrinogen(fibrin)deposition have been studied in depth,little is known about the relationship between fibrinogen deposition and reactive carbonyl compounds(RCCs),compounds which are produced and released into the blood and react with plasma protein especially under conditions of oxidative stress and ***,we investigated the effect of glycolaldehyde on the activity and deposition of fibrinogen compared with the common RCCs acrolein,methylglyoxal,glyoxal and *** the same concentration(1 mmol/L),glycolaldehyde and acrolein had a stronger suppressive effect on fibrinogen activation than the other three *** aggregated when it was respectively incubated with glycolaldehyde and the other RCCs,as demonstrated by SDS-PAGE,electron microscopy and intrinsic fluorescence intensity *** with Congo Red showed that glycolaldehyde-and acrolein-fibrinogen distinctly formed amyloid-like ***,the five RCCs,particularly glycolaldehyde and acrolein,delayed human plasma *** glycolaldehyde showed a markedly suppressive effect on fibrinogenesis,none did the other four RCCs when their physiological blood concentrations were employyed,*** together,it is glycolaldehyde that suppresses fibrinogenesis and induces protein aggregation most effectively,suggesting a putative pathological process for fibrinogen(fibrin)deposition in the blood.

关键词： fibrinogen acrolein glycolaldehyde glyoxal malondialdehyde methylglyoxal

To perceive a perfect Dora Maar in peripheral vision

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Science China(Life Sciences) 2016年第6期59卷 640-642页

作者： Rong-Ding he Tao Su Yang Yang Ying Liu Yan Wei Rong-qiao he Fine Art College Chengdu University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences

The Portrait of Dora Maar（92 cm×65 cm）painted by Pablo Picasso（1937）is an aesthetic masterpiece in the world（Brigitte,1996）.Picasso paints Dora seating on a chair in frontal view with an off-set profile and disjunctive facial features（André,1976）：that is,Dora’s nose becomes an extension of her face on which the＂far＂eye is seen looking straight at *** did Picasso paint his lover Dora in such a tortured style？

关键词： perfect straight masterpiece facial chair looking frontal aesthetic Figure lover