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Transcriptomic Analysis Reveals the Formation Mechanism of Anthocyanins Light-Independent Synthesis in Chrysanthemum

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1599-1621页

作者： Fangye Liu Jiaping Qu Yajun Li Jiawei Fan Yumeng Cui Jingwen Wu Xueqi Gu Xia Li he huang Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Key Laboratory of Ornamental Plants Germplasm Innovation&Molecular BreedingNational Engineering Research Center for FloricultureBeijing Laboratory of Urban and Rural Ecological EnvironmentKey Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Education MinistrySchool of Landscape ArchitectureBeijing Forestry UniversityBeijing100083China Urban Construction School Beijing City UniversityBeijing100083China

Chrysanthemum×morifolium is a horticultural crop which plays a vital role in theﬂower industry with signiﬁ-cant economic value and has a cultivation history of over three thousand years in *** accumulation of anthocyanins is always affected by ***,we revealed that anthocyanin accumulation is highly dependent on light in‘2021135’genotype chrysanthemum,while it is light-independent in‘2001402’genotype ***,no literature has been reported regarding the non-photosensitive chrysanthemum in anthocya-nins light-independent synthesis *** the phenotype analysis of 44 F1 generations,we found that light-independence is a dominant trait which can be stable inherited by *** transcriptome of the rayﬂorets of‘2021135’and‘2001402’under light and bagging treatment were sequenced and *** on weighted gene co-expression network analysis(WGCNA),K-means analysis,and Real-Time Quantitative Poly-merase Chain Reaction(RT-qPCR)analysis,16 genes were highly correlated with the anthocyanin *** anthocyanin content of rayﬂorets treated with different light-quality conditions indicated that blue light signiﬁ-cantly affected anthocyanin *** Yeast one-hybrid analysis,CmBIC1.1 and CmBIC1.2 can directly regulate the anthocyanin structural gene *** our study,we revealed the important characteristics of light-independent anthocyanin synthesis in chrysanthemums and screened regulatory factors in light-depen-dent and light-independent anthocyanin synthesis *** results laid the groundwork for subsequent ana-lysis of the molecular mechanism involved in the light-independent synthesis of anthocyanins in chrysanthemums.

关键词： Chrysanthemum non-photosensitive transcriptome anthocyanin biosynthesis

Review of Empirical Studies on Climate Risk—Effects and Activism

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American Journal of Climate Change 2024年第2期13卷 194-208页

作者： Yehuda Davis henry he huang Sy Syms School of Business Yeshiva University New York USA

This review focuses on major contemporary empirical studies that examine both the physical and regulatory sides of climate risk. These studies explore how climate risk affects firms’ operating performance and leverage, stock and bond valuation, cost of capital, and managerial behavior. We also discuss how the effect of climate risk on real estate markets depends on individuals’ beliefs about climate change. Furthermore, we summarize papers on climate risk activism and how firms can employ financial devices and technology to mitigate their climate risk. Finally, we make some recommendations for further research areas.

关键词： Climate Risk Climate Risk Activism Climate Risk Mitigation

Dietary oxidized cholesterol causes mucus barrier thinner via decreasing Muc2 expression in the proximal colon and increasing the abundance of mucus-degrading bacteria

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Food Science and Human Wellness 2024年

作者： Chi Yan Shou-he huang Zi-Xing Chen Hua-Fang Ding Zhen-Yu Chen School of Life Sciences， Faculty of Science， The Chinese University of Hong Kong

Oxidized cholesterol (OXC) is a harmful dietary substance. Although the consumption of OXC has been associated with colonic inflammation， related underlying mechanisms are still limited. We evaluated the influence of dietary OXC on gut health and ecology by applying the murine model. Results showed that the thickness of the mucus layer was significantly reduced in healthy mice treated with OXC. Short-term intake of OXC did not influence the expression of pro-inflammatory factors in healthy mice but it induced the decrease of Muc2 expression in the proximal colon， accompanied by an increase in the abundance of two mucus-degrading bacteria， namely A. muciniphila and B. acidifaciens. Consistently， oral exposure of OXC promoted mucus barrier erosion in DSS-induced colitis mice and facilitated bacteria infiltration in the colon. The adverse effect of OXC on mucus layer disappeared in antibiotics-treated healthy mice， suggesting that the damaging effect of OXC on the gut mucus layer was not direct and instead was mediated by causing microbiota dysbiosis. Finally， the impact of OXC on the mucus layer and colitis was partly alleviated by green tea catechins. These studies demonstrated that the OXC-induced mucus barrier damage was mainly induced by the dysregulation of gut microbiota at least in this mouse model.

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习近平文化思想的系统思维

思想理论教育导刊 2024年第5期 16-23页

作者：黄河四川外国语大学马克思主义学院

习近平文化思想深刻体现了前瞻性思考、全局性谋划和整体性推进的系统思维。习近平文化思想在新的历史起点上指明了继续推动文化繁荣、建设文化强国、建设中华民族现代文明这一新的文化使命,为新时代文化建设指明了远景目标和未来发展... 详细信息

习近平文化思想深刻体现了前瞻性思考、全局性谋划和整体性推进的系统思维。习近平文化思想在新的历史起点上指明了继续推动文化繁荣、建设文化强国、建设中华民族现代文明这一新的文化使命,为新时代文化建设指明了远景目标和未来发展方向。习近平文化思想以马克思主义文明观为指引,基于对文化传承和发展规律以及对中国特色社会主义文化建设规律的深刻把握,从中华文明发展的高度协调处理不忘本来、吸收外来与面向未来的关系,为建设中华民族现代文明进而探索人类文明新形态提供了理论指引和行动指南。习近平文化思想将新时代文化建设置于中华民族现代文明的高度中予以整体考量,聚焦厘清各要素之间的内在关联,着力推动总体协同与重点突破的有效融通,促使新时代文化建设呈现出协同配合、同频共振的合力。挖掘与揭示习近平文化思想中的系统思维,对于学深悟透习近平文化思想具有重要意义和深远影响。

关键词：习近平文化思想系统思维科学方法

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从史事、事势到功夫:宋明理学的历史形上学维度

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深圳大学学报（人文社会科学版） 2024年第2期41卷 132-140页

作者：黄河贵州大学哲学学院贵州贵阳550025

宋明理学虽以求内圣重“心”“性”示人,但也有“赞天地之化育”以建构社会秩序的价值取向。以“理”为最高原则,宋明儒根据“事者,为也”的理解,认为“事”是在时间意识作用下的动态展开,相应地呈现为历史过程,亦即“事以成史”。这一... 详细信息

宋明理学虽以求内圣重“心”“性”示人,但也有“赞天地之化育”以建构社会秩序的价值取向。以“理”为最高原则,宋明儒根据“事者,为也”的理解,认为“事”是在时间意识作用下的动态展开,相应地呈现为历史过程,亦即“事以成史”。这一过程每每受“势”的影响和限制,以此构成“事势”与“理势”的区分。“事势”是宋明儒用来表达“事”得以展开的具体背景,以及未来发展趋势,是客观性与必然性的统一;而“理势”则是万事万物所具有的规定及世界变迁的必然趋向,以当然与必然为双重内涵。无论是“事势”还是“理势”,皆关涉更为广泛的事实与价值,在宋明理学中别具形上意味。在“事以成史”的背景下,宋明理学中的“事中求理”可化约为“史事求理”,延及实践层面就成为“事中求理”“顺势而事”“事以成势”等功夫。对宋明理学历史形上学的关切,在于探寻其建构形而上哲学体系的终极关怀和现实逻辑。

关键词：史事事势宋明理学历史形上学功夫

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事视域中的史与势:以理学为中心

中国哲学史 2024年第4期 42-50页

作者：黄河贵州大学哲学学院

人的存在与发展内在地蕴含时间之维,并相应地展示为历史过程,在“事”之视域下呈现为“史”与“势”。“事”在时间之维的历史追溯,皆沉淀为“史”,而“事”在当下或未来的无限延展,则构成“势”之内涵。根据“史”以事成的设定,宋明儒... 详细信息

人的存在与发展内在地蕴含时间之维,并相应地展示为历史过程,在“事”之视域下呈现为“史”与“势”。“事”在时间之维的历史追溯,皆沉淀为“史”,而“事”在当下或未来的无限延展,则构成“势”之内涵。根据“史”以事成的设定,宋明儒从“事中有理”推衍出“史中求理”,并将后者作为格物致知的重要工夫。用以概括与物、人、事等相关的现象形势、存在情景或发展趋向之“势”,在实质层面关联着人的存在及其活动。宋明儒由此提出“事势”,亦即“事”得以展开的特定场景和发展趋向。以“事”的展开为背景,“势”既构成了有利的一面,又表现出与人相对或非人能够左右的一面,故而应“顺势”而为和以事“成势”。以“事”观之,“史”与“势”似乎不是宋理学的思想向度,但其义理阐发每每以“史”为基源、以“势”为背景,并演绎出独特的治史理路和颇具特色的历史哲学之维。

关键词：史势理学事视域

An Intelligent Bridge Multi-Dimension Deflection IoT Monitoring System Based on Laser Datum and Imaging

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Dan Zhao Huifeng Wang Hao Du Haoyi Cheng Lu Peng Yaru Liang he huang Yunmeng Li School of Electronic &Control Engineering， Chang'an University Research Institute of Highway Ministry of Transport State Key Laboratory of Traction Power， Southwest Jiaotong University

Aiming at the all-weather automatic monitoring of bridge structure health monitoring， an embedded bridge multi-dimensional (horizontal and vertical) deflection monitoring system based on dual laser references is proposed. The controller turns on the laser reference transmitter through instructions to emit the laser reference. The intelligent target system located in the middle of the span will calculate the multi-dimensional deflection and deformation information of the bridge structure according to the laser spot projected on the diffuse optical target， and pass this information through the wireless network communication unit transmits to the cloud platform to realize real-time monitoring of the bridge structure status and other parameters. Through the laboratory platform， it is found that the measurement error of this method is less than 300 μm， and the data update rate is less than 66 ms， which meets the requirements of bridge structural health monitoring. This method solves the problem of low efficiency of artificial bridge deflection monitoring， realizes all-weather online real-time monitoring of bridge deflection detection， and ensures the accuracy and efficiency of the measurement system.

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Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series

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World Journal of Clinical Cases 2024年第9期12卷 1560-1568页

作者： Jin-Long Zhao Xiao Jin he-Tao huang Wei-Yi Yang Jia-Hui Li Ming-Hui Luo Jun Liu Jian-Ke Pan The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Chinese Medicine The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina The Second School of Clinical Medical Sciences Guangzhou University of Chinese MedicineGuangdong Academy of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Affiliated Hospital Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120Guangdong ProvinceChina The Affiliated TCM Hospital Guangzhou Medical UniversityGuangzhou 510405Guangdong ProvinceChina The Research Team on Bone and Joint Degeneration and Injury Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Unicompartmental knee arthroplasty(UKA)has great advantages in the treatment of unicompartmental knee osteoarthritis,but its revision rate is higher than that of total knee *** To summarize and analyse the causes of revision after *** This is a retrospective case series study in which the reasons for the first revision after UKA are *** analysed the clinical symptoms,medical histories,laboratory test results,imaging examination results and treatment processes of the patients who underwent revision and summarized the reasons for primary revision after *** A total of 13 patients,including 3 males and 10 females,underwent revision surgery after *** average age of the included patients was 67.62 *** prosthesis was used for 3 d to 72 *** main reasons for revision after UKA were improper suturing of the surgical opening(1 patient),osteophytes(2 patients),intra-articular loose bodies(2 patients),tibial prosthesis loosening(2 patients),rheumatoid arthritis(1 patient),gasket dislocation(3 patients),anterior cruciate ligament injury(1 patient),and medial collateral ligament injury with residual bone cement(1 patient).CONCLUSION The causes of primary revision after UKA were gasket dislocation,osteophytes,intra-articular loose bodies and tibial prosthesis *** of these factors may greatly reduce the rate of revision after UKA,improve patient satisfaction and reduce medical burden.

关键词： Unicompartmental knee arthroplasty Total knee arthroplasty Causes Revision Case series

Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia:a multicenter,randomized,open-label,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2669-2678页

作者： Biqi Zhou Jia Chen Tianhui Liu Yishan Ye Yanming Zhang Yiyang Ding Hong Liu MingQing Zhu Xiao Ma Xiaoli Li Longfei Zhao Zhihong Lin he huang Yang Xu Depei Wu National Clinical Research Center for hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina Institute of Blood and Marrow Transplantation Collaborative Innovation Center of HematologySoochow UniversitySuzhouChina Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of hematology The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anHuai’anChina Soochow Hopes hematology Hospital SuzhouChina Department of hematology Hygeia Suzhou Yongding HospitalSuzhouChina

Coinfusion of unrelated cord blood(UCB)units in haploidentical hematopoietic cell transplantation(haplo-HCT)(haplo-cord HCT)for hematopoietic malignancies showed promising results in previous reports,but the efficiency of haplo-cord HCT in acute myeloid leukemia(AML)still lacks sufficient *** multicenter,randomized,phase 3 trial(*** NCT03719534)aimed to assess the efficacy and safety of haplo-cord HCT in AML patients.A total of 268 eligible patients aged 18-60 years,diagnosed with measurable residual disease in AML(excluding acute promyelocytic leukemia),with available haploidentical donors and suitable for allotransplantation,were randomly allocated(1:1)to receive haplo-cord HCT(n=134)or haplo-HCT(n=134).The 3-year overall survival(OS)was the primary endpoint in this *** median follow-up was 36.50 months(IQR 24.75-46.50).The 3-year OS of Haplo-cord HCT group was better than haplo-HCT group(80.5%,95%confidence interval[CI]:73.7-87.9 vs.67.8%95%CI 60.0-76.5,p=0.013).Favorable progression-free survival(70.3%,95%CI 62.6-78.8 vs.57.6%,95%CI 49.6-67.0,p=0.012)and cumulative incidence of relapse(12.1%,95%CI 12.0-12.2 vs.30.3%,95%CI 30.1-30.4,p=0.024)were observed in haplo-cord HCT *** 3-4 adverse events(AEs)within two years posttransplantation in the two groups were ***-cord HCT patients exhibited a faster cumulative incidence of neutrophil recovery(p=0.026)and increased T-cell reconstitution in the early period ***-cord HCT can improve OS in AML patients without excessive AEs,which may exert additional benefits for recipients of haplo-HCT.

关键词： hematopoietic acute phase