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一种基于非参数密度估计和马尔可夫上下文的SAR图像分割算法

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电子与信息学报 2006年第12期28卷 2209-2213页

作者：夏桂松何楚孙洪武汉大学电子信息学院信号处理实验室武汉430079

在研究传统的基于参数的合成孔径雷达(SAR)图像统计模型基础上,为了精确估计高分辨率SAR图像的统计分布,该文提出了一种结合基于核函数的非参数估计和马尔可夫上下文的SAR图像分割算法。该算法首先采用基于核函数的非参数方法估计SAR图... 详细信息

在研究传统的基于参数的合成孔径雷达(SAR)图像统计模型基础上,为了精确估计高分辨率SAR图像的统计分布,该文提出了一种结合基于核函数的非参数估计和马尔可夫上下文的SAR图像分割算法。该算法首先采用基于核函数的非参数方法估计SAR图像的统计分布,然后将此统计量作为图像分割的似然函数,利用马尔可夫上下文约束进行SAR图像分割。该文通过软件仿真对新算法和基于参数的统计模型的算法的效果进行了比较。研究发现,基于核函数的非参数估计方法仅仅依赖实际数据,在无法准确获取分布函数解析式的情况下往往具有更好的效果。实验证明,基于核函数的非参数估计方法对高分辨率SAR图像中较为复杂的场景如城区的提取取得了更为满意的结果。

关键词：合成孔径雷达(SAR) 图像分割 MRF模型核函数方法 Fisher分布

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基于区域的MRF模型用于SAR图像分割

信号处理 2005年第Z1期21卷 324-326页

作者：何楚夏桂松曹永峰杨文孙洪武汉大学电信学院信号处理实验室武汉湖北430079 武汉大学电信学院信号处理实验室武汉湖北430079 武汉大学电信学院信号处理实验室武汉湖北430079 武汉大学电信学院信号处理实验室武汉湖北430079 武汉大学电信学院信号处理实验室武汉湖北430079

本文提出了一种建立在流域算法过分割结果区域图上的马尔可夫随机场模型的SAR图像分割算法.由于将马尔可夫场随机场(MRF)模型建立在预分割的基础上,极大减少了计算复杂度,并利用SAR图像的分布模型建立多层MRF模型,采用模拟退火优化得到... 详细信息

本文提出了一种建立在流域算法过分割结果区域图上的马尔可夫随机场模型的SAR图像分割算法.由于将马尔可夫场随机场(MRF)模型建立在预分割的基础上,极大减少了计算复杂度,并利用SAR图像的分布模型建立多层MRF模型,采用模拟退火优化得到MAP估计的分割结果.实验证明较传统的基于像素的马尔可夫随机场分割算法,该方法极大提高了运算速度,并能取得较为满意的分割结果.

关键词：马尔可夫随机场(MRF) 流域分割图像分割

加味褚氏安胎方联合常规治疗对肾虚血瘀型血栓前状态致复发性流产患者的临床疗效

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中成药 2022年第10期44卷 3170-3174页

作者：李晖褚玉霞孙红河南省中医院/河南中医药大学第二附属医院生殖医学科河南郑州450002

目的探讨加味褚氏安胎方联合常规治疗对肾虚血瘀型血栓前状态致复发性流产患者的临床疗效。方法 90例患者随机分为对照组和观察组,每组45例,对照组给予常规治疗(地屈孕酮、阿司匹林),观察组在对照组基础上加用加味褚氏安胎方,疗程4周... 详细信息

目的探讨加味褚氏安胎方联合常规治疗对肾虚血瘀型血栓前状态致复发性流产患者的临床疗效。方法 90例患者随机分为对照组和观察组,每组45例,对照组给予常规治疗(地屈孕酮、阿司匹林),观察组在对照组基础上加用加味褚氏安胎方,疗程4周。检测临床疗效、中医证候评分、凝血-纤溶指标(APTT、PT、TT、FIB、D-D、PS、PC)、孕12周胚胎存活率、不良反应发生率变化。结果观察组总有效率、孕12周胚胎存活率高于对照组(P<0.05),不良反应发生率更低(P<0.05)。治疗后,2组中医证候评分、FIB、D-D降低(P<0.05),PS、PC升高(P<0.05),APTT、TT延长(P<0.05),PT缩短(P<0.05),以观察组更明显(P<0.05)。结论加味褚氏安胎方联合常规治疗可安全有效地改善肾虚血瘀型血栓前状态致复发性流产患者血栓前状态,缓解临床症状,提高胚胎存活率。

关键词：加味褚氏安胎方常规治疗复发性流产血栓前状态肾虚血瘀

Establishment of an orthotopic transplantation tumor model of hepatocellular carcinoma in mice

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World Journal of Gastroenterology 2012年第47期18卷 7087-7092页

作者： Gui-Jun Zhao Li-xia Xu Eagle SH chu Ning Zhang Jia-Yun Shen Alatangaole Damirin xiao-Xing Li College of Life Sciences Inner Mongolia University Department of Gastroenterology and hepatology Inner Mongolia People's Hospital Institute of Digestive Disease Department of Medicine and TherapeuticsLi Ka Shing Institute of Health Sciencesthe Chinese University of Hong Kong Shenzhen Research Institute the Chinese University of Hong Kong Department of Gastroenterology First Affiliated HospitalSun Yat-sen University

AIM:To improve the outcome of orthotopic transplantation in a mouse model,we used an absorbable gelatin sponge(AGS) in nude mice to establish an orthotopic implantation tumor ***:MHCC-97L hepatocellular carcinoma(HCC)cells stably expressing the luciferase gene were injected into the subcutaneous region of nude *** week later,the ectopic tumors were harvested and transplanted into the left liver lobe of nude *** AGS was used to establish the nude mouse orthotopic implantation tumor *** tumor suppressor gene,paired box gene 5(PAX5),which is a tumor suppressor in HCC,was transfected into HCC cells to validate the *** growth was measured by bioluminescence imaging ***-quantitative reverse transcription polymerase chain reaction(RT-PCR) and histopathology were used to confirm the tumorigenicity of the implanted tumor from the MHCC-97L cell ***:We successfully developed an orthotopic transplantation tumor model in nude mice with the use of an *** success rate of tumor transplantation was improved from 60% in the control group to 100% in the experimental group using *** detection of fluorescent signals showed that tumors grew in all live nude *** mice were divided into 3 groups:AGS-,AGS+/PAX5-and AGS+/PAX5 +.Tumor size was significantly smaller in PAX5 transfected nude mice compared to control mice(P hese fluorescent signal results were consistent with observations made during *** examination further confirmed that the tissues from the ectopic tumor were *** from RT-PCR proved that the HCC originated from MHCC-97L ***:Using an AGS is a convenient and efficient way of establishing an indirect orthotopic liver transplantation tumor model with a high success rate.

关键词： hepatocellular carcinoma Orthotopic transplantation tumor model Absorbable gelatin sponge Nude mice Bioluminescence imaging

实时剪切波弹性成像技术评价乙型肝炎肝纤维化严重程度的价值

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中国热带医学 2022年第12期22卷 1169-1173页

作者：孙小玲何薇李霞褚洪毅成都医学院第三附属医院(成都市郫都区人民医院)超声医学科四川成都611730

目的探讨实时剪切波弹性成像技术在评价乙型肝炎肝纤维化严重程度中的价值,并分析影响其准确性的因素。方法选择2018年2月—2020年10月成都医学院第三附属医院接诊的196例慢性乙型肝炎患者进行回顾性分析。收集患者性别、年龄、体质量指... 详细信息

目的探讨实时剪切波弹性成像技术在评价乙型肝炎肝纤维化严重程度中的价值,并分析影响其准确性的因素。方法选择2018年2月—2020年10月成都医学院第三附属医院接诊的196例慢性乙型肝炎患者进行回顾性分析。收集患者性别、年龄、体质量指数(BMI)等人口学指标及空腹血糖、肝功能、血脂组合等实验室指标。采用实时剪切波弹性成像技术对患者进行检测,以病理学检测结果为金标准,分析实时剪切波弹性成像技术对慢性乙型肝炎肝纤维化严重程度的诊断价值,并以Logistic回归分析评估各因素对实时剪切波弹性成像诊断准确度的综合作用。结果不同严重程度乙型肝炎肝纤维化患者实时剪切波弹性成像检测值比较差异有统计学意义(P<0.05),且F0级

关键词：实时剪切波弹性成像乙型肝炎肝纤维化诊断价值多因素分析

Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma

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Cancer Communications 2018年第1期38卷 81-94页

作者： Meng-Jie Yang Jie Guo Yan-Fang Ye Sui-hong Chen Li-xia Peng chu-Yang Lin Ting Hu Shang-Hang Xie chuan-Bo Xie Qi-hong Huang Yu-Qiang Lu Qing Liu Chao-Nan Qian Su-Mei Cao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Cancer Prevention Research Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China School of Public health Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China Department of Experimental Research Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Sihui Cancer Institute Sihui 526200GuangdongP.R.China

Background:The association of circulating inflammation markers with nasopharyngeal carcinoma(NPC)is still largely *** study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study in southern ***:The serum levels of 33 inflammatory cytokines were first measured in a hospital-based case-control study(150 NPC patients and 150 controls)using multiplex assay *** levels were categorized into two or more groups based on the proportion of sample measurements that was above the lower limit of *** ratios(ORs)and 95%confidence intervals(CIs)relating the serum marker concentration to the risk of NPC were computed by multivariable logistic regression *** associations were validated in 60 patients with NPC and 120 con-trols in a subsequent nested case-control study within a NPC screening *** interactions between serum cytokines and Epstein-Barr virus(EBV)relating to the risk of NPC were assessed using a likelihood ratio ***:The levels of serum macrophage inflammatory protein(MIP)-1αand MIP-1βin the highest categories were associated with a decreased risk of NPC in both the case-control study(MIP-1α:OR=0.49,95%CI=0.26-0.95;MIP-1β:OR=0.47,95%CI=0.22-1.00)and the nested case-control study(MIP-1α:OR=0.13,95%CI=0.03-0.62;MIP-1β:OR=0.20,95%CI=0.04-0.94),compared with those in the lowest ***,individuals with lower levels of these two cytokine markers who were EBV seropositive presented with a largely higher risk of NPC compared with patients with higher levels who were EBV seronegative in both the case-control study(MIP-1α:OR=16.28,95%CI=7.11-37.23;MIP-1β:OR=12.86,95%CI=5.9-28.05)and the nested case-control study(MIP-1α:OR=86.12,95%CI=10.58-701.03;MIP-1β:OR=115.44,95%CI=13.92-957.73).Conclusions:Decreased preclinical MIP-1αand MIP-1βlevels might be associated with a subsequently increased risk of NPC.

关键词： Nasopharyngeal carcinoma Prospective study Inflammatory cytokine Macrophage inflammatory protein Epstein-Barr virus

Increased Endogenous Sulfur Dioxide Involved in the Pathogenesis of Postural Tachycardia Syndrome in Children： A Case-Control Study

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Chinese Medical Journal 2018年第4期131卷 435-439页

作者： hong-xia Li xiao-chun Zheng Si-Yao Chen Ying Liao Zhen-Hui Han Pan Huang chu-Fan sun Jia Liu Jing-Yuan Song Chao-Shu Tang Jun-Bao Du Yong-hong Chen hong-Fang Jin Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Cardiac Surgery Guangdong General Hospital Guangzhou Guangdong 510000 China Department of Intensive Care Kaifeng Children's Hospital Kaifeng Henan 475000 China Department of Physiology and Pathophysiology Peking University Health Science Center and Key Laboratory of Molecular Cardiology of Ministry of Education Beijing 100191 China

Background： The pathogenesis of postural tachycardia syndrome （POTS） remains unclear. This study aimed to explore the changes and significance of sulfur dioxide （SO2） in patients with POTS. Methods： The study included 31 children with POTS and 27 healthy children from Peking University First Hospital between December 2013 and October 2015. A detailed medical history, physical examination results, and demographic characteristics were collected. hemodynamics was recorded and the plasma SO2was determined. Results： The plasma SO2was significantly higher in POTS children compared to healthy children （64.0 ± 20.8 μmol/L vs. 27.2 ± 9.6 μmol/L, respectively, P 〈 0.05）. The symptom scores in POTS were positively correlated with plasma SO2levels （r = 0.398, P 〈 0.05）. In all the study participants, the maximum heart rate （HR） was positively correlated with plasma levels of SO2（r = 0.679, P 〈 0.01）. The change in systolic blood pressure from the supine to upright （ΔSBP） in POTS group was smaller than that in the control group （P 〈 0.05）. The ΔSBP was negatively correlated with baseline plasma SO2levels in all participants （r = ？0.28, P 〈 0.05）. In the control group, ΔSBP was positively correlated with the plasma levels of SO2（r = 0.487, P 〈 0.01）. The change in HR from the supine to upright in POTS was obvious compared to that of the control group. The area under curve was 0.967 （95% confidence interval： 0.928–1.000）, and the cutoff value of plasma SO2level 〉38.17 μmol/L yielded a sensitivity of 90.3% and a specificity of 92.6% for predicting the diagnosis of POTS. Conclusions： Increased endogenous SO2levels might be involved in the pathogenesis of POTS.

关键词： Blood Pressure Children: Pathogenesis Postural Tachycardia Syndrome Sulfur Dioxide

Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

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Environment & health 2024年第6期2卷 390-400页

作者： Lu-Yin Wu Li-xia Liang Yang Zhou Zeeshan Mohammed Zhengmin Min Qian Stephen Edward McMillin Maya Tabet chu chu Yuan-Yuan Fan Jia-Xin Zhou Jing-Wen Huang Wei-hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping he Shuang Dai xiao-Dong Wang Hai-Feng Wang chun-Long Liu hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song hong Wang Bo Zhu Chang-Bo chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainhe mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—sun flares—sun coronal mass ejections(CMEs)—sun UV radiation