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Science China Chemistry 2009年第9期52卷 1388-1393页

作者： XIA JianJun LONG yi GUO minJie WANG ying mi HuaiFeng Biochemical Section of Key Laboratory of Functional Polymer Materials Ministry of Education of ChinaInstitute of Polymer ChemistryNankai UniversityTianjin 300071China

We introduce a new method for separation/enrichment of the low-content cellular protein in high mo-lecular weight on the basis of molecular imprinting. The template protein, bacterial cloned immu-noglobulin binding protein (BiP), was selectively assembled with assistant recognition polymer chains (ARPCs) from their library, which consists of numerous limited length polymer chains with randomly distributed recognition and immobilizing sites. The assemblies of proteins and ARPCs were adsorbed by porous polymeric beads and immobilized by cross-linking polymerization. After the template was removed, the synthesized imprinted polymer was used to adsorb authentic BiP from endoplasmic re-ticulum (ER) extract, and its proportional content was enriched 45 times. It is the first time that the low-content cellular natural protein, whose molecular weight reaches 78 kDa, is enriched by molecular imprinting.

关键词： molecular imprinting technique assistant recognition polymer chains (ARPCs) bacterial cloned protein high molecular weight protein

高频彩色多普勒超声诊断乳腺癌腋窝淋巴结转移的价值

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中华医学超声杂志（电子版） 2009年第1期6卷 27-29页

作者：林盈薛恩生林礼务何以敉高上达王艳吴丽足俞丽云福建医科大学附属协和医院福建省超声医学研究所福建医科大学医学影像学系福州350001

目的探讨高频彩色多普勒超声在乳腺癌腋窝淋巴结转移诊断中的应用价值。方法对266例乳腺癌患者的腋窝淋巴结行术前超声检查,对超声检出的152例腋窝淋巴结与术后病理结果对照,将其分为淋巴结转移组(93例)与淋巴结无转移组(59例),并对超... 详细信息

目的探讨高频彩色多普勒超声在乳腺癌腋窝淋巴结转移诊断中的应用价值。方法对266例乳腺癌患者的腋窝淋巴结行术前超声检查,对超声检出的152例腋窝淋巴结与术后病理结果对照,将其分为淋巴结转移组(93例)与淋巴结无转移组(59例),并对超声所显示的两组淋巴结的最大径、纵横比、皮髓比及血流分布类型行对比分析,并运用受试者工作特性(ROC)曲线进行评价。结果淋巴结转移组93例与淋巴结无转移组59例患者的淋巴结最大径分别为(18.9±6.7)mm及(19.6±7.2)mm,差异无统计学意义(P>0.05);而淋巴结转移组淋巴结的纵横比及皮髓比的中位数值分别为1.5(1～2.6)与2.0(0.8～4),与淋巴结无转移组的1.9(1～4.5)与0.5(0.2～2)比较差异均有统计学意义(均P<0.05);淋巴结转移组淋巴结血流分布以周围型及混合型居多,分别为54.5%(18/33)与30.3%(10/33);淋巴结无转移组淋巴结血流分布则以中央型居多,占63.2%(12/19)。ROC曲线分析显示:取淋巴结纵横比≤1.8对诊断淋巴结转移的敏感度及特异度分别高达62.4%与62.7%;取淋巴结皮髓比≥1.0对诊断淋巴结转移的敏感度及特异度分别高达75.3%与86.4%。结论高频彩色多普勒超声观察乳腺癌腋窝淋巴结形态,并取淋巴结的纵横比≤1.8和(或)皮髓比≥1.0进行分析,可提高乳腺癌腋窝淋巴结转移的诊断率,值得深入探讨。

关键词：乳腺肿瘤淋巴结肿瘤转移彩色多普勒超声检查

12-bit 2.6 GS/s RF DAC based on return-to-zero technology

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The Journal of China Universities of Posts and Telecommunications 2019年第4期26卷 36-42页

作者： Li Xiaopeng Wang Zhigong Zhang yi Zhang Youtao Zhang mi Institute of RF and OE ICs Southeast UniversityNanjing 210096China Nanjing Guobo Electronics Company Limited Nanjing 210016China Nanjing Electronic Devices Institute Nanjing 210016China National and Local Joint Engineering Laboratory of RF Integration and micro-assembly Technology Nanjing 210046China College of microelectronics Nanjing University of Posts and TelecommunicationsNanjing 210046China State Key Laboratory of millimeter Waves Southeast UniversityNanjing 210096China Science and Technology on Monolithic Intergrated Circuits and Modules Laboratory Nanjing 210016China

A 12-bit 2.6 GS/s radio frequency digital to analog converter(RF DAC)based on 1 um GaAs heterojunction bipolar transistor(HBT)process is *** DAC integrates a 4:1 multiplexer to reduce the data rate of input ports,which greatly facilitates the *** core adopts 4+8 segmented current steering structure.R-2R ladder network is used for 8 least significant bit(LSB)to realize binary current weighting and thermometer coding is used for 4 most significant bit(MSB).Return-to-zero(RZ)technology is used to expand the effective bandwidth of DAC output to the third Nyquist *** proposed DAC has a better output power flatness and spurious-free dynamic range(SFDR).Compared to traditional DAC,measured results demonstrate that the output power of this RZ DAC is increased by 33 dB and the SFDR is enhanced by 27 dB near the second Nyquist band.

关键词： DAC RZ Nyquist band

Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration

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Neural Regeneration Research 2016年第9期11卷 1506-1511页

作者： Guang-bin Zha mi Shen Xiao-song Gu Sheng yi Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University

Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated, wheth- er tau is involved in peripheral nerve regeneration remains unknown. In the current study, we obtained sciatic nerve tissue from adult rats 0, 1, 4, 7, and 14 days after sciatic nerve crush and examined tau mRNA and protein expression levels and the location of tau in the sciatic nerve following peripheral nerve injury. The results from our quantitative reverse transcription polymerase chain reaction analysis showed that compared with the uninjured control sciatic nerve, mRNA expression levels for both tau and tau tubulin kinase 1, a serine/ threonine kinase that regulates tau phosphorylation, were decreased following peripheral nerve injury. Our western blot assay results suggested that the protein expression levels of tau and phosphorylated tau initially decreased 1 day post nerve injury but then gradually increased. The results of our immunohistochemical labeling showed that the location of tau protein was not altered by nerve injury. Thus, these results showed that the expression of tau was changed following sciatic nerve crush, suggesting that tau may be involved in periph- eral nerve repair and regeneration.

关键词： nerve regeneration sciatic nerve crush microtubule-associated protein tau phosphorylated tau (Ser 404) tau hyper-phosphorylation tau tubulin kinase 1 microtubule structure microtubule assembly and disassembly peripheral nervous system neural regeneration

Cerebral metastasis from hepatoid adenocarcinoma of the stomach

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World Journal of Gastroenterology 2007年第43期13卷 5787-5793页

作者： Sheng Zhang mi Wang yi-Hui Xue Yu-Peng Chen Department of Pathology The First Affiliated Hospital of FujianMedical University Fuzhou 350005 Fujian Province China

We first report a rare case of metastasis from gastric hepatoid adenocarcinoma (HAC) to cerebral parenchyma, in a 50-year-old Chinese patient. he complained of a one-month history of a paroxysm of headache in the left temple and pars parietalis accompanied with binocular caligation caligo, insensible feeling of limbs and transient anepia. Magnetic resonance (MR) imaging revealed a spherical occupying lesion in the left posterior-temple lobe which was clinically diagnosed as a metastatic tumor. Three years ago, the patient accepted total gastrectomy as he was pathologically diagnosed at gastroscopy having an adenocarcinoma. Eight months after gastrectomy, the occupying lesion in liver was detected by ultrasound and CT, and he accepted transcatheter arterial embolization. Before operation of the brain metastasis, no obvious abnormality was found in liver by ultrasound. Histopathological characteristics of the brain tumor were identical to those of stomach tumor. The growth pattern of both tumors showed solid cell nests. The tumor cells were polygonal, and had abundant eosinophilic cytoplasm and round nuclei with obvious nucleoli. Sinusoid-like blood spaces were located between nodular tumor cells. Immunohistochemistry-stained tumor cells were positive for AFP and negative for hep-Par-1. According to these histopathological findings, both tumors were diagnosed as HAC and metastatic HAC. The patient remained alive 16 mo after tumorectomy of the cerebral metastasis. The differential diagnosis of brain metastasis from metastatic tumors should use a panel of antibodies to avoid confusing with the brain metastasis of hepatocellular carcinoma (HCC). This paper describes this rare case of metastasis from gastric hepatoid adenocarcinoma to cerebral parenchyma, and provides a review of the literature concerning its histopathological and immunohistochemical characteristics.

关键词： Cerebral metastasis Gastric hepatoidadenocarcinoma Immunohistochemistry

Enhanced catalytic degradation process of o-nitrochlorobenzene by palladium-catalyzed Fe^0 particles

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Journal of Environmental Sciences 2005年第5期17卷 849-852页

作者： XU Xin-hua ZHOU Hong-yi ZHOU mi WANG Da-hui Department of Environmental Engineering Zhejiang University Hangzhou 310027 China College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310032 China

Over Pd/Fe bimetallic catalyst, o-nitrochlorobenzene（o-NCB）, at a concentration of 20 mg/L in aqueous solutions, is rapidly converted to o-chloroaniline（o-CAN） first, and then quickly dechlorinated to aniline（AN） and Cl^- , without other intermediate reaction products. The aminated and dechlorinated reactions are believed to take place on the surface site of the Pd/Fe. The o-NCB removal efficiency and the next dechlorination rate increase with an increase of bulk loading of palladium and catalysts addition due to the increase of both the surface loading of palladium and the total surface area. These results indicate that reduction, amination and dechlorination of o- NCB by palladium-catalyzed Fe^0 particles, can be designed for remediation of contaminated groundwater.

关键词： palladium-catalyzed Fe^0 amination dechlornation o-NCB

The Most Comprehensive Database of Ionic Transport Characteristics to Date

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材料导报 2020年第20期34卷 20001-20002页

作者： he Bing mi Penghui ZHANG Liwen CHI Shuting YE Anjiang SHI Siqi School of Computer Engineering and Science Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Materials Genome Institute Shanghai UniversityShanghai 200444China

(a)The architecture of the ionic transport characteristics database;(b)the flow chart of the combination of geometric analysis and BVSE method;(c)the architecture of high-throughput screening platform for solid *** blue bidirectional lines indicate dataflow Transport characteristics of ionic conductors play a key role in the performance of electrochemical devices[1-2].Any optimization of the performance of the ionic compounds is inseparable from the understanding of the basic transport *** has been previously established that ion transport properties are defined by framework transport channel geometry,*** size,and resulting migration energy[3-4].

关键词： database flow characteristics

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Electrical and thermal transport properties of kagome metals AV3Sb5(A=K,Rb,Cs)

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Tungsten 2023年第3期5卷 300-316页

作者： Xin-Run mi Kun-Ya Yang Yu-Han Gan Long Zhang Ai-Feng Wang yi-Sheng Chai Xiao-Yuan Zhou ming-Quan he Low Temperature Physics Lab College of Physics and Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China

The interplay between lattice geometry,band topology and electronic correlations in the newly discovered kagome compounds AV3Sb5(A=K,Rb,Cs) makes this family a novel playground to investigate emergent quantum phenomena,such as unconventional superconductivity,chiral charge density wave and electronic *** exotic quantum phases naturally leave nontrivial fingerprints in transport properties of AV3Sb5,both in electrical and thermal channels,which are prominent probes to uncover the underlying *** this brief review,we highlight the unusual electrical and thermal transport properties observed in the unconventional charge ordered state of A V3Sb5,including giant anomalous Hall,anomalous Nernst,ambipolar Nernst and anomalous thermal Hall *** of these anomalous transport properties to time-reversal symmetry breaking,topological and multiband fermiology,as well as electronic nematicity,are also ***,a perspective together with challenges of this rapid growing field are given.

关键词： Kagome superconductors Charge density wave Anomalous Hall effect Anomalous Nernst effect Ambipolar Nernst Effect Anomalous thermal Hall effect

高频彩色多普勒超声诊断外周神经源性肿瘤的价值

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中外医疗 2017年第30期36卷 25-27页

作者：王艳薛恩生何以敉叶琴陈舜梁荣喜郭晶晶林文金林礼务福建医科大学附属协和医院超声科福建省超声医学研究所福建福州350001

目的探讨高频彩色多普勒超声对外周神经源性肿瘤的临床诊断价值。方法分析研究该院2012年1月—2016年3月经手术或穿刺病理证实的70例外周神经源性肿瘤患者的超声表现,观察肿瘤的大小、形态、边界、内部回声、血流信号,以及重点观察肿瘤... 详细信息

目的探讨高频彩色多普勒超声对外周神经源性肿瘤的临床诊断价值。方法分析研究该院2012年1月—2016年3月经手术或穿刺病理证实的70例外周神经源性肿瘤患者的超声表现,观察肿瘤的大小、形态、边界、内部回声、血流信号,以及重点观察肿瘤与神经干的关系。结果外周神经源性肿瘤患者,声像图表现以椭圆形、梭形为主,边界清晰,有完整清晰的包膜或假包膜。神经鞘瘤部分肿瘤内部回声均匀,部分出现液化。神经纤维瘤及神经纤维瘤病的肿瘤内部回声均匀,均无液化。CDFI显示大部分肿瘤内部及周边可见血流信号,且以I^II级血流为主。外周神经源性肿瘤特征性表现是肿瘤两端或一端或其旁可见条状低回声的神经干相连,该研究中28例可发现此征象,其中位于四肢22例(占78.6%)。结论外周神经源性肿瘤具有一定的特征性声像图改变,特别是对于四肢部位的神经源性肿瘤,高频彩色多普勒超声可以清晰地观察到肿瘤与神经干的关系。术前超声明确诊断对临床手术成功治愈且不留后遗症具有重要的指导作用。

关键词：高频彩色多普勒超声外周神经源性肿瘤