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Chinese Journal of Chemical engineering 2024年第6期70卷 251-260页

作者： Xiaoxiao Dong Zhuohong he Xu yan Dong Gao Jingyu Jiao yan Sun Haibin Wang Haibin Qu Pharmaceutical Informatics institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hisun Biopharmaceutical Co.Ltd. Hangzhou 311404China

Raman spectroscopy has found extensive use in monitoring and controlling cell culture *** this context,the prediction accuracy of Raman-based models is of paramount ***,models established with data from manually fed-batch cultures often exhibit poor performance in Raman-controlled ***,there is a need for effective methods to rectify these *** objective of this paper is to investigate the efficacy of Kalman filter(KF)algorithm in correcting Raman-based models during cell ***,partial least squares(PLS)models for different components were constructed using data from manually fed-batch cultures,and the predictive performance of these models was ***,various correction methods including the PLS-KF-KF method proposed in this study were employed to refine the PLS ***,a case study involving the auto-control of glucose concentration demonstrated the application of optimal model correction *** results indicated that the original PLS models exhibited differential performance between manually fed-batch cultures and Raman-controlled *** glucose,the root mean square error of prediction(RMSEP)of manually fed-batch culture and Raman-controlled culture was 0.23 and 0.40 g·L^(-1).With the implementation of model correction methods,there was a significant improvement in model performance within Raman-controlled *** RMSEP for glucose from updating-PLS,KF-PLS,and PLS-KF-KF was 0.38,0.36 and 0.17 g·L^(-1),***,the proposed PLS-KF-KF model correction method was found to be more effective and stable,playing a vital role in the automated nutrient feeding of cell cultures.

关键词： Raman spectroscopy Model correction Algorithm Model-predictive control Bioprocess

Stability behavior of the Lanxi ancient flood control levee after reinforcement with upside-down hanging wells and grouting curtain

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Journal of Mountain Science 2024年第1期21卷 84-99页

作者： QIN Zipeng TIAN yan GAO Siyuan ZHOU Jianfen he Xiaohui he Weizhong GAO Jingquan School of Water Conservancy and Environment engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Department of Civil engineering Imperial College LondonLondonSW71BFEngland Lanxi Water Affairs Bureau Lanxi 321102China Zhejiang Water Conservancy engineering Consulting Co. LtdHangzhou 310051China

The stability of the ancient flood control levees is mainly influenced by water level fluctuations, groundwater concentration and rainfalls. This paper takes the Lanxi ancient levee as a research object to study the evolution laws of its seepage, displacement and stability before and after reinforcement with the upside-down hanging wells and grouting curtain through numerical simulation methods combined with experiments and observations. The study results indicate that the filled soil is less affected by water level fluctuations and groundwater concentration after reinforcement. A high groundwater level is detrimental to the levee's long-term stability, and the drainage issues need to be fully considered. The deformation of the reinforced levee is effectively controlled since the fill deformation is mainly borne by the upside-down hanging wells. The safety factors of the levee before reinforcement vary significantly with the water level. The minimum value of the safety factors is 0.886 during the water level decreasing period, indicating a very high risk of the instability. While it reached 1.478 after reinforcement, the stability of the ancient levee is improved by a large margin.

关键词： Stability analysis Multiple factors Antiseepage reinforcement Upside-down hanging well Grouting curtain Ancient levee

PDOL-Based Solid Electrolyte Toward Practical Application:Opportunities and Challenges

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Nano-Micro Letters 2024年第7期16卷 109-141页

作者： Hua yang Maoxiang Jing Li Wang Hong Xu Xiaohong yan Xiangming he institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013People’s Republic of China institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084People’s Republic of China

Polymer solid-state lithium batteries(SSLB)are regarded as a promising energy storage technology to meet growing demand due to their high energy density and *** conductivity,interface stability and battery assembly process are still the main challenges to hurdle the commercialization of *** the main component of SSLB,poly(1,3-dioxolane)(PDOL)-based solid polymer electrolytes polymerized in-situ are becoming a promising candidate solid elec-trolyte,for their high ion conductivity at room temperature,good battery elec-trochemical performances,and simple assembly *** review analyzes opportunities and challenges of PDOL electrolytes toward practical application for polymer *** focuses include exploring the polymerization mechanism of DOL,the performance of PDOL composite electrolytes,and the application of ***,we provide a perspective on future research directions that need to be emphasized for commercialization of PDOL-based electrolytes in *** exploration of these schemes facilitates a comprehensive and profound understanding of PDOL-based polymer electrolyte and provides new research ideas to boost them toward practical application in solid-state batteries.

关键词： Poly(1,3-dioxolane) Solid electrolyte Polymerization mechanism Composite electrolyte Practical application

Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing

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Regenerative Biomaterials 2024年第1期3卷 69-81页

作者： yan Li Jiawei Liu Chenxi Lian he yang Mingjiang Zhang Youfa Wang Honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Chaozhou Branch of Chemistry and Chemical engineering Guangdong Laboratory Chaozhou 521000China Shenzhen Research institute of Wuhan University of Technology Shenzhen 518000China

As a superior alternative to sutures,tissue adhesives have been developed significantly in recent ***,existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces,bond weakly in wet environments and lack *** this study,a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue *** hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments,which can effectively improve the wet bonding *** citrate-based polyurethane adhesive provides rapid,non-invasive,liquid-tight and seamless closure of skin incisions,overcoming the limitations of sutures and commercial tissue *** addition,it exhibits biocompatibility,biodegradability and hemostatic *** degradation product citrate could promote the process of angiogenesis and accelerate wound *** study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.

关键词： tissue adhesive polyurethane citrate wet adhesion

A systematic understanding of microbial reductive dechlorination towards an improved “one health” soil bioremediation: A review and perspective

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Science China Technological Sciences 2024年第10期67卷 3009-3031页

作者： he yan LI ShuYao YUAN Jing CheNG Jie DOU JiBo yanG XueLing XU JianMing Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang University Key Laboratory of Environment Remediation and Ecological health Ministry of Education Microbiome Network and Department of Agricultural Biology Colorado State University Departments of Chemistry and Chemical & Biomolecular engineering Institute for Functional Intelligent Materials (I-FIM)National University of Singapore

Chlorinated organic pollutants(COPs), both emerging and traditional, are typical persistent pollutants that harm soil health worldwide. Dechlorinators mediated reductive dechlorination is the optimal way to completely remove COPs from anaerobic soil through a redox reaction driven by electron transfer during microbial anaerobic respiration. Generally, the dechlorinated depletion of COPs in situ often interacts with multiple element biogeochemical activities, e.g., methanogenesis, sulfate reduction, iron reduction, and denitrification. Elucidating the relevance of biogeochemical cycles between COPs and multiple elements and the coupled mechanisms involved, thus, helps to develop effective pollution control strategies with the balance between pollution degradation and element cycles in heterogeneous soil, ultimately contributing to “one health” goal. In this review, we summarized the microbial-chemical coupling redox processes and the driving factors, elucidated the interspecies metabolites exchange and electron transfer mechanisms within COP-dechlorinating communities, and further proposed a detailed design, construction, and analysis framework of engineering COP-dechlorinating microbiomes via “top-down” selfassembly and “bottom-up” synthesis to pave the way from laboratory to practical field application. Especially, we delve into the major challenges and perspectives surrounding the design of state-of-the-art synthetic microbial communities. Our goal is to improve the understanding of the microbial-mediated coupling between reductive dechlorination and element biogeochemical cycling, with a particular focus on the implications for health-integrated soil bioremediation under the “one health” concept.

关键词： reductive dechlorination biogeochemical redox processes interspecies interaction synthetic microbiomes, anaerobic soils

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Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-toK base editing in rice plants

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aBIOTECH 2024年第2期5卷 127-139页

作者： Yucai Li Shaoya Li Chenfei Li Chen Zhang Lei yan Jingying Li Yubing he yan Guo Lanqin Xia institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Hainan Yazhou Bay Seed Laboratory/National Nanfan Research institute(Sanya) CAASSanya 572024China

engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the scope and potential of base editing in directed evolution and crop ***,we isolated a rice endogenous hypoxanthine excision protein,N-methylpurine DNA glycosylase(OsMPG),and engineered two plant A-to-K(K=G or T)base editors,rAKBE01 and rAKBE02,for simultaneous adenine transition and transversion base editing in rice by fusing OsMPG or its mutant mOsMPG to a plant adenine transition base editor,*** further coupled either OsMPG or mOsMPG with a transactivation factor VP64 to generate rAKBE03 and rAKBE04,*** these four rAKBEs,at five endogenous loci in rice protoplasts,indicated that rAKBE03 and rAKBE04 enabled higher levels of A-to-G base transitions when compared to ABE8e and ***,whereas rAKBE01 only enabled A-to-C/T editing at one endogenous locus,in comparison with rAKBE02 and rAKBE03,rAKBE04 could significantly improve the A-to-C/T base transversion efficiencies by up to 6.57-and 1.75-fold in the rice protoplasts,***,although no stable lines with A-to-C transversion were induced by rAKBE01 and rAKBE04,rAKBE04 could enable simultaneous A-to-G and A-to-T transition and transversion base editing,at all the five target loci,with the efficiencies of A-to-G transition and A-to-T transversion editing ranging from 70.97 to 92.31%and 1.67 to 4.84%in rice stable lines,***,these rAKBEs enable different portfolios of editing products and,thus,now expands the potential of base editing in diverse application scenario for crop improvement.

关键词： Rice(Oryza sativa L) Rice N-methylpurine DNA glycosylase(OsMPG) A-to-K base editor(AKBE) Transactivation module VP64

A comprehensive review on surface modifications of black phosphorus using biological macromolecules

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Frontiers of Materials Science 2024年第2期18卷 37-59页

作者： Chaiqiong Guo Xuhong he Xuanyu Liu Yuhui Wang yan Wei Ziwei Liang Di Huang Department of Biomedical engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda institute of Advanced Materials and Chemical engineering Taiyuan 030032China

Black phosphorus(BP),a novel two dimensional material,exhibits remarkable photoelectric characteristics,ultrahigh photothermal conversion efficiency,substantial specific surface area,high carrier mobility,and tunable band gap *** attributes have positioned it as a promising candidate in domains such as energy,medicine,and the ***,its vulnerability to light,oxygen,and water can lead to rapid degradation and loss of crystallinity,thereby limiting its synthesis,preservation,and ***,BP has demonstrated cytotoxic tendencies,substantially constraining its viability in the realm of ***,the imperative for surface modification arises to bolster its stability and biocompatibility,while concurrently expanding its utility *** macromolecules,integral components of living organisms,proffer innate advantages over chemical agents and polymers for the purpose of the BP *** review comprehensively surveys the advancements in utilizing biological macromolecules for the modifications of *** doing so,it aims to pave the way for enhanced stability,biocompatibility,and diversified applications of this material.

关键词： blackphosphorus tumor therapy biocompatibility surface modification biomacromolecule

Differences in Precipitation and Related Wind Dynamics and Moisture and heat Features in Separate Areas of the South China Sea before and after Summer Monsoon Onset

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Advances in Atmospheric Sciences 2024年第8期41卷 1643-1660页

作者： Chunyan ZHANG Donghai WANG Kaifeng ZHANG Wanwen he yanping ZheNG yan XU Guangdong Meteorological Data Center Guangdong Meteorological BureauGuangzhou 510640China School of Atmospheric Sciences Sun Yat-sen UniversityGuangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesKey Laboratory of Tropical Atmosphere-Ocean SystemMinistry of EducationZhuhai 519082China Southern Marine Science and engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China National Observation and Research Station of Coastal Ecological Environments in Macao Macao Environmental Research InstituteMacao University of Science and TechnologyMacao SAR 999078China Foshan Meteorological Service Foshan 528000China Ningjiang District Meteorological Bureau Songyuan 138000China

Using surface and balloon-sounding measurements, satellite retrievals, and ERA5 reanalysis during 2011–20, this study compares the precipitation and related wind dynamics, moisture and heat features in different areas of the South China Sea(SCS) before and after SCS summer monsoon onset(SCSSMO). The rainy sea around Dongsha(hereafter simply referred to as Dongsha) near the north coast, and the rainless sea around Xisha(hereafter simply referred to as Xisha) in the western SCS, are selected as two typical research subregions. It is found that Dongsha, rather than Xisha, has an earlier and greater increase in precipitation after SCSSMO under the combined effect of strong low-level southwesterly winds, coastal terrain blocking and lifting, and northern cold air. When the 950-h Pa southwesterly winds enhance and advance northward, accompanied by strengthened moisture flux, there is a strong convergence of wind and moisture in Dongsha due to a sudden deceleration and rear-end collision of wind by coastal terrain blocking. Moist and warm advection over Dongsha enhances early and deepens up to 200 h Pa in association with the strengthened upward motion after SCSSMO, thereby providing ample moisture and heat to form strong precipitation. However, when the 950-h Pa southwesterly winds weaken and retreat southward, Xisha is located in a wind-break area where strong convergence and upward motion centers move in. The vertical moistening and heating by advection in Xisha enhance later and appear far weaker compared to that in Dongsha, consistent with later and weaker precipitation.

关键词： Dongsha Xisha South China Sea summer monsoon onset precipitation wind dynamics moisture heat

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Spatial construction of ultrasmall Pt-decorated 3D spinel oxidemodified N-doped graphene nanoarchitectures as high-efficiency methanol oxidation electrocatalysts

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Rare Metals 2024年第1期43卷 186-197页

作者： Qi Zhang Min-Min yan Wen-Fa Du Chen-Yu Yin Jian Zhang Lu yang Yun-Qing Kang Hai-yan he Hua-Jie Huang College of Mechanics and Materials Hohai UniversityNanjing 210098China New Energy Technology engineering Lab of Jiangsu Province College of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China International Center for Materials Nanoarchitectonics(WPIMANA) National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan

Direct methanol fuel cell technology recently becomes the focus of both academic and engineering circles,which stimulates the exploitation and utilization of advanced electrode catalysts with high activity and long ***,we demonstrate a robust bottom-up approach to the spatial construction of three-dimensional(3D) spinel manganese-cobalt oxide-modified N-doped graphene nanoarchitectures decorated with ultrasmall Pt nanoparticles(Pt/MnCo_(2)O_(4)-NG) via a controllable selfassembly *** incorporation of MnCo_(2)O_(4)nanocrystals provides abundant hydroxyl sources to promote the oxidative removal of CO-like byproducts on Pt sites,while the existence of 3D porous N-doped graphene networks facilitates the transportation of both ions and electrons in the hybrid system,thus giving rise to remarkable synergetic coupling effects during the methanol oxidation ***,the optimized Pt/MnCo_(2)O_(4)-NG nano architecture expres ses exceptional electrocatalytic properties with a large electrochemically active surface area of 99.5 m^(2)·g^(-1),a high mass activity of1508.3 mA·mg^(-1),strong toxicity resistance and reliable long-term durability,which have obvious competitive advantages over those of conventional Pt/carbon black,Pt/carbon nano tube,Pt/graphene,and Pt/N-doped graphene catalysts with the same Pt usage.

关键词： Platinum MnCo_(2)O_(4) 3D graphene Electrocatalysts Methanol oxidation