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Safety and efficacy of posterior sub-Tenon＇s carboplatin injection versus intravitreal melphalan therapy in the management of retinoblastoma with secondary vitreous seeds

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 445-455页

作者： Azza Mohamed Ahmed Said Mohamed Gamil Al hazem omar rashed Anwaar Mahmoud Rady Department of Ophthalmology Faculty of Medicine Ain Shams University Cairo 11566 Egypt Oncology and Radiation Medicine Department Faculty of Medicine Ain Shams University Cairo 11566 Egypt

AIM： To evaluate the safety and efficacy of posterior sub-Tenon＇s carboplatin injection compared to intravitreal melphalan injection in the management of retinoblastoma （RB） with secondary vitreous seeds. The outcome measures were vitreous seeds regression, need for other treatment modalities to achieve ocular salvage and treatment side effects. METHODS： A prospective interventional comparative nonrandomized study included RB eyes developed secondary vitreous seeds during the period of follow up. They subdivided into two groups： study group Ⅰ where posterior sub-Tenon＇s carboplatin （20 mg/2 mL） was injected and study group Ⅱ where intravitreal melphalan （20 μg/0.1 mL） was injected. The injections repeated every 2-4wk. RESULTS： Thirty-three eyes were included in the study. Seventeen eyes （16 patients） in study group Ⅰ and 16 eyes （16 patients） in study group Ⅱ. Ten eyes （30.3%） were completely salvaged following local chemotherapies, Ocular salvage was 23.5% following posterior sub-Tenon＇s carboplatin injection versus 37.5% following intravitreal melphalan raised to 47.1% and 75% with addition of external beam radiotherapy （EBR） with no statistically significant difference between the study groups （P=0.16）. A statistically significant correlation was found between ocular salvage rate and type of vitreous seeds either dust, spheres and clouds （r=0.42, P=-0.015） and eyes harbor new solid tumor growth （r=0.35, P=0.045）. The mean and median follow up periods following local chemotherapy injections were 2.0y in the study group Ⅰand 2.37y in the study group Ⅱ. Few complications were reported： periorbital edema in all eyes and ocular motility disturbances in 13 eyes （76.5%） following posterior sub-Tenon＇s carboplatin injection. Vitreous hemorrhage developed in 2 eyes （12.5%） and localized retinopathy in 5 eyes （31.25%） following intravitreal melphalan. ~ CONCLUSION： Local chemotherapy for treatment of RB with secondary vitreous seeds is safe and can salvage 30.3% of eyes

关键词： intravitreal melphalan posterior sub-Tenon'scarboplatin retinoblastoma secondary vitreous seeds

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Developed Fall Detection of Elderly Patients in Internet of Healthcare Things

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Computers, Materials & Continua 2023年第8期76卷 1689-1700页

作者： omar Reyad hazem Ibrahim Shehata Mohamed Esmail Karar College of Computing and Information Technology Shaqra UniversityP.O.Box 33Shaqra11961Saudi Arabia Faculty of Computers and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Zagazig UniversityZagazig44519Egypt Faculty of Electronic Engineering Menoufia UniversityMenouf32952Egypt

Falling is among the most harmful events older adults may *** the continuous growth of the aging population in many societies,developing effective fall detection mechanisms empowered by machine learning technologies and easily integrable with existing healthcare systems becomes *** paper presents a new healthcare Internet of Health Things(IoHT)architecture built around an ensemble machine learning-based fall detection system(FDS)for older *** to deep neural networks,the ensemble multi-stage random forest model allows the extraction of an optimal subset of fall detection features with minimal *** number of cascaded random forest stages is automatically *** study uses a public dataset of fall detection samples called SmartFall to validate the developed fall detection *** SmartFall dataset is collected based on the acquired measurements of the three-axis accelerometer in a *** scenario in this dataset is classified and labeled as a fall or a *** comparison to the three machine learning models—K-nearest neighbors(KNN),decision tree(DT),and standard random forest(SRF),the proposed ensemble classifier outperformed the other models and achieved 98.4%*** developed healthcare IoHT framework can be realized for detecting fall accidents of older people by taking security and privacy concerns into account in future work.

关键词： Elderly population fall detection wireless sensor networks Internet of health things ensemble machine learning

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Deep Forest-Based Fall Detection in Internet of Medical Things Environment

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Computer Systems Science & Engineering 2023年第6期45卷 2377-2389页

作者： Mohamed Esmail Karar omar Reyad hazem Ibrahim Shehata College of Computing and Information Technology Shaqra UniversityP.O.Box 33Shaqra11961Saudi Arabia Department of Industrial Electronics and Control Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Computer Science Department Faculty of Computers and Artificial IntelligenceSohag UniversitySohag82524Egypt Department of Computer and Systems Engineering Faculty of EngineeringZagazig UniversityZagazig44519Egypt

This article introduces a new medical internet of things(IoT)framework for intelligent fall detection system of senior people based on our proposed deep forest *** cascade multi-layer structure of deep forest classifier allows to generate new features at each level with minimal hyperparameters compared to deep neural ***,the optimal number of the deep forest layers is automatically estimated based on the early stopping criteria of validation accuracy value at each generated *** suggested forest classifier was successfully tested and evaluated using a public SmartFall dataset,which is acquired from three-axis accelerometer in a *** includes 92781 training samples and 91025 testing samples with two labeled classes,namely non-fall and *** results of our deep forest classifier demonstrated a superior performance with the best accuracy score of 98.0%compared to three machine learning models,i.e.,K-nearest neighbors,decision trees and traditional random forest,and two deep learning models,which are dense neural networks and convolutional neural *** considering security and privacy aspects in the future work,our proposed medical IoT framework for fall detection of old people is valid for real-time healthcare application deployment.

关键词： Elderly population fall detection wireless sensor networks internet of medical things deep forest

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Residual Attention Deep SVDD for COVID-19 Diagnosis Using CT Scans

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Computers, Materials & Continua 2023年第2期74卷 3333-3350页

作者： Akram Ali Alhadad omar Tarawneh Reham R.Mostafa hazem M.El-Bakry Information Systems Department Faculty of Computers and InformationMansoura UniversityMansoura35511Egypt Computer Science Department Ibb UniversityIbbYemen SE Department Faculty of Computer Sciences and InformaticsAmman Arab UniversityAmman11953Jordan

COVID-19 is the common name of the disease caused by the novel coronavirus(2019-nCoV)that appeared in Wuhan,China in *** the infected people is the most important factor in the fight against the *** gold-standard test to diagnose COVID-19 is polymerase chain reaction(PCR),but it takes 5–6 h and,in the early stages of infection,may produce false-negative *** Computed Tomography(CT)images to diagnose patients infected with COVID-19 has become an urgent *** this study,we propose a residual attention deep support vector data description SVDD(RADSVDD)approach to diagnose *** is a novel approach combining residual attention with deep support vector data description(DSVDD)to classify the CT *** the best of our knowledge,we are the first to combine residual attention with DSVDD in general,and specifically in the diagnosis of *** attention with DSVDD naively may cause model *** in the proposed RADSVDD guides the network during training and enables quick learning,residual connectivity prevents vanishing *** approach consists of three models,each model is devoted to recognizing one certain disease and classifying other diseases as *** models learn in an end-to-end *** proposed approach attained high performance in classifying CT images into intact,COVID-19,and non-COVID-19 *** evaluate the proposed approach,we created a dataset from published datasets and had it assessed by an experienced *** proposed approach achieved high performance,with the normal model attained sensitivity(0.96–0.98),specificity(0.97–0.99),F1-score(0.97–0.98),and area under the receiver operator curve(AUC)0.99;the COVID-19 model attained sensitivity(0.97–0.98),specificity(0.97–0.99),F1-score(0.97–0.99),and AUC 0.99;and the non-COVID pneumoniamodel attained sensitivity(0.97–1),specificity(0.98–0.99),F1-score(0.97–0.99),and AUC 0.99.

关键词： Deep learning deep SVDD residual attention anomaly detection COVID-19 Coronavirus

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Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 424-439页

作者： omar Elshaarawy Aya Aman hazem Mohamed Zakaria Talaat Zakareya Asmaa Gomaa Esam Elshimi Eman Abdelsameea Department of Hepatology Gastroenterology and Liver TransplantationNational Liver InstituteMenoufia UniversityShebine Elkom 32511MenoufiaEgypt Department of Hepatobiliary Pancreatic Surgery National Liver InstituteMenoufia UniversityShebine Elkom 32511MenoufiaEgypt

BACKGROUND Given the poor synthetic function of cirrhotic liver,successful resection for patients with hepatocellular carcinoma(HCC)necessitates the ability to achieve resections with tumor free *** To validate post hepatectomy liver failure score(PHLF),compare it to other established systems and to stratify risks in patients with cirrhosis who underwent curative liver resection for *** Between December 2010 and January 2017,120 patients underwent curative resection for HCC in patients with cirrhosis were included,the pre-operative,operative and post-operative factors were recorded to stratify patients'risks of decompensation,survival,and *** The preoperative model for end-stage liver disease(MELD)score[odds ratio(OR)=2.7,95%CI:1.2-5.7,P=0.013],tumor diameter(OR=5.4,95%CI:2-14.8,P=0.001)and duration of hospital stay(OR=2.5,95%CI:1.5-4.2,P=0.001)were significant independent predictors of hepatic decompensation after *** the preoperative MELD score[hazard ratio(HR)=1.37,95%CI:1.16-1.62,P<0.001]and different grades of PHLF(grade A:HR=2.33,95%CI:0.59-9.24;Grade B:HR=3.15,95%CI:1.11-8.95;Grade C:HR=373.41,95%CI:66.23-2105.43;P<0.001)and HCC recurrence(HR=11.67,95%CI:4.19-32.52,P<0.001)were significant independent predictors for *** Preoperative MELD score and tumor diameter can independently predict hepatic ***,preoperative MELD score,different grades of PHLF and HCC recurrence can precisely predict survival.

关键词： Cirrhosis Liver Resection Scores Hepatocellular carcinoma

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Assessment of heme oxygenase-1 （HO-1） activity in the cavernous tissues of sildenafil citrate-treated rats

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Asian Journal of Andrology 2007年第3期9卷 377-381页

作者： M. Talaat Abdel Aziz M. Farid Al-Asmar Taymour Mostafa hazem Atta Laila rashed Dina Sabry Shedeed Ashour Ahmed T. Abdel Aziz Molecular Biology Unit Medical Biochemistry Department Faculty of Medicine Cairo University Cairo 11553 Egypt Medical Biochemistry Department Faculty of Medicine Ain Shams University Cairo Egypt Andrology Department Faculty of Medicine Cairo University Cairo 11553 Egypt

Aim： To assess heine oxygenase-1 （HO-1） activity in the cavemous tissue of sildenafil citrate-treated rats. Methods： One hundred and ninety-two Sprague-Dawley male rats, divided into four equal groups, were investigated. Group 1, the control group, received regular animal chow; group 2 received sildenafil citrate by intragastric tube; group 3 received sildenafil and HO inhibitor （zinc protoporphyrin, ZnPP）; and group 4 received sildenafil and nitric oxide synthase （NOS） inhibitor L-nitroarginine methyl ester （L-NAME）. Twelve rats from each group were killed after 0.5 h, 1 h, 2 h and 3 h of drug administration. Then HO-1 activity, cGMP levels and NOS enzymatic activity in the cavernous tissues were estimated. Results： In cavemous tissue, HO-1 activity, NOS enzymatic activity and cGMP concentration increased significantly in sildenafil-treated rats compared to other groups throughout the experiment. Rats receiving either HO or NOS inhibitors showed a significant decrease in these parameters. HO- 1 cavemous tissue activity and NOS enzymatic activity demonstrated a positive significant correlation with cGMP levels （r = 0.646, r = 0.612 respectively; P 〈 0.001）. Conclusion： The actions of PDE5 inhibitor sildenafil citrate in the cavernous tissue are partly mediated through the interdependent relationship between both HO-1 and NOS activities.

关键词： erectile dysfunction heme oxygenase sildenafil citrate nitric oxide synthase carbon monoxide

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Association between Pentraxin-3 and Cardiac Troponin-I with Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction: Evaluation by Speckle Tracking Echocardiography

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World Journal of Cardiovascular Diseases 2019年第2期9卷 57-68页

作者： Mousa Alharbi Mohamed Yahia Mustafa rashed omar S. El-Masry Department of Internal Medicine College of Medicine Imam Abdulrahman Bin Faisal University Dammam KSA Department of Cardiology College of Medicine University of Menoufia Shebin-Alkoum Egypt Department of Cardiac Technology College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University Dammam KSA Department of Clinical Laboratory Sciences College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University Dammam KSA

Background: Pentraxin 3 is an inflammatory biomarker whose serum level is increased during acute myocardial infarction (AMI). The aim of this study was to measure the serum pentraxin-3 level in anterior ST-segment elevation myocardial infarction (STEMI), to investigate correlation with the left ventricular (LV) systolic function assessed by speckle tracking echocardiography, and compare with the well-established cardiac biomarkers of myocardial injury such as troponin-I. Methods: Serum pentraxin-3 level was measured by ELISA in 50 patients with anterior STEMI. LV strain was measured by speckle tracking echocardiography. The results were compared to twenty sex- and age-matched persons who had history of stable angina and normal LV ejection fraction (LVEF). Results: Serum level of pentraxin-3 was significantly higher in STEMI patients in comparison to the control group (8.3 ± 3.1 versus 3.4 ± 1.2 ng/ml, p 0.001). Average LV global longitudinal strain (GLS) was reduced in STEMI patients in comparison to control subjects (11.2 ± 2.4 versus 20.2 ± 2.1, p 0.001). In addition, there was a significant negative correlation between serum pentraxin-3 level and LVEF (r = -0.557, p 0.001) and the average LVGLS (r =-0.529, p 0.001). Serum pentraxin-3 cutoff value > 8.3 ng/ml had sensitivity of 81.8% and specificity of 86.4% to detect LVEF less than 50% (p 0.001). While, peak cardiac troponin-I level > 34 ng/ml was 86% sensitive to detect LVEF less than 50% with specificity of 90.9%. Conclusions: The elevated serum level of pentraxin-3 and cardiac troponin-I in STEMI patients and their association with both LVEF and GLS support the concept that the magnitude of these biomarkers correlates to the severity of myocardium injury.

关键词： Anterior MI Pentraxin-3 Speckle Tracking Echocardiography

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Ontology-Based Cyber Security Policy Implementation in Saudi Arabia

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Journal of Information Security 2018年第4期9卷 315-333页

作者： Amir Mohamed Talib Fahad omar Alomary Hanan Fouad Alwadi Rawan rashed Albusayli College of Computer and Information Sciences Al Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh KSA

Cyber security is an important element of national security and the safekeeping of a nation’s constituency and assets. In Saudi Arabia, the point of interest on cyber security is particularly outstanding due to the fact that Saudi Arabia has a highly cyber attacks all over the Arab countries. This paper displays on contemporary studies done in Saudi Arabia in regards to cyber security policy coverage. The point of interest of this paper is the use of ontology to identify and suggest a formal, encoded description of the cyber security strategic environment, and propose the development of ontology to be able to permit the implementation of the sort of policy. The intention of the ontology is to become aware of and constitute the multi-layered company of gamers and their related roles and obligations within the cyber security environment. This could make contributions in large part to the improvement, implementation and rollout of a country wide cyber security policy in Saudi Arabia.

关键词： Cyber Security Cyber Security Policy Implementation Ontology Saudi Arabia

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Time Comparing between Java and C++ Software

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Journal of Software Engineering and Applications 2012年第8期5卷 630-633页

作者： As’ad Mahmoud Alnaser omar AlHeyasat Ashraf Abdel-Karim Abu-Ein hazem Hatamleh Ahmed A. M. Sharadqeh Computer Engineering Department Faculty of Engineering Technology Al-Balqa’ Applied University Amman Jordan Computer Science Department Ajlun University College Al-Balqa’ Applied University Amman Jordan Computer Science Department Ajlun University College Al-Balqa’ Applied University Amman Jordan

This paper construct a comparison between two main software’s used in programming applications that are Java and C++, the comparison operation includes the time needed to perform some algorithm i.e. speed of operation, flexibility to adjusting some code, and efficiency. The same code is used to compare between the two software to determine which one is better. It is found that C++ needs less time to execute the same code comparing with Java. Java needs about 10% excess time to execute the same code segment comparing to C++.

关键词： Java C++ Algorithm Speed Code Flexibility

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Review and Measuring the Efficiency of SQL Injection Method in Preventing E-Mail Hacking

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International Journal of Communications, Network and System Sciences 2012年第6期5卷 337-342页

作者： Ahmed A. M. Sharadqeh As'ad Mahmoud Alnaser omar Al Heyasat Ashraf Abdel-Karim Abu-Ein hazem (Moh'd Said) Hatamleh Computer Engineering Department Al-Balqa’ Applied University Salt Jordan Computer Engineering Department Faculty of Engineering Technology Al-Balqa’ Applied University Amman Jordan Computer Science Department Ajloun University College Al-Balqa’ Applied University Ajloun Jordan

E-mail hackers use many methods in their work, in this article, most of such efficient methods are demonstrated and compared. Different methods and stages of such methods are listed here, in order to reveal such methods and to take care of them but the most common discussed method in this paper is SQL method. SQL injection is a type of security exploit in which the attacker adds SQL statements through a web application's input fields or hidden parameters to gain access to resources or make changes to data. It is found that the SQL is an efficient way in preventing E-mail hacking and its efficiency reaches about 80%. The method of SQL injection can be considered as an efficient way comparing with other methods.

关键词： E-Mail Hackers SQL Security

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