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Free radical scavenging activity of three different flowers-Hibiscus rosa-sinensis,Quisqualis indica and Senna surattensis

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 771-777页

作者： Abd El-Moneim Mohamed Radwan Afify hazem Mohamed mahmoud hassan Biochemistry Department Faculty of AgricultureCairo University

Objective:To evaluate three flowers of Hibiscus rosa-sinensis(***-sinensis),Quisqualis indica(***) and Senna surattensis(***) for their antioxidant activity by different methods in addition to total phenolic,flavonoid and pigment ***:Antioxidant activity of water,ethanol and absolute ethanol extracts of three flowers; ***-sinensis,*** and *** was *** antioxidant activity was assessed by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity,ferrous chelating activity,reducing power,nitric oxide scavenging activity,hydroxyl radical scavenging activity as well as total antioxidant *** flavonoids,total phenols and total pigments including chlorophylls and carotenoids were measured for the three ***:The results showed that the highest total antioxidant capacity at concentration of 500 mg/L was found in *** as 0.479 ± *** activity of ***,*** and *** flower extracts against 1,1-diphenyl-2-picrylhydrazyl radical showed the highest activity of(90.20 ± 0.29)% with 500 mg/*** screening of the three flowers extracts were carried out for alkaloids,flavonoids,saponins,tannins,steroids,glycosides,terpenoids,amino acid and ***-sinensis showed the total phenolic in water extract of(235.77 ± 14.31) mg/100 g,the other two flowers *** and *** had the total phenolic in ethanol extracts of(937.70 ± 25.06) and(850.30 ± 13.81) mg/100 g,*** the other hand total flavonoids were identified in absolute ethanol extracts in the three flowers[(32.83 ± 1.34),(49.24 ± 4.87) and(2.79 ± 0.23) mg/100 g,respectively].Conclusions:The extracts in the constituents of the three flowers could be used as additives as supplement fractions in foods.

关键词： Free radical Antioxidant Hibiscus rosa-sinensis Quisqualis indica Senna surattensis

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Ultra Sensitive Determination and Preconcentration of Cd2+, Cu2+and Pb2+after Multi-Walled Carbon Nanotubes Adsorption

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Journal of Analytical Sciences, Methods and Instrumentation 2013年第1期3卷 8-12页

作者： Ashraf Mohamed Abdel-Lateef Ramadan Abdel-Wahed Mohamed hazem hassan mahmoud Central Laboratory for Elemental and Isotopic Analysis Nuclear Research Center Atomic Energy Authority Cairo Egypt Central Laboratory for Elemental and Isotopic Analysis Nuclear Research Center Atomic Energy Authority Cairo Egypt Chemistry Department Faculty of Science Jazan University Jazan KSA Central Laboratory for Elemental and Isotopic Analysis Nuclear Research Center Atomic Energy Authority Cairo Egypt Physics Department Faculty of Science and Human Studies Shaqra University Shaqra KSA

Multi-Walled carbon nanotubes are used as preconcentrating probes for the quantitative determination of trace cadmium, copper and lead in environmental and biological sample using graphite Furnace Atomic Absorption Spectrometry and inductively coupled Plasma Optical Emission spectrometry. The method is based on the electrostatic interactions of positively charged Cd+, Cu+ and Pb+ with the negatively charged multi-walled carbon nanotubes (MWCNTs) for the preconcentration and isolation of analytes from sample solutions. Effective preconcentration of trace cadmium, copper and lead was achieved in a pH range of 5 - 7, 5 - 7 and 4 - 7, respectively. The retained cadmium, copper and lead were efficiently eluted with 0.3 mol·L-1 HCl for graphite Furnace Atomic Absorption Spectrometry determination. The multi-walled carbon nanotubes packed micro-column exhibited fairly fast kinetics for the adsorption of cadmium, copper and lead, permitting the use of high sample flow rates up to at least 3 mL·min-1 for the flow injection on micro-column preconcentration without the loss of the retention efficiency. The detection limits (3σ) were 0.03, 0.01 and 0.5 ng·mL-1 for Cd, Cu and Pb, respectively. The relative standard deviation under optimum condition is less than 2.9% (n = 10). The developed method was successfully applied to the determination of trace Cd, Cu and Pb in a variety of environmental and biological samples.

关键词： Multi-Walled Carbon Nanotubes Graphite Furnace Atomic Absorption Spectrometry Inductively Coupled Plasma Optical Emission Spectrometry

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Insights into CYP2B6-mediated drug–drug interactions

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Acta Pharmaceutica Sinica B 2016年第5期6卷 413-425页

作者： William D.Hedrich hazem E.hassan Hongbing Wang Department of Pharmaceutical Sciences University of Maryland School of Pharmacy

Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously *** discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the *** expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor(CAR) and pregnane X receptor(PXR) in the *** addition to CYP2B6,these receptors also mediate the inductive expression of CYP3A4,and a number of important phase II enzymes and drug ***2B6 has been demonstrated to play a role in the metabolism of 2%–10% of clinically used drugs including widely used antineoplastic agents cyclophosphamide and ifosfamide,anesthetics propofol and ketamine,synthetic opioids pethidine and methadone,and the antiretrovirals nevirapine and efavirenz,among *** inter-individual variability in the expression and function of the human CYP2B6 gene exists and can result in altered clinical outcomes in patients receiving treatment with CYP2B6-substrate *** variances arise from a number of sources including genetic polymorphism,and xenobiotic *** this review,we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions.

关键词： CYP2B6 CAR PXR Polymorphism Drug–drug interaction Cyclophosphamide Efavirenz

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A Hybrid Heuristic Algorithm for Solving COVID-19’s Social Distancing at Universities Campus

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Computer Systems Science & Engineering 2022年第6期41卷 933-944页

作者： hassan Al-Tarawneh Khalid Al-Kaabneh Aysh Alhroob hazem Migdady Issam Alhadid Department of Data sciences and Artificial Intelligence Al-Ahlyyia Amman UniversityAmmanJordan Department of Software Engineering Isra UniversityAmmanJordan Department of CSMIS Oman college of management and technologyMuscatOman Faculty of Information Technology and Systems University of JordanAqabaJordan

Social distancing during COVID-19 has become one of the most important measures in reducing the risks of the spread of the virus. Implementing thesemeasures at universities is crucial and directly related to the physical attendance ofthe populations of students, professors, employees, and other members on campus. This research proposes an automated scheduling approach that can help universities and schools comply with the social distancing regulations by providingassistance in avoiding huge assemblages of people. Furthermore, this paper proposes a novel course timetable-scheduling scheme based on four main ***, a distance of two meters must be maintained between each student inside theclassroom. Second, no classrooms should contain more than 20% of their regularcapacity. Third, there would be no back-to-back classes. Lastly, no lectures shouldbe held simultaneously in adjacent classrooms. The proposed approach wasimplemented using a variable neighborhood search (VNS) approach with an adaptive neighborhood structure (AD-NS) to resolve the problem of scheduling coursetimetables at Al-Ahlyyia Amman University. However, the experimental resultsshow that the proposed techniques outperformed the standard VNS tested on university course timetabling benchmark dataset ITC2007-Track3. Meanwhile, theapproach was tested using datasets collected from the faculty of information technology at Al-Ahlyyia Amman University (Jordan). Where the results showed that,the proposed technique could help educational institutes to resume their regularoperations while complying with the social distancing guidelines.

关键词： COVID-19 social distance variable neighborhood search adaptive neighborhood structure university course timetable

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Safety and efficacy of posterior sub-Tenon＇s carboplatin injection versus intravitreal melphalan therapy in the management of retinoblastoma with secondary vitreous seeds

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 445-455页

作者： Azza Mohamed Ahmed Said Mohamed Gamil Al hazem Omar Rashed Anwaar mahmoud Rady Department of Ophthalmology Faculty of Medicine Ain Shams University Cairo 11566 Egypt Oncology and Radiation Medicine Department Faculty of Medicine Ain Shams University Cairo 11566 Egypt

AIM： To evaluate the safety and efficacy of posterior sub-Tenon＇s carboplatin injection compared to intravitreal melphalan injection in the management of retinoblastoma （RB） with secondary vitreous seeds. The outcome measures were vitreous seeds regression, need for other treatment modalities to achieve ocular salvage and treatment side effects. METHODS： A prospective interventional comparative nonrandomized study included RB eyes developed secondary vitreous seeds during the period of follow up. They subdivided into two groups： study group Ⅰ where posterior sub-Tenon＇s carboplatin （20 mg/2 mL） was injected and study group Ⅱ where intravitreal melphalan （20 μg/0.1 mL） was injected. The injections repeated every 2-4wk. RESULTS： Thirty-three eyes were included in the study. Seventeen eyes （16 patients） in study group Ⅰ and 16 eyes （16 patients） in study group Ⅱ. Ten eyes （30.3%） were completely salvaged following local chemotherapies, Ocular salvage was 23.5% following posterior sub-Tenon＇s carboplatin injection versus 37.5% following intravitreal melphalan raised to 47.1% and 75% with addition of external beam radiotherapy （EBR） with no statistically significant difference between the study groups （P=0.16）. A statistically significant correlation was found between ocular salvage rate and type of vitreous seeds either dust, spheres and clouds （r=0.42, P=-0.015） and eyes harbor new solid tumor growth （r=0.35, P=0.045）. The mean and median follow up periods following local chemotherapy injections were 2.0y in the study group Ⅰand 2.37y in the study group Ⅱ. Few complications were reported： periorbital edema in all eyes and ocular motility disturbances in 13 eyes （76.5%） following posterior sub-Tenon＇s carboplatin injection. Vitreous hemorrhage developed in 2 eyes （12.5%） and localized retinopathy in 5 eyes （31.25%） following intravitreal melphalan. ~ CONCLUSION： Local chemotherapy for treatment of RB with secondary vitreous seeds is safe and can salvage 30.3% of eyes

关键词： intravitreal melphalan posterior sub-Tenon'scarboplatin retinoblastoma secondary vitreous seeds

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Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 907-912页

作者： mahmoud Abdel-Radi Zeiad Eldaly hazem Abdelmotaal Reham Abdelrahman Mohamed Sayed Kamel Soliman Department of Ophthalmology Assiut UniversityAssiut 71516Egypt

AIM:To compare corneal demarcation line(DL)depth in both accelerated epithelium-off and trans-epithelium cross linking(CXL)using anterior segment optical coherence tomography(AS-OCT)and its relation to maximum keratometry(Kmax)progression in both ***:A prospective comparative interventional study where patients with mild to moderate keratoconus(KC)were classified into two groups:accelerated epitheliumoff and trans-epithelium CXL based on corneal *** of corneal DL depth was carried out after 3mo by *** readings were evaluated after one year follow up using the Scheimpflug imaging ***:Study included 74 eyes of 44 *** A underwent epithelium-off CXL(41 eyes),while Group B underwent trans-epithelium CXL(33 eyes).At 3mo follow up,mean corneal DL depth in Group A was 219.9±58.4μm while in Group B was 127.2±7.8μm(P0.05).In addition,no significant change in corneal pachymetry was found in both groups(meanchange at 1y:6.4±4.7 and-10.1±2.3μm in Groups A and B respectively).CONCLUSION:Despite a significantly deeper corneal DL depth created by accelerated epithelium-off CXL technique compared to accelerated trans-epithelium CXL,there is no significant impact on keratoconus progression.

关键词： anterior segment optical coherence tomography cross linking demarcation line keratoconus

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UAV-Aided Data Acquisition Using Gaining-Sharing Knowledge Optimization Algorithm

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Computers, Materials & Continua 2022年第9期72卷 5999-6013页

作者： Rania M Tawfik hazem A.A.Nomer M.Saeed Darweesh Ali Wagdy Mohamed hassan Mostafa Wireless Intelligent Networks Center(WINC) School of Engineering and Applied SciencesNile UniversityGiza12677Egypt School of Information Technology and Computer Science(ITCS) Nile UniversityGiza12677Egypt Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Department of Mathematics and Actuarial Science School of Science and EngineeringThe American University in CairoEgypt Electronics and Communications Engineering Department Cairo UniversityEgypt University of Science and Technology Nanotechnology and Nanoelectronics ProgramZewal City of Science and TechnologyOctober Gardens6th of OctoberGiza12578Egypt

Unmanned Aerial Vehicles(UAVs)provide a reliable and energyefficient solution for data collection from the Narrowband Internet of Things(NB-IoT)***,the UAV’s deployment optimization,including locations of the UAV’s stop points,is a necessity to minimize the energy consumption of the UAV and the NB-IoT devices and also to conduct the data collection *** this regard,this paper proposes GainingSharing Knowledge(GSK)algorithm for optimizing the UAV’s *** GSK,the number of UAV’s stop points in the three-dimensional space is encapsulated into a single individual with a fixed length representing an entire *** superiority of using GSK in the tackled problem is verified by simulation in seven *** provides significant results in all seven scenarios compared with other four optimization algorithms used before with the same ***,the NB-IoT is proposed as the wireless communication technology between the UAV and IoT devices.

关键词： NB-IoT UAV GSK stop points optimization

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Performance Comparison of Field-oriented Control,Direct Torque Control,and Model-predictive Control for SynRMs

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Chinese Journal of Electrical Engineering 2022年第1期8卷 24-37页

作者： hazem Hadla Fernando Santos Polytechnic Institute of Viseu Higher School of Technology and Management of LamegoLamego 5100-074Portugal

Simulation studies of three synchronous reluctance motor(SynRM)control strategies are presented:field-oriented control(FOC),direct torque control(DTC),and finite-set model-predictive control(FS-MPC).FOC uses linear controllers and pulse-width modulation to control the fundamental components of the load voltages *** contrast,DTC and FS-MPC are nonlinear strategies wherein the voltage vectors are directly generated in the absence of a *** operating principles and control structures of these control strategies are ***,a comparative analysis of the static and dynamic performance of the control strategies is conducted using Matlab/Simulink to identify their advantages and *** is confirmed that each of the control strategies has merits and that all three of them satisfy the requirements of modern high-performance drives.

关键词： Field-oriented control direct torque control model-predictive control synchronous reluctance motor

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Genetic characterization of FSH beta-subunit gene and its association with buffalo fertility

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Asian pacific Journal of Reproduction 2017年第5期6卷 193-196页

作者： Ahmed S.A.Sosa Karima Gh M.mahmoud Mohamed M.M.Kandiel hazem A.A.Eldebaky mahmoud F.Nawito mahmoud E.A.Abou El-Roos Department of Animal Reproduction&A.I National Research CentreDokkiTahrir Street12622 GizaEgypt Department of Theriogenology Faculty of Veterinary MedicineBenha UniversityKaliobiaEgypt

Objective:To study genetic variation in buffalo follicle stimulating hormone beta-subunit (FSHB) gene and its association with ***: In this experimental study, blood samples were collected by standard methods using EDTA anticoagulant and transrectal ultrasound examination was conducted on fertile (n=74) and infertile buffaloes with a history of anestrum (n=30) or repeat breeding (n=12). The genomic DNA was extracted for PCR followed by single strand conformation polymorphism analysis. DNA sequencing was performed for the determination of single nucleotide polymorphism ofFSHB ***:The study results showed that there was genetic polymorphism with two different single strand conformation polymorphism patterns, AA and AB. The former pattern was associated with fertility in Egyptian buffaloes. Pair wise alignment of the two patterns sequences revealed that FSHB pattern II (AB) has C nucleotide insertion as SNP at the site of 208 bp of sequenced ***:FSHB is polymorphic in the infertile Egyptian buffaloes, suggesting its practicability as a candidate marker for female fertility.

关键词： Buffalo FSH beta-subunit gene Nucleotide sequences SSCP analysis

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基于高阶黎曼近似解的膛内多相燃烧过程研究

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弹道学报 2013年第3期25卷 79-82页

作者：程诚张小兵 mahmoud M.Rashad hazem Elsadek 南京理工大学能源与动力工程学院南京210094

为了更加精确地描述制导炮弹膛内多相燃烧过程,保证其发射安全性,基于高阶近似黎曼解模型,构造了某制导炮弹双一维内弹道两相流高精度近似黎曼离散格式,对膛内高温高压多相燃烧过程进行了相关数值模拟。数值仿真结果与实验结果符合较好... 详细信息

为了更加精确地描述制导炮弹膛内多相燃烧过程,保证其发射安全性,基于高阶近似黎曼解模型,构造了某制导炮弹双一维内弹道两相流高精度近似黎曼离散格式,对膛内高温高压多相燃烧过程进行了相关数值模拟。数值仿真结果与实验结果符合较好,数值结果准确地描述了制导炮弹膛内复杂多相燃烧过程,完整地呈现了高温高压变截面条件下的膛内复杂波系发展过程,为后续研究不同装药条件对制导炮弹的内弹道特性及发射安全性的影响奠定了理论基础。

关键词：内弹道制导炮弹两相流近似黎曼解多相燃烧

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