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Role of endoscopic ultrasound in pediatric patients: A single tertiary center experience and review of the literature

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World Journal of Gastrointestinal Endoscopy 2020年第10期12卷 355-364页

作者： Ahmed Youssef Altonbary hazem hakim Wagdi Elkashef Department of Gastroenterology and Hepatology Mansoura Specialized Medical HospitalMansoura UniversityMansoura 35516Egypt Department of Pathology Mansoura UniversityMansoura 35111Egypt

BACKGROUND Although endoscopic ultrasound(EUS)is now widely available and has an established role in adults,the utility of EUS and EUS-guided fine needle aspiration(EUS-FNA)in pediatrics is insufficiently described compared to adults and is supported by only a few *** To report the experience of a single tertiary center in the use of EUS and EUS-FNA in a pediatric population and to further assess its safety,feasibility,and clinical impact on *** A retrospective study of 13 children(aged 18 years or younger)identified from our medical database was conducted.A retrospective review of demographic data,procedure indications,EUS findings,and the clinical impact of EUS on the subsequent management of these patients was *** During the 4-year study period,a total of 13(1.7%)pediatric EUS examinations out of 749 EUS procedures were performed in our *** mean age of these 8 females and 5 males was 15.6 years(range:6-18).Six of the 13 EUS examinations were pancreatobiliary(46.1%),followed by mediastinal 2/13(15.4%),peri-gastric 2/13(15.4%),abdominal lymphadenopathy 1/13(7.7%),tracheal 1/13(7.7%)and rectal 1/13(7.7%).Overall,EUS-FNA was performed in 7 patients(53.8%)with a diagnostic yield of 100%.The EUS results had a significant impact on clinical care in 10/13(77%)*** complications occurred in these patients during or after any of the *** EUS and EUS-FNA in the pediatric population are safe,feasible,and have a significant clinical impact on the subsequent management;thus avoiding invasive and unnecessary procedures.

关键词： Endoscopic ultrasound Endoscopic ultrasound-guided fine needle aspiration Pediatric

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A Practical Study of Intelligent Image-Based Mobile Robot for Tracking Colored Objects

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Computers, Materials & Continua 2024年第8期80卷 2181-2197页

作者： Mofadal Alymani Mohamed Esmail Karar hazem Ibrahim Shehata College of Computing and Information Technology Shaqra UniversityShaqra11961Saudi Arabia Faculty of Electronic Engineering Menoufia UniversityMenouf32952Egypt Faculty of Engineering Zagazig UniversityZagazig44519Egypt

Object tracking is one of the major tasks for mobile robots in many real-world ***,artificial intelligence and automatic control techniques play an important role in enhancing the performance of mobile robot *** contrast to previous simulation studies,this paper presents a new intelligent mobile robot for accomplishing multi-tasks by tracking red-green-blue(RGB)colored objects in a real experimental ***,a practical smart controller is developed based on adaptive fuzzy logic and custom proportional-integral-derivative(PID)schemes to achieve accurate tracking results,considering robot command delay and tolerance *** design of developed controllers implies some motion rules to mimic the knowledge of experienced *** scenarios of three colored object combinations have been successfully tested and evaluated by using the developed controlled image-based robot *** PID control failed to handle some tracking scenarios in this *** proposed adaptive fuzzy PID control achieved the best accurate results with the minimum average final error of 13.8 cm to reach the colored targets,while our designed custom PID control is efficient in saving both average time and traveling distance of 6.6 s and 14.3 cm,*** promising results demonstrate the feasibility of applying our developed image-based robotic system in a colored object-tracking environment to reduce human workloads.

关键词： Mobile robot autonomous systems fuzzy logic control real-time image processing

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Eco-toxicity and health risk assessment of polycyclic aromatic hydrocarbons in surface sediments of Burullus Lake in Egypt

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China Geology 2024年第3期7卷 460-468页

作者： Hanan E Osman Mohamed H E El-Morsy hazem T Abd El-Hamid Department of Biology Faculty of Applied ScienceUmm Al-Qura UniversityMecca 24382Saudi Arabia Deanship of Scientific Research Umm Al-Qura UniversityMakkah 24372Saudi Arabia National Institute of Oceanography and Fisheries(NIOF) Cairo 11865Egypt Botany and Microbiology Department Faculty of ScienceAl-Azhar UniversityCairo 11651Egypt

Polycyclic aromatic hydrocarbons(PAHs)are ubiquitous environmental contaminants of growing concern due to their potential ecological and human health *** study presents a comprehensive assessment of PAHs contamination in the surface sediments of Burullus Lake,a vital and second largest delta lake in *** aim was to evaluate the eco-toxicity and potential health risks associated with the presence of these *** seven sediment samples were collected from various drains in the southern part of Burullus *** extraction method was employed to extract PAHs(16PAHs)from the sediment ***,target compounds were located using *** results showed that samples contained PAHs levels ranging from 0.038×10^(-6)to 0.459×10^(-6),which is considered heavily polluted by the European standard for PAHs ***,there was no apparent source of PAHs in the ElKhashah drain or the Brinbal Canal,as HPLC found none of the *** most prevalent compound in sediment samples along the study area was *** diagnostic indices in the present study indicated that the hydrocarbons in the region originated from pyrolytic and man-made sources along the drains of Burullus *** principal component analysis(PCA)and diagnostic ratios revealed that coal combustion and pyrolytic sources were responsible for the PAHs contamination in the surface *** non-carcinogenic risk(HI),which is the product of the HQs for the adult and child populations,respectively,was *** values under 1,therefore,demonstrated that they had no carcinogenic effects on human *** and MEQs in the sediments of Burullus Lake do not have a cancer-causing impact on *** the safety of nearby wildlife,aquatic life,and people,all activities that raise petroleum hydrocarbon levels in Burullus Lake must be adequately regulated and *** to the ecological risk assessment,there is little chance that PAHs will be found

关键词： Polycyclic aromatic hydrocarbons Diagnostic indices Toxicity Delta lake sediment Burullus Lake Human health risk Aquatic ecosystem HPLC Coal combustion

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Performance Comparison of Field-oriented Control,Direct Torque Control,and Model-predictive Control for SynRMs

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Chinese Journal of Electrical Engineering 2022年第1期8卷 24-37页

作者： hazem Hadla Fernando Santos Polytechnic Institute of Viseu Higher School of Technology and Management of LamegoLamego 5100-074Portugal

Simulation studies of three synchronous reluctance motor(SynRM)control strategies are presented:field-oriented control(FOC),direct torque control(DTC),and finite-set model-predictive control(FS-MPC).FOC uses linear controllers and pulse-width modulation to control the fundamental components of the load voltages *** contrast,DTC and FS-MPC are nonlinear strategies wherein the voltage vectors are directly generated in the absence of a *** operating principles and control structures of these control strategies are ***,a comparative analysis of the static and dynamic performance of the control strategies is conducted using Matlab/Simulink to identify their advantages and *** is confirmed that each of the control strategies has merits and that all three of them satisfy the requirements of modern high-performance drives.

关键词： Field-oriented control direct torque control model-predictive control synchronous reluctance motor

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Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky Jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.Eid hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

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Developed Fall Detection of Elderly Patients in Internet of Healthcare Things

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Computers, Materials & Continua 2023年第8期76卷 1689-1700页

作者： Omar Reyad hazem Ibrahim Shehata Mohamed Esmail Karar College of Computing and Information Technology Shaqra UniversityP.O.Box 33Shaqra11961Saudi Arabia Faculty of Computers and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Zagazig UniversityZagazig44519Egypt Faculty of Electronic Engineering Menoufia UniversityMenouf32952Egypt

Falling is among the most harmful events older adults may *** the continuous growth of the aging population in many societies,developing effective fall detection mechanisms empowered by machine learning technologies and easily integrable with existing healthcare systems becomes *** paper presents a new healthcare Internet of Health Things(IoHT)architecture built around an ensemble machine learning-based fall detection system(FDS)for older *** to deep neural networks,the ensemble multi-stage random forest model allows the extraction of an optimal subset of fall detection features with minimal *** number of cascaded random forest stages is automatically *** study uses a public dataset of fall detection samples called SmartFall to validate the developed fall detection *** SmartFall dataset is collected based on the acquired measurements of the three-axis accelerometer in a *** scenario in this dataset is classified and labeled as a fall or a *** comparison to the three machine learning models—K-nearest neighbors(KNN),decision tree(DT),and standard random forest(SRF),the proposed ensemble classifier outperformed the other models and achieved 98.4%*** developed healthcare IoHT framework can be realized for detecting fall accidents of older people by taking security and privacy concerns into account in future work.

关键词： Elderly population fall detection wireless sensor networks Internet of health things ensemble machine learning

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Acoustic of monolithic dome structures

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Frontiers of Architectural Research 2018年第1期7卷 56-79页

作者： Mostafa Refat Ismail hazem Eidaly Department of Architecture Engineering Faculty of Engineering Ain Shams University Egypt

Monolithic dome structures were built in the 1970s in Europe and America. These dome structures share common benefits of being cost-efficient, earth-friendly, extremely durable, and easily maintained. Monolithic shells are easily constructed and are extremely cost- effective. Monolithic domes respond efficiently to any climate, even to extremely cold or hot temperatures. In terms of utility savings, monolithic domes can cut electricity consumption by up to one-third, thereby saving 60-70% of total enersy costs. Moreover, monolithic structures provide the hishest survivability rates from destructions. The interior of monolithic domes have perfect, concave shapes to ensure that sound travels throush the dome and perfectly collected at different vocal points. These dome structures are utilized for domestic use because the scale allows the focal points to be positioned across daily life activities, thereby affecting the sonic comfort of the internal space. This study examines the various acoustic treatments and parametric configurations of monolithic dome sizes. A geometric relationship of acoustic treatment and dome radius is established to provide architects guidelines on the correct selection of absorption needed to maintain the acoustic comfort of these special spaces.

关键词： Acoustic Eco Dome Monotithic structures Sound treatment

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Predicting lateral displacement caused by seismic liquefaction and performing parametric sensitivity analysis:Considering cumulative absolute velocity and fine content

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 506-519页

作者： Nima PIRHADI Xiaowei TANG Qing YANG Afshin ASADI hazem Samih MOHAMED School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu 610500China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Civil Engineering Discipline Department of EngineeringInternational College of AucklandAuckland 1010New Zealand

Lateral displacement due to liquefaction(D_(H))is the most destructive effect of earthquakes in saturated loose or semi-loose sandy *** all earthquake parameters,the standardized cumulative absolute velocity(CAV_(5))exhibits the largest correlation with increasing pore water pressure and ***,the complex effect of fine content(FC)at different values has been studied and ***,these two contexts have not been entered into empirical and semi-empirical models to predict D_(H)This study bridges this gap by adding CAV_(5)to the data set and developing two artificial neural network(ANN)*** first model is based on the entire range of the parameters,whereas the second model is based on the samples with FC values that are less than the 28%critical *** results demonstrate the higher accuracy of the second model that is developed even with less ***,according to the uncertainties in the geotechnical and earthquake parameters,sensitivity analysis was performed via Monte Carlo simulation(MCS)using the second developed ANN model that exhibited higher *** results demonstrated the significant influence of the uncertainties of earthquake parameters on predicting D_(H).

关键词： lateral spreading displacement cumulative absolute velocity fine content artificial neural network sensitivity analysis Monte Carlo simulation

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Deep Forest-Based Fall Detection in Internet of Medical Things Environment

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Computer Systems Science & Engineering 2023年第6期45卷 2377-2389页

作者： Mohamed Esmail Karar Omar Reyad hazem Ibrahim Shehata College of Computing and Information Technology Shaqra UniversityP.O.Box 33Shaqra11961Saudi Arabia Department of Industrial Electronics and Control Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Computer Science Department Faculty of Computers and Artificial IntelligenceSohag UniversitySohag82524Egypt Department of Computer and Systems Engineering Faculty of EngineeringZagazig UniversityZagazig44519Egypt

This article introduces a new medical internet of things(IoT)framework for intelligent fall detection system of senior people based on our proposed deep forest *** cascade multi-layer structure of deep forest classifier allows to generate new features at each level with minimal hyperparameters compared to deep neural ***,the optimal number of the deep forest layers is automatically estimated based on the early stopping criteria of validation accuracy value at each generated *** suggested forest classifier was successfully tested and evaluated using a public SmartFall dataset,which is acquired from three-axis accelerometer in a *** includes 92781 training samples and 91025 testing samples with two labeled classes,namely non-fall and *** results of our deep forest classifier demonstrated a superior performance with the best accuracy score of 98.0%compared to three machine learning models,i.e.,K-nearest neighbors,decision trees and traditional random forest,and two deep learning models,which are dense neural networks and convolutional neural *** considering security and privacy aspects in the future work,our proposed medical IoT framework for fall detection of old people is valid for real-time healthcare application deployment.

关键词： Elderly population fall detection wireless sensor networks internet of medical things deep forest

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Insights into CYP2B6-mediated drug–drug interactions

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Acta Pharmaceutica Sinica B 2016年第5期6卷 413-425页

作者： William D.Hedrich hazem E.Hassan Hongbing Wang Department of Pharmaceutical Sciences University of Maryland School of Pharmacy

Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously *** discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the *** expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor(CAR) and pregnane X receptor(PXR) in the *** addition to CYP2B6,these receptors also mediate the inductive expression of CYP3A4,and a number of important phase II enzymes and drug ***2B6 has been demonstrated to play a role in the metabolism of 2%–10% of clinically used drugs including widely used antineoplastic agents cyclophosphamide and ifosfamide,anesthetics propofol and ketamine,synthetic opioids pethidine and methadone,and the antiretrovirals nevirapine and efavirenz,among *** inter-individual variability in the expression and function of the human CYP2B6 gene exists and can result in altered clinical outcomes in patients receiving treatment with CYP2B6-substrate *** variances arise from a number of sources including genetic polymorphism,and xenobiotic *** this review,we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions.

关键词： CYP2B6 CAR PXR Polymorphism Drug–drug interaction Cyclophosphamide Efavirenz

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