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Improving signature quality for network application identification

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Digital Communications and Networks 2019年第3期5卷 139-146页

作者： Justin tharp Sang C·Suh Hyeonkoo Cho Jinoh Kim Department of Computer Science Texas A&M University-Commerce P.O. Box 3011 Commerce TX 75429 USA Sysmate Inc. 41 Yuseong-daero 1184 beon-gil Yuseong-gu Daejeon 34109 North Korea

Network application identification is one of the core elements in network operations and management to provide enhanced network service and security. For accurate identification, an approach using common patterns called "signatures" is widely used to compensate the limitations of the traditional transport-layer port-based classification. However, our simulation results indicate that using the signatures generated from a set of well known algorithms may lead to very poor identification performance, with less than 60% of true positives even in an optimal case. To improve the quality of signatures, we present a technique in this paper, which consists of two steps:(i) pairwise merging to consider every possible combination of the initially collected signatures to reduce their specificity that causes the signatures to be less common;and (ii) signature reduction to identify effective signatures with greater importance from a large set of signatures produced in the merging step, so as to manage the space/time complexity in the identification process for greater scalability. Our experimental results show that the proposed technique can dramatically improve the performance, even with a small number of signatures (e.g., 95% true positives rate with 30 signatures per application) which is more compact than the initial signature set.

关键词： Network application identification Application signatures Pairwise merging Signature reduction Explicit string patterns

Co-delivery of PARP and PI3K inhibitors by nanoscale metal-organic frameworks for enhanced tumor chemoradiation

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Nano Research 2019年第12期12卷 3003-3017页

作者： megan J.Neufeld Allison N.DuRoss madeleine R.Landry hayden Winter Andrea m.Goforth Conroy Sun Department of Pharmaceutical Sciences College of PharmacyOregon State UniversityPortlandOregon 97201USA Department of Chemistry Portland State University1719 SW 10th AvePortlandOregon 97201USA Department of Radiation medicine Oregon Health&Science University3181 S.W.Sam Jackson Park RdPortlandOregon 97239USA

Due to their complementary activity,the use of DNA damage repair(DDR)inhibitors during radiotherapy(RT)has yielded promising ***,this approach is often hindered by toxicity and poor in vivo stability of the DDR in *** scale metal-organic frameworks(nmOFs)represent an emerging class of crystalline materials which exhibit advantageous properties over traditional nanomaterials and demonstrate great potential in ***,a unique,synergistic treatment strategy for enhancing the therapeutic efficacy of RT vianmOF-mediated drug delivery and RT enhancement was evaluated.A nmOF containing the high-Zelement Hf and the ligand 1,4-dicarboxybenzene(Hf-BDC)was synthesized and loaded with the two DDR inhibitor drugs,talazoparib and buparlisib(TB@Hf-BDC-PEG).TB@Hf-BDC-PEGaugmented RT by increasing reactive oxygen species generation and thus DNA damage of which repair was inhibited *** enhancement was demonstrated in vivo where the combination of concurrent radiation with in travenous TB@Hf-BDC-PEG administration resulted in improved tumor control and increased ***,no apparent toxicity was observed with nmOF treatment,supporting its potential as an attractive candidate over traditional nano *** work provides the first report of nmOFs employed to enhance thetherapeutic response to RT through DDR inhibitor delivery and physical radiation dose enhancement.

关键词： nano scale metal-organic frameworks chemoradiotherapy DNA damage repair inhibitors drug delivery radiation dose enhancement

Personalized precision radiotherapy and its evolving role for human papillomavirus-positive oropharyngeal cancer

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Journal of the National Cancer Center 2023年第1期3卷 72-82页

作者： hayden Ansinelli Chris Gay Steven Nguyen Christopher m.morrison Jared R.Robbins University of Arizona College of medicine Department of Radiation OncologyTucsonUnited States

Human papilloma virus(HPV)-associated oropharyngeal cancer(OPC)is a unique entity with increased respon-siveness to treatment and excellent oncologic *** purpose of this narrative review is to highlight how an improved prognosis for HPV(+)tumors and an ever-increasing understanding of the risk factors,risk stratification,and areas of potential spread are shaping management ***,we aim to detail how advances in treatment technology on both the surgical and radiation fronts are facilitating the delivery of increas-ingly personalized and precise *** review will describe key aspects of recent and currently-ongoing trials investigating the de-escalation and individualization of treatment in this patient cohort,and how they are building a foundation for distinct treatment paradigms for HPV(+)*** studies into the integration of biomarker-guided treatments combined with clinical trial enrollment will help ensure a future of personalized treatments and improved outcomes,both in terms of oncologic outcomes and toxicity,for patients with HPV(+)OPC.

关键词： Radiotherapy De-escalation Human papillomavirus Oropharyngeal cancer

Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia

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World Journal of Psychiatry 2020年第3期10卷 21-28页

作者： Sheila m Dowd Alyson K Zalta Helen J Burgess Elizabeth C Adkins Zerbrina Valdespino-hayden mark H Pollack Department of Psychiatry and Behavioral Sciences Rush University Medical CenterChicagoIL 60601United States Department of Psychological Science University of California IrvineIrvineCA 92697United States Sleep and Circadian Research Laboratory Department of PsychiatryUniversity of MichiganAnn ArborMI 48109United States Center for Behavioral Intervention Technologies|Department of Preventive medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Psychology Montclair State UniversityMontclairNJ 07043United States

BACKGROUND Sleep disturbance is a core feature of post-traumatic stress disorder(PTSD).Given the relationship between sleep disturbance and PTSD,there has been a relative paucity of studies examining the potential therapeutic impact of using pharmacotherapy to target sleep disturbance in patients with ***(ESZ)is a non-benzodiazepine y-aminobutyric acid-A receptor agonist indicated for the treatment of sleep and may affect sleep in patients with *** To evaluate the efficacy of ESZ vs placebo(PBO)for patients with PTSD and *** The study was a 12-wk,double blind,randomized controlled trial with 3 mg of ESZ(n=13)or PBO(n=12).RESULTS Patients in both arms experienced significant improvement in PTSD symptoms as assessed by the Clinician-Administered PTSD Scale for DSm-IV(CAPS):ESZ(t11=-3.12,P=0.005)and PBO(t11=-3.5,P=0.002)and by self-report with the Short PTSD Rating Interview(ESZ t11=-3.38,P=0.003 and PBO t11=-4.48,P=0.0005).There were no significant differences between treatments on the CAPS(t22=-0.13,P=0.70)or the Short PTSD Rating Interview(t22=-0.58,P=0.56).Similarly,both treated groups improved on sleep measures as assessed by the Pittsburgh Sleep Quality Index with PTSD Addendum(PSQI)and on total sleep time(TST)and sleep latency assessed by actigraphy with no significant differences between groups(PSQI t22=-0.24,P=0.81;total sleep time t10=0.13,P=0.90 and sleep latency t10=0.68,P=0.50).There was a significant correlation between improvement in sleep and overall improvement in PTSD as measured by change scores on the PSQI and CAPS,r(8)=0.79,P=0.01 for ESZ treated subjects,but not for those treated with PBO r(9)=0.16,P=*** events of ESZ were consistent with the known profile of the medication including dysgeusia(30%,mild),sedation(20%,mild)and headache(20%,moderate to severe).CONCLUSION Results do not support the hypothesis of a specific positive effect of ESZ compared to PBO for measures of PTSD and associated sleep disturban

关键词： Trauma Sleep disturbance Hypnotic Post-traumatic stress disorder

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磷处理粉煤灰可作农业土壤磷源

地学前缘 2008年第6期15卷 112-117页

作者：申俊峰 m.A.Powell D.B.hayden 中国地质大学(北京)地球科学与资源学院北京100083 环境地质咨询公司西安大略大学生物系

粉煤灰(简称CCP或ash)具有改良土壤,增加植物产量的功能。此外,由于它特殊的多孔结构,也可用作吸纳并承载植物养分的载体。用NaH2PO4配制成含磷0.10mol/L浓度的溶液,对采自加拿大西安大略省Sarnia地区Lambton电厂的底灰(bottomash)进行... 详细信息

粉煤灰(简称CCP或ash)具有改良土壤,增加植物产量的功能。此外,由于它特殊的多孔结构,也可用作吸纳并承载植物养分的载体。用NaH2PO4配制成含磷0.10mol/L浓度的溶液,对采自加拿大西安大略省Sarnia地区Lambton电厂的底灰(bottomash)进行振荡浸渍处理。结果表明,振荡浸渍66h后的粉煤灰中磷含量可达784×10-6。以磷处理粉煤灰、未进行磷处理的粉煤灰和石英砂按比例混合,作为基本生长介质进行玉米种植实验,其中实验配方设计为生长介质中含磷量分别为标准含磷浓度(50×10-6)的10%、25%、50%、75%和100%。生长26、34和46d后分别与不含磷的空白配方、施加含氮-磷-钾为0-20-0标准磷肥并控制磷含量为标准浓度(50×10-6)配方进行生物产量对比。生长实验结果表明,以磷处理粉煤灰供磷的生长介质,当含磷量为标准浓度的25%至100%时,其植物生长量就比添加标准浓度磷肥的配方好。种植46d后的生物生长量统计结果显示,含磷分别为标准浓度50%、75%和100%的实验介质中,玉米杆的鲜重较施标准磷肥介质中玉米分别增长39.46%、42.73%和46.13%;玉米杆干重依次增加29.71%、13.39%和28.87%;根鲜重平均增加16.62%;根干重平均增加14.03%。上述实验结果启示,粉煤灰可以很好地吸纳承载磷养分,并持续供给植物吸收生长,如果采用吸纳磷(或其他养分)的粉煤灰改良砂质土壤将有重要意义。

关键词：粉煤灰磷载体植物生长量砂土改良

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BmW m235i

汽车与运动 2014年第3期 46-53页

作者： Henry Catchpole Barry hayden 范围

m135i的姊妹车型终于在今年面世，相比起m135i来说动力更强，底盘调校更加精良，更加趋近于完美。

关键词：轿车车型品牌发动机

Estimate of the energy value of soybean meal relative to corn based on growth performance of nursery pigs

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Journal of Animal Science and Biotechnology 2020年第3期11卷 912-919页

作者： Henrique S.Cemin hayden E.Williams mike D.Tokach Steve S.Dritz Jason C.Woodworth Joel m.DeRouchey Robert D.Goodband Kyle F.Coble Brittany A.Carrender mandy J.Gerhart Department of Animal Sciences and Industry College of AgricultureKansas State UniversityManhattanKS 66506USA Department of Diagnostic medicine/Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS 66506USA JBS USA GreeleyCO 80634USA

Background:Two experiments were conducted to determine the effects of increasing amounts of soybean meal(SBm)in swine diets and estimate the energy value of ***:A total of 2233 pigs(PIC 337×1050,Hendersonville,TN)and 3796 pigs(PIC 359×C40),initially 11.0 kg and 17.6 kg body weight(BW),were used in Exp.1 and 2,*** Exp.1,pigs were placed in 92 pens each containing 20 to 27 *** Exp.2,pigs were placed in 84 pens each containing 37 to 43 *** were assigned in a randomized complete block design with BW as the blocking *** treatments consisted of 21%,27%,33%,or 39%SBm in Exp.1 and 17.5%,22%,26.5%,31%,35.5%,or 40%SBm in Exp.2,obtained by changing the inclusion rate of feed-grade amino acids and corn *** Exp.1,representative samples of corn grain,SBm,and distillers dried grains with solubles were analyzed for total AA content prior to diet *** Exp.2,diets were formulated using NRC(2012)nutrient *** diets were fed for 21 and 22 d(Exp.1 and 2)and there were 23 replicates in Exp.1 and 14 replicates in *** were weighed and feed disappearance measured weekly to calculate average daily gain(ADG),average daily feed intake(ADFI),gain-to-feed ratio(G:F),and caloric efficiency(CE).Data were analyzed with block as a random effect and treatment as a fixed effect,and contrasts were constructed to test the linear and quadratic effects of increasing ***:In Exp.1,there was a tendency(linear,P=0.092)for a decrease in ADFI as SBm *** was a tendency(P=0.090)for a quadratic response for ADG,with a decrease in ADG observed with 39%SBm *** fed diets with increasing SBm had a tendency(quadratic,P=0.069)for an increase in G:F up to 33%SBm and an improvement(linear,P=0.001;quadratic,P=0.063)in CE with increasing *** CE to estimate the energy of SBm relative to corn,a value of 105.4%of corn energy or 2816 kcal/kg NE was determined using all data *** removing the CE value

关键词： Caloric efficiency Energy Soybean meal Swine

Towards understanding of geometrical structure in microstructured optical fibres

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Towards understanding of geometrical structure in microstruc...

Innovative Thermophotovoltaic Power Source Using Silicon Concentrator Solar Cells

23rd International Congress of Theoretical and Applied mechanics

作者： Yvonne m.Stokes Darren G.Crowdy hayden Tronnolone Heike Ebendorff-Heidepriem Tanya m.monro School of mathematical Sciences The University of AdelaideAdelaideAustralia Department of mathematics Imperial College LondonLondonUK Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideAustralia

＜正＞Development of microstructured optical fibres with complex structures promise fibres for a wide range of *** of a preform and drawing to form a fibre is a fabrication process that can be automated for mass ***,t...

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Innovative Thermophotovoltaic Power Source Using Silicon Con...