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Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer

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World Journal of Gastroenterology 2006年第24期12卷 3878-3882页

作者： Kenoki Ohuchida Kazuhiro Mizumoto Nami Ishikawa Yasuhiro Ogura Daisuke Yamada Takuya Egami hayato fujita Seiji Ohashi Eishi Nagai Masao Tanaka Department of Surgery and Oncology Graduate School of Medical Sciences Kyushu UniversityFukuokaJapan

AIM： To investigate c-met expression during early pancreatic carcinogenesis. METHODS： We used 46 bulk tissues and 36 microdissected samples, including normal pancreas, chronic pancreatitis, and pancreatic cancer, for quantitative realtime reverse transcription-polymerase chain reaction. RESULTS： In bulk tissue analyses, pancreatic cancer tissues expressed significantly higher levels of c-met than did chronic pancreatitis and normal pancreas tissues. c-met levels did not differ between chronic pancreatitis and normal pancreas tissues. In microdissection-based analyses, c-met was expressed at higher levels in microclissected pancreatic cancer cells and pancreatitisaffected epithelial cells than in normal ductal epithelial cells （both, P 〈 0.01）. Interestingly, pancreatitis-affected epithelial cells expressed levels of c-met similar to those of pancreatic cancer cells. CONCLUSION： Overexpression of c-met occurs during the early stage of pancreatic carcinogenesis, and a single alteration of c-met expression is not sufficient for progression of chronic pancreatitis-affected epithelial cells to pancreatic cancer cells.

关键词： c-met', Pancreatic cancer Chronic pancreatitis Pancreatic carcinogenesis

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Single Oral Administration of Anthocyanin Rescues Smoking-Induced Endothelial Dysfunction in Young Smokers but Facilitates Oxidative Stress in Non-Smokers

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Food and Nutrition Sciences 2018年第3期9卷 179-190页

作者： Akane Yoshizaki Toshiko Tomisawa Tomohiro Osanai Naoki Nanashima Maiko Kitajima Kasumi Mikami Toshifumi fujita hayato Maeda Yoji Kato Hirosaki University Medical Hospital Hirosaki Japan Department of Nursing Science Hirosaki University Graduate School of Health Sciences Hirosaki Japan Department of Biomedical Sciences Hirosaki University Graduate School of Health Sciences Hirosaki Japan Department of Disability and Health Hirosaki University Graduate School of Health Sciences Hirosaki Japan Faculty of Agriculture and Life Science Hirosaki University Hirosaki Japan Faculty of Education Hirosaki University Hirosaki Japan

Objectives: Smoking causes endothelial dysfunction, but it still remains unclear whether oral administration of anthocyanin brings benefits to endothelial function and redox states in young healthy smokers. We tested the hypothesis that supplement anthocyanin may rescue endothelial dysfunction and redox states in young healthy smokers. Methods: Young healthy male non-smoker (n = 8) and smokers (n = 14) were enrolled to measure the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) levels and brachial artery flow-mediated dilation (FMD) before and 2 hours after one cigarette smoking or resting under administration of blackcurrant supplements (anthocyanins 210 mg) or not. Results: FMD, d-ROMs, and BAP at baseline were similar between non-smokers and smokers. One cigarette smoking induced a decrease in FMD at 2 hours (9.0% ± 2.6% vs 7.5% ± 2.3%, p Conclusions: Single oral administration of anthocyanin rescued smoking-induced endothelial dysfunction in young healthy smokers, but facilitated oxidative stress in non-smokers. When anthocyanin is taken as supplements, it seems important to pay attention to the dose and timing of administration.

关键词： Blackcurrant Anthocyanin Young Health Smoker Oxidative Stress Antioxidants

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Proposal of Lunar GIS with Visualized and Auditory Data of Japan＇s Lunar Explorer ＂KAGUYA （SELENE）＂

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通讯和计算机（中英文版） 2010年第1期7卷 63-68页

作者： Shin-ichi Sobue Hiroshi Araki Seiichi Tazawa Hirotomo Noda Izumi Kamiya Aya Yamamoto Takeo fujita Ichiro Higashiizumi hayato Okumura Japan Aerospace Exploration Agency Ibaraki 305-8505 Japan National Astronomical Observation of Japan Oshu lwate 023-0861 Japan Geographical Survey Institute Ibaraki 305-0811 Japan Remote Sensing Technology Center of Japan Tokyo 106-0032 Japan Moonbell Project Tokyo 150-0001 Japan

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