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Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2021年第9期27卷 866-885页

作者： Katia farias e Silva hayandra f nanini Cynthia Machado Cascabulho Siane L B Rosas Patricia T Santana Antonio Joséde V Carneiro Elias Anaissie Marcio Nucci Heitor Siffert Pereira de Souza Department of Clinical Medicine School of MedicineFederal University of Rio de JaneiroRio de Janeiro 21941-913Brazil Laboratory of Innovations in Therapies Education and BioproductsInstituto Oswaldo CruzRio de Janeiro 21040-360Brazil Clinical Trial and Consulting Services CincinnatiOH 45267United States Internal Medicine D'Or Institute for Research and Education(IDOR)Rio de Janeiro 22281-100Brazil

BACKGROUND 1,3-beta-D-glucan(BG)is a ubiquitous cell wall component of gut *** hypothesized that the serum levels of BG could reflect active intestinal inflammation in patients with inflammatory bowel *** To determine whether the serum BG concentrations correlate with intestinal *** A prospective observational study was performed in a tertiary referral center,from 2016 to 2019,in which serum BG was determined in 115 patients with Crohn’s disease(CD),51 with ulcerative colitis(UC),and 82 controls using a photometric detection *** activity was determined by ileocolonoscopy,histopathology,magnetic resonance enterography,and biomarkers,including fecal calprotectin(fC),C-reactive protein,and a panel of *** ability of BG to detect active vs inactive disease was assessed using the area under the receiver operating characteristic *** subgroup analysis,serial BG was used to assess the response to therapeutic *** The serum BG levels were higher in CD patients than in controls(P=0.0001).The BG levels paralleled the endoscopic activity in CD patients and histologic activity and combined endoscopic and histologic activity in both CD and UC *** area under the curve(AUC)in receiver operating characteristic analysis to predict endoscopic activity was 0.694[95%confidence interval(CI):0.60-0.79;P=0.001]in CD,and 0.662(95%CI:0.51-0.81;P=0.066)in UC *** AUC in receiver operating characteristic analysis to predict histologic activity was 0.860(95%CI:0.77-0.95;Pff values of BG for both endoscopic and histologic activity were 60μg/mL in CD,and 40μg/mL in UC *** analysis showed that the results based on BG of 40 and 60μg/mL were more specific for predicting endoscopic activity(71.8%and 87.2%for CD;and 87.5%and 87.5%for UC,respectively)than fC(53.3%and 66.7%for CD;and 20%and 80%for UC,respectively);and

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Beta-glucan Histologic activity Noninvasive test

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Damage-associated molecular patterns in inflammatory bowel disease:from biomarkers to therapeutic targets

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World Journal of Gastroenterology 2018年第41期24卷 4622-4634页

作者： hayandra ferreira nanini Claudio Bernardazzi fernando Castro Heitor Siffert Pereira de Souza Servico de Gastroenterologia e Laboratorio Multidisciplinar de Pesquisa Departamento de Clinica MedicaHospital Universitario Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil D’Or Institute for Research and Education(IDOR) Rua Diniz Cordeiro 30BotafogoRio de JaneiroRJ 22281-100Brazil

The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. for decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the complex cellular and molecular network underlying chronic intestinal inflammation. These factors need to be appreciated within the milieu of nonimmune components. Damage-associated molecular patterns (DAMPs), which are essentially endogenous stress proteins expressed or released as a result of cell or tissue damage, have been shown to act as direct proinflammatory mediators. Excessive or persistent signalling mediated by such molecules can underlie several chronic inflammatory disorders, including IBD. The release of endogenous DAMPs amplifies the inflammatory response driven by immune and non-immune cells and promotes epigenetic reprogramming in *** effects determine pathologic changes,which may sustain chronic intestinal inflammation and also underlie specific disease *** addition to highlighting the potential use of DAMPs such as calprotectin as biomarkers,research on DAMPs may reveal novel mechanistic associations in IBD pathogenesis and is expected to uncover putative therapeutic targets.

关键词： Damage-associated molecular patterns Environmental factors Epigenetics Inflammatory bowel disease Therapeutic targets

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Maternal PAPP-A Levels at 11 - 13 Weeks of Gestation Predict foetal and Neonatal Growth

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Open Journal of Obstetrics and Gynecology 2015年第6期5卷 365-372页

作者： M. Gentile M. Schifano S. Lunardi C. nanini f. Moscuzza C. Sergiampietri M. Ciantelli f. Monacci A. Boldrini C. Luchi P. Ghirri Department of Clinical and Experimental Medicine Neonatal Intensive Care and Neonatology Unit University Hospital of Pisa Pisa Italy Department of Clinical and Experimental Medicine Division of Obstetrics and Gynaecology University Hospital of Pisa Pisa Italy

Recent reports suggest that maternal serum levels of pregnancy-associated plasma protein A (PAPP-A) may predict perinatal outcome. PAPP-A is a syncytiotrophoblast derived protease for insulin-like growth factor binding protein (IGfBP4);its protease activity cleaves complexed growth factor binding protein increasing insulin-like growth factor I (IGf-I) bioavailability. The aim of our study was to evaluate the correlation between maternal PAPP-A serum levels and neonatal growth. We analysed 100 full term and preterm (30 - 36 weeks) small for gestational age (SGA) and adequate for gestational age (AGA) babies whose mothers had been tested for serum PAPP-A at 11 - 13 weeks of gestation. We found a significant positive correlation between maternal PAPP-A and neonatal weight, length, and head circumference at birth in both term and preterm infants. Low maternal PAPP-A serum levels (maternal PAPP-A for gestational age neonates. A significant positive correlation was also evident between maternal PAPP-A and babies’ growth parameters at 6 months of age. Our results suggest that maternal levels of PAPP-A in early pregnancy affect growth during both foetal and early postnatal life.

关键词： Maternal Predictors foetal Growth Neonatal Outcome

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