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L-Norvaline, a new therapeutic agent against Alzheimer’s disease

Neural Regeneration Research 2019年第9期14卷 1562-1572页

作者： Baruh Polis Kolluru D.Srikanth Vyacheslav Gurevich hava gil-henn Abraham O.Samson Drug Discovery Laboratory The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael Laboratory of Cell Migration and Invasion The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael Laboratory of Cancer Personalized Medicine and Diagnostic Genomics The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer’s disease(AD).Upregulation of arginase was shown to contribute to *** of arginase activity appears to be a promising approach for interfering with the pathogenesis of ***,the enzyme represents a novel therapeutic *** this study,we administered an arginase inhibitor,L-norvaline(250 mg/L),for 2.5 months to a triple-transgenic model(3×Tg-AD)harboring PS1M146V,APPSwe,and tauP301L ***,the neuroprotective effects of L-norvaline were evaluated using immunohistochemistry,proteomics,and quantitative polymerase chain reaction ***,we identified the biological pathways activated by the ***,L-norvaline treatment reverses the cognitive decline in AD *** treatment is neuroprotective as indicated by reduced beta-amyloidosis,alleviated microgliosis,and reduced tumor necrosis factor transcription ***,elevated levels of neuroplasticity related postsynaptic density protein 95 were detected in the hippocampi of mice treated with ***,we disclosed several biological pathways,which were involved in cell survival and neuroplasticity and were activated by the *** these modes of action,L-norvaline has the potential to improve the symptoms of AD and even interferes with its *** such,L-norvaline is a promising neuroprotective molecule that might be tailored for the treatment of a range of neurodegenerative *** study was approved by the Bar-Ilan University Animal Care and Use Committee(approval No.82-10-2017)on October 1,2017.

关键词： dementia arginase inhibition arginine urea cycle microgliosis neuroinflammation cytokines tumor necrosis factor mTOR neurodegeneration

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Addiction as a dynamical rationality disorder

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Frontiers of Electrical and Electronic Engineering in China 2011年第1期6卷 151-158页

作者： hava T.SIEGELMANN Department of Computer Science UMass AmherstAmherstMA 01003USA

Addiction is frequently modeled as a behavioral disorder resulting from the internal battle between two subsystems:one model describes slow planning versus fast habitual action;another,hot versus cold *** another model,one subsystem pushes the individual toward substance abuse,while the other tries to pull him *** models all describe one side winning over the other at each point of confrontation,represented as a simple binary switch:on or off,win or *** propose however,an alternative model,in which opposing systems work in parallel,tipping toward one subsystem or the other,in greater or lesser degree,based on a continuous rationality *** approach results in a dynamical system that qualitatively emulates seeking behavior,cessation,and relapse—enabling the accurate description of a process that can lead to *** an adjunct to the model,we are in the process of creating an associated,interactive website that will enable addicts to journal their thoughts,emotions and actions on a daily *** site is not only a potentially rich source of data for our model,but will in its primary function aid addicts to individually identify parameters affecting their decisions and behavior.

关键词： addiction emotional-cognitive rationality dynamical systems dynamical disease dynamical rehabilitation relapse higher power

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Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation

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World Journal of Gastroenterology 2011年第45期17卷 5007-5013页

作者： Nitsan Maharshak Philippe Halfon Varda Deutsch hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno Ran Oren Department of Gastroenterology and Liver diseases Tel Aviv Sourasky Medical Center aff iliated to the Sackler School of Medicine Tel Aviv University Department of Virology Laboratoire Alphabio 23 Rue de Friedland Hpital Ambroise Paré The Hematology Institute Tel Aviv Sourasky Medical Center affi liated to the Sackler School of Medicine Tel Aviv University Clinical Biochemistry Laboratory Tel Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine Tel Aviv University Internal Medicine "E" Tel Aviv Sourasky Medical Center affi liated to the Sackler School of Medicine Tel Aviv University

AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective "Fibroscore Study" in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as "fast fi brosers" and 116 as "slow fi brosers"; 13% of the "fast fi brosers" carried the PT20210 mutation as compared with 5.5% of the "slow fi brosers", with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for "fast" liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients.

关键词： Hepatitis C virus Liver fi brosis Hyperco-agulation Prothrombin 20210

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In-depth investigation and applications of novel silicon photonics microstructures supporting optical vorticity and waveguiding for ultranarrowband near-infrared perfect absorption

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Photonics Research 2020年第3期8卷 381-394页

作者： ROY AVRAHAMY MOSHE ZOHAR MARK AUSLENDER BENNY MILGROM SHLOMO hava RAFI SHIKLER School of Electrical and Computer Engineering Ben-Gurion University of the NegevBeer-Sheva 84105Israel Electrical and Electronics Engineering Department Shamoon College of EngineeringBeer-Sheva 84100Israel School of Electrical Engineering The Jerusalem College of TechnologyJerusalem 91160Israel Ilse Katz Institute for Nanoscale Science&Technology Ben-Gurion University of the NegevBeer-Sheva 84105Israel

We propose a novel concept of designing silicon photonics metamaterials for perfect near-infrared light *** study's emphasis is an in-depth investigation of various physical mechanisms behind the^100%ultranarrowband record peak absorptance of the designed structures,comprising an ultrathin silicon *** electromagnetic power transport,described by the Poynting vector,is innovatively explored,which shows combined vortex and crossed-junction two-dimensional waveguide-like flows as outcomes of optical field *** flows,though peculiar for each of the designed structures,turn out to be key factors of the perfect resonant optical *** electromagnetic fields show tight two-dimensional confinement:a sharp vertical confinement of the resonant-cavity type combined with a lateral metasurface supported *** siliconabsorbing layer and its oxide environment are confined between two subwavelength metasurfaces such that the entire design is well compatible with silicon-on-insulator *** design concept and its outcomes meet the extensive challenges of ultrathin absorbers for minimum noise and an ultra-narrowband absorptance spectrum,while maintaining an overall very thin structure for planar *** these materials and such objectives,the proposed designs seem essential,as standard approaches fail,mainly due to a very low silicon absorption coefficient over the near-infrared *** tests for fabrication errors show fair tolerability while maintaining a high absorptance peak,along with a controllable deviation off the central-design *** applications are suggested and analyzed,which include but are not limited to:efficient photodetectors for focal plane array and on-chip integrated silicon photonics,high-precision spectroscopic chemical and angular-position sensing,and wavelength-division multiplexing.

关键词： optical waveguide perfect

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分光光度滴定法测某些多齿配体与Ni(Ⅱ)配合物的稳定常数(英文)

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无机化学学报 2012年第8期28卷 1680-1686页

作者： hava Ozay Ahmet Ulgen Yakup Baran Onsekiz Mart大学文理学院化学系土耳其恰纳卡莱17100 Erciyes大学文理学院化学系开塞利土耳其

制备了多齿大环配体1,4,7,10-四氮杂环十二烷(L1);1,4,8,11-四(2-羟乙基)-1,4,8,11-四氮杂环十四烷(L2)和无环多齿配体;3-(2-氨基环己氨基)-2-(2-氨基环己氨基甲基)丙酸(L3),4,7,10-十三烷二腈三氢氯化物(L4),2,2′-(1,2-二乙基-双((甲基二氮杂烷基)二乙醇(L5)and 1,1′-(1,2-二乙基-双((2-氨基乙基)二氮杂烷基))-2-二丙醇(L6),并用FTIR,NMR和MS进行了表征,用配有二极管阵列检测器、蠕动泵和pH计的UV-VIS光度仪,经分光光度滴定法测定了它们与Ni髤的配合物的稳定常数。将稳定常数的数据与配体的开链和环状结构特性进行了关联讨论。还讨论了侧基对配合物稳定常数的影响。

关键词：配合物多齿分光光度滴定 Ni髤

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面向对象查询的完整隐式回答

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计算机科学 1993年第1期20卷 45-50页

作者： hava T.Siegelmann B.R.Badrinath 冯铃

根据类公式化OODB中的查询,可检索某些满足类属性谓词的实例。OO数据模型的类层次概念允许依据类和实例,隐式地表达具有不同抽象级的查询结果。Shum和Muntz[SM88]提出了基于DB分类的隐式表达方法,其算法在查询结果长度上是最佳的,但不... 详细信息

根据类公式化OODB中的查询,可检索某些满足类属性谓词的实例。OO数据模型的类层次概念允许依据类和实例,隐式地表达具有不同抽象级的查询结果。Shum和Muntz[SM88]提出了基于DB分类的隐式表达方法,其算法在查询结果长度上是最佳的,但不够清晰。本文提出一种易理解的唯一相关回答。为了以自顶向下方式有效地获得并操纵相关回答,借助访问DB的查询算子,公式化用户查询并对标准查询算子进行重定义。这种相关回答的抽象表示,对处理复杂信息十分有用。

关键词：面向对象查询隐式回答

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A new species in the genus Globicornis Latreille(Coleoptera: Dermestidae: Megatominae) from China

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Entomotaxonomia 2016年第3期38卷 197-200页

作者：杨美霞 Jiri hava 杨星科陕西省动物研究所陕西西安710032 中国科学院动物研究所北京100101 Department of Forest Protection and Entomology Faculty of Forestry and Wood SciencesCzech University of Life SciencesKamycka 1176CZ-165 21Prague 6-SuchdolCzech Republic

General characteristics of Globicornis Latreille and a key of known subgenera of the genus are given. The new species G.（Globicornis） yushuensis sp. nov. from China（Qinghai Province） is described and illustrated.

关键词： Dermestoidea Globicornis yushuensis taxonomy key

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The Yellow Spot Pattern of Salamander (Salamandra infraimmaculata) in Various Habitats at the Southern Border of Its Distribution in Israel

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Open Journal of Animal Sciences 2023年第1期13卷 114-125页

作者： Gad Degani Gad Ish Am Amit Biran Ish Am Neria Yatom Amir Marshansky Sivan Margalit Eitan Nissim hava Goldstein Niva Shaked MIGAL—Galilee Research Institute Kiryat Shmona Israel Faculty of Science and Technology Tel-Hai Academic College Kiryat Shmona Israel Kibbutz Sasa Upper Galilee Israel Kibbutz Yehiam Galil Maaravi Israel Israel Nature and Parks Authority Jerusalem Israel

The present study describes the different color-pattern phenotypes of yellow spots on the black back of Salamandra infraimmaculata in various habitats at the southern border of its distribution in Israel. At Tel Dan, we photographed 454 salamanders in moist habitats where water flows year round;100 of these were sampled to measure the percentage of yellow and black color on the back, and the number of spots on the head. At Kibbutz Sasa, 201 salamanders were photographed, of which 62 were sampled for the measurements. In Kibbutz Yehiam, 200 salamanders were photographed, and 60 were sampled for the measurements. At all sites, about a third of the salamanders were photographed more than once. For all three populations, yellow spots on the salamander back were found in one row, two rows or scattered. For two indices (proportion of yellow/black and number of spots on the head), the Dan population (under wet, running water all year round conditions) differed from the two other populations of salamanders (under semi-arid mountain conditions). The number of yellow spots on the head of the salamanders in the three populations varied from 1 to 7. In all populations, 4 spots pattern was the most common. In the Dan population, there were significantly more salamanders with 1 to 3 spots on their head than in the Sasa or Yehiam populations. No difference was found in the number of head spots for Sasa vs. Yehiam salamanders. The percentage of yellow on the black back was significantly larger for the Dan salamanders vs. the two other populations. The main question examined was whether there is an effect of the habitat conditions in isolated populations on the spot pattern on the salamander back. The answer is positive and is supported by previous studies.

关键词： Salamandra infraimmaculata Color-Pattern Habitats Spots Yellow

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用加筋土技术控制隆胀

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路基工程 1996年第2期 74-78页

作者： B.R.Srinivasa Murthy A.Sridharan Bindumad hava 王桢铁道科研院西北分院

由于膨胀土中含水量变化所引起的隆胀问题,已经试图应用加筋土原理解决。膨胀压力本身在各个方向上扩展,由于它作用在加筋上的法向分力,这将动用土和加筋接触面上的摩擦力。这说明了,这种摩擦力在平行于加筋的方向上抵销膨胀压力从而减... 详细信息

由于膨胀土中含水量变化所引起的隆胀问题,已经试图应用加筋土原理解决。膨胀压力本身在各个方向上扩展,由于它作用在加筋上的法向分力,这将动用土和加筋接触面上的摩擦力。这说明了,这种摩擦力在平行于加筋的方向上抵销膨胀压力从而减少膨胀。有限的试验结果已经证实了上述的可能性。而且,也说明了,在膨胀土中,提供一个砂层包裹加筋,或者使用表面硬脂酸脂的加筋,可以增大摩擦系数。

关键词：铁路路基加筋土隆胀控制技术

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