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Omics-based biomarkers as useful tools in metabolic dysf.n.tionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks María f Mascardi Adrián Gadano Sebastián Marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-Consejo nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysf.n.tion-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysf.n.tion-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics

Effects of synthesis parameters on the performance of crosslinked Co-polymers with clays for conformance control

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Petroleum Research 2024年第1期9卷 98-108页

作者： A.A.Roslan n.A.A.Aziz n.f.A.Deraman I.Dzulkarnain Petroleum Engineering Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia Chemical Engineering Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

Conformance control or water shut-off is a technique used to improve oil *** conformance control,polymers block high permeability water areas and redistribute water drive toward unswept oil *** this study,co-polymers(denoted ATP-PGV/AM-co-AMPS)were synthesized using acrylamide(AM)and 2-acrylamide-2-methylpropane sulf.n.c acid(AMPS)as the monomers,polyethylene glycol(PEG)-200 and methylenebisacrylamide(MBA)as the crosslinkers,attapulgite(ATP)and bentonite(PGV)as the clay types,and ammonium persulfate(APS)as the initiator,in addition to paraff.n.oil and *** were synthesized using inverse emulsion polymerization with different concentrations of monomers,crosslinkers,and clays,and they were characterized using fourier-transform infrared(fTIR)spectroscopy and scanning electron microscopy(SEM)with energy dispersive X-ray spectroscopy(EDX).fTIR spectra of the samples confirmed the existence of sulf.n.te and hydroxyl groups,which are important for polymer ***-EDX images indicated that the morphology and elemental composition were different before and after swelling,confirming the occurrence of ***,samples were placed in sodium chloride solution(20,000 ppm)for 7 days to evaluate swelling at both room temperature and 90°*** analysis(TGA)and differential scanning calorimetry(DSC)were used to determine the thermal characteristics of the ***,rheological measurements were used to assess the deformation and rheological behavior of the *** results showed that after 1 day,good swelling without loss of mechanical strength was achieved with the composite synthesized using 10%AM,15%AMPS,6%PGV,and 10%ATP.

关键词： Polymer Clay Water shut-off Conformance Swelling

Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： n.IQBAL J.CHOI S.f.SHAH C.LEE S.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline ni-rich LinixMnyCo_(z)O_(2)(x≥0.8)(nMC)particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary nMC particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the lower stif.n.ss,higher ionic conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framework for calculating the chemo-mechanical responses of anisotropic electrode materials and f.n.amental insights into how the coating of.n.C active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating f.n.te element simulation ni-rich LinixMnyCo_(z)O_(2)(x>0.8)(nMC)

Characterization of bright betatron radiation generated by direct laser acceleration of electrons in plasma of.n.ar critical density

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Matter and Radiation at Extremes 2024年第2期9卷 26-35页

作者： J.Cikhardt M.Gyrdymov S.Zähter P.Tavana M.M.Günther n.Bukharskii n.Borisenko J.Jacoby X.f.Shen A.Pukhov n.E.Andreev O.n.Rosmej faculty of Electrical Engineering Czech Technical University in Prague16627 Prague 6Czech Republic Goethe University FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany focused Energy GmbH Im Tiefen See 4564293 DarmstadtGermany national Research nuclear University MEPhI Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev Physical Institute RAS Leninskiy Prospekt 53119991 MoscowRussian Federation Heinrich-Heine-University Düsseldorf Universitätsstrasse 1DüsseldorfGermany Joint Institute for High Temperatures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation Moscow Institute of Physics and Technology Institutskiy Pereulok 9141700 DolgoprudnyRussia

Directed x-rays produced in the interaction of sub-picosecond laser pulses of moderate relativistic intensity with plasma of.n.ar-critical density are investigated. Synchrotron-like (betatron) radiation occurs in the process of direct laser acceleration (DLA) of electrons in a relativisticlaser channel when the electrons undergo transverse betatron oscillations in self-generated quasi-static electric and magnetic fields. In anexperiment at the PHELIX laser system, high-current directed beams of DLA electrons with a mean energy ten times higher than the ponderomotive potential and maximum energy up to 100 MeV were measured at 10^(19) W/cm^(2)laser intensity. The spectrum of directed x-raysin the range of 5–60 keV was evaluated using two sets of Ross filters placed at 0°and 10°to the laser pulse propagation axis. The differential x-ray absorption method allowed for absolute measurements of the angular-dependent photon fluence. We report 10^(13) photons/sr withenergies >5 keV measured at 0°to the laser axis and a brilliance of 10^(21) photons s^(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular distributionof the emission has an fWHM of 14°–16°. Thanks to the ultra-high photon fluence, point-like radiation source, and ultra-short emissiontime, DLA-based keV backlighters are promising for various applications in high-energy-density research with kilojoule petawatt-class laserfacilities.

关键词： laser acceleration critical

numerical Analysis of the Magnetic Dipole Effect on a Radiative ferromagnetic Liquid flowing over a Porous Stretched Sheet

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fluid Dynamics & Materials Processing 2024年第2期20卷 293-310页

作者： G.Dharmaiah f.Mebarek-Oudina K.S.Balamurugan n.Vedavathi Department of Mathematics Narasaraopeta Engineering CollegeNarasaraopetIndia Department of Physics Faculty of SciencesUniversity of 20 Août 1955-SkikdaSkikdaAlgeria Department of Mathematics RVR&JC College of EngineeringGunturIndia Department of Mathematics Koneru Lakshmaiah Education FoundationVaddeswaramIndia

The effects of a magnetic dipole on a nonlinear thermally radiative ferromagnetic liquidﬂowing over a stretched surface in the presence of Brownian motion and thermophoresis are *** means of a similarity transformation,ordinary differential equations are derived and solved afterwards using a numerical(the BVP4C)*** impact of various parameters,namely the velocity,temperature,concentration,is presented *** is shown that the nanoparticles properties,in conjunction with the magnetic dipole effect,can increase the thermal conductivity of the engineered nanoﬂuid and,consequently,the heat *** with earlier studies indicates high accuracy and effectiveness of the numerical *** increase in the Brow-nian motion parameter and thermophoresis parameter enhances the concentration and the related boundary *** skin-friction rises when the viscosity parameter is increased.A larger value of the ferromagnetic para-meter results in a higher skin-friction and,vice versa,in a smaller nusselt number.

关键词： Brownian motion thermo-phoresis radiation magnetic dipole BVP4C non-linear

Radiative capture of proton through the ^(14)n(p,γ)^(15)O reaction at low energy

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Chinese Physics C 2024年第4期48卷 183-192页

作者： B.f.Irgaziev Abdul Kabir Jameel-Un nabi national University of Uzbekistan Tashkent 100174Uzbekistan Space and Astrophysics Research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan

The CnO cycle is the main source of energy in stars more massive than our *** process def.n.s the energy production,the duration of which can be used to determine the lifetime of massive *** cycle is an important tool for determining the age of globular *** proton capture via p+^(14)n→^(15)O+γ,at energies of astrophysical interest,is an important process in the CnO *** this project,we apply a potential model to describe both non-resonant and resonant reactions in the channels where radiative capture occurs through electric E1 *** employed the R-matrix method to describe the ongoing reactions via M1 resonant transitions,when it was not possible to correctly reproduce the experimental data using the potential *** partial components of the astrophysical S-factor are calculated for all possible electric and magnetic dipole transitions in ^(15)*** linear extrapolated S-factor at zero energy(S(0))agrees well with earlier reported values for all transition types considered in this *** on the value of the total astrophysical S-factor,depending on the collision energy,we calculate the nuclear reaction rates for p+^(14)n→^(15)O+γ.The computed rates agree well with the results reported in the nACRE II Collaboration and most recent existing measurements.

关键词： CnO cycle potential model R-matrix method cross-section astrophysical S-factor nuclear rates.

Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： Luis A.Pesantes Ruben Hidalgo-León Johnny Rengifo Miguel Torres Jorge Aragundi JoséCordova-Garcia Luis f.Ugarte facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to f.n. solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. for the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

Localized-states quantum conf.n.ment induced by roughness in CdMnTe/CdTe heterostructures grown on Si(111) substrates

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Journal of Semiconductors 2024年第9期45卷 28-35页

作者： Leonarde n.Rodrigues Wesley f.Inoch Marcos L.f.Gomes Odilon D.D.Couto Jr. Bráulio S.Archanjo Sukarno O.ferreira Physics Department Federal University of ViçosaViçosa36570-900Minas GeraisBrazil Instituto de física Gleb Wataghin Universidade Estadual de CampinasCampinas13083-859São PauloBrazil national Institute of Metrology Quality and Technology(Inmetro) Materials Metrology Division(DIMAT)Xerém2525-020Rio de JaneiroBrazil

This work shows that despite a lattice mismatch of almost 20%, CdMnTe/CdTe/CdMnTe heterostructures grown directly on Si(111) have surprisingly good optical emission properties. The investigated structures were grown by molecular beam epitaxy and characterized by scanning transmission electron microscopy, macro-and micro-photoluminescence. Low temperature macro-photoluminescence experiments indicate three emission bands which depend on the CdTe layer thickness and have different conf.n.ment characteristics. Temperature measurements reveal that the lower energy emission band (at 1.48 eV)is associated to defects and bound exciton states, while the main emission at 1.61 eV has a weak 2D character and the higher energy one at 1.71 eV has a well-def.n.d (zero-dimensional, 0D) 0D nature. Micro-photoluminescence measurements show the existence of sharp and strongly circularly polarized (up to 40%) emission lines which can be related to the presence of Mn in the heterostructure. This result opens the possibility of producing photon sources with the typical spin control of the diluted magnetic semiconductors using the low-cost silicon technology.

关键词： CdMnTe/CdTe/CdMnTe heterostructure CdTe/CdMnTe quantum emitters quantum dot-like emission silicon(111)substrate

Design of a novel Exoskeleton with Passive Magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon f.Rodríguez-León Betsy D.M.Chaparro-Rico Daniele Cafolla francesco Lago Eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of freedom(Dof).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot