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Evaluating the safety of intracameral bevacizumab application using oxidative stress and apoptotic parameters in corneal tissue

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 697-702页

作者： Ali Akal Turgay Ulas Tugba Goncu Muhammet Emin Guldur sezen Kocarslan Abdullah Taskin hatice sezen Kudret Ozkan Omer Faruk Yilmaz Hakan Buyukhatipoglu Department of Ophthalmology Harran University Faculty of Medicine Department of Internal Medicine Harran University Faculty of Medicine Department of Pathology Harran University Faculty of Medicine Department of Biochemistry Harran University Faculty of Medicine

·AIM: To investigate the possible effects of intracameral bevacizumab on oxidative stress parameters and apoptosis in corneal tissue.·METHODS: In total, 30 rats were assigned randomly into the following three groups of 10 rats each: a sham group(Group 1; n =10), a control group [Group 2;balanced salt solution(BSS) was administered at 0.01 m L;n =10], and a treatment group(Group 3; bevacizumab was administered at 0.25 mg/0.01 m L; n =10). The total antioxidant status(TAS) and the total oxidant status(TOS) in the corneal tissue and blood samples were measured, and the oxidative stress index(OSI) was calculated. Additionally, corneal tissue histopathology was evaluated for caspase-3 and 8 staining and apoptotic activity.·RESULTS: In the blood samples, the TAS, TOS, and OSI levels were not significantly different(all P >0.05).Compared with the sham and control groups, the TOS and OSI levels in the corneal tissues were significantly different in the bevacizumab group(all P 0.05).However, compared with the sham and control groups,greater immunohistochemical staining for caspases-3and 8 and an elevated level of apoptotic activity were observed in the bevacizumab group.·CONCLUSION: This study revealed that intracameral bevacizumab injections seemed to be systemically safe but may have elicited local toxic effects in the corneal tissue, as indicated by the oxidative stress parameters and histopathological evaluations.

关键词： apoptosis cornea intracameral bevacizumab oxidative stress

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Usefulness of the epicardial fat tissue thickness as a diagnostic criterion for geriatric patients with metabolic syndrome

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Journal of Geriatric Cardiology 2015年第4期12卷 373-377页

作者： Bema Kaya Bedri Caner Kaya Emel Yigit Karakas Sadettin Selcuk Baysal Dursun Cadirci Emre Erkus Ibrahim Halil Altiparmak Emin Savik hatice sezen Tttrgay Ulas Department of Internal Medicine Sanliurfa Training and Research Hospital Sanliurfa Turkey Department of Cardiology Sanliurfa Training and Research Hospital Sanliurfa Turkey Department of Internal Medicine Faculty of Medicine Harran University Sanliurfa Turkey Department of Family Medicine Faculty of Medicine Harran University Sanliurfa Turkey Department of Cardiology Faculty of Medicine Harran University Sanliurfa Turkey Department of Biochemistry Faculty of Medicine Harran University Sanliurfa Turkey

Objective To evaluate the epicardial fat tissue thickness （EFTT） as a diagnostic criterion for geriatric patients with metabolic syn- drome （MetS）. Methods Sixty geriatric patients over 65 years of age were recruited for the study. Patients were divided into two groups： Group 1 （n = 30） consisted of patients with MetS; Group 2 （n = 30） consisted of patients without MetS. Echocardiography was used to measure EFTT in all patients, and blood samples were analyzed for biochemical parameters. Results Compared to Group 2, EFTT levels of Group 1 were statistically higher （P 〈 0.05）. In a binary logistic regression analysis, EFTT levels served as the independent factor for meta- bolic syndrome 03 = 17.35, SE = 4.93, Wald = 12.36, P 〈 0.001）. Receivers operating characteristic Curve （ROC-curve） analysis revealed that EFTT predicted MetS with 96.7% sensitivity and 86.7% specificity above the level of 7.3 mm [area under the curve = 0.969; 95% con- fidence interval （CI）： 0.928-1.00]. Conclusions The present study demonstrated that serum EFTT levels were higher in geriatric patients with MetS and can therefore be used as a diagnostic criterion for MetS.

关键词： Epieardial fat tissue thickness Geriatrics Metabolic syndrome

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Effect of gamification applications on success of dentistry students

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World Journal of Methodology 2025年第1期15卷 80-87页

作者： hatice Ahsen Deniz Elif Polat Balkan Burak İncebeyaz Kıvanç Kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

BACKGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** To evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications Kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and Kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,Kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the Kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).There was a statistically significant difference in average success scores between students of different groups(P=0.003<0.05)and grades(P=0.036<0.05).The average success score was the highest in the Mentimeter group(71.64)and the lowest in the Kahoot!group(62.15).In the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCLUSION Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the Kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter Kahoot! Education Dentistry

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Benthic foraminiferal assemblages from the Safranbolu Formation(Cuisian,Eocene),Northwest Anatolia,Turkey

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Journal of Palaeogeography 2020年第1期9卷 21-41页

作者： Kubra Okur hatice Kutluk Department of Geology Eskisehir Osmangazi UniversityBati Meselik26480 EskisehirTurkey

Twenty-one outcrop samples collected from a 28-m-thick section from the Safranbolu Formation of the southwestern part of the Safranbolu Basin,Anatolia,Turkey yielded well-preserved benthic foraminifera belonging mainly to the genera Alveolina,Nummulites,Assilina,Rotalia,Disclocyclina and *** is the most diversified genus that is represented by sixteen species:Alveolina archiaci,***,***,***,***,***,***,***,***,***,***,*** gueroli,***,***,*** and *** safranboluensis and *** are described *** of the fossil assemblage with those assemblages previously reported from both Turkey and other Tethyan sub-basins revealed that the deposition occurred during the Cuisian(Eocene)and corresponded to Shallow Benthic Foraminiferal Zones(SBFZ)10–*** abundance and diversity of the larger benthic foraminifera indicated that the Safranbolu Formation was deposited under transgressive conditions.

关键词： Eocene Cuisian Safranbolu Formation Benthic foraminifera Alveolina Northwest Anatolia

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Pollen Morphology of Acinos Miller Species Growing in Turkey

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Journal of Integrative Plant Biology 2007年第9期49卷 1386-1392页

作者： Ayla Kaya hatice Kutluk Anadolu University Faculty of PharmacyDepartment of Pharmaceutical BotanyEskisehir 26470 Turkey Osmangazi University Department of Geology (Paleobotany)Bati Meselik Eskisehir 26040 Turkey

The pollen morphology of six taxa of the genus Acinos Miller has been examined under scanning electron microscopy （SEM） and a description of each taxon has been given. Acinos pollen is stephanocolpate （hexacolpate）. Two main exine sculpturing types, foveolate-reticulate （only in subspecies of A. troodi） and reticulate have been defined. The dimension for the polar length ranges between 25.8-47.4 μm, equatorial width 24.5-34.4μm, colpus length 20.0-40.5μm and colpus width 1.2-2.5 μm. The shape is mostly subprolate to prolate, seldomly prolate-spheroidal. The results reveal rather uniform morphological features, however fine details are characteristic to differentiate the pollen taxa. Acinos pollen also share some common morphological features with the other Lamiaceae pollen.

关键词： Acinos Lamiaceae morphology polen scanning electron microscopy.

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Efects of Die Corner Radius and Temperature on the Formability of AA7075-T6 Alloy

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Acta Metallurgica Sinica(English Letters) 2013年第5期26卷 623-629页

作者： hatice Evlen brahim Kad Mustafa Ya sar Technology Faculty Karabuk University

This study focused on the formability of aluminium alloy（7075-T6） sheets through hydroforming route. Formability of these sheets was tested using a warm forming setup at three diferent temperatures and four diferent die corner radii. Forming limit diagrams（FLD） were generated by measuring the grids of the sheet formed. The results show that the forming limit of AA7075-T6 can be significantly improved when the blank was heated to 140–250℃. It was also observed that as the temperature increases above 140℃, dome height began to decrease. Also the results indicated that both the die corner radius and temperature have a significant efect on the stress-strain curve and warm forming of AA7075-T6 sheets. Thus, with the temperature increased from room temperature（RT） to 140℃, the flow stress decreased and the strain increased, hence, the formability is enhanced. However, further increase in temperature causes decreases the flow stress and strain. Similar changes of the flow curve were seen in die corner radius. Decreasing the die corner radius decreases the flow stress and increase the strain. Moreover, an equation was obtained by establishing correlations between the experimental parameters and their results. In this way, it became possible to make predictions.

关键词： Al-Zn-Mg-Cu Alloy Drawing process Formability Forming limit curve Deformation

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Global existence and decay of solutions for the generalized bad Boussinesq equation

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Applied Mathematics(A Journal of Chinese Universities) 2013年第3期28卷 253-268页

作者： hatice Taskesen Necat Polat Abdulkadir Ertas Department of Statistics Yuzuncu Yil UniversityVan 65080 Turkey Department of Mathematics Dicle UniversityDiyarbakir 21280 Turkey

In this paper, we consider the global existence of solutions for the Cauchy problem of the generalized sixth order bad Boussinesq equation. Moreover, we show that the supremum norm of the solution decays algebraically to zero as （1 ＋ t）-（1/7） when t approaches to infinity, provided the initial data are sufficiently small and regular.

关键词： bad Boussinesq equation global existence asymptotic behavior oscillatory integral.

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Factors Affecting Internet Banking Adoption: An Application of Adaptive LASSO

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Computers, Materials & Continua 2022年第9期72卷 6167-6184页

作者： hatice Jenkins Siamand Hesami Fulden Yesiltepe Department of Banking and Finance Eastern Mediterranean UniversityFamagustaMersin 1099628Turkey Finnprints Inc. LefkosaMersin 10Turkey

This research investigates a broad range of possible factors affecting the adoption of new technology in the banking industry using adaptive LASSO and a standard logit *** research integrated the adoption of the innovation framework and the technology acceptance theory to develop a conceptual framework for the *** data was collected from 400 bank customers in North *** perception and other customerspecific factors such as perceived risk index and negative attitude toward new technologies index were formulated for the proposed conceptual *** findings indicated that individuals with a negative attitude toward new technology are least likely to adopt internet *** addition,the logit model suggested that age,education level,and general(innate)innovativeness significantly impact the adoption of internet ***,gender,income,occupation,perceived risk,familiarity with the internet,and social inclusion have no significant impact on internet banking adoption in North Cyprus.

关键词： E-banking business technology internet banking adoption adaptive LASSO method

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Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung

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Biomedical and Environmental Sciences 2016年第2期29卷 143-147页

作者： hatice BAS Dilek PANDIR Bozok University Faculty of Arts and Science Department of Biology 66100 Yozgat Turkey

We assessed the effects of furan and lycopene on the histopathological and biochemical changes on lungs, body and lung weights, and food consumption of rats. Furan and diabetes caused histopathological changes, increment in malondialdehyde levels, and decrease in antioxidant enzyme activities. Lycopene showed a protective effect against these damages, except for glutathione-S-transferase and glutathione peroxidase activities. Consequently, furan and diabetes resulted in lung toxicity. Our findings demonstrate that furan treatment resulted in more alterations in histology and biochemical parameters in diabetic rats and lycopene showed protective effects against these alterations.

关键词： Protective Effects Lycopene Furan-treated Diabetic

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Outcomes in spasticity after repetitive transcranial magnetic and transcranial direct current stimulations

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Neural Regeneration Research 2014年第7期9卷 712-718页

作者： Aysegul Gunduz hatice Kumru Alvaro Pascual-Leone Department of Neurology Cerrahpasa School of Medicine Istanbul University Institut Guttmann Institut Universitari de Neurorehabilitació adscrit a la UAB Universitat Autonoma de Barcelona Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol Badalona Berenson-Allen Center for Noninvasive Brain Stimulation Beth Israel Deaconess Medical Center and Harvard Medical School

Non-invasive brain stimulations mainly consist of repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Repetitive transcranial magnetic stimulation exhib- its satisfactory outcomes in improving multiple sclerosis, stroke, spinal cord injury and cerebral palsy-induced spasticity. By contrast, transcranial direct current stimulation has only been studied in post-stroke spasticity. To better validate the efficacy of non-invasive brain stimulations in im- proving the spasticity post-stroke, more prospective cohort studies involving large sample sizes are needed.

关键词： reviews muscle spasticity motor cortex transcranial magnetic stimulation transcranialdirect current stimulation central nervous system stroke

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