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Incidence and outcome of rhabdomyolysis after type A aortic dissection surgery:A retrospective analysis

World Journal of Critical Care Medicine 2025年第2期14卷 121-130页

作者： Praveen C Sivadasan Cornelia S Carr Abdul Rasheed A Pattath Samy Hanoura Suraj Sudarsanan Hany O Ragab hatem sarhan Arunabha Karmakar Rajvir Singh Amr S Omar Cardiac Anesthesia and ICU Section Department of Cardiothoracic SurgeryHamad Medical CorporationDoha 3050Qatar Department of Clinical Surgery College of MedicineQatar UniversityDoha 3050Qatar Department of Cardiothoracic Surgery Hamad Medical CorporationDoha 3050Qatar Department of Anesthesia and Intensive Care Al-Azhar UniversityCairo 11651Egypt Department of Thoracic and Cardiovascular Surgery Cleveland ClinicClevelandOH 44106United States Department of Medical Education Hamad Medical CorporationDoha 3050Qatar Department of Medical Research Hamad Medical CorporationDoha 3050Qatar Department of Critical Care Medicine Beni Suef UniversityBeni Suef 2722165Egypt

BACKGROUND Rhabdomyolysis(RML)as an etiological factor causing acute kidney injury(AKI)is sparsely reported in the *** To study the incidence of RML after surgical repair of an ascending aortic dissection(AAD)and to correlate with the outcome,especially regarding renal *** pinpoint the perioperative risk factors associated with the development of RML and adverse renal outcomes after aortic dissection *** Retrospective single-center cohort study conducted in a tertiary cardiac *** included all patients who underwent AAD repair from ***-operative RML workup is part of the institutional protocol;studied patients were divided into two groups:Group 1 with RML(creatine kinase above cut-off levels 2500 U/L)and Group 2 without *** potential determinants of RML and impact on patient outcome,especially postoperative renal function,were *** outcome parameters studied were markers of cardiac injury,length of ventilation,length of stay in the intensive care unit),and length of *** Out of 33 patients studied,21 patients(64%)developed RML(Group RML),and 12 did not(Group non-RML).Demographic and intraoperative factors,notably body mass index,duration of surgery,and cardiopulmonary bypass,had no significant impact on the incidence of *** visceral/peripheral malperfusion,though not statistically significant,was higher in the RML group.A significantly higher incidence of renal complications,including de novo postoperative dialysis,was noticed in the RML *** morbidity parameters were also higher in the RML *** was a significantly higher incidence of AKI in the RML group(90%)than in the non-RML group(25%).All four patients who required de novo dialysis belonged to the RML *** peak troponin levels were significantly higher in the RML *** In this study,we noticed a high incidence of RML after aortic dissection surgery,coupled with an adverse renal outcome and th

关键词： Rhabdomyolysis Ascending aortic dissection surgery Acute kidney injury Postoperative renal outcome Open heart surgery Type A aortic dissection

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