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CAR-T cells: Early successes in blood cancer and challenges in solid tumors

Acta Pharmaceutica Sinica B 2021年第5期11卷 1129-1147页

作者： hassan dana Ghanbar Mahmoodi Chalbatani Seyed Amir Jalali Hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina Raposo Thomas J.Webster Cancer Research Center Cancer Institute of IranTehran University of Medical SciencesTehran 13145-158Iran Department of Medical Immunology School of MedicineTehran University of Medical SciencesTehran ***Iron Department of Immunology School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Division of Oncology Department of Pediatricsthe Children's Hospital of PhiladelphiaPhiladelphiaPA 19104USA Center for Natural and Human Sciences Federal University of ABCSanto AndreSP 09210-580Brazil Faculty of Pharmaceutical Sciences State University of Campinas(UNICAMP)CampinasSP 13083-87JBrazil Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA

New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully.

关键词： Immunotherapy T cell therapy Chimeric antigen receptor(CAR) Genetic engineering

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The Role and Function of Ras-association domain family in Cancer:A Review

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Genes & Diseases 2019年第4期6卷 378-384页

作者： Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani hassan dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri Cancer Research Center Shahid Beheshti University of Medical SciencesTehranIran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehranIran Uro-Oncology Research Center Tehran University of Medical SciencesTehranIRIran Cancer Research Center Shohadae Tajrish HospitalDepartment of Radiation OncologyShahid Beheshti University of Medical SciencesTehranIran

Ras gene mutation has been observed in more than 30%of cancers,and 90%of pancreatic,lung and colon *** proteins(K-Ras,H-Ras,N-Ras)act as molecular switches which are activated by binding to *** play a role in the cascade of cell process control(proliferation and cell division).In the inactive state,transforming GTP to GDP leads to the activation of GTpase in Ras ***,the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the *** activated Ras can promote the cell death or stop cell growth,which are facilitated by Ras-association domain *** studies have been conducted to determine the importance of losing RASSF proteins in Rasinduced *** paper examines the role of Ras and RASSF *** general,RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors.

关键词： Cancer Colon H-Ras K-Ras Lung N-Ras Pancreatic

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Leukemia Study in Sulaymaniyah Province, Kurdistan, Iraq

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Chinese Medical Journal 2016年第2期129卷 244-245页

作者： Zhala AA Karim Karzan G Khidhir Rebaz A Ahmed Halgord A hassan dana Omer Karim Department of Molecular Biology Kurdistan Institution for Strategic Studies and Scientific Research AI-Sulaymaniyah Iraq Department of Biology School of Science University of Sulaimani AI-Sulaymaniyah Iraq Department of Hematology Hiwa Hospital Ministry of Health AI-Sulaymaniyah Iraq

To the Editor： The increased rate of leukemia in several Iraqi cities has been linked to exposure to depleted uranium, which was used during the consequent wars in lraq from 1990 to 2010.11-41 Here, we investigated leukemia occurrence in the Sulaymaniyah Governorate （SG）, which has been exposed to wars and crises at the same level as the rest of Iraq.151 To the best of our knowledge, this study is the first population-based study on leukemia in SG.

关键词： several Iraqi population-based depleted uranium

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Evaluation of immune response to anti-COVID-19 booster in cancer patients and chronic medical cannabis users and its association with circulating Eosinophils levels

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Cancer Communications 2022年第12期42卷 1417-1420页

作者： Cohen Idan Campisi-Pinto Salvatore Rozenberg Orit Abaev Ariel Khoury Marah Agbaria dana Eitam Harel Colodner Raul Khoury Mona Shalabna hassan Samih Yousef Mahamid Camel Abu-Amna Mahmoud Bar-Sela Gil Department of Oncology Emek Medical CenterAfula 1834111Israel Research Authority Emek Medical CenterAfula 1834111Israel Clalit Clinical Laboratories Emek Medical CenterAfula 1834111Israel Department of Cancer Science Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifa 320002Israel

Dear Editor On July 29,2021,the Israeli Ministry of Health approved the third anti-Coronavirus disease 2019(COVID-19)vaccination(3rd-BNT162b2-booster-dose),leading to a sharp daily drop in diagnosed positive COVID-19 cases and mortality rates in Israel[1].The booster dose increased severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)neutralization efficiency approximately a hundred-fold compared to individuals receiving only the second dose,providing significant protection against infection[2].

关键词： mortality acute Israel

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IPv6 Cryptographically Generated Address:Analysis,Optimization and Protection

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Computers, Materials & Continua 2021年第7期68卷 247-265页

作者： Amjed Sid Ahmed Rosilah hassan Faizan Qamar Mazhar Malik Department of Computing and Information Technology Global College of Engineering and TechnologyRuwi112Sultanate of Oman Faculty of Information Science and Technology Center for Cyber SecurityUniversiti Kebangsaan MalaysiaBangi43600Malaysia Faculty of Information Science and Technology Universiti Kebangsaan Malaysia43600BangiMalaysia

In networking,one major difficulty that nodes suffer from is the need for their addresses to be generated and verified without relying on a third party or public authorized *** resolve this issue,the use of selfcertifying addresses have become a highly popular and standardized method,of which Cryptographically Generated Addresses(CGA)is a prime *** was primarily designed to deter the theft of IPv6 addresses by binding the generated address to a public key to prove address *** though the CGA technique is highly effective,this method is still subject to several vulnerabilities with respect to security,in addition to certain limitations in its *** this study,the authors present an intensive systematic review of the literature to explore the technical specifications of CGA,its challenges,and existing proposals to enhance the *** that CGA generation is a time-consuming process,this limitation has hampered the application of CGA in mobile environments where nodes have limited energy and *** Hash2 conditions in CGA is the heaviest and most timeconsuming part of *** improve the performance of CGA,we replaced the Secure Hash Algorithm(SHA1)with the Message Digest(MD5)hash ***,this study also analyzes the possible methods through which a CGA could be *** conducting this analysis,Denial-of-Service(DoS)attacks were identified as the main method of attack toward the CGA verification process,which compromise and threaten the privacy of ***,we propose some modifications to the CGA standard verification algorithm to mitigate DoS attacks and to make CGA more security conscious.

关键词： IPv6 GCA SEND DoS attacks RSA SHA-1

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Novel Approach to Data Encryption Based on Matrix Computations

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Computers, Materials & Continua 2021年第2期66卷 1139-1153页

作者： Rosilah hassan Selver Pepic Muzafer Saracevic Khaleel Ahmad Milan Tasic Centre for Cyber Security Faculty of Information Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKMBangi SelangorMalaysia Technical Machine School of Professional Studies Radoja Krstića 19Trstenik37240Serbia University of Novi Pazar Dimitrija Tucovića bbNovi Pazar36300Serbia Maulana Azad National Urdu University HyderabadTelangana500032India University of Nis Višegradska 33Niš18106Serbia

In this paper,we provide a new approach to data encryption using generalized *** is based on the implementation of weighted Moore–Penrose inverse A y MNenxmT over the nx8 constant *** square Hermitian positive definite matrix N8x8 p is the *** proposed solution represents a very strong key since the number of different variants of positive definite matrices of order 8 is *** have provided NIST(National Institute of Standards and Technology)quality assurance tests for a random generated Hermitian matrix(a total of 10 different tests and additional analysis with approximate entropy and random digression).In the additional testing of the quality of the random matrix generated,we can conclude that the results of our analysis satisfy the defined strict *** proposed MP encryption method can be applied effectively in the encryption and decryption of images in multi-party *** the experimental part of this paper,we give a comparison of encryption methods between machine learning *** learning algorithms could be compared by achieved results of classification concentrating on *** a comparative analysis,we give results of classifying of advanced encryption standard(AES)algorithm and proposed encryption method based on Moore–Penrose inverse.

关键词： Security data encryption matrix computations cloud computing machine learning

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Phytopharmacological potential of different species of Morus alba and their bioactive phytochemicals:A review

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 950-956页

作者： Fahad Hussain Zohaib Rana hassan Shafique Arif Malik Zahid Hussain Institute of Molecular Biology and Biotechnology(IMBB) The University of LahoreRaiwind Road55150LahorePakistan Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam CampusBandar Puncak Alam42300SelangorMalaysia

Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions, cancer, infectious diseases, and gastrointestinal disorders. The present review was aimed to summarize and critically discuss the biomedical implications of Morus species, their bioactive compounds, and phytochemicals. Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids, flavonoids, anthocyanins and tannins were present. The critical analysis of the literature revealed that the aqueous, methanolic, and ethanolic extracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative,anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer,anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects. Based on the literature review and bioactivity guided investigation of Morus species and their phytomedicinal effects, we anticipate that these herbal products hold excellent potential for future research.

关键词： Moraceae Phytochemicals Pharmacological activities Anti-inflammatory Immunomodulatory Anticancer

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Propagation Characterization and Analysis for 5G mmWave Through Field Experiments

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Computers, Materials & Continua 2021年第8期68卷 2249-2264页

作者： Faizan Qamar Mhd Nour Hindia Tharek Abd Rahman Rosilah hassan Kaharudin Dimyati Quang Ngoc Nguyen Centre for Cyber Security Faculty of Information Science and TechnologyUniversiti Kebangsaan Malaysia(UKM)43600BangiSelangorMalaysia Department of Electrical Engineering Faculty of EngineeringUniversity of Malaya50603Kuala LumpurMalaysia Wireless Communication Centre Faculty of Electrical EngineeringUniversiti Teknologi Malaysia81310SkudaiJohorMalaysia Department of Computer Science and Communications Engineering Faculty of Science and EngineeringWaseda UniversityTokyo169-8050Japan

The 5G network has been intensively investigated to realize the ongoing early deployment stage as an effort to match the exponential growth of the number of connected users and their increasing demands for high throughput,bandwidth with Quality of Service(QoS),and low *** that most of the spectrums below 6 GHz are nearly used up,it is not feasible to employ the traditional spectrum,which is currently in ***,a promising and highly feasible effort to satisfy this insufficient frequency spectrum is to acquire new frequency bands for next-generation mobile *** this end,the primary effort has been focused on utilizing the millimeter-wave(mmWave)as the most promising candidate for the frequency ***,though the mmWave frequency band can fulfill the desired bandwidth requirements,it has been demonstrated to endure several issues like scattering,atmospheric absorption,fading,and especially penetration losses compared to the existing sub-6 GHz frequency ***,it is fundamental to optimize the mmWave band propagation channel to facilitate the practical 5G implementation for the network ***,this study intends to investigate the outdoor channel characteristics of 26,28,36,and 38 GHz frequency bands for the communication infrastructure at the building to the ground floor in both Line of Sight(LOS)and Non-Line of Sight(NLOS)*** experimental campaign has studied the propagation path loss models such as Floating-Intercept(FI)and Close-In(CI)for the building to ground floor environment in LOS and NLOS *** findings obtained from the field experiments clearly show that the CI propagation model delivers much better performance in comparison with the FI model,thanks to its simple setup,accuracy,and precise function.

关键词： 5G mmWave propagation channel path loss channel characterization field experiment

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3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing

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Asian Journal of Pharmaceutical Sciences 2018年第4期13卷 317-325页

作者： Luay Thanoon Younis Mohamed Ibrahim Abu hassan Tara Bai Taiyeb Ali Tommy Julianto Bustami Faculty of Dentistry Universiti Teknologi MARA Faculty of Dentistry Universiti Teknologi MARAMAHSA University Faculty of Pharmacy

This study was designed to investigate the effect of 3 D TECA hydrogel on the inflammatory-induced senescence marker, and to assess the influence of the gel on the periodontal lig-ament fibroblasts(PDLFs) migration in wound healing in vitro. PDLFs were cultured with20 ng/ml TNF-α to induce inflammation in the presence and absence of 50 μM 3 D TECA gelfor 14 d. The gel effect on the senescence maker secretory associated-β-galactosidase(SA-β-gal) activity was measured by a histochemical staining. Chromatin condensation and DNAsynthesis of the cells were assessed by 4,6-diamidino-2-phenylindole and 5-ethynyl-2-deoxyuridine fluorescent staining respectively. For evaluating fibroblasts migration, scratchwound healing assay and Pro-Plus Imaging software were used. The activity of senescencemarker, SA-β-gal, was positive in the samples with TNF-α-induced inflammation. SA-β-galpercentage is suppressed( > 65%, P < 0.05) in the treated cells with TECA gel as compared tothe non-treated cells. Chromatin foci were obvious in the non-treated samples. DNA syn-thesis was markedly recognized by the fluorescent staining in the treated compared to non-treated cultures. Scratch wound test indicated that the cells migration rate was significantlyhigher(14.9 μm^2/h, P < 0.05) in the treated versus(11 μm^2/h) for control PDLFs. The new for-mula of 3 D TECA suppresses the inflammatory-mediated cellular senescence and enhancedfibroblasts proliferation and migration. Therefore, 3 D TECA may be used as an adjunct to ac-celerate repair and healing of periodontal tissues.

关键词： 3D TECA Cellular senescence SA-β-gal TNF-α Fibroblast migration

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