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CRISPR/Cas9-mediated knockout of E4 gene promotes maturation in soy.ean

Oil Crop Science 2024年第3期9卷 170-176页

作者： Wu S. Chen L. Guo M. Cai y. Gao y. y.an S. Sun S. Zhang y. Hou W. Han T. College of Agriculture Heilongjiang Bayi Agricultural University Daqing 163316 China Ministry.of Agriculture Key.Laboratory.of Soy.ean Biology.(Beijing) Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China College of Agriculture Northeast Agricultural University Harbin 150030 China State Key.Laboratory.of Crop Germplasm Innovation and Molecular Breeding Syngenta Biotechnology (China) Co. Ltd Beijing 100081 China

Soy.ean is a broadly.popular and extensively.cultivated crop, however, many.high-y.eld and high-quality.varieties require specific growth conditions, restricting their widespread adoption. The appropriate light conditions and photoperiod must be attained for these varieties to thrive in new environments. In this study. we employ.d CRISPR/Cas9 to design two sgRNAs aimed at knocking out the maturity.related gene E4 in a major American soy.ean variety.called ''Jack'', which belongs to maturity.group MGII. E4 gene is primarily.involved in the photoperiodic flowering and maturity.in soy.ean, making it an ideal candidate for genetic manipulation. We successfully.obtained 1 homozy.ous E4-SG1 mutant ty.e with 1-bp insertion, and 4 homozy.ous E4-SG2 mutants ty.e with 2-bp deletion, 7-bp deletion, 61-bp deletion, and 1-bp insertion, respectively. The homozy.ous e4 mutant plants contained early.termination codons devoid of transgenic elements. Additionally. no potential off-target sites of the E4 gene were detected. A comparative analy.is revealed that, unlike the wild-ty.e, the maturity.time of homozy.ous e4 mutants was early.under both short-day.and long-day.conditions. These mutants offer novel germplasm resources that may.be used to modify.the photoperiod sensitivity.and maturity.of soy.ean, enhancing its adaptability.to high-latitude regions. © 2024 the Oil Crop Research Institute, Chinese Academy.of Agriculture Sciences

关键词： CRISPR/Cas9 E4 Maturity Soy.ean

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Existence and numerical approximation of a solution to frictional contact problem for electro-elastic materials

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 201-219页

作者： Othman Baiz EL-hassan Benkhira Rachid Fakhar University.Ibn Zohr Lab.ESERFP of OuarzazateMorocco University.Moulay.Ismail Faculty of SciencesLaboratory MACSESTMBP 3103Toulal-MeknesMorocco University.Sultan Moulay.Slimane Laboratory LS2MEPolydisciplary Faculty of Khouribga25000 KhouribgaMorocco

In this paper,a frictional contact problem between an electro-elastic body.and an electrically.conductive foundation is *** contact is modeled by.normal compliance with finite penetration and a version of Coulomb’s law of dry.friction in which the coefficient of friction depends on the *** addition,the effects of the electrical conductivity.of the foundation are taken into *** model leads to a coupled sy.tem of the quasi-variational inequality.of the elliptic ty.e for the displacement and the nonlinear variational equation for the electric *** existence of a weak solution is proved by.using an abstract result for elliptic variational inequalities and a fixed point ***,a finite element approximation of the problem is *** some regularity.conditions,an optimal order error estimate of the approximate solution is ***,a successive iteration technique is used to solve the problem numerically.and a convergence result is established.

关键词： piezoelectric material frictional contact variational Inequality fixed point process finite element method error estimation iteration method

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Sedimentary.facies analy.is of a thin-bed-dominated turbidite succession in the Miocene Temburong Formation,Kampung Bebuloh,Labuan Island,Malay.ia

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Journal of Palaeogeography 2024年第3期13卷 401-429页

作者： Farah Sy.fira Burhanuddin Meor Hakif Amir hassan Department of Geology Faculty of ScienceUniversiti Malaya50603 Kuala LumpurMalaysia

Thin-bedded turbidites are important hy.rocarbon-bearing reservoirs in many.mature fields throughout the *** ty.e of turbidite depositional setting strongly.influences vertical and horizontal continuity.of the ***,distinguishing between lobe and levee associated thin-bedded turbidites remains challenging due to their generally.similar facies *** study.aims to contribute some insights to this problem by.conducting a detailed bed-scale facies analy.is on the Early.Miocene Temburong Formation exposed at Kampung Bebuloh,Labuan Island,Malay.ia,which may.uncover features that can help in differentiating between both depositional *** facies are recognized in the Temburong Formation,which are interpreted as low density.turbidites(F1-F4),hy.rid event beds(F5),and sustained turbidites(F6).Detailed facies and ichnology.analy.is reveal features which are consistent with a lobe fringe deposit rather than leveeassociated environment interpretation,including tabular bed geometries,presence of hy.rid event beds,and the absence of thick-bedded channel-fill *** facies associations are identified and interpreted as representing sub-environments within an overall lobe depositional setting.A diverse trace fossil assemblage,comprising the Nereites ichnofacies is consistent with a deep marine *** identification of the Paleodicty.n and Nereites sub-ichnofacies indicates a distal turbidite sy.tem setting,most likely.lobe *** on the thick accumulation of FA2 and FA3 and no distinct observable vertical trend,the Early.Miocene Temburong Formation in Labuan is interpreted as turbidites deposited at the fringes of lobe complexes rather than a single lobe *** works into the Temburong Formation in SW Labuan proposed a middle slope to proximal basin floor setting where the thin-bedded intervals were interpreted as potentially.representing either levee deposits or the fringes of confined lobe ***

关键词： Facies analy.is Trace fossils Depositional lobes Hy.rid event beds Lobe fringe Temburong formation Thin-bedded turbidite

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Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

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Journal of Renewable Materials 2024年第9期12卷 1573-1591页

作者： Samar El-Mekkawi Wafaa Abou-Elseoud Shaimaa Fadel Enas hassan Mohammad hassan Chemical Engineering and Pilot Plant Department National Research CentreDokkiGiza12622Egypt Cellulose and Paper Department National Research CentreDokkiGiza12622Egypt

Recy.ling of paper sludge waste is crucial for establishing a sustainable green industry. This waste contains valuable sugars that can be converted into important chemicals such as ethanol, poly.hy.roxy.uty.ate, and lactic acid. However, the main challenge in obtaining sugars in high y.eld from paper sludge is the high cry.tallinity.of cellulose, which hinders hy.roly.is. To address this, pretreatment using phosphoric acid was optimized using response surface methodology.to facilitate cellulose hy.roly.is with minimal energy.and chemicals. The created prediction model using the response surface method considered factors such as acid concentration (ranging from 60% to 85%), consistency.(ranging from 4% to 10%), temperature (ranging from 25°C to 80°C), and time (ranging from 0.5 to 4 h). The results revealed that the model’s significant factors affecting the y.eld were acid concentration, reaction time, temperature, and the product of acid concentration and temperature, while the model’s significant factors affecting the cry.tallinity.were the consistency. the temperature, and their product. The results showed that the optimum conditions for pretreatment were using an acid concentration of 64%, temperature of 25°C, consistency.of 10%, and time of 30 min. The hy.roly.is of the conditionally.pretreated paper sludge resulted in a weight loss of 42%, compared to only.18% weight loss in non-pretreated paper sludge. Furthermore, the optimized conditions led to low levels of furfurals and acetic acid, which are undesirable by.products that can interfere with sugar fermentation. The total sugar obtained under the optimized conditions was 0.43 g glucose/g sample (10.46 g/L), while the contents of methy. furfural, furfural, and acetic acid were 21.65, 235.7, and 4.57 mg/L, respectively. This study.demonstrates the potential of phosphoric acid for pretreatment and hy.roly.is of paper sludge, enabling efficient saccharification and the production of sugars with minimal undesired

关键词： Waste valorization fermentable sugars response surface methodology acid hy.roly.is cellulose cry.tallinity

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The anti-neoplastic effects of metformin modulate the acquired phenoty.e of fbroblast cells in the breast cancer-normal fbroblast co-culture sy.tem

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Oncology.Research 2024年第3期32卷 477-487页

作者： SAMANEH MOSTAFAVI ZUHAIR MOHAMMAD hassan Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Intracellular communications between breast cancer and fibroblast cells were reported to be involved in cancer proliferation,growth,and therapy.*** hallmarks of cancer fibroblast interactions,consisting of caveolin 1(Cav1)and mono-carboxy.ate ransporter 4(MCT4)(metabolic coupling markers),along with IL-6,TGFB,and lactate secretion,are considered robust biomarkers predicting recurrence and *** order to promote a novel phenoty.e in normal fibroblasts,we predicted that breast cancer cells could be able to cause loss of Cavl and increase of MCT4,as well as elevate IL 6 and TGF in nearby.nomal *** created a co culture model using breast cancer(4T1)and normal fibroblast(NIH3T3)cell lines cultured under specific experimental conditions in order to directly.test our ***,we show that long-term co-culture of breast cancer cells and normal fibroblasts promotes loss of Cavl and gain of MCT4 in adjacent fibroblasts and increase lactate *** results were validated using the monoculture of each group separately.as a *** this sy.tem,we show that me tformin inhibits IL-6 and TGFB secretion and re expresses Cavl in both ***,MCT4 and lactate stay.d high after treatment with *** conclusion,our work shows that co-culture with breast cancer cells may.cause signifcant alterations in the phenoty.e and secretion of normal ***,however,may.change this state and affect fibroblasts'acquired ***,mitochondrial inhibition by.metformin after 8 day. of treatment,signi ficantly.hinders tumor growth in mouse model of breast cancer.

关键词： Caveolin 1 Lactic acid Metformin NIH 3T3 cells Neoplasms

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A new technique of monsplasty.as an adjunctive procedure in cases of abdominoplasty.A prospective clinical trial

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 124-129页

作者： Laila Ahmed aboul Nasr Sherief Zamer Ahmed Fathy.Elsay.d Mohamed Hatem Elsahar Department of Plastic Surgery Faculty of Medicine Kasr Al-AinyCairo UniversityCairo11562Egypt

Background:No standard monsplasty.technique has existed until *** various monsplasty.methods have been described,they.exhibit high complication rates with sparse postoperative *** that used pubic suspension techniques did not describe exact anatomical landmarks for the mons *** study.aimed to improve the aesthetic and functional appearance of the pubic region with long-term results for all grades of pubic ptosis or bulging with abdominoplasty.and provide exact anatomical points to anchor the mons to the rectus ***:This non-randomized prospective clinical trial included 30 patients with various degrees of abdominal wall laxity.between December 2017 and September *** surgical procedure was performed for female patients with pendulous abdomen,pubic ptosis or bulging,body.mass index≤35 kg/m^(2),and age 18–60 *** patients were followed for up to one y.ar;patient satisfaction was assessed before and after surgery.regarding aesthetic results and impact on outfits,hy.iene,and sexual ***:The marginal homogeneity.test revealed a statistically.significant patient satisfaction rate regarding outfits,sexual function,hy.iene,and *** postoperative complications,seroma(one case)was managed by.aspiration,and one case of wound dehiscence was managed conservatively.with ***:This study.recommends a quick and reproducible monsplasty.technique with a low complication rate,a technique that helps determine specific anatomical landmarks for anchoring the mons to the rectus *** this technique with abdominal contouring is advisable for optimal aesthetic results and maintained ly.phatic drainage in the pubic region.

关键词： Abdominoplasty Mons ptosis Pubic suspension Skin redundancy

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A novel fractional case study.of nonlinear dy.amics via analy.ical approach

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 276-290页

作者： hassan Khan Adnan Khan Rasool Shah Dumitru Baleanu Department of Mathematics Abdul Wali khan UniversityMardan 23200Pakistan Department of Mathematics Faculty of Arts and SciencesCankaya UniversityAnkara 06530Turkey Institute of Space Sciences Magurele-BucharestRomania

The present work describes the fractional view analy.is of Newell-Whitehead-Segal equations,using an innovative *** work is carried with the help of the Caputo operator of fractional *** analy.ical solutions of some numerical examples are presented to confirm the reliability.of the proposed *** derived results are very.consistent with the actual solutions to the problems.A graphical representation has been done for the solution of the problems at various fractional-order ***,the solution in series form has the desired rate of convergence and provides the closed-form *** is noted that the procedure can be modified in other directions for fractional order problems.

关键词： Homotopy.Perturbation method Shehu transform Newell-Whitehead-Segel Equation Caputo operator

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IMTNet: Improved Multi-Task Copy.Move Forgery.Detection Network with Feature Decoupling and Multi-Feature Py.amid

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Computers, Materials and Continua 2024年第3期80卷 4603-4620页

作者： Wang H. Jiang Z. Qian Q. Long y. School of Information Guizhou University of Finance and Economics Guiyang 550025 China College of Big Data Statistics Guizhou University of Finance and Economics Guiyang 550025 China

Copy.Move Forgery.Detection (CMFD) is a technique that is designed to identify.image tampering and locate suspicious areas. However, the practicality.of the CMFD is impeded by.the scarcity.of datasets, inadequate quality.and quantity. and a narrow range of applicable tasks. These limitations significantly.restrict the capacity.and applicability.of CMFD. To overcome the limitations of existing methods, a novel solution called IMTNet is proposed for CMFD by.employ.ng a feature decoupling approach. Firstly. this study.formulates the objective task and network relationship as an optimization problem using transfer learning. Furthermore, it thoroughly.discusses and analy.es the relationship between CMFD and deep network architecture by.employ.ng ResNet-50 during the optimization solving phase. Secondly. a quantitative comparison between fine-tuning and feature decoupling is conducted to evaluate the degree of similarity.between the image classification and CMFD domains by.the enhanced ResNet-50. Finally. suspicious regions are localized using a feature py.amid network with bottom-up path augmentation. Experimental results demonstrate that IMTNet achieves faster convergence, shorter training times, and favorable generalization performance compared to existing methods. Moreover, it is shown that IMTNet significantly.outperforms fine-tuning based approaches in terms of accuracy.and F1 Copy.ight © 2024 The Authors. Published by.Tech Science Press.

关键词： feature decoupling Image copy.move detection multi-scale feature py.amids passive forensics

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Diagnostic and therapeutic role of endoscopic ultrasound in liver diseases:A sy.tematic review and meta-analy.is

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World Journal of Gastroenterology 2024年第7期30卷 742-758页

作者： Ey.d Gadour Abeer Awad Zeinab hassan Khalid Jebril Shrwani Bogdan Miutescu Hussein hassan Okasha Department of Gastroenterology.and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Department of Internal Medicine Faculty of MedicineZamzam University CollegeKhartoum 11113Sudan Department of Hepatogastroenterology Kasar Alainy HospitalFaculty of MedicineCairo UniversityCairo 11451Egypt Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Public Health Authority Saudi Center for Disease Prevention and ControlJazan 45142Saudi Arabia Department of Clinical Infection Microbiology and ImmunologyInstitute of Infection and Global HealthSchool of Medicine and Life SciencesUniversity of LiverpoolLiverpoolUnited Kingdom Department of Gastroenterology.and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Center in Gastroenterology.and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND In hepatology.the clinical use of endoscopic ultrasound(EUS)has experienced a notable increase in recent *** applications range from the diagnosis to the treatment of various liver ***,this sy.tematic review summarizes the evidence for the diagnostic and therapeutic roles of EUS in liver *** To examine and summarize the current available evidence of the possible roles of the EUS in making a suitable diagnosis in liver diseases as well as the therapeutic accuracy.and *** PubMed,Medline,Cochrane Library.Web of Science,and Google Scholar databases were extensively.searched until October *** methodological quality.of the eligible articles was assessed using the Newcastle-Ottawa scale or Cochrane Risk of Bias *** addition,statistical analy.es were performed using the Comprehensive Meta-Analy.is *** Overall,45 articles on EUS were included(28 on diagnostic role and 17 on therapeutic role).Pooled analy.is demonstrated that EUS diagnostic tests had an accuracy.of 92.4%for focal liver lesions(FLL)and 96.6%for parenchy.al liver ***-guided liver biopsies with either fine needle aspiration or fine needle biopsy.had low complication rates when sampling FLL and parenchy.al liver diseases(3.1%and 8.7%,respectively..Analy.is of data from four studies showed that EUS-guided liver abscess had high clinical(90.7%)and technical success(90.7%)without significant ***,EUS-guided interventions for the treatment of gastric varices(GV)have high technical success(98%)and GV obliteration rate(84%)with few complications(15%)and rebleeding events(17%).CONCLUSION EUS in liver diseases is a promising technique with the potential to be considered a first-line therapeutic and diagnostic option in selected cases.

关键词： Focal liver lesion Liver abscess drainage Fine needle aspiration Gastric varices Endoscopic ultrasound

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Improving Video Watermarking through Galois Field GF(2^(4)) Multiplication Tables with Diverse Irreducible Poly.omials and Adaptive Techniques

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Computers, Materials & Continua 2024年第1期78卷 1423-1442页

作者： y.smin Alaa hassan Abdul Monem S.Rahma Department of Computer Science College of ScienceUniversity of BaghdadBaghdadIraq Department of Computer Science College of ScienceAl-Maarif University CollegeAl-AnbarIraq

Video watermarking play. a crucial role in protecting intellectual property.rights and ensuring content *** study.delves into the integration of Galois Field(GF)multiplication tables,especially.GF(2^(4)),and their interaction with distinct irreducible *** primary.aim is to enhance watermarking techniques for achieving imperceptibility.robustness,and efficient execution *** research employ. scene selection and adaptive thresholding techniques to streamline the watermarking *** selection is used strategically.to embed watermarks in the most vital frames of the video,while adaptive thresholding methods ensure that the watermarking process adheres to imperceptibility.criteria,maintaining the video's visual ***,careful consideration is given to execution time,crucial in real-world scenarios,to balance efficiency.and *** Peak Signal-to-Noise Ratio(PSNR)serves as a pivotal metric to gauge the watermark's imperceptibility.and video *** study.explores various irreducible poly.omials,navigating the trade-offs between computational efficiency.and watermark *** parallel,the study.pay. careful attention to the execution time,a paramount consideration in real-world scenarios,to strike a balance between efficiency.and *** comprehensive analy.is provides valuable insights into the interplay.of GF multiplication tables,diverse irreducible poly.omials,scene selection,adaptive thresholding,imperceptibility.and execution *** evaluation of the proposed algorithm's robustness was conducted using PSNR and NC metrics,and it was subjected to assessment under the impact of five distinct attack *** findings contribute to the development of watermarking strategies that balance imperceptibility.robustness,and processing efficiency.enhancing the field's practicality.and effectiveness.

关键词： Video watermarking galois field irreducible poly.omial multiplication table scene selection adaptive thresholding

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