检索结果-南通市图书馆

International Journal of Dermatology and Venereology 2021年第2期4卷 82-85页

作者： Sirous Zeinali Leila Youssefian hassan vahidnezhad Amir Hossein Saeidian Soheila Sotoudeh Hamideh Bagherian Jouni Uitto Department of Molecular Medicine Biotechnology Research CenterPasteur Institute of IranTehranIran Kawsar Human Genetics Research Center TehranIran Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical Collegeand Jefferson Institute of Molecular MedicineThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Medical Genetics School of MedicineTehran University of Medical SciencesTehranIran Department of Dermatology Children’s Medical CenterCenter of ExcellenceTehran University of Medical SciencesTehranIran

Objective:Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different *** conventional mutation detection strategy consists of sequencing of individual candidate genes separately,a time consuming and costly *** this study,we perform genome-wide single nucleotide polymorphism(SNP)array to identify candidate genes of hereditary ***:A consanguineous family with two patients with hereditary hypotrichosis was enrolled,and autozygosity mapping by genome-wide SNP array was utilized to identify candidate ***:Autozygosity mapping delineated runs of homozygosity,and alignment of the 11 genes identified the hairless(HR)gene as the candidate *** sequencing revealed a novel homozygous mutation c.381delT,***:This study illustrates how autozygosity mapping by a high-density SNP array streamlines mutation detection in heritable skin diseases.

关键词： familial hypotrichosis hair loss homozygosity mapping mutation detection hairless gene mutations

An Online Fake Review Detection Approach Using Famous Machine Learning Algorithms

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第2期78卷 2767-2786页

作者： Asma hassan Alshehri Department of Computer Sciences College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia

Online review platforms are becoming increasingly popular,encouraging dishonest merchants and service providers to deceive customers by creating fake reviews for their goods or *** Sybil accounts,bot farms,and real account purchases,immoral actors demonize rivals and advertise their *** academic and industry efforts have been aimed at detecting fake/fraudulent product or service evaluations for *** primary hurdle to identifying fraudulent reviews is the lack of a reliable means to distinguish fraudulent reviews from real *** paper adopts a semi-supervised machine learning method to detect fake reviews on any website,among other *** reviews are classified using a semi-supervised approach(PU-learning)since there is a shortage of labeled data,and they are ***,classification is performed using the machine learning techniques Support Vector Machine(SVM)and Nave *** performance of the suggested system has been compared with standard works,and experimental findings are assessed using several assessment metrics.

关键词： Security fake review semi-supervised learning ML algorithms review detection

Genetic Predisposition to Numerous Large Ulcerating Basal Cell Carcinomas and Response to Immune Therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2021年第2期4卷 70-75页

作者： Bahar Dasgeb Leila Youssefian Amir Hossein Saeidian Jun Kang Wenyin Shi Elizabeth Shoenberg Adam Ertel Paolo Fortina hassan vahidnezhad Jouni Uitto Department of Surgical Oncology Rutgers Cancer Institute of New JerseyNew BrunswickNJ 08903USA Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical Collegeand Jefferson Institute of Molecular MedicineThomas Jefferson UniversityPhiladelphiaPA 19107USA Genetics Genomics and Cancer Biology PhD ProgramThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Radiation Oncology Thomas Jefferson UniversityPhiladelphiaPAUSA Department of Internal Medicine Mercy Medical CenterBaltimoreMD 21202USA Department of Cancer Biology Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaPA 19107USA

Objective:Well-defined germ-line mutations in thePTCH1 gene are associated with syndromic multiple basal cell carcinomas(BCCs).Here,we used whole exome sequencing(WES)to identify the role of patched-1 in patients with multiple,unusually large ***:A 72-year old patient presenting with numerous BCCs progressing to large ulcerating lesions was *** was used to identify the pathogenic gene ***:Genetic work-up by WES identified a homozygousPTCH1 nonsense mutation in the tumor tissue but not present in her blood cells or in non-lesional *** addition,heterozygous missense mutations were identified in three cancer-associated genes(EPHB2,RET,andGALNT12)in blood cells as well as in lesional and non-lesional *** also tested systemic immune therapy as a potentially beneficial approach to treat patients with numerous large BCCs on scatted areas of involvement.A rapid and sustained response to nivolumab was noted,suggesting that it is an efficacious drug for long-term therapeutic ***:PTCH1,EPHB2,RET,andGALNT12 may potentially contribute to the synergistic oncogene driven malignant transformation manifesting as multiple,unusually large BCCs.

关键词： immune therapy malignant transformation gene-susceptibility non-syndromic basal cell carcinoma PTCH1 skin neoplasms

Distributed Hybrid Model Predictive Secondary Control of DC Microgrids with Random Communication Disorders

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 925-935页

作者： Meysam Yaribeygi Zeinab Karami Qobad Shafiee hassan Bevrani the Department of Electrical Engineering K.N.Toosi University of TechnologyTehranIranand he is now with the Sportradar CompanyTrondheimNorway the Department of Engineering Cybernetics(ITK) Norwegian University of Science and Technology(NTNU)TrondheimNorway the Smart/Micro Grids Research Center Department of Electrical EngineeringUniversity of KurdistanSanandajIran

A reliable and robust communication network is essential to exchange information between distributed generators(DGs)and accurately calculate their control actions in microgrids(MGs).However,the integration of the communication network and MGs poses challenges related to the flexibility,availability,and reliability of the ***,random communication disorders such as time delays and packet loss can negatively impact the system ***,it is essential to design a suitable secondary controller(SC)with a fast dynamic response to restore voltage and appropriate powersharing,while ensuring that the effects of random communication disorders are *** this regard,an optimal distributed hybrid model predictive secondary control method is presented in this *** simulations are carried out in a mixed simulation environment based on MATLAB and OMNET++,by considering IEEE 802.11(Wi Fi)using the recently developed Internet networking(INET)*** the implemented application layer,the recovery Unit is responsible for reducing the impact of random communication *** effectiveness and performance of the proposed method in comparison with a conventional model predictive control are verified by simulation results.

关键词： Microgrid model predictive control random communication disorder secondary control

Existence and numerical approximation of a solution to frictional contact problem for electro-elastic materials

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 201-219页

作者： Othman Baiz EL-hassan Benkhira Rachid Fakhar University Ibn Zohr Lab.ESERFP of OuarzazateMorocco University Moulay Ismail Faculty of SciencesLaboratory MACSESTMBP 3103Toulal-MeknesMorocco University Sultan Moulay Slimane Laboratory LS2MEPolydisciplary Faculty of Khouribga25000 KhouribgaMorocco

In this paper,a frictional contact problem between an electro-elastic body and an electrically conductive foundation is *** contact is modeled by normal compliance with finite penetration and a version of Coulomb’s law of dry friction in which the coefficient of friction depends on the *** addition,the effects of the electrical conductivity of the foundation are taken into *** model leads to a coupled system of the quasi-variational inequality of the elliptic type for the displacement and the nonlinear variational equation for the electric *** existence of a weak solution is proved by using an abstract result for elliptic variational inequalities and a fixed point ***,a finite element approximation of the problem is *** some regularity conditions,an optimal order error estimate of the approximate solution is ***,a successive iteration technique is used to solve the problem numerically and a convergence result is established.

关键词： piezoelectric material frictional contact variational Inequality fixed point process finite element method error estimation iteration method

Sedimentary facies analysis of a thin-bed-dominated turbidite succession in the Miocene Temburong Formation,Kampung Bebuloh,Labuan Island,Malaysia

在线全文

学校读者我要写书评

暂无评论

Journal of Palaeogeography 2024年第3期13卷 401-429页

作者： Farah Syafira Burhanuddin Meor Hakif Amir hassan Department of Geology Faculty of ScienceUniversiti Malaya50603 Kuala LumpurMalaysia

Thin-bedded turbidites are important hydrocarbon-bearing reservoirs in many mature fields throughout the *** type of turbidite depositional setting strongly influences vertical and horizontal continuity of the ***,distinguishing between lobe and levee associated thin-bedded turbidites remains challenging due to their generally similar facies *** study aims to contribute some insights to this problem by conducting a detailed bed-scale facies analysis on the Early Miocene Temburong Formation exposed at Kampung Bebuloh,Labuan Island,Malaysia,which may uncover features that can help in differentiating between both depositional *** facies are recognized in the Temburong Formation,which are interpreted as low density turbidites(F1-F4),hybrid event beds(F5),and sustained turbidites(F6).Detailed facies and ichnology analysis reveal features which are consistent with a lobe fringe deposit rather than leveeassociated environment interpretation,including tabular bed geometries,presence of hybrid event beds,and the absence of thick-bedded channel-fill *** facies associations are identified and interpreted as representing sub-environments within an overall lobe depositional setting.A diverse trace fossil assemblage,comprising the Nereites ichnofacies is consistent with a deep marine *** identification of the Paleodictyon and Nereites sub-ichnofacies indicates a distal turbidite system setting,most likely lobe *** on the thick accumulation of FA2 and FA3 and no distinct observable vertical trend,the Early Miocene Temburong Formation in Labuan is interpreted as turbidites deposited at the fringes of lobe complexes rather than a single lobe *** works into the Temburong Formation in SW Labuan proposed a middle slope to proximal basin floor setting where the thin-bedded intervals were interpreted as potentially representing either levee deposits or the fringes of confined lobe ***

关键词： Facies analysis Trace fossils Depositional lobes Hybrid event beds Lobe fringe Temburong formation Thin-bedded turbidite

An Adaptive Data-driven Method Based on Fuzzy Logic for Determining Power System Voltage Status

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 707-718页

作者： Sirwan Shazdeh Hêmin Golpîra hassan Bevrani the SMGRC University of KurdistanSanandajIran Power Systems Modeling&Simulation Lab Department of Electrical EngineeringUniversity of KurdistanKurdistanSanandaj 66177-15175Iran

This paper proposes an adaptive method based on fuzzy logic that utilizes data from phasor measurement units(PMUs) to assess and classify generating-side voltage trajectories. The voltage variable and its associated derivatives are used as the input variables of a fuzzy-logic block. In addition, the voltage trajectory is compared with the pre-selected pilot-bus voltage to make a reliable decision about the voltage operational state. Different types of short-term voltage dynamics are considered in the proposed method. The fuzzy membership functions are determined using a systematic method that considers the current situation of the voltage trajectory. Finally, the voltage status is categorized into four classes to determine appropriate remedial actions. The proposed method is validated on a IEEE 73-bus power system in a MATLAB environment.

关键词： Fuzzy logic fault-induced delayed voltage recovery phasor measurement unit(PMU) short-term voltage stability situational awareness voltage classification

The anti-neoplastic effects of metformin modulate the acquired phenotype of fbroblast cells in the breast cancer-normal fbroblast co-culture system

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第3期32卷 477-487页

作者： SAMANEH MOSTAFAVI ZUHAIR MOHAMMAD hassan Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Intracellular communications between breast cancer and fibroblast cells were reported to be involved in cancer proliferation,growth,and therapy *** hallmarks of cancer fibroblast interactions,consisting of caveolin 1(Cav1)and mono-carboxylate ransporter 4(MCT4)(metabolic coupling markers),along with IL-6,TGFB,and lactate secretion,are considered robust biomarkers predicting recurrence and *** order to promote a novel phenotype in normal fibroblasts,we predicted that breast cancer cells could be able to cause loss of Cavl and increase of MCT4,as well as elevate IL 6 and TGF in nearby nomal *** created a co culture model using breast cancer(4T1)and normal fibroblast(NIH3T3)cell lines cultured under specific experimental conditions in order to directly test our ***,we show that long-term co-culture of breast cancer cells and normal fibroblasts promotes loss of Cavl and gain of MCT4 in adjacent fibroblasts and increase lactate *** results were validated using the monoculture of each group separately as a *** this system,we show that me tformin inhibits IL-6 and TGFB secretion and re expresses Cavl in both ***,MCT4 and lactate stayed high after treatment with *** conclusion,our work shows that co-culture with breast cancer cells may cause signifcant alterations in the phenotype and secretion of normal ***,however,may change this state and affect fibroblasts'acquired ***,mitochondrial inhibition by metformin after 8 days of treatment,signi ficantly hinders tumor growth in mouse model of breast cancer.

关键词： Caveolin 1 Lactic acid Metformin NIH 3T3 cells Neoplasms

A novel fractional case study of nonlinear dynamics via analytical approach

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 276-290页

作者： hassan Khan Adnan Khan Rasool Shah Dumitru Baleanu Department of Mathematics Abdul Wali khan UniversityMardan 23200Pakistan Department of Mathematics Faculty of Arts and SciencesCankaya UniversityAnkara 06530Turkey Institute of Space Sciences Magurele-BucharestRomania

The present work describes the fractional view analysis of Newell-Whitehead-Segal equations,using an innovative *** work is carried with the help of the Caputo operator of fractional *** analytical solutions of some numerical examples are presented to confirm the reliability of the proposed *** derived results are very consistent with the actual solutions to the problems.A graphical representation has been done for the solution of the problems at various fractional-order ***,the solution in series form has the desired rate of convergence and provides the closed-form *** is noted that the procedure can be modified in other directions for fractional order problems.

关键词： Homotopy Perturbation method Shehu transform Newell-Whitehead-Segel Equation Caputo operator

Diagnostic and therapeutic role of endoscopic ultrasound in liver diseases:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第7期30卷 742-758页

作者： Eyad Gadour Abeer Awad Zeinab hassan Khalid Jebril Shrwani Bogdan Miutescu Hussein hassan Okasha Department of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Department of Internal Medicine Faculty of MedicineZamzam University CollegeKhartoum 11113Sudan Department of Hepatogastroenterology Kasar Alainy HospitalFaculty of MedicineCairo UniversityCairo 11451Egypt Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Public Health Authority Saudi Center for Disease Prevention and ControlJazan 45142Saudi Arabia Department of Clinical Infection Microbiology and ImmunologyInstitute of Infection and Global HealthSchool of Medicine and Life SciencesUniversity of LiverpoolLiverpoolUnited Kingdom Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND In hepatology,the clinical use of endoscopic ultrasound(EUS)has experienced a notable increase in recent *** applications range from the diagnosis to the treatment of various liver ***,this systematic review summarizes the evidence for the diagnostic and therapeutic roles of EUS in liver *** To examine and summarize the current available evidence of the possible roles of the EUS in making a suitable diagnosis in liver diseases as well as the therapeutic accuracy and *** PubMed,Medline,Cochrane Library,Web of Science,and Google Scholar databases were extensively searched until October *** methodological quality of the eligible articles was assessed using the Newcastle-Ottawa scale or Cochrane Risk of Bias *** addition,statistical analyses were performed using the Comprehensive Meta-Analysis *** Overall,45 articles on EUS were included(28 on diagnostic role and 17 on therapeutic role).Pooled analysis demonstrated that EUS diagnostic tests had an accuracy of 92.4%for focal liver lesions(FLL)and 96.6%for parenchymal liver ***-guided liver biopsies with either fine needle aspiration or fine needle biopsy had low complication rates when sampling FLL and parenchymal liver diseases(3.1%and 8.7%,respectively).Analysis of data from four studies showed that EUS-guided liver abscess had high clinical(90.7%)and technical success(90.7%)without significant ***,EUS-guided interventions for the treatment of gastric varices(GV)have high technical success(98%)and GV obliteration rate(84%)with few complications(15%)and rebleeding events(17%).CONCLUSION EUS in liver diseases is a promising technique with the potential to be considered a first-line therapeutic and diagnostic option in selected cases.

关键词： Focal liver lesion Liver abscess drainage Fine needle aspiration Gastric varices Endoscopic ultrasound