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SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： hassan M Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.Methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nM against JAK2 kinase and 200.9 nM against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nM, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 Molecular docking Molecular dynamics simulation PI3KCD SBL-JP-0004

Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TiAlC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

Review of Techniques for Integrating Security in Software Development Lifecycle

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Computers, Materials & Continua 2025年第1期82卷 139-172页

作者： hassan Saeed Imran Shafi Jamil Ahmad Adnan Ahmed Khan Tahir Khurshaid Imran Ashraf College of Electrical and Mechanical Engineering National University of Sciences and Technology(NUST)Rawalpindi46604Pakistan Department of Computer Science Abasyn University Islamabad CampusIslamabad45510Pakistan Military College of Signals National University of Sciences and Technology(NUST)Rawalpindi46600Pakistan Department of Electrical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Software-related security aspects are a growing and legitimate concern,especially with 5G data available just at our *** conduct research in this field,periodic comparative analysis is needed with the new techniques coming up *** purpose of this study is to review the recent developments in the field of security integration in the software development lifecycle(SDLC)by analyzing the articles published in the last two decades and to propose a way *** review follows Kitchenham’s review *** review has been divided into three main stages including planning,execution,and *** the selected 100 articles,it becomes evident that need of a collaborative approach is necessary for addressing critical software security risks(CSSRs)through effective risk management/estimation *** risks using a numeric scale enables a comprehensive understanding of their severity,facilitating focused resource allocation and mitigation *** a comprehensive understanding of potential vulnerabilities and proactive mitigation efforts facilitated by protection poker,organizations can prioritize resources effectively to ensure the successful outcome of projects and initiatives in today’s dynamic threat *** review reveals that threat analysis and security testing are needed to develop automated tools for the *** estimation of effort required to prioritize potential security risks is a big challenge in software *** accuracy of effort estimation can be further improved by exploring new techniques,particularly those involving deep *** is also imperative to validate these effort estimation methods to ensure all potential security threats are *** challenge is selecting the right model for each specific security *** achieve a comprehensive evaluation,researchers should use well-known benchmark checklists.

关键词： Software development lifecycle systematic literature review critical software security risks national institute of standards and technology DevSecOps open web application security project McGraw’s touch points

Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

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Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah Song Jian Muhammad Naeem Ul hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Dynamic anti-plane analysis for two symmetrically interfacial cracks near circular cavity in piezoelectric bi-materials

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Applied Mathematics and Mechanics(English Edition) 2014年第10期35卷 1261-1270页

作者： A.hassan 宋天舒 Department of Civil Engineering Military Technical College College of Aerospace and Civil Engineering Harbin Engineering University

The present paper is exposed theoretically to the influence on the dynamic stress intensity factor （DSIF） in the piezoelectric bi-materials model with two symmet- rically permeable interracial cracks near the edges of a circular cavity, subjected to the dynamic incident anti-plane shearing wave （SH-wave）. An available theoretical method to dynamic analysis in the related research field is provided. The formulations are based on Green＇s function method. The DSIFs at the inner and outer tips of the left crack are obtained by solving the boundary value problems with the conjunction and crack- simulation technique. The numerical results are obtained by the FORTRAN language program and plotted to show the influence of the variations of the physical parameters, the structural geometry, and the wave frequencies of incident wave on the dimensionless DSIFs. Comparisons with previous work and between the inner and outer tips are con- cluded.

关键词： symmetrically interfacial crack piezoelectric bi-material Green's function,dynamic stress intensity factor (DSIF) dynamic anti-plane shearing wave (SH-wave)

Liquation cracking in the heat-affected zone of IN939 superalloy tungsten inert gas weldments

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 764-773页

作者： hassan Kazempour-Liasi Mohammad Tajally hassan Abdollah-Pour Faculty of Materials and Metallurgical Engineering Semnan UniversitySemnanIran

The main aim of this study was to investigate liquation cracking in the heat-affected zone(HAZ)of the IN939 superalloy upon tungsten inert gas welding.A solid solution and age-hardenable filler metals were further *** the pre-weld heat-treated samples,upon solving the secondaryγ′particles in the matrix,primaryγ′particles in the base metal grew to"ogdoadically diced cubes"of about 2μm in side *** pre-weld heat treatment reduced the hardness of the base metal to about HV *** studies using optical and fieldemission scanning electron microscopy revealed that the IN939 alloy was susceptible to liquation cracking in the *** constitutional melting of the secondary,eutectic,and Zr-rich phases promoted the liquation cracking in the *** microstructure of the weld fusion zones showed the presence of fine spheroidalγ′particles with sizes of about 0.2μm after the post-weld heat treatment,which increased the hardness of the weld pools to about HV 350 and 380 for the Hastelloy X and IN718 filler metals,*** of a suitable solid solution filler metal could partially reduce the liquation cracking in the HAZ of IN939 alloy.

关键词： superalloy tungsten inert gas weld heat-affected zone liquation cracking

Dry face milling of titanium alloys

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Journal of University of Science and Technology Beijing 2004年第6期11卷 545-548页

作者： Ahmed hassan Manufacturing and Automation Department

In machining titanium alloys, cutting tools generally wear out very rapidlybecause of the high cutting temperature resulted from the low thermal conductivity and density ofthe work material. In order to increase the tool life, it is necessary to suppress the cutting heatas much as possible by applying an abundant amount of coolant, but this will entail serioustechno-environmental and biological problems. To study the performance and avoid these limitations,a PVD-coated insert was used to the dry face mill of (alpha + beta) titanium alloys. As a result itwas found that the inserts exhibit an excellent cutting performance at low cutting speeds and feedrates, and there is no significant difference in the dominant insert failure mode between the wetand dry cutting in discontinuous cutting.

关键词： carbide tool face milling titanium alloy