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An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

Acta Pharmaceutica Sinica B 2021年第9期11卷 2694-2708页

作者： Mirja Harms Monica MWHabib Simona Nemska Antonella Nicolò Andrea Gilg Nico Preising Pandian Sokkar Sara Carmignani Martina Raasholm Gilbert Weidinger Gönül Kizilsavas Manfred Wagner Ludger Ständker Ashraf HAbadi hassan jumaa Frank Kirchhoff Nelly Frossard Elsa Sanchez-Garcia Jan Münch Institute of Molecular Virology Ulm University Medical CenterUlm 89081Germany Department of Pharmaceutical Chemistry Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo 11835Egypt Laboratoire D'Innovation Thérapeutique UMR7200 CNRS/Universitéde Strasbourg and LabEx MEDALISFacultéde PharmacieIllkirch 67412France Institute of Immunology Ulm University Medical CenterUlm 89081Germany Core Facility Functional Peptidomics Ulm University Medical CenterUlm 89081Germany Center of Medical Biotechnology University of Duisburg-EssenDuisburg 47057Germany Max-Planck-Institute for Coal Research Düsseldorf 45470Germany Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkam 603103India Max-Planck-Institut für Molekulare Physiologie Dortmund 44227Germany Institute of Biochemistry and Molecular Biology Ulm UniversityUlm 89081Germany Max Planck Institute for Polymer Research Mainz 55128Germany

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases.A natural fragment of serum albumin,named EPI-X4,has previously been identified as endogenous peptide antagonist and inverse agonist of CXCR4 and is a promising compound for the development of improved analogues for the therapy of CXCR4-associated *** generate optimized EPI-X4 derivatives we here performed molecular docking analysis to identify key interaction motifs of EPI-X4/*** rational drug design allowed to increase the anti-CXCR4 activity of *** EPI-X4 derivative JM#21 bound CXCR4 and suppressed CXCR4-tropic HIV-1 infection more efficiently than the clinically approved small molecule CXCR4 antagonist ***-X4 JM#21 did not exert toxic effects in zebrafish embryos and suppressed allergen-induced infiltration of eosinophils and other immune cells into the airways of animals in an asthma mouse ***,topical administration of the optimized EPI-X4 derivative efficiently prevented inflammation of the skin in a mouse model of atopic ***,rationally designed EPIX4 JM#21 is a novel potent antagonist of CXCR4 and the first CXCR4 inhibitor with therapeutic efficacy in atopic *** clinical development of this new class of CXCR4 antagonists for the therapy of atopic dermatitis,asthma and other CXCR4-associated diseases is highly warranted.

关键词： CXCR4 antagonist Asthma Allergy Inflammation Atopic dermatitis

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MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TiAlC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

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Comparative study of living donor kidney transplants:Right vs left

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World Journal of Transplantation 2025年第1期15卷 115-123页

作者： Taqi Khan Nadeem Ahmad Qaisar Iqbal Muneeb hassan Lajward Asnath Naveed Khan Sajid Shakeel Kidney Transplant Unit Rehman Medical InstitutePeshawar 25100Khyber PakhtunkhwaPakistan Department of Surgery Princess Noura Binti AbdulRehman UniversityRiyadh 84428Saudi Arabia

BACKGROUND Transplant teams often hesitate to use the right kidney(RK)in living donor(LD)transplants due to the complexities of anastomosing the short,thin-walled right renal veins,which can potentially lead to graft loss or graft ***,circumstances may arise where selecting the RK over the left kidney(LK)is ***,it is crucial to thoroughly examine the implications of such a choice on the overall transplant *** To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these *** We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December *** included all kidney donors who were over 18,fit to donate,and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based *** variables examined comprised donor and recipient demographics,and outcome measures included technical graft loss(TGL),delayed or slow graft function(SGF),and post-transplant serum creatinine(SC)*** used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney *** Of the 250 transplants performed during the period,56(22%)were *** recipient demographics and transplant factors were comparable for the right and LKs,except that the donor warm and cold ischemia time were shorter for *** and SGF each occurred in 2%(n=1)of RKs and 0.5%(n=1)of LKs,the difference being *** complications,however,were not related to the venous *** RK(2%)developed delayed graft function after 48 hours,which was attributable to postoperative hypoxia rather than the surgical *** post-transplant SC trend and mean SC at the last follow-up were similar across both kidney *** The donor kidney side has little impact on post-transplant

关键词： Living donor Right kidney Right renal vein Venous anastomosis Technical graft loss Early graft function

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Dynamic anti-plane analysis for two symmetrically interfacial cracks near circular cavity in piezoelectric bi-materials

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Applied Mathematics and Mechanics(English Edition) 2014年第10期35卷 1261-1270页

作者： A.hassan 宋天舒 Department of Civil Engineering Military Technical College College of Aerospace and Civil Engineering Harbin Engineering University

The present paper is exposed theoretically to the influence on the dynamic stress intensity factor （DSIF） in the piezoelectric bi-materials model with two symmet- rically permeable interracial cracks near the edges of a circular cavity, subjected to the dynamic incident anti-plane shearing wave （SH-wave）. An available theoretical method to dynamic analysis in the related research field is provided. The formulations are based on Green＇s function method. The DSIFs at the inner and outer tips of the left crack are obtained by solving the boundary value problems with the conjunction and crack- simulation technique. The numerical results are obtained by the FORTRAN language program and plotted to show the influence of the variations of the physical parameters, the structural geometry, and the wave frequencies of incident wave on the dimensionless DSIFs. Comparisons with previous work and between the inner and outer tips are con- cluded.

关键词： symmetrically interfacial crack piezoelectric bi-material Green's function,dynamic stress intensity factor (DSIF) dynamic anti-plane shearing wave (SH-wave)

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Liquation cracking in the heat-affected zone of IN939 superalloy tungsten inert gas weldments

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 764-773页

作者： hassan Kazempour-Liasi Mohammad Tajally hassan Abdollah-Pour Faculty of Materials and Metallurgical Engineering Semnan UniversitySemnanIran

The main aim of this study was to investigate liquation cracking in the heat-affected zone(HAZ)of the IN939 superalloy upon tungsten inert gas welding.A solid solution and age-hardenable filler metals were further *** the pre-weld heat-treated samples,upon solving the secondaryγ′particles in the matrix,primaryγ′particles in the base metal grew to"ogdoadically diced cubes"of about 2μm in side *** pre-weld heat treatment reduced the hardness of the base metal to about HV *** studies using optical and fieldemission scanning electron microscopy revealed that the IN939 alloy was susceptible to liquation cracking in the *** constitutional melting of the secondary,eutectic,and Zr-rich phases promoted the liquation cracking in the *** microstructure of the weld fusion zones showed the presence of fine spheroidalγ′particles with sizes of about 0.2μm after the post-weld heat treatment,which increased the hardness of the weld pools to about HV 350 and 380 for the Hastelloy X and IN718 filler metals,*** of a suitable solid solution filler metal could partially reduce the liquation cracking in the HAZ of IN939 alloy.

关键词： superalloy tungsten inert gas weld heat-affected zone liquation cracking

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Dry face milling of titanium alloys

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Journal of University of Science and Technology Beijing 2004年第6期11卷 545-548页

作者： Ahmed hassan Manufacturing and Automation Department

In machining titanium alloys, cutting tools generally wear out very rapidlybecause of the high cutting temperature resulted from the low thermal conductivity and density ofthe work material. In order to increase the tool life, it is necessary to suppress the cutting heatas much as possible by applying an abundant amount of coolant, but this will entail serioustechno-environmental and biological problems. To study the performance and avoid these limitations,a PVD-coated insert was used to the dry face mill of (alpha + beta) titanium alloys. As a result itwas found that the inserts exhibit an excellent cutting performance at low cutting speeds and feedrates, and there is no significant difference in the dominant insert failure mode between the wetand dry cutting in discontinuous cutting.

关键词： carbide tool face milling titanium alloy

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Parametric study of hexagonal castellated beams in post-tensioned self-centering steel connections

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1020-1035页

作者： hassan ABEDI SARVESTANI Faculty of Water and Environmental Engineering Shahid Beheshti UniversityTehran 16589-53571Iran

The effects o f important parameters (beam reinforcing plates, initial post-tensioning, and material properties o f steel angles) on the behavior o f hexagonal castellated beams in post-tensioned self-centering (PTSC) connections undergone cyclic loading up to 4% lateral drift have been investigated by finite element (FE) analysis using ABAQUS. The PTSC connection is comprised o f bolted top and bottom angles as energy dissipaters and steel strands to provide self-centering capacity. The FE analysis has also been validated against the experimental test. The new formulations derived from analytical method has been proposed to predict bending moment o f PTSC connections. The web-post buckling in hexagonal castellated beams has been identified as the dominant failure mode when excessive initial post-tensioning force is applied to reach greater bending moment resistance, so it is required to limit the highest initial post-tensioning force to prevent this failure. Furthermore, properties o f steel material has been simulated using bilinear elastoplastic modeling with 1.5% strain-hardening which has perfectly matched with the real material of steel angles. It is recommended to avoid using steel angles with high yielding strength since they lead to the yielding o f bolt shank. The necessity o f reinforcing plates to prevent beam flange from local buckling has been reaffirmed.

关键词： finite element analysis hexagonal castellated beam parametric study post-tensioned self-centering steel connection steel moment-resisting frame

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Sound waves in fluidized bed using CFD-DEM simulations

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Particuology 2018年第3期16卷 126-133页

作者： hassan Abbas Khawaja Process and Gas Group Department of Engineering & Safety UiT-The Arctic University of Norway 9037 Langnes Tromso Norway

The speed of sound waves in a fluidized bed is investigated using CFD-DEM numerical simulations, Appro- priate initial and boundary conditions are applied to reproduce bed phenomena. The effect of varying the height of the bed is also studied. The results of the simulations matched those from the literature. The pressure and particle velocity profiles obtained feature oscillatory behavior to which functions （based on a damped standing wave） were fitted, enabling an explicit dependence on time and space variables to be established. These fitted functions were substituted into the linearized governing equations for the two-phase flow. These solutions enabled a new relationship to be derived for the speed of sound and damping in the system. The conclusion drawn is tbat the damping in the system is governed by the effective bulk viscosity of the solid phase, which arises from the particle viscosity.

关键词： Fluidized bed Sound waves Speed of sound Damping time CFD-DEM simulations

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