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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： hassan Saad Bachar el Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali Khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa el-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

Solid Waste Management:A MADM Approach Using Fuzzy Parameterized Possibility Single-Valued Neutrosophic Hypersoft Expert Settings

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 531-553页

作者： Tmader Alballa Muhammad Ihsan Atiqe Ur Rahman Noorah Ayed Alsorayea Hamiden Abd el-Wahed Khalifa Department of Mathematics College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia 2 Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

The dramatic rise in the number of people living in cities has made many environmental and social problems *** search for a productive method for disposing of solid waste is the most notable of these *** scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated *** goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site *** characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these *** tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s *** this,an intelligent algorithm is *** steps of the suggested algorithm are explained with an example that explains *** compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their *** study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,*** uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior *** is simpler for the decisionmakers to look at each option separately because the decision is *** the computed results,it is discovered that they are consistent and dependable because of their preferred properties.

关键词： Hypersoft expert set Sanchez’s method decision making optimization solid waste management possibility grade fuzzy parameterization

Regional constrained control problem for a class of semilinear distributed systems

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Control Theory and Technology 2018年第3期16卷 221-231页

作者： el hassan ZERRIK Nihale el BOUKHARI MACS team Faculty of Sciences Moulay Ismail University Meknes Morocco

The aim of this paper is to investigate a regional constrained optimal control problem for a class of semi[inear distributed systems, which are linear in the control but nonlinear in the state. For a quadratic cost functional and a closed convex set of admissible controls, the existence of an optimal control is proven, and then this is characterized for three cases of constraints. A useful algorithm is developed, and the approach is illustrated through simulations for a heat equation.

关键词： Semilinear distributed systems regional optimal control constraints heat equation

Experimental and numerical investigation of the abrasive waterjet machining of aluminum-7075-T6 for aerospace applications

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Advances in Manufacturing 2021年第2期9卷 286-303页

作者： Joseck Nyaboro Mahmoud Ahmed hassan el-Hofy Mohamed el-Hofy Department of Industrial and Manufacturing Engineering Egypt-Japan University of Science and Technology(E-JUST)Alexandria 21934Egypt Department of Energy Resources Engineering Egypt-Japan University of Science and Technology(E-JUST)Alexandria 21934Egypt Advanced Manufacturing Research Centre(AMRC)with Boeing The University of SheffieldRotherham S605TZUK

The machining of hard-to-cut materials with a high degree of precision and high surface quality is one of the most critical considerations when fabricating various state-of-the-art engineered *** this investigation,a comprehensive three-dimensional model was developed and numerically simulated to predict kerf profiles and material removal rates while drilling the aluminum-7075-T6 aerospace *** profile and material removal prediction involved three stages:jet dynamic flow modeling,abrasive particle tracking,and erosion rate *** investigations were conducted to validate the developed *** results indicate that the jet dynamic characteristics and flow of abrasive particles alter the kerf profiles,where the top kerf diameter increases with increasing jet pressure and standoff *** kerf depth and hole aspect ratio increase with jet pressure,but decrease with standoff distance and machining *** profiles were characterized by progressive edge rounding and parabolic *** can be minimized by utilizing high jet pressure and small standoff *** material removal rate increases with increasing jet pressure,abrasive particle size,and exposure time,but decreases with increasing standoff distance.

关键词： Non-traditional machining Abrasive waterjet machining Computational fluid dynamics(CFD) Erosion modeling Kerf characteristics

Rapid conversion of cellulose to 5-hydroxymethylfurfural using single and combined metal chloride catalysts in ionic liquid

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燃料化学学报 2013年第2期41卷 214-222页

作者： Hussein Abou-Yousef el Barbary hassan Philip Steele Department of Forest Products Mississippi State University Cellulose & Paper Department National Research CenterDokkiCairoEgypt

Direct conversion of cellulose into 5-hydroxymethylfurfural(HMF) was performed by using single or combined metal chloride catalysts in 1-ethyl-3-methylimidazolium chloride(Cl) ionic *** study demonstrated formation of 2-furyl hydroxymethyl ketone(FHMK),and furfural(FF) simultaneously with the formation of *** reaction parameters were addressed to optimize yields of furan derivatives produced from cellulose by varying reaction temperature,time,and the type of metal chloride *** reaction by using FeCl3 resulted in 59.9% total yield of furan derivatives(HMF,FHMK,and FF) from ***3 was the most effective catalyst for selective conversion of cellulose into HMF(35.6%) with less concentrations of FHMK,and *** the yields of furans produced from cellulose could be achieved via reactions catalyzed by different combinations of two metal *** optimization was carried out to produce total furans yield 75.9% by using FeCl3/CuCl2 ***3/CuCl2 was the most selective combination to convert cellulose into HMF(39.9%) with total yield(63.8%) of furans produced from the *** temperature and time of the catalytic reaction played an important role in cellulose conversion,and the yields of *** the reaction temperature could enhance the cellulose conversion and HMF yield for short reaction time intervals(5~20 min).

关键词：化学动力学燃料化学理论 EMIM HMF

Existence and numerical approximation of a solution to frictional contact problem for electro-elastic materials

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 201-219页

作者： Othman Baiz el-hassan Benkhira Rachid Fakhar University Ibn Zohr Lab.ESERFP of OuarzazateMorocco University Moulay Ismail Faculty of SciencesLaboratory MACSESTMBP 3103Toulal-MeknesMorocco University Sultan Moulay Slimane Laboratory LS2MEPolydisciplary Faculty of Khouribga25000 KhouribgaMorocco

In this paper,a frictional contact problem between an electro-elastic body and an electrically conductive foundation is *** contact is modeled by normal compliance with finite penetration and a version of Coulomb’s law of dry friction in which the coefficient of friction depends on the *** addition,the effects of the electrical conductivity of the foundation are taken into *** model leads to a coupled system of the quasi-variational inequality of the elliptic type for the displacement and the nonlinear variational equation for the electric *** existence of a weak solution is proved by using an abstract result for elliptic variational inequalities and a fixed point ***,a finite element approximation of the problem is *** some regularity conditions,an optimal order error estimate of the approximate solution is ***,a successive iteration technique is used to solve the problem numerically and a convergence result is established.

关键词： piezoelectric material frictional contact variational Inequality fixed point process finite element method error estimation iteration method

Fermion Mass Hierarchies in Singlet-Extended Minimal-Supersymmetric-Standard-Model Quivers

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Chinese Physics Letters 2011年第11期28卷 64-67页

作者： Salah Eddine Ennadifi Adil Belhaj el hassan Saidi Laboratory of High Energy Physics Modeling and SimulationFaculty of ScienceMohammed V-Agdal UniversityRabatMorocco Centre of Physics and Mathematics CPM-CNESTENRabatMorocco

In the context of type-IIA orientifold compactifications,we discuss the fermion masses in a two-singlet-extended minimal-supersymmetric-standard-model four-stack quiver with U(3)×Sp(1)×U(1)×U(1)gauge *** corresponding effective superpotential exhibits hierarchical coupling term scales giving a partial solution to the fermion masses *** the known data with upper bound neutrino masses mvt≤2 eV,we estimate the relevant scales for the model.

关键词： symmetry problem symmetric

Optical and magnetic properties of perovskite materials:Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3)

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Journal of Rare Earths 2022年第4期40卷 652-659,I0005页

作者： Fatima el Bachraoui Zakaria Chchiyai Youssef Tamraoui hassan el Moussaoui Jones Alami Bouchaib Manoun Materials Science Energy and Nano-engineering Department(MSN)University Mohammed VI Polytechnic43150BenguerirMorocco hassan First University of Settat FSTRayonnement-Matière et InstrumentationS3M26000SettatMorocco Materials and Nanomaterials Center Moroccan Foundation for Advanced ScienceInnovation and Research10100RabatMorocco

Structural,optical and magnetic properties are reported for new synthesized perovskite ***_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid state reaction.X-ray analysis confirms that both compositions show feature of perovskite *** refinement method was used to confirm the phase formation and investigate the structure and space *** study demonstrates the formation of orthorhombic structure with Pnma space group for Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) while the composition Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) structure adopts Pbnm ***–vis spectroscopy measurements show very broad and intense UV–visible light absorption,the estimated band gap ranges between 2.07 and 2.15 *** measurements were carried out for the compositions Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3).The hysteresis loops of both samples at 300 and 10 K show a strong ferromagnetic *** temperature dependent magnetization at 0.05 T under field-cooled(FC)and zero field cooled(ZFC)modes shows magnetic frustration or spin glass-like behavior.

关键词： Perovskites Co-substitution effect Phase transition Band gap Ferromagnetic Visible light absorption