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Pegylated interferon alfa-2b plus ribavirin for treatment of chronic hepatitis C

World Journal of Hepatology 2014年第7期6卷 520-526页

作者： PN Rao Abraham Koshy Jacob Philip Narayanan Premaletha Joy Varghese Krishnasamy Narayanasamy Samir Mohindra Nitin Vikas Pai Manoj Kumar Agarwal Ashokna Konar hasmukh b vora Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad 500082 India Department of Hepatology Lakeshore Hospital Kochi 682040 India Department of Gastroenterology Cosmopolitan Hospital Thiruvananthapuram 695004 India Department of Gastroenterology Medical College Thiruvananthapuram 695011 India Department of Hepatology Global Hospitals and Health City Chennai 600100 India Department of Hepatology GGHand MMC Chennai 600003 India Department of Gastroenterology SGPGIMS Lucknow 226014 India Department of Gastroenterology Pai Clinic and Diagnostic Center Pune 411005 India Department of Gastroenterology Belle Vue Clinic Kolkata 700017 India Department of Gastroenterology PeerlessHospital and B.K. Roy Research Center Kolkata 700094 India Department of Gastroenterology Alka Hospital Ahmedabad 380019 India

AIM: To study the safety and efficacy of pegylated interferon alfa-2b, indigenously developed in India, plus ribavirin in treatment of hepatitis C virus(HCV). METHODS: One-hundred HCV patients were enrolled in an open-label, multicenter trial. Patients were treated with pegylated interferon alfa-2b 1.5 μg/kg per week subcutaneously plus oral ribavirin 800 mg/d for patients with genotypes 2 and 3 for 24 wk. The same dose of peginterferon plus weight-based ribavirin(800 mg/d for ≤ 65 kg; 1000 mg/d for > 65-85 kg; 1200 mg/d for > 85-105 kg; 1400 mg/d for > 105 kg body weight) was administered for 48 wk for patients with genotypes 1 and 4. Serological and biochemical responses of patients were ***: Eighty-two patients(35 in genotypes 1 and 4 and 47 in 2 and 3), completed the study. In genotype 1, 25.9% of patients achieved rapid virologic response(RVR): while the figures were 74.1% for early virologic response(EVR) and 44.4% for sustained virologic response(SVR). For genotypes 2 and 3, all patients bar one belonged to genotype 3, and of those, 71.4%, 87.5%, and 64.3% achieved RVR, EVR, and SVR, respectively. In genotype 4, 58.8%, 88.2%, and 52.9% of patients achieved RVR, EVR, and SVR, respectively. The majority of patients attained normal levels of alanine aminotransferase by 4-12 wk of therapy. Most patients showed a good tolerance for the treatment, although mild-to-moderate adverse events were exhibited; only two patients discontinued the study medication due to serious adverse events(SAEs). Eleven SAEs were observed in nine patients; however, only four SAEs were related to study ***: Peginterferon alfa-2b, which was developed in India, in combination with ribavirin, is a safe and effective drug in the treatment of HCV.

关键词： Hepatitis C virus Genotype Peginterferon alfa-2b Ribavirin Treatment

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