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Skeletal muscle mechanisms contributing to improved glycemic control following intense interval exercise and training

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运动医学与健康科学(英文) 2023年第1期5卷 20-28页

作者： hashim islam Jenna B.Gillen School of Health and Exercise Sciences Faculty of Health and Social DevelopmentUniversity of British Columbia OkanaganKelownaBCCanada Faculty of Kinesiology and Physical Education University of TorontoTorontoONCanada

High-intensity and sprint interval training(HIIT and SIT,respectively)enhance insulin sensitivity and glycemic control in both healthy adults and those with cardiometabolic diseases.The beneficial effects of intense interval training on glycemic control include both improvements seen in the hours to days following a single session of HIIT/SIT and those which accrue with chronic training.Skeletal muscle is the largest site of insulin-stimulated glucose uptake and plays an integral role in the beneficial effects of exercise on glycemic control.Here we summarize the skeletal muscle responses that contribute to improved glycemic control during and following a single session of interval exercise and evaluate the relationship between skeletal muscle remodelling and improved insulin sensitivity following HIIT/SIT training interventions.Recent evidence suggests that targeting skeletal muscle mechanisms via nutritional interventions around exercise,particularly with carbohydrate manipulation,can enhance the acute glycemic benefits of HIIT.There is also some evidence of sex-based differences in the glycemic benefits of intense interval exercise,with blunted responses observed after training in females relative to males.Differences in skeletal muscle metabolism between males and females may contribute to sex differences in insulin sensitivity following HIIT/SIT,but well-controlled studies evaluating purported muscle mechanisms alongside measurement of insulin sensitivity are needed.Given the greater representation of males in muscle physiology literature,there is also a need for more research involving female-only cohorts to enhance our basic understanding of how intense interval training influences muscle insulin sensitivity in females across the lifespan.

关键词： HIIT Insulin sensitivity Type 2 diabetes Nutrition Sex differences

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Risk of bias and reporting practices in studies comparing VO2max responses to sprint interval vs.continuous training:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第5期11卷 552-566页

作者： Jacob T.Bonafiglia hashim islam Nicholas Preobrazenski Brendon J.Gurd School of Kinesiology and Health Studies Queen’s UniversityKingstonOntarioK7L 3N6Canada

Background:It remains unclear whether studies comparing _(max)imal oxygen uptake(VO_(2max))response to sprint interval training(SIT)vs.moderate-intensity continuous training(MICT)are associated with a high risk of bias and poor reporting quality.The purpose of this study was to evaluate the risk of bias and quality of reporting in studies comparing changes in VO_(2max) between SIT and MICT.Methods:We conducted a comprehensive literature search of 4 major databases:AMED,CINAHL,EMBASE,and MEDLINE.Studies were excluded if participants were not healthy adult humans or if training protocols were unsupervised,lasted less than 2 weeks,or utilized mixed exercise modalities.We used the Cochrane Collaboration tool and the CONSORT checklist for non-pharmacological trials to evaluate the risk of bias and reporting quality,respectively.Results:Twenty-eight studies with 30 comparisons(3 studies included 2 SIT groups)were included in our meta-analysis(n=360 SIT participants:body mass index(BMI)=25.9±3.7 kg/m^(2),baseline VO_(2max)=37.9±8.0 mL/kg/min;n=359 MICT participants:BMI=25.5±3.8 kg/m^(2),baseline VO_(2max)=38.3±8.0 mL/kg/min;all mean±SD).All studies had an unclear risk of bias and poor reporting quality.Conclusion:Although we observed a lack of superiority between SIT and MICT for improving VO_(2max)(weighted Hedge’s g=0.004,95%con-fidence interval(95%CI):-0.08 to 0.07),the overall unclear risk of bias calls the validity of this conclusion into question.Future studies using robust study designs are needed to interrogate the possibility that SIT and MICT result in similar changes in VO_(2max).

关键词： Bias Cardiorespiratory fitness CONSORT Moderate-intensity continuous training Sprint interval training

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零食式锻炼与心脏代谢健康

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中国运动医学杂志 2023年第9期42卷 677-681页

作者： hashim islam Martin J.Gibala Jonathan P.Little 聂金雷(翻译) 时庆德(翻译) 孔兆伟(翻译) 加拿大不列颠哥伦比亚大学健康与运动科学学院加拿大麦克马斯特大学运动系澳门理工大学中国澳门澳门大学中国澳门

低心肺适能和久坐是心脏代谢疾病的独立风险因素。零食式锻炼(exercise snacks)是指分散在全天中反复进行单次小于1分钟的剧烈运动。作为一种新颖的运动锻炼策略,零食式锻炼既可提高心肺适能,同时又能打破久坐时间。与传统锻炼方式相比... 详细信息

低心肺适能和久坐是心脏代谢疾病的独立风险因素。零食式锻炼(exercise snacks)是指分散在全天中反复进行单次小于1分钟的剧烈运动。作为一种新颖的运动锻炼策略,零食式锻炼既可提高心肺适能,同时又能打破久坐时间。与传统锻炼方式相比,零食式锻炼的突出特点是耗时极少且安排灵活。本文概述零食式锻炼的方法及其有益于心脏代谢健康的现有证据和未来研究方向。

关键词：零食式锻炼剧烈运动心肺适能心脏代谢健康

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Exploring Nutritional Compositions,Volatile Compounds,Health Benefits,Emerging Processing Technologies,and Potential Food Products of Glutinous Rice:A Review

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Rice science 2024年第3期31卷 251-268页

作者： Maimunah Mohd ALI Norhashila hashim Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600SelangorMalaysia Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia SMART Farming Technology Research Centre Faculty of EngineeringUniversiti Putra MalaysiaUPM Serdang 43400SelangorMalaysia Innovation Center for Confectionary Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM Bangi 43600Selangor Darul EhsanMalaysia

Glutinous rice(Oryza sativa var.glutinosa)stands out as one of the most popular rice varieties globally,amidst thousands of rice cultivars.Its increasing popularity is attributed to its rich nutritional compositions and health benefits.This review aims to summarize the nutritional compositions,volatile compounds,and health benefits of glutinous rice.Further,in-depth studies are necessary to explore the utilization of glutinous rice in enhancing processing technologies and developing new food products.Glutinous rice has been shown to possess numerous health benefits,including antioxidant activity,bioactive compounds,anti-cancer properties,anti-inflammatory effects,anti-diabetic potential,and cholesterol-lowering effects.Besides its nutritional compositions,the major volatile compounds identified in glutinous rice could serve as a functional food for human consumption.Emerging processing technologies related to glutinous rice are elaborated to improve the latest developments for incorporating them into various food products.

关键词： glutinous rice health benefit volatile compound nutritional composition processing technology

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Can the Bass innovation diffusion model describe adsorption breakthrough curves of pharmaceutical contaminants?

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Green Chemical Engineering 2024年第2期5卷 145-149页

作者： Khim Hoong Chu Mohd Ali hashim Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

1.Introduction Fixed bed adsorption is a widely used separation process in the chemical industry for the processing of liquids and gases.The performance of fixed bed adsorption systems is often evaluated by analyzing the breakthrough curves,which represent the variation of the solute concentration in the effluent stream as a function of time or bed volume.

关键词： adsorption breakthrough curves

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A review of salivary composition changes induced by fasting and its impact on health

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Food Science and Human Wellness 2024年第1期13卷 50-64页

作者： Nurul Fadhilah Kamalul Aripin NIdayu Zahid Mohd Aizat Abdul Rahim hashim Yaacob Parvez I.Haris Zubaidah Haji AbdRahim Rauzah hashim School of Chemical Engineering College of EngineeringUniversiti Teknologi MARAShah Alam 40450Malaysia Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly Department of ChemistryFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Department of Oral and Craniofacial Sciences Faculty of DentistryUniversiti MalayaKuala Lumpur 50603Malaysia UMSC Dental Specialist Clinic UM Dentistry TowerUniversiti MalayaMedical CentreKuala Lumpur 50603Malaysia Leicester School of Allied Health Sciences De Montfort UniversityLeicester LE19BHUnited Kingdom Chancellery(Research and Innovation) Universiti MalayaKuala Lumpur 50603Malaysia

Human saliva is an indispensable fluid that maintains a healthy oral cavity which otherwise can lead to oral diseases(dental caries and periodontitis).In addition,salivary metabolites and microbiome profile provide early detection of systemic diseases such as cancer and obesity.Salivary diagnostic has gained popularity due to its non-invasive sampling technique.Fasting(abstinence from food or drink or both)research for weight loss and improve health is common,but studies using fasting saliva are scarce.Some metabolites in fasting saliva have been reported with interesting results,which can be enhanced by considering different confounding factors.For example,fasting saliva contains higher salivary nitrite,which is related to nitric oxide(NO).NO is a vasodilator supporting the healthy function of endothelial cells and its deficiency is connected to many diseases.The timely supply of NO through exogenous and endogenous means is highlighted and the potential advantage of fasting salivary composition changes in relation to COVID-19 infection is speculated.This review aims to provide a general discussion on the salivary composition,properties,and functions of the whole saliva,including the health benefits of fasting.

关键词： Saliva Fasting Nitrate Nitrite Nitric oxide

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Facies development and sedimentology of the Middle Miocene carbonates of the Raghama Formation, northeastern Saudi Arabia

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Acta Geochimica 2024年第1期43卷 87-96页

作者： Mansour H.Al-hashim Abdelbaset S.El-Sorogy Meshal Wadani Department of Geology and Geophysics College of ScienceKing Saud University2455Riyadh 11451Saudi Arabia

Ragahama Formation comprises a siliciclastic continental deposits followed by marine carbonates, representing prograding alluvial fans from adjacent high hinterlands seaward into lagoons and fringing reef environments. The present work aimed to document the facies development and sedimentology of the Raghama carbonates exposed along the eastern coastal plain of the Red Sea, northwestern Saudi Arabia. Four stratigraphic sections were measured and sampled(D1–D4) and thin sections and major and trace element analyses were prepared and applied for petrographic and geochemical approaches. The carbonates were subdivided into three successive fore-reef, reef-core, and back-reef depositional facies. Sandy stromatolitic boundstone, microbial laminites, dolomitic ooidal grainstone, bioclastic coralline algal wackestone, sandy bioclastic wackestone, and coral boundstones were the reported microfacies types. Petrographic analysis reveals that the studied carbonates were affected by dissolution, dolomitization, and aggrading recrystallization, which affects both the original micrite matrix and grains or acts as fracture and veinlet filling leading to widespread vuggy and moldic porosity. No evidence of physical compaction, suggesting rapid lithification and recrystallization during early diagenesis and prior to substantial burial and intensive flushing by meteoric waters. Most of the original microstructure of corals were leached and destructed. This is indicated by the higher depletion in Sr and Ca levels and increase in Mg,Na, Fe, and Mn levels, especially in section D1, in comparison with the worldwide carbonates.

关键词： Raghama Formation Miocene Diagenesis Geochemistry Saudi Arabia

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A Hybrid and Lightweight Device-to-Server Authentication Technique for the Internet of Things

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Computers, Materials & Continua 2024年第3期78卷 3805-3823页

作者： Shaha Al-Otaibi Rahim Khan hashim Ali Aftab Ahmed Khan Amir Saeed Jehad Ali Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science Abdul Wali Khan University MardanMardan23200Pakistan Department of Computer Science and IT UET PeshawarJalozai Campus PeshawarPeshawar24240Pakistan Department of AI Convergence Network Ajou UniversitySuwon16499South Korea

The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective server module.Although IoTs are cornerstones in different application domains,the device’s authenticity,i.e.,of server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority basis.Therefore,various field-proven methodologies were presented to streamline the verification process of the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are mobile.This paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location information along with other measures.Initially,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of 128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of the original ID,for every device,i.e.,server and member,and are shared in the offline phase.Secondly,TA shares a list of authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT for the onward verification process,which is required to be executed before the initialization of the actual communication process.Additionally,every device should be located such that it lies within the coverage area of a server,and this location information is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT domain.Moreover,proposed authentication and existing state-of-the-art approaches have been simulated in the real environment of IoT to verif

关键词： Internet of things authenticity security location communication

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Smart Farming for Sustainable Rice Production:An Insight into Application,Challenge,and Future Prospect

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Rice science 2024年第1期31卷 47-61页

作者： Norhashila hashim Maimunah Mohd ALI Muhammad Razif MAHADI Ahmad Fikri ABDULLAH Aimrun WAYAYOK Muhamad Saufi Mohd KASSIM Askiah JAMALUDDIN Department of Biological and Agricultural Engineering/SMART Farming Technology Research Centre Faculty of EngineeringUniversiti Putra MalaysiaSelangor 43400Malaysia Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaSelangor 43600Malaysia Department of Resource Management&Consumer Studies Faculty of Human EcologyUniversiti Putra MalaysiaSelangor 43400Malaysia

Rice has a huge impact on socio-economic growth,and ensuring its sustainability and optimal utilization is vital.This review provides an insight into the role of smart farming in enhancing rice productivity.The applications of smart farming in rice production including yield estimation,smart irrigation systems,monitoring disease and growth,and predicting rice quality and classifications are highlighted.The challenges of smart farming in sustainable rice production to enhance the understanding of researchers,policymakers,and stakeholders are discussed.Numerous efforts have been exerted to combat the issues in rice production in order to promote rice sector development.The effective implementation of smart farming in rice production has been facilitated by various technical advancements,particularly the integration of the Internet of Things and artificial intelligence.The future prospects of smart farming in transforming existing rice production practices are also elucidated.Through the utilization of smart farming,the rice industry can attain sustainable and resilient production systems that could mitigate environmental impact and safeguard food security.Thus,the rice industry holds a bright future in transforming current rice production practices into a new outlook in rice smart farming development.

关键词： rice production smart farming food security agriculture sustainability

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Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

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Journal of Renewable Materials 2024年第1期12卷 29-43页

作者： Thean Heng Tan Najihah Mohd hashim Wageeh Abdulhadi Yehya Dabdawb Mochamad Zakki Fahmi Hwei Voon Lee Nanotechnology&Catalysis Research Center(NANOCAT) Universiti MalayaKuala Lumpur50603Malaysia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversiti MalayaKuala Lumpur50603Malaysia Department of Chemistry Faculty of Science and TechnologyUniversitas AirlanggaCampus CMulyorejoSurabaya60115Indonesia

The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose(NCC)as a potential drug delivery system for targeting folate receptor-positive cancer cells.The FA-functionalized NCCs were synthesized through a series of chemical reactions,resulting in nanoparticles with favorable properties for biomedical applications.The microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor tissues.Importantly,these nanoparticles possessed a negative surface charge,enhancing their stability and repelling potential aggregation.The binding specificity of FA-functionalized NCCs to folate receptor-positive cancer cells was demonstrated through various assays.The free folic acid inhibition assay showed approximately 30%decrease in the binding of functionalized NCCs in the presence of just 5 mM free FA,confirming their selectivity for folate receptor-positive cells.Confocal microscopy further validated this specificity,as only cancer cells displayed significant binding of functionalized NCCs.Crucially,biocompatibility tests revealed that both NCCs and FA-functionalized NCCs had minimal effects on red blood cells,and they did not induce erythrocyte aggregation.Furthermore,cell viability assays demonstrated functionalized NCCs have selective cytotoxicity against colorectal cancer cells HT-29 and SW-620(68%–88%cell viability)while sparing noncancerous colon cells CCD-18Co(81%–97%cell viability).In summary,FA-functionalized NCCs exhibit promising characteristics for targeted drug delivery in cancer therapy.Their biocompatibility,stability,and selective cytotoxicity make them an attractive option for delivering therapeutic agents to folate receptor-positive cancer cells,potentially improving the effectiveness of cancer treatments while minimizing harm to healthy tissues.

关键词： Agricultural wastes sustainable nanocarrier blood biocompatibility folic acid receptor drug delivery system nanomedicine

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