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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-hashem Salah O.Bashir Amal F.Dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni mohamed D.morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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Optimization of Ti-5Al-2.5Sn Chemical milling Process Parameters Using Taguchi Design for Enhanced Performance

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Suha K.Shihab Ahmed AAG Alrubaiy ayad Naseef Jasim Jabbar Gattmah Department of materials Engineering， Engineering of College， University of Diyala

One of the nontraditional manufacturing processes is the chemical machining that deals with the removal of material substances using acidic or alkaline chemical solutions. This study aimed to determine the maximum material removal rate （mRR）， and minimum surface roughness （SRa） of Ti-5Al-2.5Sn alloy during chemical milling that is possible to achieve by varying the etching chemical milling parameters in terms of time， concentration of the chemical solution [hydrofluoric acid （HF） and nitric acid (HNO3)]， and chemical milling temperature. The Taguchi method based on a statistical design of experiments （DOE） technique with an L16orthogonal array， is efficiently used to obtain the objective of this study and to detect optimal chemical milling parameters for the Ti-5Al-2.5Sn alloy. The experimental results were analyzed using ANOVA analysis to determine the importance of each system parameter on the response variables （mRR and SRa）. The optimal process parameters were found to be at a chemical solution concentration of 22.5 HF and 17 HNO3， a temperature of 45 ℃， and a time of 60 min. These parameters resulted in a maximum mRR of 0.0842 mg/min and a minimum SRa of 0.30 μm. The ANOVA result signalized that the concentration of the etching acids has the most impact on both responses with contribution percentages of 81% and 67% respectively. This takes a look at the efficacy of the Taguchi technique in optimizing chemical milling procedures and offers precious insights for selecting process parameters to attain favored results.

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modelling of Gettering by mechanical Damage of metallic Impurities in Silicon

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Chinese Physics Letters 2006年第11期23卷 3058-3060页

作者： F. ayad m. Remram Department of Electronics University of Mentourl Route of Ain El-Bay Constantine 25000 Algeria

Reducing the concentration of the metallic impurities present in silicon-based electronic components plays a vital role in manufactures. Gettering by induced mechanical damage is one of the methods used in neutralizing these impurities. To simulate this type of gettering, we explicitly include the role of the traps due to mechanical damage, based on the mechanism of kick-out. In our model, we choose the essential parameters including concentration of impurities, thickness, temperature, time, etc. The diffusion coefficient and equilibrium concentration of the silicon interstitials estimated from the literature have been adjusted to be in good agreement with the experimental data.

关键词： DIFFUSION GOLD

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Drought trend analysis in a semi-arid area of Iraq based on Normalized Difference Vegetation Index, Normalized Difference Water Index and Standardized Precipitation Index

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Journal of Arid Land 2021年第4期13卷 413-430页

作者： ayad m F AL-QURAISHI Heman A GAZNAYEE mattia CRESPI Department of Surveying and Geomatics Engineering Faculty of EngineeringTishk International UniversityErbil 44001Iraq Department of Forestry College of Agricultural Engineering SciencesSalahaddin UniversityErbil 44002Iraq Geodesy and Geomatics Division Department of CivilConstructional and Environmental EngineeringSapienza University of RomeRome 00185Italy Sapienza School for Advanced Studies Sapienza University of RomeRome 00185Italy

Drought was a severe recurring phenomenon in Iraq over the past two decades due to climate change despite the fact that Iraq has been one of the most water-rich countries in the middle East in the *** Iraqi Kurdistan Region(IKR)is located in the north of Iraq,which has also suffered from extreme *** this study,the drought severity status in Sulaimaniyah Province,one of four provinces of the IKR,was investigated for the years from 1998 to ***,Landsat time series dataset,including 40 images,were downloaded and used in this *** Normalized Difference Vegetation Index(NDVI)and the Normalized Difference Water Index(NDWI)were utilized as spectral-based drought indices and the Standardized Precipitation Index(SPI)was employed as a meteorological-based drought index,to assess the drought severity and analyse the changes of vegetative cover and water *** study area experienced precipitation deficiency and severe drought in 1999,2000,2008,2009,and *** findings also revealed a drop in the vegetative cover by 33.3%in the year ***,the most significant shrinkage in water bodies was observed in the Lake Darbandikhan(LDK),which lost 40.5%of its total surface area in *** statistical analyses revealed that precipitation was significantly positively correlated with the SPI and the surface area of the LDK(correlation coefficients of 0.92 and 0.72,respectively).The relationship between SPI and NDVI-based vegetation cover was positive but not *** precipitation did not always correspond to vegetative drought;the delay of the effect of precipitation on NDVI was one year.

关键词： climate change drought Normalized Difference Vegetation Index(NDVI) Normalized Difference Water Index(NDWI) Standardized Precipitation Index(SPI) delay effect

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Constraints on the nuclear symmetry energy and its density slope from theαdecay process

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Chinese Physics C 2018年第6期42卷 79-87页

作者： W.m.Seif A.S.hashem Cairo University Faculty of ScienceDepartment of Physics12613 GizaEgypt

We study the impact of the nuclear symmetry energy and its density dependence on the α-decay *** the framework of the preformed cluster model and the energy density formalism, we use different parameterizations of the Skyrme energy density functionals that yield different equations of state（EOS）. Each EOS is characterized by a particular symmetryenergy coefficient（asym） and a corresponding density-slope parameter L. The stepwise trends of the neutron（proton） skin thickness of the involved nuclei with both asym and L do not clarify the oscillating behaviors of the α-decay half-life Tα with these quantities. We find that the change of the skin thickness after α-decay satisfactorily explains these behaviors. The presented results provide constraints on asym centered around an optimum value asym = 32 meV, and on L between 41 and 57 meV. These values of asym and L, which indicate larger reduction of the proton-skin thickness and less increase in the neutron-skin thickness after an α-decay,yield a minimum calculated half-life with the same extracted value of the α-preformation factor inside the parent nucleus.

关键词： alpha decay symmetry energy neutron-skin thickness proton-skin

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Spatial correlation of pit and mound topography with canopy gaps in a virgin mixed beech forest, northern Iran

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Journal of Forestry Research 2019年第1期30卷 295-303页

作者： hashem Habashi Faculty of Forest Sciences Gorgon University of Agricultural Sciences and Natural Resources

In a reserved forest parcel in a virgin eastern Hyrcanian mixed beech forest,80 ha was surveyed to determine the pit and mound topography,canopy gaps and dead *** aim was to investigate the spatial patterns and correlation of pit and mound features with canopy ***-five canopy gaps and 61 pit and mound features were *** univariate first order nearest neighbor(R_(CE))and bivariate second order test(Ripley’s K)statistic were applied.R_(CE) statistics highlighted a general aggregation pattern for canopy gaps and pits and mounds,while pits and mounds alone were more *** between canopy gaps were 130 m average,whereas distances between pit and mound features and dead trees were 60 and 78 m,*** positive correlation of canopy gaps with pits and mounds were observed with all *** result of spatial correlations between canopy gaps with pits and mounds confirmed that windthrows cause micro successions in fallen tree ecosystem-scale correlated with gap phase dynamics in the forest community-scale.

关键词： Pit and mound Canopy gap mixed beech Spatial pattern Spatial correlation

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PeachNet: Peach Diseases Detection for Automatic Harvesting

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Computers, materials & Continua 2021年第5期67卷 1665-1677页

作者： Wael Alosaimi hashem Alyami m.Irfan Uddin Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Institute of Computing Kohat University of Science and TechnologyKohat26000Pakistan

To meet the food requirements of the seven billion people on Earth,multiple advancements in agriculture and industry have been *** main threat to food items is from diseases and pests which affect the quality and quantity of *** scientific mechanisms have been developed to protect plants and fruits from pests and diseases and to increase the quantity and quality of *** these mechanisms require manual efforts and human expertise to diagnose *** the current decade Artificial Intelligence is used to automate different processes,including agricultural processes,such as automatic *** Learning techniques are becoming popular to process images and identify different *** can use machine Learning algorithms for disease identification in plants for automatic harvesting that can help us to increase the quantity of the food produced and reduce crop *** this paper,we develop a novel Convolutional Neural Network(CNN)model that can detect diseases in peach plants and *** proposed method can also locate the region of disease and help farmers to find appropriate treatments to protect peach *** the detection of diseases in Peaches VGG-19 architecture is *** the localization of disease regions mask R-CNN is *** proposed technique is evaluated using different techniques and has demonstrated 94%*** hope that the system can help farmers to increase peach production to meet food demands.

关键词： Convolutional neural network computer vision image processing segmentation plant diseases

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A COUPLED SYSTEm OF INTEGRAL EQUATIONS IN REFLEXIVE BANACH SPACES

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Acta mathematica Scientia 2012年第5期32卷 2021-2028页

作者： A.m.A.El-Sayed H.H.G.hashem Faculty of Science Alexandria UniversityAlexandriaEgypt Collage of Science & Arts Qassim UniversityBuraidahSaudi Arabia

We present an existence theorem for at least one weak solution for a coupled system of integral equations of Volterra type in a reflexive Banach spaces relative to the weak topology.

关键词： weak solution Volterra integral equation coupled system

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Effect of the mesh Transparency on the Electrical Characteristics of DC Pseudo Discharge

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Plasma Science and Technology 2015年第6期17卷 481-487页

作者： m.A.Abd AL-HALIm A.ABU-hashem D.I.mOUBARAK Physics Department Faculty of ScienceBenha University Basic Science Department Thebes High Institute of Engineering

A DC pseudo discharge for air has been studied. Air pressure is used in the range between 0.7 Torr and 12 Torr. The breakdown occurs between a plane cathode and a mesh anode at transparencies of 19%, 46%, and 65%. The current-voltage characteristic curves of the discharge, which are measured at different pressures, distances, and mesh transparences, take effect in the region of abnormal glow. The discharge voltage decreases as the air pressure increases, while more voltage is needed to maintain the discharge when either the mesh transparency or the inter- electrode distance is increased. An increment of mesh transparency causes high negative potential behind the mesh due to the high concentration of electrons, which accumulate and collide with neutral atoms. Paschen curves deviate from the expected regular one. The left side of Paschen curves appears at inter-electrode distance of 1 mm, whereas the right side appears at inter-electrode distance of 5 mm. The intermediate region is observed only at 3 mm distance between the two electrodes. For the transparency range used in this work, it is found that the decrement of the breakdown voltage, on the right side, depends on the mesh transparency. For different electrode separations, the measured Paschen curves are coincident and deviate from the standard ones of Paschen＇s law.

关键词： pseudo discharge mesh transparency Paschen curves

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Control of purity and entanglement for two spatially two-separated qubits via phase damping

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Chinese Physics B 2012年第10期21卷 115-121页

作者： A.S.F.Obada H.A.Hessian A.B.A.mohamed m.hashem Faculty of Science Al-Azhar UniversityNasr CityCairoEgypt Faculty of Science Assiut UniversityAssiutEgypt Faculty of Science Al-Baha UniversityAl-BahaSaudi Arabia Al-Aflaj Community College Salman Bin Abdulaziz University Al-AflajSaudi Arabia

Control of purity and entanglement of two two-qubits dispersively coupled to a field with a reservoir are *** the qubits are entangled,while the field is either in a coherent state or a statistical mixture of two coherent *** an alternative entanglement measure we calculate the negativity of the eigenvalues of the partially transposed density matrix.A measure related to the mutual entropy,namely the index of entropy,is employed to measure the *** results agree well with the *** is found that the entanglement and purity have strong sensitivity to phase *** asymptotic behaviour of the states of the field,the two two-qubits,and the total system fall into mixed states.

关键词： entanglement phase damping purity separated qubits

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