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uPAR antibody(huATN-658) and Zometa reduce breast cancer growth and skeletal lesions

Bone Research 2020年第2期8卷 197-208页

作者： Niaz Mahmood Ani Arakelian haseeb ahmed khan Imrana Tanvir Andrew P.Mazar Shafaat A.Rabbani Department of Medicine McGill UniversityMontréalQC H4A3J1Canada Fatima Memorial Hospital System LahorePakistan Monopar Therapeutics WilmetteIL 60091USA

Urokinase plasminogen activator receptor(uPAR) is implicated in tumor growth and metastasis due to its ability to activate latent growth factors, proteases, and different oncogenic signaling pathways upon binding to different ligands. Elevated u PAR expression is correlated with the increased aggressiveness of cancer cells, which led to its credentialing as an attractive diagnostic and therapeutic target in advanced solid cancer. Here, we examine the antitumor effects of a humanized anti-u PAR antibody(huATN-658) alone and in combination with the approved bisphosphonate Zometa(Zoledronic acid) on skeletal lesion through a series of studies in vitro and in vivo. Treatment with huATN-658 or Zometa alone significantly decreased human MDA-MB-231 cell proliferation and invasion in vitro, effects which were more pronounced when huATN-658 was combined with Zometa. In vivo studies demonstrated that huATN-658 treatment significantly reduced MDA-MB-231 primary tumor growth compared with controls. In a model of breast tumor-induced bone disease, huATN-658 and Zometa were equally effective in reducing skeletal lesions. The skeletal lesions were significantly reduced in animals receiving the combination of huATN-658 + Zometa compared with monotherapy treatment. These effects were due to a significant decrease in osteoclastic activity and tumor cell proliferation in the combination treatment group. Transcriptome analysis revealed that combination treatment significantly changes the expression of genes from signaling pathways implicated in tumor progression and bone remodeling. Results from these studies provide a rationale for the continued development of huATN-658 as a monotherapy and in combination with currently approved agents such as Zometa in patients with metastatic breast cancer.

关键词： skeletal breast invasion

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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz khan Muhammad Shoaib khan Muhammad Yasir khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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A survey on trust based detection and isolation of malicious nodes in ad-hoc and sensor networks

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Frontiers of Computer Science 2015年第2期9卷 280-296页

作者： Adnan ahmed Kamalrulnizam ABU BAKAR Muhammad Ibrahim CHANNA Khalid haseeb Abdul Waheed khan Faculty of Computing Universiti Teknologi Malaysia Johor Bahru 81310 Malaysia Department of Information Technology Quaid-e-Awam University of Engineering Science and Technology Nawabshah 67450 Pakistan

Mobile ad-hoc networks （MANETs） and wireless sensor networks （WSNs） have gained remarkable apprecia- tion and technological development over the last few years. Despite ease of deployment, tremendous applications and significant advantages, security has always been a challeng- ing issue due to the nature of environments in which nodes operate. Nodes＇ physical capture, malicious or selfish behav- ior cannot be detected by traditional security schemes. Trust and reputation based approaches have gained global recog- nition in providing additional means of security for decision making in sensor and ad-hoc networks. This paper provides an extensive literature review of trust and reputation based models both in sensor and ad-hoc networks. Based on the mechanism of trust establishment, we categorize the state- of-the-art into two groups namely node-centric trust mod- els and system-centric trust models. Based on trust evidence, initialization, computation, propagation and weight assign- ments, we evaluate the efficacy of the existing schemes. Fi- nally, we conclude our discussion with identification of some unresolved issues in pursuit of trust and reputation manage- ment.

关键词： trust reputation wireless sensor network mo-bile ad-hoc networks routing node misbehavior

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Efficiency of seed bio-priming technique for healthy mungbean productivity under terminal drought stress

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Journal of Integrative Agriculture 2021年第1期20卷 87-99页

作者： Hamid NAWAZ Nazim HUSSAIN Niaz ahmed haseeb-ur-REHMAN Javaiz ALAM Department of Agronomy The Islamia University of BahawalpurBahawapur 63100Pakistan Department of Agronomy Bahauddin Zakariya UniversityMultan 60000Pakistan Department of Soil Science Bahauddin Zakariya UniversityMultan 60000Pakistan

Recently, drought-induced damaging impact in reducing the crop growth and development is drastically ranked at the top under various abiotic stresses. And especially water stress at the reproductive growth stages termed as terminal drought has become a severe threat for mungbean productivity. To mitigate the drought stress condition, "bio-priming" has emerged as a newly agronomic and sustainable technique in improving the mungbean production. A 2-year field study during Kharif season 2017–2018 was conducted to investigate the efficacy of rhizobacteria seed priming in mungbean(AZRI mung-06), at Agronomic Research Area, Department of Agronomy, Bahauddin Zakariya University, Multan, Pakistan. The experiment comprised two factors containing FA(seed treatments, control(dry seeds), hydro-priming, silicon(Si)-priming, and bio-priming(mixture strains of Pseudomonas fluorescens+Rhizobium phaseoli)) and FB(irrigation water-regimes at various growth stages including leaf formation(L), stem elongation(S)+flowering(F)+pod formation(P) containing treatments are normal irrigation(I(L+S+F+P)) and terminal drought stress(I(F+P))). All the treatments were arranged in randomized complete block design under factorial design and were replicated thrice. Results indicated that the exposure of drought stress at flowering and pod formation stages hampered the morpho-physiological growth and yield of mungbean. Nevertheless, seed priming treatments particularly bio-priming were effective in alleviating the detrimental effects of drought stress. Bio-priming significantly increased the yield and yield components(seeds/plant, 1 000-grain weight and harvest index) of mungbean and regulated the activities/levels of antioxidants(superoxide dismutase, catalase, peroxidase, ascorbic acid, and total phenolics) under drought stress. Compared with the control, bio-priming increased the seed yield of mungbean by 8–12% under normal as well as drought stress conditions during both years of study. Bio-primi

关键词： bio-priming antioxidant activities drought nutrients uptake mungbean

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Primitives towards verifiable computation： a survey

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Frontiers of Computer Science 2018年第3期12卷 451-478页

作者： haseeb AHMAD Licheng WANG Haibo HONG Jing LI Hassan DAWOOD Manzoor ahmed Yixian YANG State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China School of Computer Science and Information Engineering Zhejiang Gongshang University Hangzhou 310018 China Department of Computer Engineering University of Engineering and Technology Taxila 47050 Pakistan Future Internet & Communication Lab Department of Electronic Engineering Tsinghua University Beijing 100084 China

Verifiable computation （VC） paradigm has got the captivation that in real term is highlighted by the concept of third party computation. In more explicate terms, VC allows resource constrained clients/organizations to securely outsource expensive computations to untrusted service providers, while acquiring the publicly or privately verifiable results. Many mainstream solutions have been proposed to address the diverse problems within the VC domain. Some of them imposed assumptions over performed computations, while the others took advantage of interactivity /non-interactivity, zero knowledge proofs, and arguments. Further proposals utilized the powers of probabilistic checkable or computationally sound proofs. In this survey, we present a chronological study and classify the VC proposals based on their adopted domains. First, we provide a broader overview of the theoretical advancements while critically analyzing them. Subsequently, we present a comprehensive view of their utilization in the state of the art VC approaches. Moreover, a brief overview of recent proof based VC systems is also presented that lifted up the VC domain to the verge of practicality. We use the presented study and reviewed resuits to identify the similarities and alterations, modifications, and hybridization of different approaches, while comparing their advantages and reporting their overheads. Finally, we discuss implementation of such VC based systems, their applications, and the likely future directions.

关键词： verifiable computation cloud computation interactive non-interactive zero knowledge probabilisticcheckable proofs computationally sound proofs

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A low complexity online controller using fuzzy logic in energy harvesting WSNs

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Science China(Information Sciences) 2019年第4期62卷 167-176页

作者： Talha AZFAR Waqas ahmed Abdul haseeb Rizwan AHMAD Sufi Tabassum GUL Fu-Chun ZHENG Department of Electrical Engineering Pakistan Institute of Engineering and Applied Sciences (PIEAS) School of Electrical Engineering and Computer Science National University of Sciences and Technology (NUST) School of Electronic and Information Engineering Harbin Institute of Technology

In this paper, we present a fuzzy logic based scheme for a two hop energy harvesting(EH)wireless sensor network(WSN). Incorporating data and energy causality constraints, discrete transmission rates, finite energy and data buffers, a fuzzy model is developed which uses network throughput, battery level and channel gain as inputs. The fuzzy scheme is then compared with optimum, modified optimum, and Markov decision process(MDP) schemes in terms of computational complexity, throughput, battery level and data buffer capacity. The throughput results show that the fuzzy online scheme preforms closely to the compared schemes and avoids battery depletion even when the number of discrete transmission rates are increased.

关键词： wireless sensor networks energy harvesting cooperative communications fuzzy logic

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Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics

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World Journal of Hepatology 2023年第2期15卷 216-224页

作者： Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M ahmed Rasheda Tarik I Zaher Mona Talaat haseeb Emad Hassan Emara Hassan Elbatae Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Internal Medicine Gastroenterology UnitSecurity Forces HospitalRiyadh 11481Saudi Arabia Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Diagnostic and Interventional Radiology Kafrelsheikh UniversityKafr-Elshikh 33516Egypt

Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive *** cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT.

关键词： Sonographic Gallbladder wall thickness Prediction Esophageal varices Portal hypertension Esophago-gastro-duodenoscopy

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Actin-depolymerizing factor from Eimeria tenella promotes immunogenic function of chicken dendritic cells

Actin-depolymerizing factor from Eimeria tenella promotes im...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Shakeel ahmed Lakho Muhammad haseeb Jianmei Huang Zhang Yang Muhammad Waqqas Hasan Muhammad Tahir Aleem Muhammad Ali Memon XiaoKai Song RuoFeng Yan Lixin Xu 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

Dendritic cells play a crucial role in inducing antigen-specific immunity to *** host-parasite interaction,host immune response to the parasite molecules is considered essential for recognizing novel antigens for control ***,in the present study,chicken dendritic cells(DCs)(ChDCs),derived from spleens were used to evaluate their capacity to proliferate and differentiate autologous T lymphocytes in response to actin-depolymerizing factor from Eimeria tenella(EtADF).Immunoblot analysis showed that recombinant EtADF protein(rEtADF) was able to interact with rat anti-rEtADF *** immunofluorescence test confirmed rEtADF binding on ChDCs *** *** revealed that phenotypes for MHCII,CD1.1,CD11 c,CD80,and CD86 were increased in ChDCs after rEtADF ***-PCR results indicated that ChDCs triggered TLR signaling in response to rEtADF,and suppressed Wnt *** levels of CD83,CCL5,and CCR7 in ChDCs were improved following rEtADF *** addition,rEtADF promoted DC-directed T cell proliferation and differentiation of naive T cells into CD3/CD4T cells in DC/T cell co-incubation *** analysis of rEtADF-pulsed ChDCs showed increased levels of IL-12 and IFN-γ,while IL-10 and TGF-β remained ***,rEtADF-treated ChDCs enhanced production of IFN-γ when incubated with T cells,and IL-4 secretion remained *** findings indicted that rEtADF could facilitate the polarization of Th1 immune cells by triggering both host DCs and T *** findings provide useful insights into future work aimed at anticoccidial vaccine strategies.

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Poly(D,L-lactide-co-glycolide) delivery system improve the protective efficacy of recombinant antigen TA4 against Eimeria tenella infection

Poly(D,L-lactide-co-glycolide) delivery system improve the p...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Jianmei Huang Siying Chen Zhouyang Zhou Xiaoting Sun Muhammad haseeb Shakeel ahmed Lakho Yang Zhang Jiabin Liu Muhammad Ali A Shah Xiaokai Song Lixin Xu Ruofeng Yan 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University Departure of Parasitology and Microbiology PMAS Arid Agriculture University

Eimeria tenella is a protozoan parasite endemic in chickens and is one of the causative agents of avian *** aim of this research was to determine if poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles carrying recombinant TA4 protein of ***(rEtTA4) could improve the level of protective immunity against *** *** TA4 protein was expressed and ***(D,L-lactide-co-glycolide) loaded with rEtTA4(PLGA-rEtTA4) nanoparticles was prepared and was delivered to 2-week-old layer chickens via intramuscular *** injected with PBS and PLGA nanoparticles were served as control *** rEtTA4 and PLGA-rEtTA4 nanoparticles induced changes of serum cytokines,IgY levels,and T lymphocytes subpopulation,and the protective efficacy against *** challenge was *** showed that both rEtTA4 and PLGA-rEtTA4 vaccination groups induced significantly higher levels of specific EtTA4 IgY antibody and IL-17 and higher proportion of CD8 T ***,no significant differences were observed in the proportion of CD4 T lymphocytes compared with the PBS *** immunized with rEtTA4 and PLGA-rEtTA4 prominently increased the BW gains and decreased oocyst output compared with chickens immunized with PBS and PLGA after oral challenge with ***(D,L-lactide-co-glycolide) encapsulated rEtTA4 nanoparticles-immunized chickens significantly induced higher levels of interferon gamma,IL-6,and IL-17 and a little bit higher proportion of CD8+T lymphocytes compared with rEtTA4 subunit vaccine-immunized ***,PLGA encapsulated rEtTA4 nanoparticles appeared to have great potential to enhance the immune response and improved the protective efficacy against *** *** results provided available protective subunit vaccine rEtTA4 and PLGA loaded with rEtTA4 nanoparticles against coccidiosis and suggested that PLGA nanoparticles could be an effective adjuvant to enhance the protective efficacy

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Nanoparticles(PLGA and Chitosan)-Entrapped ADP-Ribosylation Factor 1 of Haemonchus contortus Enhances the Immune Responses in ICR Mice

Nanoparticles(PLGA and Chitosan)-Entrapped ADP-Ribosylation ...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Muhammad Waqqas Hasan Muhammad haseeb Muhammad Ehsan Javaid Ali Gadahi Muhammad Ali-Ul-Husnain Naqvi Qiang Qiang Wang Xinchao Liu Shakeel ahmed Lakho Ruofeng Yan Lixin Xu Xiaokai Song 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

ADP-ribosylation factor 1(HcARF1) is one of the Haemonchus contortus(***)excretory/secretory proteins involved in modulating the immune response of goat peripheral blood mononuclear cells(PBMC).Here,we evaluated the immunogenic potential of recombinant HcARF1(rHcARF1) against *** infection in Institute of Cancer Research(ICR) ***,rHcARF1 was entrapped in poly(D,L-lactide-co-glycolide)(PLGA) and chitosan(CS)nanoparticles(NP) and injected into mice as a ***-six ICR mice were assigned randomly into seven groups,with eight animals in each group,and they were vaccinated *** the end of the experiment(14 th day),the blood and the spleen were collected from euthanized mice to detect lymphocyte proliferation,cytokine analysis,and the production of antigen-specific *** electron microscope was used to determine the size,morphology,and zeta potential of *** cytometry was performed,which presented the increase percentages of CD4+T cells(CD3 e+CD4+),CD8+T cells(CD3 e+CD8+) and dendritic cells(CD11 c+CD83+,CD11 c+CD86+) in mice vaccinated with rHcARF1+PLGA *** analysis show raised humoral(Immunoglobulin(Ig)G1,IgG2 a,IgM) and cell-mediated immune response(Interleukin(IL)-4,IL-12,and IL-17,and Interferon(IFN)-γ)induced by rHcARFl+PLGA *** groups that were treated with the antigen-loaded NP yield higher lymphocyte proliferation than the control *** on these results,we could propose that the rHcARF1 encapsulated in NP could stimulate a strong immune response in mice rather than administering alone against the infection of ***.

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