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Development and Characterization of Calcium Based Biocomposites Using Waste Material (Calcite Stones) for Biomedical Applications

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Materials Sciences and Applications 2024年第5期15卷 113-135页

作者： Tasmim Adry Nuzhat Tabassum Maisha Md. Abdul Gafur Suraya Sabrin Soshi Maruf hasan Department of Biomedical Engineering Military Institute of Science and Technology Dhaka Bangladesh Pilot Plant and Process Development Center Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhaka Bangladesh Department of Mechanical Engineering Ahsanullah University of Science and Tecnology (AUST) Tejgaong Dhaka Bangladesh

Calcium-based biocomposite materials have a pivotal role in the biomedical field with their diverse properties and applications in combating challenging medical problems. The study states the development and characterization of Calcium-based biocomposites: Hydroxyapatite (HAP), and PVA-Gelatin-HAP films. For the preparation of Calcium-based biocomposites, an unconventional source, the waste material calcite stone, was used as calcium raw material, and by the process of calcination, calcium oxide was synthesized. From calcium oxide, HAP was prepared by chemical precipitation method, which was later added in different proportions to PVA-Gelatin solution and finally dried to form biocomposite films. Then the different properties of PVA/Gelatin/HAP composite, for instance, chemical, mechanical, thermal, and swelling properties due to the incorporation of various proportions of HAP in PVA-Gelatin solution, were investigated. The characterization of the HAP was conducted by X-ray Diffraction Analysis, and the characterization of HAP-PVA-Gelatin composites was done by Fourier Transform Infrared Spectroscopy, Thermomechanical Analysis, Tensile test, Thermogravimetric Differential Thermal Analysis, and Swelling Test. The produced biocomposite films might have applications in orthopedic implants, drug delivery, bone tissue engineering, and wound healing.

关键词： Hydroxyapatite Calcium-Based Biocomposites PVA-Gelatin Films Drug Delivery Bone Tissue Engineering

Solitary fibrous tumor:A case report of this multifaceted tumor

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World Journal of Clinical Cases 2024年第25期12卷 5791-5797页

作者： Hani Maalouf Ribal Aby Hadeer Souad Ghattas Omar Tabbikha hasan Numan Raja Wakim Department of General Surgery University of BalamandBeirut 100Lebanon Department of General Surgery Mount Lebanon Hospital University Medical CenterBeirut 7031Lebanon

BACKGROUND Solitary fibrous tumor(SFT)is a remarkably uncommon mesenchymal ***6 level and a combination of clinical,pathological,and molecular features are required to arrive at a proper *** SUMMARY In this report,we present an intriguing case involving a 43-year-old woman who initially exhibited symptoms of a bleeding retroperitoneal tumor,initially resembling a gastrointestinal stromal tumor,but later confirmed as an ***,a year later,what was initially believed to be a recurrence of her SFT was instead identified as a desmoid *** Distinguishing SFT from other tumors was *** misdiagnoses of tumor type initially and of recurrence later was necessary for appropriate treatment of the correct desmoid type.

关键词： Solitary fibrous tumor Retroperitoneal tumor Soft tissue neoplasms Sarcoma NAB2-STAT6 Case report

红花籽粕对小鼠的急性毒性及抗溃疡性结肠炎作用研究

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中草药 2024年第8期55卷 2601-2610页

作者：戚曼王文萱付向磊姜超张亮 MD hasan ALI 李剑楚生辉刘敏石河子大学药学院新疆植物药资源利用教育部重点实验室新疆石河子832003 华东理工大学药学院生物反应器工程国家重点实验室上海200000

目的评价红花籽粕(红花Carthamus tinctorius的种子经过压榨提取红花籽油后的副产品)对小鼠的急性毒性及抗溃疡性结肠炎(ulcerative colitis,UC)作用。方法C57BL/6小鼠ig不同剂量的红花籽粕,7 d后计算脏器指数,采用苏木素-伊红(HE)染色... 详细信息

目的评价红花籽粕(红花Carthamus tinctorius的种子经过压榨提取红花籽油后的副产品)对小鼠的急性毒性及抗溃疡性结肠炎(ulcerative colitis,UC)作用。方法C57BL/6小鼠ig不同剂量的红花籽粕,7 d后计算脏器指数,采用苏木素-伊红(HE)染色观察肝、脾、肾组织病理变化,测定血清中肝功能、肾功能及血脂水平,以评价红花籽粕的急性毒性。建立葡聚糖硫酸钠(dextran sulphate sodium,DSS)诱导的UC小鼠模型,每天记录小鼠体质量,测定疾病活动指数(disease activity index,DAI)评分、结肠长度以及脏器指数,采用HE染色和阿利新蓝-过碘酸雪夫(AB-PAS)染色评价结肠组织病理学变化,采用qRT-PCR和Western blotting检测结肠组织中炎症和黏膜屏障相关因子表达。结果急性毒性实验中,与对照组比较,红花籽粕组小鼠脏器指数、血液生化指标没有显著差异,脏器病理切片也未见异常。红花籽粕对DSS诱导的UC小鼠具有较好的保护作用,可以显著改善体质量减轻、DAI评分升高、结肠长度缩短等临床症状(P<0.01),减轻结肠组织病理损伤,抑制肠道炎症细胞的浸润,保护杯状细胞,提高紧密连接蛋白和黏蛋白的表达(P<0.05、0.01、0.001),改善肠道屏障完整性。结论红花籽粕具有较高的安全性,且对DSS诱导的UC小鼠具有显著的治疗作用。

关键词：红花籽粕急性毒性溃疡性结肠炎炎症肠道屏障

Unsheltered: Navigating California’s Homelessness Crisis

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Journal of Sociology Study 2024年第3期14卷 143-156页

作者： Rakibul hasan Md Abdullah Al Mahmud Sayeda Farjana Farabi Jahanara Akter Fatema Tuz Johora Westcliff University CaliforniaUSA International American University CaliforniaUSA

This paper presents a comprehensive exploration of the complex phenomenon of homelessness in California,with a specific focus on the state’s three largest cities-Los Angeles,San Francisco,and San *** the backdrop of a high cost of living and a housing market strained by insufficient affordable options,the multifaceted nature of social diversity further complicates the landscape,leading to a widespread presence of homelessness that spans both major urban centers and rural *** an in-depth examination of the distinct challenges confronting each city,ranging from housing shortages to intricate social dynamics,this study seeks to illuminate the underlying factors driving homelessness and identify potential avenues for ***,the paper delves into the unique vulnerabilities experienced by certain demographics within the homeless population,including veterans,families with children,and LGBTQ+individuals,highlighting the critical need for targeted solutions tailored to their specific *** synthesizing existing research and incorporating firsthand accounts,this research endeavor aims to contribute to a deeper understanding of homelessness in California and inform the development of comprehensive strategies aimed at fostering inclusive,sustainable communities statewide.

关键词： homeless California veterans children LGBTQ

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 85-94页

作者： Iffat Ara Rita Turcio Tasmia Islam Md.Sabbir Hossain Md.Kamrul hasan Department of Biochemistry and Molecular Biology Tejgaon CollegeNational UniversityGazipur-1700Bangladesh Department of Pharmacy University of Naples Federico IIvia Domenico Montesano49-80131 Napoli NAItaly Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore-7408Bangladesh Department of Public Health North South UniversityDhaka-1229Bangladesh

Background:Licochalcone A(LCA)is a flavonoid derived from the roots of Glycyrrhiza uralensis *** DC and other related *** natural source has been extensively used in complementary medicine,especially traditional Chinese medicine,to treat various *** as a phenolic chalcone compound,LCA has gained significant attention in recent years due to its various pharmacological ***:The objective of this review article is to assess the anti-aging ralated pharmacological properties of ***:An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA,focusing on its therapeutic applications and anti-aging-related pharmacological *** inclusion and exclusion criteria were strictly followed to retrieve updated relevant ***:A collection of 292 papers were screened,and 131 were included in this review for an in-depth analysis of Licochalcone A,focusing on its anti-aging-related pharmacological activities and relevant mechanisms,and its toxicity and side ***,the potential of LCA as a pharmacological product is discussed,emphasizing its health benefits and potential as a pharmaceutical ***:These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.

关键词： Licochalcone A Glycyrrhiza uralensis Chalcone Anti-aging Neuroprotective Antioxidant Skin protection Therapeutic agent

Advanced hepatocellular carcinoma in a patient with neurofibromatosis type 1 and malignant peripheral nerve sheath tumor

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 530-532页

作者： Ahmad Alhaskawi Yan-Zhao Dong Xiao-Di Zou Sohaib hasan Abdullah Ezzi Ze-Wei Wang Hai-Ying Zhou Sahar Ahmed Abdalbary Hui Lu Department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Chinese Medicine the Second Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou 310005China Department of Orthopedics the Third Xiangya HospitalCentral South UniversityChangsha 410083China Zhejiang University School of Medicine Hangzhou 310000China Department of Orthopedic Physical Therapy Faculty of Physical TherapyNahda University in Beni SuefBeni SuefEgypt

To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosome 17, accounting for 96% of all neurofibromatosis cases. This condition can affect multiple systems and often leads to the formation of tumors along the nervous system [1]. Patients with NF-1 may exhibit various symptoms, including Lisch nodules, neurofibromas, scoliosis, café au lait spots, learning disabilities, vision disorders, and epilepsy.

关键词： epilepsy hepatocellular malignant

Adequate Closed Form Wave Solutions to the Generalized KdV Equation in Mathematical Physics

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Journal of Applied Mathematics and Physics 2024年第6期12卷 2069-2082页

作者： Md. Munnu Miah Md. Al Amin Meia Md. Matiur Rahman Sarker Ahammodullah hasan Department of Mathematics Islamic University Kushtia Bangladesh Department of Mathematics Government Titumir College Dhaka Bangladesh Department of Pharmacy University of Asia Pacific Dhaka Bangladesh

In this paper, we consider the generalized Korteweg-de-Vries (KdV) equations which are remarkable models of the water waves mechanics, the shallow water waves, the quantum mechanics, the ion acoustic waves in plasma, the electro-hydro-dynamical model for local electric field, signal processing waves through optical fibers, etc. We determine the useful and further general exact traveling wave solutions of the above mentioned NLDEs by applying the exp(−τ(ξ))-expansion method by aid of traveling wave transformations. Furthermore, we explain the physical significance of the obtained solutions of its definite values of the involved parameters with graphic representations in order to know the physical phenomena. Finally, we show that the exp(−τ(ξ))-expansion method is convenient, powerful, straightforward and provide more general solutions and can be helping to examine vast amount of travelling wave solutions to the other different kinds of NLDEs.

关键词： The Generalized KdV Equation The exp(-τ(ξ)) -Expansion Method Travelling Wave Solitary Wave

Innovations in endoscopic ultrasound for portal hypertension and its role in managing complications in clinical practice:Lessons learned from a tertiary referral public hospital

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Portal Hypertension & Cirrhosis 2024年第1期3卷 31-35页

作者： Cosmas R.A.Lesmana Kemal F.Kalista Saut H.H.Nababan Juferdy Kurniawan Chyntia O.M.Jasirwan Andri S.Sulaiman Irsan hasan Rino A.Gani Department of Internal Medicine Hepatobiliary DivisionDr.Cipto Mangunkusumo National General HospitalMedical Faculty Universitas IndonesiaJakartaIndonesia Digestive Disease&GI Oncology Center Medistra HospitalJakartaIndonesia Gastrointestinal Cancer Center MRCCC Siloam Semanggi HospitalJakartaIndonesia

Portal hypertension(PH)poses significant *** paper presents an innovative study on the utilization of endoscopic ultrasound(EUS)for both the diagnosis and management of *** at *** Mangunkusumo National General Hospital in Jakarta,this retrospective case series included patients diagnosed with PH through clinical examination,imaging evaluation,and *** criteria comprised a history of reduced blood consumption within the last 5 days,hepatocellular carcinoma,massive ascites,or elevated international normalized ratio(>1.4).EUS-guided portal pressure gradient(PPG)measurements were performed using an innovative standard *** study involved 15 patients,with 14 having liver cirrhosis and 1 diagnosed with Budd–Chiari *** them,nine patients experienced bleeding due to gastroesophageal *** and large esophageal varices were identified in four and eight patients,*** varices type 1 were observed in two patients,and type 2 in four *** gastric fundal varices type 1 were present in one *** on EUS-PPG measurements,14 patients exhibited clinically significant portal *** patients underwent endoscopic band ligation and three underwent EUS-guided cyanoacrylate injection during the same session as the EUS-PPG measurement ***,no adverse events,such as abdominal pain,perforation,or bleeding were observed during or after the *** emerges as a promising and accurate tool for both diagnosis and management.

关键词： cyanoacrylate injection endoscopic ultrasound liver cirrhosis portal hypertension portal pressure gradient

A Framework for Driver DrowsinessMonitoring Using a Convolutional Neural Network and the Internet of Things

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Intelligent Automation & Soft Computing 2024年第2期39卷 157-174页

作者： Muhamad Irsan Rosilah Hassan Anwar Hassan Ibrahim Mohamad Khatim hasan Meng Chun Lam Wan Mohd Hirwani Wan Hussain School of Computing Telkom UniversityBandung40257Indonesia Faculty of Information Science and Technology Universiti Kebangsaan MalaysiaBangi43600Malaysia Department of Electrical Engineering College of EngineeringQassim UniversityAl-Gassim51411Saudi Arabia Graduated School of Business Universiti Kebangsaan MalaysiaBangi43600Malaysia

One of the major causes of road accidents is sleepy *** accidents typically result in fatalities and financial losses and disadvantage other road *** studies have been conducted to identify the driver’s sleepiness and integrate it into a warning *** studies have examined how the mouth and eyelids ***,this limits the system’s ability to identify drowsiness ***,this study designed an Accident Detection Framework(RPK)that could be used to reduce road accidents due to sleepiness and detect the location of *** drowsiness detectionmodel used three facial parameters:Yawning,closed eyes(blinking),and an upright head *** model used a Convolutional Neural Network(CNN)consisting of two *** initial phase involves video processing and facial landmark coordinate *** second phase involves developing the extraction of frame-based features using normalization *** these phases used OpenCV and *** dataset contained 5017 images with 874 open eyes images,850 closed eyes images,723 open-mouth images,725 closed-mouth images,761 sleepy-head images,and 1084 non-sleepy head *** dataset of 5017 images was divided into the training set with 4505 images and the testing set with 512 images,with a ratio of 90:*** results showed that the RPK design could detect sleepiness by using deep learning techniques with high accuracy on all three parameters;namely 98%for eye blinking,96%for mouth yawning,and 97%for head ***,the test results have provided an overview of how the developed RPK prototype can accurately identify drowsy *** findings will have a significant impact on the improvement of road users’safety and mobility.

关键词： Drowsy drivers convolutional neural network openCV microprocessor face detection