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Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World Journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： hasan m isa marwa J Abdulnabi Nawra S Naser Fatema N Lahmda Noor m AlAnsari Zahra H isa Afaf m mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CmPA).AIm To evaluate CmPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CmPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya medical Complex,Bahrain,between 2014 and 2022,and assessed CmPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CmPA and 595(96.3%)were included;CmPA prevalence was 2%.most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CmPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Pmore cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pmediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CmPA was associated with a longer follow-up duration than non-IgE-mediated CmPA(17.3 months±14.0 mo

关键词： Children milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

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Fever assessment in children under five: Are we following the guidelines?

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World Journal of Clinical Pediatrics 2024年第1期13卷 62-72页

作者： hasan m isa Ahmed J isa murtadha A Alnasheet mahmood m mansoor Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of General Surgery Salmaniya Medical ComplexManama 26671Bahrain

BACKGROUND Fever is a common cause of medical consultation and hospital admission,particularly among ***,the United Kingdom’s National Institute for Health and Care Excellence(NICE)updated its guidelines for assessing fever in children under five years of *** efficient assessment and management of children with fever are crucial for improving patient *** To evaluate fever assessment in hospitalized children and to assess its adherence with the NICE Fever in under 5s *** We conducted a retrospective cohort review of the electronic medical records of children under five years of age at the Department of Pediatrics,Salmaniya medical Complex,Bahrain,between June and July *** data,vital signs during the first 48 h of admission,route of temperature measurement,and indications for admission were *** was defined according to the NICE *** children were divided into five groups according to their age(0-3 months,>3-6 months,>6-12 months,>12-36 months,and>36-60 months).Patients with and without fever were compared in terms of demography,indication for admission,route of temperature measurement,and other vital *** with the NICE Fever in the under 5s guideline was *** compliance was defined as>95%,partial compliance as 70%-95%,and minimal compliance as≤69%.Pearson’sχ^(2),Student’s t test,the mann-Whitney U test,and Spearman’s correlation coefficient(rs)were used for *** Of the 136 patients reviewed,80(58.8%)were *** median age at admission was 14.2[interquartile range(IQR):1.7-44.4]months,with the most common age group being 36-60 ***-six(26.4%)patients had fever,and 100(73.6%)were *** commonest age group for febrile patients(>12-36 months)was older than the commonest age group for afebrile patients(0-3 months)(P=0.027).The median weight was 8.3(IQR:4.0-13.3)*** with fever had higher weight than those without fever[10.2(IQR:7.3-13.0)vs 7

关键词： Fever Pediatrics Admission patterns Temperature measurement Guidelines Bahrain

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Accidental ingestion of foreign bodies/harmful materials in children from Bahrain:A retrospective cohort study

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World Journal of Clinical Pediatrics 2023年第4期12卷 205-219页

作者： hasan m isa Shaikha A Aldoseri Aysha S Abduljabbar Khaled A Alsulaiti Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Radiology Salmaniya Medical ComplexManama 26671Bahrain

BACKGROUND Children like to discover their environment by putting substances in their *** behavior puts them at risk of accidentally ingesting foreign bodies(FBs)or harmful materials,which can cause serious *** To study the clinical characteristics,diagnosis,complications,management,and outcomes of accidental ingestion of FBs,caustics,and medications in *** We conducted a retrospective cohort study of all children admitted for accidental ingestion to the Department of Pediatrics,Salmaniya medical Complex,Bahrain,between 2011 and *** data,type of FB/harmful material ingested,and investigations used for diagnosis and management were *** patients were divided into three groups based on the type of ingested material(FBs,caustics,and medications).The three groups were compared based on patient demographics,socioeconomic status(SES),symptoms,ingestion scenario,endoscopic and surgical complications,management,and *** FB anatomical location was categorized as the esophagus,stomach,and bowel and compared with respect to *** Fisher’s exact,Pearson’s χ^(2),mann-Whitney U,and Kruskal-Wallis tests were used for *** A total of 161 accidental ingestion episodes were documented in 153 *** children were boys(n=85,55.6%),with a median age of 2.8(interquartile range:1.8-4.4)*** participants ingested FBs(n=108,70.6%),31(20.3%)ingested caustics,and the remaining 14(9.2%)ingested *** with caustic ingestion were younger at the time of presentation(Pmore symptomatic(n=26/31,89.7%)than those who ingested medications(n=8/14,57.1%)or FBs(n=52/108,48.6%)(Pmore vomiting(Pmptomatic(n=55/108,51.4%).In terms of FB location,most esophageal FBs were symptomatic(n=14/16,87.5%),whereas most gastric(n=34/56,60.7%)and intestinal FBs(n=19/32,59.4%)were asymptomati

关键词： Pediatric Accidental ingestion Foreign body Caustic Complication Bahrain

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Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities

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World Journal of Transplantation 2024年第1期14卷 96-111页

作者： hasan m isa Fatema A Alkharsi Jawad K Khamis Sawsan A hasan Zainab A Naser Zainab N mohamed Afaf m mohamed Shaikha A Altamimi Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of medicine Salmaniya Medical ComplexManama 26671Bahrain Public Health Directorate Ministry of HealthManama 26671Bahrain The Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BACKGROUND Liver transplantation(LT)is a life-saving procedure for patients with end-stage liver disease and has become the standard and most effective treatment method for these *** are many indications for LT that vary between countries and *** outcome of LT depends on the available facilities and surgical expertise,as well as the types of liver graft donors *** To assess the clinical characteristics of patients from Bahrain who underwent LT overseas,and analyze factors affecting their *** In this retrospective cohort study,we reviewed the medical records and overseas committee registry information of all pediatric and adult patients who were sent overseas to undergo LT by the Pediatric and medical Departments of Salmaniya medical Complex and Bahrain Defence Force Hospital via the Overseas Treatment Office,ministry of Health,Kingdom of Bahrain,between 1997 and *** data,LT indication,donor-recipient relationship,overseas LT center,graft type,post-LT medications,and LT complications,were *** measured included the overall and 5-year LT survival ***’s exact,Pearsonχ2,and mann-Whitney U tests were used to compare the pediatric and the adults’group in terms of clinical characteristics,donor-recipient relationship,medication,complications,and *** analysis was estimated via the Kaplan-meier’s *** and multivariate analyses were used to detect predictors of *** Of the 208 eligible patients,170(81.7%)were sent overseas to undergo LT while 38(18.3%)remained on the waiting *** the 170 patients,167(80.3%)underwent LT and were included in the *** majority of the patients were Bahraini(91.0%),and most were males(57.5%).One-hundred-and-twenty(71.8%)were adults and 47(28.3%)were *** median age at transplant was 50.0[interquartile range(IQR):14.9–58.4]*** main indication for pediatric LT was biliary atresia(31.9%),while that of adult LT was

关键词： Overseas liver transplantation End-stage liver disease Liver transplant facilities Liver donor Biliary atresia Hepatitis C

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Hepatic involvement in children with acute bronchiolitis

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World Journal of Hepatology 2022年第10期14卷 1907-1919页

作者： hasan m isa Asma Z hasan Sara I Khalifa Sana S Alhewaizem Abdulrahman D mahroofi Fatema N Alkhan mohammed Al-Beltagi Department of Pediatrics Salmaniya Medical ComplexManama 12Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Pediatrics Sulwan Psychiatric HospitalManama 973Bu QuwahBahrain Department of Pediatrics Dream Reem Medical CenterMuharraq 50573Bahrain Department of Pediatrics King Hamad University HospitalMuharraq 24343Bahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31527AlgharbiaEgypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Department of Pediatrics University Medical CenterDr.Sulaiman Al-Habib Medical GroupBahrainManama 26671Bahrain

BACKGROUND Respiratory syncytial virus(RSV)is a prevalent cause of lower respiratory tract *** may be associated with hepatocellular involvement,as indicated by increased liver enzymes aspartate aminotransferase and alanine transaminase(ALT).AIm To evaluate the rate of increased liver enzyme levels in children with acute bronchiolitis and correlate them with clinical,laboratory,and radiological *** The study was a retrospective review of the medical records of children who presented with acute bronchiolitis when admitted to the Pediatric Department,Salmaniya medical Complex,the Kingdom of Bahrain,between 2019 and *** collected the demographic data,the clinical presentation,the laboratory and radiological findings,and the clinical *** compared the patients with elevated liver enzymes to those with normal levels at the time of presentation and at *** We included 166(57.8%)of 287 patients with acute bronchiolitis who fulfilled the inclusion ***-three(56%)patients were *** median age at presentation was 3.4(interquartile range 1.1 to 12.4)***-four(28%)patients tested positive for RSV,which was confirmed in 15 of them(28%)by *** findings of 161 patients tested at presentation showed high ALT levels in 14(8.7%)patients and normal ALT in 147(91.3%).Coagulation profiles were measured in 46(27.7%)of 166 *** prothrombin time was present in 15(32.6%),a high international normalized ratio was present in 13(28.3%),and high activated partial thromboplastin time was present in three(6.5%).Thrombin time was elevated in nine(27.3%)of 33 ***(21.7%)of 23 patients with available radiological data had hepatomegaly;one of them had findings suggestive of fatty *** ALT had a significant association with lengthy hospital stays(Pmented follow-up with liver function tests over a median follow-up period of

关键词： involvement elevated bronchiolitis

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Causes of gastrointestinal bleeding in children based on endoscopic evaluation at a tertiary care center in Bahrain

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World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 297-308页

作者： hasan m isa Fatema A Alkharsi Hana A Ebrahim Kamel J Walwil Jumana A Diab Nafelah m Alkowari Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Pediatrics Royal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503Bahrain Department of Pediatrics King Hamad University HospitalMuharraq 24343Bahrain

BACKGROUND Gastrointestinal bleeding(GIB)is a serious health problem worldwide,particularly during *** can be an alarming sign of an underlying *** endoscopy(GIE)is a safe method for the diagnosis and treatment of GIB in most *** To determine the incidence,clinical presentation,and outcomes of GIB in children in Bahrain over the last two *** This was a retrospective cohort review of the medical records of children with GIB who underwent endoscopic procedures in the Pediatric Department at Salmaniya medical Complex,Bahrain,between 1995 and *** data,clinical presentation,endoscopic findings,and clinical outcomes were *** was classified into upper(UGIB)and lower(LGIB)GIB according to the site of *** were compared with respect to patients’sex,age,and nationality using the Fisher’s exact,Pearson’sχ2,or the mann-Whitney U *** A total of 250 patients were included in this *** median incidence was 2.6/100000 per year(interquartile range,1.4-3.7)with a significantly increasing trend over the last two decades (P most patients were males (n = 144, 57.6%). Themedian age at diagnosis was 9 years (5-11). Ninety-eight (39.2%) patients required upper GIEalone, 41 (16.4%) required colonoscopy alone, and 111 (44.4%) required both. LGIB was morefrequent (n = 151, 60.4%) than UGIB (n = 119, 47.6%). There were no significant differences in sex (P = 0.710), age (P = 0.185), or nationality (P = 0.525) between the two groups. Abnormalendoscopic findings were detected in 226 (90.4%) patients. The common cause of LGIB was inflammatorybowel disease (IBD) (n = 77, 30.8%). The common cause of UGIB was gastritis (n = 70, 28%).IBD and undetermined cause for bleeding were higher in the 10-18 years group (P = 0.026 and P =0.017, respectively). Intestinal nodular lymphoid hyperplasia, foreign body ingestion, andesophageal varices were more common in the 0-4 years group (P = 0.034, P < 0.0001

关键词： Pediatric Gastrointestinal bleeding Endoscopy Causes Outcome Bahrain

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Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the middle East:a modified Delphi-based study

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World Journal of Pediatrics 2021年第6期17卷 576-589页

作者： moustafa A.El-Hodhod mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein Am Almehaidib Basil Nasrallah Ebtsam mohammed AIBassam Hala El Feghali hasan m.isa Khaled Al Saraf maroun Sokhn mehdi Adeli Najwa mohammed mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi Department of Pediatrics Faculty of MedicineAin Shams UniversityCairoEgypt Faculty of medicine October 6 UniversityGizaEgypt Faculty of medicine Cairo UniversityCairoEgypt International Pediatric Association(IPA) MarengoUSA International Society of Tropical Pediatrics(ISTP) ManilaPhilippines DRC Hospital MuscatOman Al Amiri and Al Adan Hospitals KuwaitKuwait Pediatric Gastroenterology Department of PediatricsKing Faisal Specialist Hospital and Research Center RiyadhRiyadhSaudi Arabia American Hospital Dubai DubaiUnited Arab Emirates Nutrition Service Department King Faisal Specialist and Research Center RiyadhRiyadhSaudi Arabia CHU Notre Dame de Secours ByblosLebanon Pediatric Department Salmaniya Medical ComplexManamaBahrain Pediatric department Arabian Gulf UniversityManamaBahrain Pediatrics Department Dar Al Shifa HospitalKuwaitKuwait Pediatric Gastroenterology Hepatologyand Nutrition DepartmentSaint George University Medical CenterUniversity of BalamandBeirutLebanon Sidra medicine DohaQatar Department of Pediatrics Doctor Sulaiman Alhabib Medical GroupAlrryan BranchRiyadhSaudi Arabia Pediatric Pulmonology and Allergology University of BalamandBeirutLebanon College of medicine Mohanuned Bin Rashid University of Medicine and Health SciencesBuilding 14505055 DubaiUnited Arab Emirates

Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CmPA)in the middle *** A three-step modified Delphi method was utilized to develop the *** specialized pediatricians participated in the development of this *** statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected ***-fed infants with confirmed CmPA should be offered a therapeutic *** panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag *** the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic *** panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional *** the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional *** cases with no symptomatic improvements after the introduction of an *** measures should be *** panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CmPA in the middle East.

关键词： Consensus Cow's milk protein allergy Infant formula middle East milk hypersensitivity

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Ru/NimnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： md Ahasan Habib Shusen Lin mehedi hasan Joni Sumiya Akter Dristy Rutuja mandavkar Jae-Hun Jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NimnB spherical cluster pillar （SCP）,denoted as Ru/NimnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NimnB matrix revealed significant improvements in electrocatalytic *** Ru/NimnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 m KOH,making them highly competitive with state-of-the-art ***,the Ru/NimnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 m KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NimnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 m KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NimnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NimnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Potassium hydroxide

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Effect of Bohm quantum potential in the propagation of ion–acoustic waves in degenerate plasmas

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Chinese Physics B 2016年第10期25卷 222-229页

作者： m m hasan m A Hossen A Rafat A A mamun Department of Physics Jahangirnagar University

A theoretical investigation has been carried out on the propagation of the ion–acoustic(IA) waves in a relativistic degenerate plasma containing relativistic degenerate electron and positron fluids in the presence of inertial non-relativistic light ion fluid. The Korteweg-de Vries(K-dV), modified K-dV(m K-dV), and mixed m K-dV(mm K-dV) equations are derived by adopting the reductive perturbation method. In order to analyze the basic features(phase speed, amplitude, width,etc.) of the IA solitary waves(SWs), the SWs solutions of the K-dV, m K-dV, and mm K-d V are numerically analyzed. It is found that the degenerate pressure, inclusion of the new phenomena like the Fermi temperatures and quantum mechanical effects(arising due to the quantum diffraction) of both electrons and positrons, number densities, etc., of the plasma species remarkably change the basic characteristics of the IA SWs which are found to be formed either with positive or negative potential. The implication of our results in explaining different nonlinear phenomena in astrophysical compact objects, e.g.,white dwarfs, neutron stars, etc., and laboratory plasmas like intense laser–solid matter interaction experiments, etc., are mentioned.

关键词： Bohm quantum potential degenerate relativistic plasma electron and positron quantum effect

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Rice plant growth and yield: foliar application of plasma activated water

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Plasma Science and Technology 2021年第7期23卷 134-143页

作者： m m RASHID mamunur RASHID m m hasan m R TALUKDER Plasma Science and Technology Lab Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology and mycology Lab Department of BotanyUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology Lab Department of Agronomy and Agricultural ExtensionUniversity of RajshahiRajshahi 6205Bangladesh

Plasma activated water(PAW)was prepared for 10 min to be applied one toﬁve times as a foliar spray to rice plants,to investigate plant growth,yield and the concentrations of total soluble protein and sugar in the rice grains *** results reveal that(1)the plant height,stem diameter,dry weight,chlorophyll and total carotene concentrations were improved by∼15%,∼25%,∼24%,∼47%and∼45%,respectively,with respect to control,(2)defense mechanisms of the plants treated with PAW were improved,(3)concentrations of total soluble protein and sugar were enhanced in the rice grains of PAW treated plants and(4)yield was increased by∼14%.

关键词： plasma agriculture plasma activated water rice plant growth rice yield total soluble protein

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