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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Critical review of cyclist speed measuring techniques

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 98-110页

作者： ali Kassim hasan Tayyeb Mubark al-Falahi Department of Civil and Environmental Engineering Carleton UniuersityOttawaON K1S 5B6Canada Department of Civil Engineering Umm Al-Qura UniversityMakkahSaudi Arabia Department of Urban Planning&Municipalities Municipal Operations SectorMadinat Zayed Center-Technical Services DepartmentAbu-DhabiUnited Arab Emirates

There is a growing global interest in developing and accommodating sustainable modes of *** is an important mode of travel which offers powerful solutions to chronic traffic problems of congestion and *** accuracy of cyclist position is considered as an important parameter for the calculation of cyclist *** speed data is required for precise design of traffic control measures,for safety studies,and for sight distance *** speed measurement techniques and results are found in the *** study critically examines peer-reviewed studies which discuss different techniques for measuring cyclist *** review covers the accuracy of the measurement techniques and highlights limitations of the reviewed *** identified limitations are classified as:limited range of movement directions,selection of observed cyclists,seasonal variation in measurements,completeness of results reporting,reporting of equipment limitations,and measurement *** study summarizes previous findings of cyclist speed *** study also reviews the level of automation in speed *** technique involving a human input during the field data collection or analysis to estimate cyclist speed is classified as a *** categories for semiautomated and automated measurement techniques are ***-analysis was conducted to test whether reported cyclist speed depends on where they were recorded;intersections or road *** result of the unpaired t-test showed that there is no significant difference between the means of the cyclists speed at road sections and signalized intersections at the 95%of confidence *** study emphasizes the growing importance of the use of automated computer vision techniques for speed *** paper contrasts the advantages of computer vision techniques with other measurement techniques.

关键词： Transportation engineering Cyclist speed Video analysis Signalized intersection

Diet fortification for mild and moderate picky eating in typically developed children:Opinion review of Middle East consensus

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World Journal of Clinical Pediatrics 2025年第1期14卷 139-148页

作者： Mohammed al-Beltagi Elie Choueiry Najat alahmadi Zeinab Demerdash Wafaa Helmi Ayesh Khoula al-Said Fatima al-Haddad Sanaa Y Shaaban Eslam Tawfik Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511Egypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Paediatric Intensive and Critical Care Unit Hospital Hôtel Dieu de FranceBeirut 166830BeyrouthLebanon Department of Pediatric Gastroenterology Hepatology and NutritionMadina Maternity and Children HospitalKing Salman Medical CityAlmadina Almonawarh 41412Almadina AlmonawarhSaudi Arabia Department of Gastroenterology Hepatology and NutritionAl Amiri HospitalKuwait City 999044Kuwait Department of Nutrition Altadawi Speciality HospitalDubai 1853DubayyUnited Arab Emirates Department of Paediatric Gastroenterology Royal HospitalMuscat 1331MuscatOman Department of Dietetic Salmaniya Medical ComplexGovernment HospitalsAl Salmaniya 12ManamaBahrain Department of Pediatrics Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Paediatric Faculty of MedicineSuez UniversitySuez 41522Egypt Department of Paediatric Sheikh Khalifa Medical CityAbu Dhabi 00000Abu DhabiUnited Arab Emirates

BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental *** common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this *** to the unavailability of data regarding picky eating,it wasn’t easy to estimate its *** To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating *** A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky *** discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet *** The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar *** of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet *** attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their *** dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle *** The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern *** recommendations would facilitate identifying and managing picky-eating children in the Middle East.

关键词： Picky eating Diet fortification Children Protocol Roundtable discussion Middle East

Impact of Portable Executable Header Features on Malware Detection Accuracy

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Computers, Materials & Continua 2023年第1期74卷 153-178页

作者： hasan H.al-Khshali Muhammad Ilyas Electrical and Computer Engineering Altinbas UniversityIstanbulTurkey Electrical and Electronics Engineering Altinbas UniversityIstanbulTurkey

One aspect of cybersecurity,incorporates the study of Portable Executables(PE)files *** Intelligence(AI)can be employed in such studies,since AI has the ability to discriminate benign from malicious *** this study,an exclusive set of 29 features was collected from trusted implementations,this set was used as a baseline to analyze the presented work in this research.A Decision Tree(DT)and Neural Network Multi-Layer Perceptron(NN-MLPC)algorithms were utilized during this *** algorithms were chosen after testing a few diverse *** work implements a method of subgrouping features to answer questions such as,which feature has a positive impact on accuracy when added?Is it possible to determine a reliable feature set to distinguish a malicious PE file from a benign one?when combining features,would it have any effect on malware detection accuracy in a PE file?Results obtained using the proposed method were improved and carried few ***,the obtained results had practical and numerical parts,for the practical part,the number of features and which features included are the main factors impacting the calculated accuracy,also,the combination of features is as crucial in these *** results included,finding accuracies with enhanced values,for example,NN_MLPC attained 0.979 and 0.98;for DT an accuracy of 0.9825 and 0.986 was attained.

关键词： AI driven cybersecurity artificial intelligence cybersecurity Decision Tree Neural Network Multi-Layer Perceptron Classifier portable executable(PE)file header features

From plasma to plasmonics:toward sustainable and clean water production through membranes

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Frontiers of Chemical Science and Engineering 2023年第12期17卷 1809-1836页

作者： Farah Abuhatab Omar Khalifa Husam al Araj Shadi W.hasan Center for Membranes and Advanced Water Technology(CMAT) Khalifa University of Science and Technology127788 Abu DhabiUnited Arab Emirates Department of Chemical Engineering Khalifa University of Science and Technology127788 Abu DhabiUnited Arab Emirates Department of Chemical and Environmental Engineering Yale UniversityNew HavenCT 06520USA

The increasing demand for potable water is *** resources are scarce and stress is accumulating on other ***,new technologies and novel optimization methods are developed for the existing ***-based processes are among the most efficient methods for water ***,membranes suffer from severe operational problems,namely fouling and temperature *** effects can harm the membrane’s permeability,permeate recovery,and *** mitigate such effects,membranes can be treated through two techniques:plasma treatment(a surface modification technique),and treatment through the use of plasmonic materials(surface and bulk modification).This article showcases plasma-and plasmonic-based treatments in the context of water desalination/*** aims to offer a comprehensive review of the current developments in membrane-based water treatment technologies along with suggested directions to enhance its overall efficiency through careful selection of material and system ***,basic guidelines and strategies are outlined on the different membrane modification techniques to evaluate its ***,we discuss the challenges and future developments about these membrane modification methods.

关键词： water treatment membrane-based process plasma treatment plasma polymerization plasmonic light-to-heat conversion

Attractive Multistep Reproducing Kernel Approach for Solving Stiffness Differential Systems of Ordinary Differential Equations and Some Error Analysis

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Computer Modeling in Engineering & Sciences 2022年第1期130卷 299-313页

作者： Radwan Abu-Gdairi Shatha hasan Shrideh al-Omari Mohammad al-Smadi Shaher Momani Department of Mathematics Faculty of ScienceZarqa UniversityZarqa13132Jordan Department of Applied Science Ajloun CollegeAl-Balqa Applied UniversityAjloun26816Jordan Department of Physics and Basic Sciences Faculty of Engineering TechnologyAl-Balqa Applied UniversityAmman11134Jordan Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman20550United Arab Emirates Department of Mathematics Faculty of ScienceThe University of JordanAmman11942Jordan

In this paper,an efficient multi-step scheme is presented based on reproducing kernel Hilbert space(RKHS)theory for solving ordinary stiff differential *** solution methodology depends on reproducing kernel functions to obtain analytic solutions in a uniform formfor a rapidly convergent series in the posed Sobolev *** the Gram-Schmidt orthogonality process,complete orthogonal essential functions are obtained in a compact field to encompass Fourier series expansion with the help of kernel properties ***,by applying the standard RKHS method to each subinterval,approximate solutions that converge uniformly to the exact solutions are *** this purpose,several numerical examples are tested to show proposed algorithm’s superiority,simplicity,and *** gained results indicate that themulti-step RKHSmethod is suitable for solving linear and nonlinear stiffness systems over an extensive duration and giving highly accurate outcomes.

关键词： Multi-step approach reproducing kernel Hilbert space method stiffness system error analysis numerical solution

2D Nanomaterials for Effective Energy Scavenging

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Nano-Micro Letters 2021年第5期13卷 151-191页

作者： Md al Mahadi hasan Yuanhao Wang Chris R.Bowen Ya Yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China SUSTech Engineering Innovation Center School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055People’s Republic of China Department of Mechanical Engineering University of BathBath BA27AKUK School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China

The development of a nation is deeply related to its energy consumption.2D nanomaterials have become a spotlight for energy harvesting applications from the small-scale of low-power electronics to a large-scale for industry-level applications,such as self-powered sensor devices,environmental monitoring,and large-scale power *** from around the world are working to utilize their engrossing properties to overcome the challenges in material selection and fabrication technologies for compact energy scavenging devices to replace batteries and traditional power *** this review,the variety of techniques for scavenging energies from sustainable sources such as solar,air,waste heat,and surrounding mechanical forces are discussed that exploit the fascinating properties of 2D *** addition,practical applications of these fabricated power generating devices and their performance as an alternative to conventional power supplies are discussed with the future pertinence to solve the energy problems in various fields and applications.

关键词： 2D nanomaterials Solar energy Tribo-/piezo-/thermo-/pyro-electricity Osmotic power generation Self-powered sensor

Chloride ingress and macro-cell corrosion of steel in concrete made with recycled brick aggregate

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Frontiers of Structural and Civil Engineering 2021年第6期15卷 1358-1371页

作者： Tarek Uddin MOHAMMED Mahfuzur RAHMAN Ahmed SABBIR Mohammad Mehedi hasan Abdullah al MAMUN Department of Civil and Environmental Engineering Islamic University of TechnologyBoard BazarGazipur 1704Bangladesh Department of Civil Engineering University of Information Technology and SciencesBaridharaDhaka 1202Bangladesh Bangladesh Road Research Laboratory Roads and Highways DepartmentMirpurDhaka 1216Bangladesh

An investigation on chloride ingress and macro-cell corrosion of steel bars in concrete made with recycled brick aggregate(RBA)was carried *** control cases,virgin brick aggregate(BA)and stone aggregate(SA)were also *** cylindrical and cracked prism specimens were studied for 16 different *** prism specimens were made with a segmented steel bar providing electrical connection from outside of the specimens to measure macro-cell corrosion current continuously under seawater splash exposure for a period of 30 d using a data *** specimens were submerged in 3%NaCl solution at a temperature of 40℃ to investigate chloride ingress in concrete made with RBA,BA,and SA after 120 and 180 ***-cell potential,corrosion area,and depths of corrosion were also *** chloride ingress as well as corrosion of steel bars in concrete made with the different types of aggregate is ordered as RBA>BA>SA.

关键词： brick aggregate chloride ingress macro-cell corrosion recycled brick aggregate

Discharging of PCM in Various Shapes of Thermal Energy Storage Systems:A Review

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Journal of Thermal Science 2023年第3期32卷 1124-1154页

作者： DHAIDAN Nabeel HASHIM hasan ABBAS Abdalrazzaq KHODADADI Jay alMOSAWY Wala al-MOUSAWI Fadhel Engineering Faculty Kerbala UniversityKerbalaIraq Department of Mechanical Engineering Auburn University1418 Wiggins HallAuburnAL 36849-5341USA al-Zahraa University for Women KerbalaIraq

Utilizing the phase change materials in different thermal storage applications attains valuable attention due to the fascinating thermal properties of these *** comprehension of the thermal behaviour of phase change materials during the melting and solidification is considered a significant priority in designing the shape of the different *** this review,analytical,computational and experimental investigations that address solidification/freezing of phase change materials within thermal energy storage systems are *** is placed on the role of the shape of adopted containers encompassing planar,spherical,cylindrical and annular *** storage for solar thermal applications,waste heat recovery,and thermal management of buildings/computing platforms/photovoltaics has been the topics that benefit from these *** all container shapes,the freezing process is controlled initially by natural convection,and a high solidification rate is ***,the conduction dominates the process,and the freezing rate *** temperature and flow of cooling heat transfer fluid affect the solidification process,but the impact of heat transfer fluid temperature is more significant than its flow ***,the freezing time increases with the container’s size and amount of contained *** aspect ratio of the planar and vertical cylindrical cavities substantially influences the discharging time and *** contrast,the orientation of the annular cavity has a lower impact on the discharging process.

关键词： containers freezing phase change materials phase transformation solidification