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Effects of Religious vs. Conventional Cognitive-Behavioral Therapy on Inflammatory Markers and Stress Hormones in Major Depression and Chronic Medical Illness: A Randomized Clinical Trial

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Open Journal of Psychiatry 2015年第3期5卷 238-259页

作者： Lee S. Berk Denise L. Bellinger Harold G. Koenig Noha Daher Michelle J. Pearce Clive J. Robins Bruce Nelson Sally F. Shaw harvey jay cohen Michael B. King Allied Health Studies School of Allied Health Professions Loma Linda University Loma Linda USA Department of Pathology and Human Anatomy School of Medicine Loma Linda University Loma Linda USA Center for Spirituality Theology and Health Duke University Durham USA Department of Psychiatry and Behavioral Sciences Duke University Medical Center Durham USA Department of Medicine Duke University Medical Center Durham USA Department of Medicine King Abdulaziz University Jeddah Saudi Arabia Epidemiology Biostatistics and Population Medicine School of Public Health Loma Linda University Loma Linda USA School of Medicine University of Maryland Baltimore USA Department of Psychology and Neuroscience Duke University Medical Center Durham USA Department of Research Glendale Adventist Medical Center Glendale USA Division of Psychiatry Faculty of Brain Sciences University College London UK

Background: Depressive disorder is often accompanied by physiological changes that may adversely affect the course of medical illness, including an increase in pro-inflammatory cytokines. Methods: We examine the effects of religious cognitive behavioral therapy (RCBT) vs. conventional CBT (CCBT) on pro-/anti-inflammatory indicators and stress hormones in 132 individuals with major depressive disorder (MDD) and chronic medical illness who were recruited into a multi-site randomized clinical trial. Biomarkers (C-reactive protein and pro-inflammatory cytokines TNF-α, IL-1β, IFN-γ, IL-6, IL-12-p70), anti-inflammatory cytokines (IL1ra, IL-4, IL-10), and stress hormones (urinary cortisol, epinephrine, norepinephrine) were assessed at baseline, 12 weeks, and 24 weeks. Differential effects of baseline religiosity on treatment response were also examined, along with effects of religiosity on changes in biomarkers over time independent of treatment group. Biomarker levels were log transformed where possible to normalize distributions. Mixed models were used to examine trajectories of change. Results: CRP increased and IL-4, IL-10, and epinephrine decreased over time, mostly in the opposite direction expected (except epinephrine). No significant difference between RCBT and CCBT was found on average trajectory of change in any biomarkers. Religiosity interacted with treatment group in effects on IL-6, such that CCBT was more effective than RCBT in lowering lL-6 in those with low religiosity whereas RCBT appeared to be more effective than CCBT in those with high religiosity. Higher baseline religiosity also tended to predict an increase in pro-inflammatory cytokines INF-γ and IL-12 (p70) and urinary cortisol over time. Conclusions: RCBT and CCBT had similar effects on stress biomarkers. CCBT was more effective in reducing IL-6 levels in those with low religiosity, whereas RCBT tended to be more effective in those with high religiosity. Unexpectedly, higher baseline religiosity w

关键词： Cognitive Behavioral Therapy Religion Depression Inflammation Immune Function Stress Hormones

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Religious Involvement, Inflammatory Markers and Stress Hormones in Major Depression and Chronic Medical Illness

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Open Journal of Psychiatry 2014年第4期4卷 335-352页

作者： Denise L. Bellinger Lee S. Berk Harold G. Koenig Noha Daher Michelle J. Pearce Clive J. Robins Bruce Nelson Sally F. Shaw harvey jay cohen Michael B. King Department of Pathology and Human Anatomy School of Medicine Loma Linda University Loma Linda CA USA Allied Health Studies School of Allied Health Professions Loma Linda University Loma Linda CA USA Center for Spirituality Theology and Health Duke University Durham NC USA Department of Psychiatry and Behavioral Sciences Duke University Medical Center Durham NC USA Department of Medicine Duke University Medical Center Durham NC USA Department of Medicine King Abdulaziz University Jeddah Saudi Arabia Epidemiology Biostatistics and Population Medicine School of Public Health Loma Linda University Loma Linda CA USA School of Medicine University of Maryland Baltimore USA Department of Psychology and Neuroscience Duke University Medical Center Durham NC USA Department of Research Glendale Adventist Medical Center Glendale CA USA Division of Psychiatry Faculty of Brain Sciences University College London UK

Background: Religious practices/experiences (RPE) may produce positive physiological changes in patients with major depressive disorder (MDD) and chronic medical illness. Here, we report cross-sectional relationships between depressive symptoms, RPE and stress biomarkers (pro-/anti-inflammatory measures and stress hormones), hypothesizing positive associations between depressive symptoms and stress biomarkers and inverse associations between RPE and stress biomarkers. Methods: We recruited 132 individuals with both MDD and chronic illness into a randomized clinical trial. First, stress biomarkers in the baseline sample were compared to biomarker levels from a community sample. Second, relationships between depressive symptoms and biomarkers were examined, and, finally, relationships between RPE and biomarkers were analyzed, controlling for demographics, depressive symptoms, and physical functioning. Results: As expected, inflammatory markers and stress hormones were higher in our sample with MDD compared to community participants. In the current sample, however, depressive symptoms were largely unrelated to stress biomarkers, and were unexpectedly inversely related to proinflammatory cytokine levels (TNF-α, IL-1β). Likewise, while RPE were largely unrelated to stress biomarkers, they were related to the anti-inflammatory cytokine IL-1RA and the stress hormone norepinephrine in expected directions. Unexpectedly, RPE were also positively related to the proinflammatory cytokine IFN-γ and to IFN-γ/IL-4 and IFN-γ/IL-10 ratios. Conclusions: Little evidence was found for a consistent pattern of relationships between depressive symptoms or religiosity and stress biomarkers. Of the few significant relationships, unexpected findings predominated. Future research is needed to determine whether religious interventions can alter stress biomarkers over time in MDD.

关键词： Religiosity Depression Inflammation Immune Function Stress Hormones

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Evolution of local perforator flaps in lower extremity reconstruction

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Plastic and Aesthetic Research 2019年第12期6卷 1-13页

作者： Rachel cohen-Shohet Mariel McLaughlin David Kerekes harvey Chim Plastic and Reconstructive Surgery University of FloridaGainesvilleFL 32608USA

Lower extremity reconstruction is challenging for a variety of *** techniques for soft tissue coverage continue to *** free flaps are always an option,free flaps require significant microsurgical expertise,a proficient staff,advanced equipment,and a patient with a somewhat healthy ***,as microsurgery has evolved,so has the identification of new anatomy and new techniques-namely,perforator based pedicled *** flaps have expanded options for lower extremity reconstruction,and continue to advance the field of *** purpose of this article is to review the evolution of perforator based pedicled flaps in the lower extremity,review the anatomy,and offer examples of design and indications.

关键词： Perforator flaps lower extremity reconstruction soft tissue coverage

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Comprehensive Level One Trauma Center Could Lower In-hospital Mortality of Severe Trauma in China

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Biomedical and Environmental Sciences 2014年第7期27卷 537-543页

作者： CAI Bin Burruss SIGRID Britt REDICK JIANG Hua SUN Ming Wei YANG Hao Charles Damien LU Mitchell jay cohen Henry CRYER ZENG Jun Department of Computational Mathematics and Bio-statistics Metabolomics and Multidisciplinary Laboratory for Trauma ResearchInstitute for Disaster and Emergency Medicine ResearchSichuan Provincial People's HospitalSichuan Academy of Medical Sciences Trauma Center University of California Los Angeles Department of Surgery San Francisco General Hospital University of California San Francisco Trauma Surgery Center East BranchSichuan Provincial People's HospitalSichuan Academy of Medical Sciences

Trauma is a major health and social problem in the US and China, It constitutes the main cause of death in people aged 45 or under in both countries112]. There is clear evidence from clinical studies that a large perc... 详细信息

关键词： ISS Comprehensive Level One Trauma Center Could Lower In-hospital Mortality of Severe Trauma in China SAMS UCLA

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Serological Targeted Analysis of an ITIH4 Peptide Isoform: A Preterm Birth Biomarker and Its Associated SNP Implications

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Journal of Genetics and Genomics 2015年第9期42卷 507-510页

作者： Zhou Tan Zhongkai Hu Emily Y.Cai Cantas Alev Ting Yang Zhen Li Joyce Sung Yasser Yehia El-Sayed Gary M.Shaw David K.Stevenson Atul J.Butte Guojun Sheng Karl G.Sylvester harvey J.cohen Xuefeng B.Ling Institute of Developmental and Regenerative Biology Hangzhou Normal University Department of Surgery Stanford University Lab for Early Embryogenesis RIKEN Center for Developmental Biology Department of Obstetrics and Gynecology Stanford University Department of Pediatrics Stanford University Stanford

Over 11% of all pregnancies in the US result in preterm birth, greatly contributing to perinatal morbidity and mortality （Goldenberg and Rouse, 1998）. Preterm birth etiologies remain largely unknown, and effective prevention methods have yet to be developed. The use of biofluid （e.g., serum or urine） for the analysis of the naturally occurring peptidome （MW 〈 4000） as a source of biomarkers has been reported for different diseases （Villanueva et al., 2006; Ling et al., 2010a, 2010b, 2010c, 2011）. Mass spectrometry-based profiling of naturally occurring peptides can provide an extensive in- ventory of serum peptides derived from either high-abundant endogenous circulating proteins or cell and tissue proteins （Liotta and Petricoin, 2006）.

关键词： Serological Targeted Analysis of an ITIH4 Peptide Isoform A Preterm Birth Biomarker and Its Associated SNP Implications SNP

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摩擦滑动起始的动力学特征

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国际地震动态 2011年第5期32卷 10-15,38页

作者： Oded Ben-David Gil cohen jay Fineberg 左玉玲（译）郑需要（校） Racah Institute of Physics the Hebrew University of Jerusalem Givat Ram Jerusalem Israel 中国地震局地球物理研究所

摩擦界面的失效方式对于我们从根本上认识工程学至地震学领域中的失效过程非常关键。摩擦运动起始于将两个剪切体分离的薄界面内传播的破裂前沿。通过测定沿界面的剪切应力和法向应力,结合随后的实际接触面积动态学特性,我们发现剪切应... 详细信息

摩擦界面的失效方式对于我们从根本上认识工程学至地震学领域中的失效过程非常关键。摩擦运动起始于将两个剪切体分离的薄界面内传播的破裂前沿。通过测定沿界面的剪切应力和法向应力,结合随后的实际接触面积动态学特性,我们发现剪切应力与法向应力之比在局部可远远超过没有发生突然滑动的静摩擦系数。而且,系统所选的不同破裂模式与局部应力比的不同控制程度相对应。这些结果表明非均匀性在摩擦稳定性及动力学特性方面起着至关重要的作用,这对不同地震模式的预测、选择和确定有着启示意义。

关键词：摩擦滑动动力学特征动力学特性剪切应力摩擦界面法向应力破裂模式静摩擦系数

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