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Alpha-fetoprotein-producing colon cancer with atypical bulky lymph node metastasis

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World Journal of Gastroenterology 2006年第47期12卷 7715-7716页

作者： Kuangi Fu Akihiro Kobayashi Norio saito Yasushi Sano Shigeharu Kato Hiroaki Ikematsu Takahiro Fujimori Yasushi Kaji Shigeaki Yoshida Department of Radiology Dokkyo University School of Medicine 880 Kitakobaysashi Mibu Shimotuga Tochigi 321-0293 Japan Department of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East Kashiwa Chiba 277-8577 Japan Department of Surgery National Cancer Center Hospital East Kashiwa Chiba 277-8577 Japan Department of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East Kashiwa Chiba 277-8577 Japan Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 Kitakobaysashi Mibu Shimotuga Tochigi 321-0293 Japan Department of Radiology Dokkyo University School of Medicine 880 Kitakobaysashi Mibu Shimotuga Tochigi 321-0293 Japan

Alpha-fetoprotein (AFP)-producing colorectal cancer is extremely rarely reported until now. All of the reported cases harboring synchronous hematogenous spread including liver and/or lung metastasis had a poor prognosis and died within 12 mo. We here describe a 71-year old man with AFP-producing colon cancer who presented with an unusual bulky lymph node metastasis instead of hematogenous spread. He underwent adjuvant chemotherapy in addition to curative surgical resection, which prolonged his survival.

关键词： Alpha-fetoprotein Colon cancer Bulky lymph node metastasis Computed tomography Colonoscopy

Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis

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World Journal of Gastroenterology 2007年第29期13卷 3977-3980页

作者： Yasuharu saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama Department of Endoscopic Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan Department of Radiology Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan Department of Internal Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan

AIM： To report 13 patients with benign esophagea stenosis treated with the biodegradable stent. METHODS： We developed a Ultraflex-type stent by knitting poly-/-lactic acid rnonofilaments. RESULTS： Two cases were esophageal stenosis caused by drinking of caustic liquid, 4 cases were due to surgical resection of esophageal cancers, and 7 cases were patients with esophageal cancer who received the preventive placement of biodegradable stents for postendoscopic mucosal dissection （ESD） stenosis. The preventive placement was performed within 2 to 3 d after ESD. In 10 of the 13 cases, spontaneous migration of the stents occurred between 10 to 21 d after placement. In these cases, the migrated stents were excreted with the feces, and no obstructive complications were experienced. In 3 cases, the stents remained at the proper location on d 21 after placement. No symptoms of re-stenosis were observed within the follow-up period of 7 mo to 2 years. Further treatment with balloon dilatation or replacement of the biodegradable stent was not required. CONCLUSION： Biodegradable stents were useful for the treatment of benign esophageal stenosis, particularly for the prevention of post-ESD stenosis.

关键词： Stents Esophageal cancer Endoscopic submucosal dissection

Deciphering Starch Quality of Rice Kernels Using Metabolite Profiling and Pedigree Network Analysis

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Molecular Plant 2012年第2期5卷 442-451页

作者： Miyako Kusano Atsushi Fukushima Naoko Fujita Yozo Okazaki Makoto Kobayashi Naoko Fujita Oitome Kaworu Ebana Kazuki saito RIKEN Plant Science Center Tsurumi Yokohama 230-0045 Japan KIHARA Institute for Biological Research Yokohama City University Totsuka Yokohama 244-0813 Japan Department of Biological Production Akita Prefectural University Akita 010-0195 Japan National Institute of Agrobiological Sciences 2-1-2 Kannondai Tsukuba Ibaraki 305-8602 Japan Graduate School of Pharmaceutical Sciences Chiba University Chiba 260-8675 Japan

The physiological properties of rice grains are immediately obvious to consumers. High-coverage metabolomic characterization of the rice diversity research set predicted a negative correlation between fatty acid and lipid levels and amylose/total starch ratio （amylose ratio）, but the reason for this is unclear. To obtain new insight into the relationships among the visual phenotypes of rice kernels, starch granule structures, amylose ratios, and metabolite changes, we investigated the metabolite changes of five Japonica cultivars with various amylose ratios and two knockout mutants （e 1, a Starch synthase Ilia （SSIIla）-deficient mutant and the SSIIla/starch branching enzyme （BE） double-knockout mutant 4019） by using mass spectrometry-based metabolomics techniques. Scanning electron microscopy clearly showed that the two mutants had unusual starch granule structures. The metabolomic compositions of two cultivars with high amylose ratios （Hoshiyutaka and Yumetoiro） exhibited similar patterns, while that of the double-knockout mutant, which has an extremely high amylose ratio, differed. Rice pedigree network analysis of the cultivars and the mutants provided insight into the association between metabolic-trait properties and their underlying genetic basis in rice breeding in Japan. Multidimensional scaling analysis revealed that the Hoshiyutaka and Yumetoiro cultivars were Indica-like, yet they are classified as Japonica subpopulations. Exploring metabolomic traits is a powerful way to follow rice genetic traces and breeding history.

关键词： starch quality traits amylose ratio metabolite profiling pedigree networks rice.

Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2023-2029页

作者： Hidemasa saito Satoru Murata Fumie Sugihara Tatsuo Ueda Daisuke Yasui Izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita Department of Radiology Nippon Medical SchoolTokyo 113-8602Japan Center for Interventional Radiology Teikyo University Chiba Medical CenterChiba 299-0011Japan

BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous *** encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic *** case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with *** SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver *** successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable *** the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 *** Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS.

关键词： Hepatic veins Portal vein Hepatic encephalopathy Endovascular procedures Embolization Therapeutic Case report

Prevalence of underweight and overweight among school-aged children and it's association with children's sociodemographic and lifestyle in Indonesia

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International Journal of Nursing Sciences 2016年第2期3卷 169-177页

作者： Syahrul Syahrul Rumiko Kimura Akiko Tsuda Tantut Susanto Ruka saito Fithria Ahmad Department of Community and Family Health Nursing School of NursingHasanuddin UniversityTamalanreaMakassarIndonesia Division of Health Sciences Graduate School of Medical SciencesKanazawa UniversityIshikawaJapan Pediatric Nursing Department Division of Health SciencesGraduate School of Medical SciencesKanazawa UniversityIshikawaJapan Family and Community Health Nursing Department School of NursingUniversitas JemberJemberJawa TimurIndonesia Division of Nutrition Office of Health of South-East Sulawesi ProvinceKendariIndonesia

Objectives:Underweight remains a health problem among Indonesian children,and the incidence of overweight continuously *** study aims to determine factors associated with underweight and overweight in school-aged children in ***:This study is a cross-sectional investigation on parents and children aged 6e13 years in elementary schools in Makassar,*** participants included 877 children and their *** data were obtained using standardized equipment,and sociodemographic and lifestyle data were determined using a *** nutritional status of the children was assessed based on the child growth standard prescribed by the ***:The prevalence rates of underweight and overweight among the children were 14.5%and 20.4%,*** was more prevalent in *** such as mother's level of education,having an underweight father,and playing outdoors on weekends for more than 2 h were significantly associated with underweight *** contrast,mothers with high levels of education,overweight parents,sleeping for less than 9 h,and playing outdoors on weekends for less than 1 h were significantly associated with overweight children.

关键词： Child Lifestyle Overweight Underweight

Enhanced thermoelectric performance in MnTe due to doping and insitu nanocompositing effects by Ag2S addition

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Journal of Materiomics 2021年第3期7卷 577-584页

作者： Jinfeng Dong Jun Pei Kei Hayashi Wataru saito Hezhang Li Bowen Cai Yuzuru Miyazaki Jing-Feng Li State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Department of Applied Physics Graduate School of EngineeringTohoku UniversitySendai980-8579Japan

Extremely low lattice thermal conductivity is always the pursuit of thermoelectric materials *** this work,we reported an exceptional effect of Ag2S addition in MnTe,an emerging promising midtemperature thermoelectric material,to enable the realization of minimum lattice thermal conductivity,namely-0.4 Wm^(-1) K^(-1).Such a low lattice thermal conductivity is guaranteed by the incorporation of in-situ formed Ag rich phase(Ag2Te)with ultralow lattice thermal conductivity and further scattering of phonons from the partial doping effects induced point defects and boundaries between various *** from the dramatically decreased lattice thermal conductivity,the partial doping of Ag and S simultaneously enhance the electrical conductivity,further contributing to enhanced thermoelectric ***,an inverse sign of Seebeck and Hall coefficient was observed and rationalized by the influence of highly electron-conductive Ag_(2)Te *** to the synergetic modulation of electrical and thermal transport properties by in-situ formed composite,a high ZT value of 1.1 was achieved in MnTe based thermoelectric materials,which also demonstrates the importance of compositing approaches to design state-of-the-art thermoelectric materials.

关键词： Manganese telluride Thermoelectric Thermal conductivity Composite

Magnetic anchor guidance for endoscopic submucosal dissection and other endoscopic procedures

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World Journal of Gastroenterology 2017年第16期23卷 2883-2890页

作者： Mohamed Mortagy Neal Mehta Mansour A Parsi Seiichiro Abe Tyler Stevens John J Vargo Yutaka saito Amit Bhatt Department of Internal Medicine Homer Stryker MD School of MedicineWestern Michigan UniversityKalamazooMI 49008United States Department of Internal Medicine Medicine InstituteCleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Hepatology Digestive Disease InstituteCleveland ClinicClevelandOH 44195United States Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan

Endoscopic submucosal dissection(ESD) is a wellestablished, minimally invasive treatment for superficial neoplasms of the gastrointestinal tract. The universal adoption of ESD has been limited by its slow learning curve, long procedure times, and high risk of complications. One technical challenge is the lack of a second hand that can provide traction, as in conventional surgery. Reliable tissue retraction that exposes the submucosal plane of dissection would allow for safer and more efficient dissection. Magnetic anchor guided endoscopic submucosal dissection(MAGESD) has potential benefits compared to other current traction methods. MAG-ESD offers dynamic tissue retraction independent of the endoscope mimicking a surgeon's "second hand". Two types of magnets can be used: electromagnets and permanent magnets. In this article we review the MAG-ESD technology, published work and studies of magnets in ESD. We also review the use of magnetic anchor guidance systems in natural orifice transluminal endoscopic surgery and the idea of magnetic non-contact retraction using surface ferromagentization. We discuss the current limitations, the future potential of MAG-ESD and the developments needed for adoption of this technology.

关键词： Endoscopic submucosal dissection Gastric cancer Magnetic anchor guidance Esophageal cancer Magnets Traction Natural orifice transluminal endoscopic surgery

Occurrence of perfluoroalkyl acids in precipitation from Shenyang,China

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Chinese Science Bulletin 2009年第14期54卷 2440-2445页

作者： LIU Wei DONG GuangHui JIN YiHe SASAKI Kazuaki saito Norimitsu SATO Itaru TSUDA Shuji NAKAYAMA Shoji F Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education School of Environmental and Biological Science and Technology Dalian University of Technology Dalian 116024 China School of Public Health China Medical University Shenyang 110001 China Research Institute for Environmental Sciences and Public Health of Iwate Prefecture Morioka Iwate 020-0852 Japan Laboratory of Veterinary Public Health Department of Veterinary Medicine Faculty of Agriculture Iwate University 3-18-8 Ueda Morioka 020-8550 Japan Oak Ridge Institute for Science and Education Oak Ridge TN 37831 USA

Perfluorosulfonates (PFSAs) and perfluorocarboxylates (PFCAs) in precipitation collected from Shenyang, China were determined. Snow samples were collected in the snow event on March 4, 2007 from 34 sites involving both the urban and suburban areas in Shenyang. The snowmelt was preconcentrated by solid phase extraction and analyzed using LC-MS method. Measurable amounts of perfluoroalkyl acids (PFAS) were found in precipitation samples from Shenyang, demonstrating that wet deposition is one possible pathway for the removing of the selected PFAS chemicals from atmosphere. Major PFAS detected were PFOS (<0.38―51 ng/L), PFOA (0.82―13 ng/L) and PFHpA (0.76―11 ng/L), with their mean concentration of 5.4, 3.3 and 2.9 ng/L, respectively. Other PFSAs and PFCAs were detected at much lower frequency or below the limit of detection in all the samples. The work presented here offers some basis for the investigation on the environmental behavior and the evaluation of human exposure to PFAS.

关键词：全氟辛烷中国酸沉淀测定方法全氟辛酸铵水样品固相萃取平均浓度

Direct peroral cholangioscopy using an ultraslim upper endoscope for biliary lesions

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 60-64页

作者： Shigefumi Omuta Iruru Maetani Takeo Ukita Tomoko Nambu Katsushige Gon Hiroaki Shigoka Yoshinori Saigusa Michihiro saito Division of Gastroenterology Department of Internal Medicine Toho University Ohashi Medical Center

BACKGROUND: The development of direct peroral cholangioscopy(DPOC) using an ultraslim endoscope simplifies biliary cannulation. The conventional techniques are cumbersome to perform and require advanced skills. The recent introduction of the guidewires and balloons has improved the therapeutic outcomes. Here we describe an effective and easier method for performing DPOC using an ultraslim upper endoscope. METHODS: Indications for DPOC were the presence of stones on follow-up of patients who had previously undergone complete sphincteroplasty, including endoscopic sphincterotomy or endoscopic papillary large balloon dilatation. Fifteen patients underwent DPOC. An ultraslim endoscope was inserted perorally and was advanced into the major papilla. The ampulla of Vater was visualized by retroflexing the endoscope in the distal second portion of the duodenum, and then DPOC was performed using a wire-guided cannulation technique with an anchored intraductal balloon catheter. RESULTS: One patient failed in the treatment due to looping of the endoscope in the fornix of the stomach. Fourteen(93.3%) were successfully treated with our modified DPOC technique. Only one patient(6.7%) experienced an adverse event(pancreatitis) who responded well to conservative management. Residual stones of the common bile duct were completely removed in 3 patients. CONCLUSION: The modified method of DPOC is simple, safe and easy to access the bile duct.

关键词： direct peroral cholangioscopy ultraslim upper endoscope endoscopic retrograde cholangioscopy biliary tract