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电子显微学报 1991年第4期10卷 381-381页

作者：林萍章 PualJ.Pearson RaymondCartier KazuhiroHashimoto hartzellv.schaff

利用老鼠之胸腔和腹部动脉做汽球内膜剥除,来探讨内皮细胞再生过程中,内皮细胞收缩、放松功能的恢复过程。内皮细胞破坏4至8周后,评估其内皮细胞功能,将控制组和实验组之主动脉内皮细胞做扫瞄电子显微镜检查,结果发现在内皮细胞破坏后4... 详细信息

利用老鼠之胸腔和腹部动脉做汽球内膜剥除,来探讨内皮细胞再生过程中,内皮细胞收缩、放松功能的恢复过程。内皮细胞破坏4至8周后,评估其内皮细胞功能,将控制组和实验组之主动脉内皮细胞做扫瞄电子显微镜检查,结果发现在内皮细胞破坏后4周,其内皮细胞之再生已完全恢复正常(图一)。在器官容器实验中,Norepirephrine使含有和未含内皮细胞之血管收缩,然后

关键词：内皮细胞再生过程电子显微镜检查控制组血管收缩恢复过程

Changes in lipid metabolism in chronic hepatitis C

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World Journal of Gastroenterology 2005年第41期11卷 6422-6428页

作者： Katalin Jármay Gizella Karácsony András Nagy Zsuzsa schaff First Department of Internal Medicine Albert Szent-Gy(o|¨)rgyi Medical University SzegedHungary County Hospital Department of Cardiology KecskemétHungary 2nd Department of Pathology Semmelweis University BudapestHungary

AIM: To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the ***: The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C (CH-C), and 28 patients with non-alcoholic fatty liver disease (NAFLD) without hepatitis C virus (HCV) infection. The serum parameters were further correlated with 1 797 age and sex matched control patients without any liver ***: Steatosis was detected in 90 out of 142 specimens (63%) with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD (P＜0.01). Inserting the score values of steatosis as part of the HAI, correlation with the ALT level (P＜0.00001) was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C (with and without steatosis), compared to the NAFLD group and to the virus-free control ***: Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation.

关键词： Lipid metabolism, Chronic hepatitis C NAFLD

The Nature of Space and of Gravitation

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Journal of Modern Physics 2012年第8期3卷 714-749页

作者： Jacob schaff Instituto de Fsica Universidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil

Many recent highly precise and unmistakable observational facts achieved thanks to the tightly synchronized clocks of the GPS, provide consistent evidence that the gravitational fields are created by velocity fields of real space itself, a vigorous and very stable quantum fluid like spatial medium, the same space that rules the propagation of light and the inertial motion of matter. It is shown that motion of this real space in the ordinary three dimensions round the Earth, round the Sun and round the galactic centers throughout the universe, according to velocity fields closely consistent with the local main astronomical motions, correctly induces the gravitational dynamics observed within these gravitational fields. In this spacedynamics the astronomical bodies all closely rest with respect to the real space, which forth-rightly leads to the observed null results of the Michelson light anisotropy experiments as well as to the absence of effects of the solar and galactic gravitational fields on the rate of clocks moving with Earth as recently discovered with the help of the GPS clocks. This spacedynamics exempts us from explaining the circular orbital motions of the planets round the Sun, likewise the rotation of Earth exempted people from explaining the diurnal transit of the heavens in the days of Copernicus and Galileo, because it is space itself that so moves. This spacedynamics also eliminates the need of dark matter and dark energy to explain respectively the galactic gravitational dynamics and the accelerated expansion of the universe. It also straightforwardly accounts in terms of well known and genuine physical effects for all the other observed effects, caused by the gravitational fields on the velocity of light and on the rate of clocks, including all the new effects recently discovered with the help of the GPS. It moreover simulates the non-Euclidean metric underlying Einstein’s spacetime curvature. This spacedynamics is the crucial innovation in the cu

关键词： Gravitation Gravitational Physics Gravitational Effects Dark Matter Dark Energy

The Nature of Space and of the Gravitational Fields Revealed by Recent Experimental Observations and Also Implicit in Quantum Field Theory

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Journal of Modern Physics 2013年第5期4卷 676-685页

作者： Jacob schaff Universidade Federal do Rio Grande do Sul (UFRGS) Instituto de Física Porto Alegre Brazil

The present work breaks the endless impasse of the current theories with space and gravitation, proposing a completely new conception in which the quantum space, ruling the propagarion of light and the inertial motion of matter, moves according to a velocity field consistent with the local main astronomical motions. This solution is clearly suggested by recent clear-cut experimental observations, achieved with the help of the GPS and also is implicit in the Quantum Field Theory (QFT) underlying the Standard Elementary Particle Model (SEPM). In a first part (Section II) it is shown that these recent experimental observations demonstrate that real space, the one that rules the propagation of light and the inertial motion of matter, is moving round each gravitational source according to a Keplerian velocity field consistent with the local main astronomical motions. This is the crucial experimental fundamentation of the spacedynamics that appropriately produces the observed gravitational dynamics on earth, in the solar system and also the galactic gravitational dynamics without the need of dark matter as well as all the observed effects of the gravitational fields on the propagation of light and on the rate of clocks. In a second part (Section III) it is shown how this spacedynamics arises within the context of the QFT underlying the SEPM. The QFT entails the idea that space is filled up with a scalar quantum field, a Bose-Einstein condensate of Higgs bosons. This Higgs condensate is a quantum fluid, responsible for giving mass to the elementary particles by the Higgs mechanism providing them with mechanical properties. This lets clear that the Higgs condensate plays the role of real quantum space that rules the propagation of light and the inertial motion of matter and is the ultimate reference for rest and for motion of matter and light. Therefore, on moving according to a Keplerian velocity field, this condensate causes the observed gravitational dynamics as well as

关键词： Gravitation Gravitational Physics Gravitational Effects Higgs Condensate Quantum Space

Gravitational Fields: Another Fortunate Manifestation of the Higgs Mechanism

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Journal of Modern Physics 2014年第6期5卷 407-448页

作者： Jacob schaff Universidade Federal do Rio Grande do Sul (UFRGS) Instituto de Fsica Porto Alegre Brazil

The present work discusses, in a comprehensible language and simple mathematics, the origin of the gravitational physics in the light of new recent experimental observations, achieved with the help of the tightly synchronized clocks of the GPS. These observations reveal that real space, ruling the inertial motion of matter and the propagation of light, is moving round the earth and round the sun according to a Keplerian velocity field, consistent with the local main astronomical motions. This Keplerian velocity field of real space is the quintessence of the gravitational fields and appropriately induces the observed gravitational dynamics. Such real space needs not to be invented. It is well at hand in the Quantum Field Theory (QFT), underlying the Standard Elementary Particle Model (SEPM). The QFT entails the idea that space is filled up with the Higgs condensate (HC), a very powerful quantum space (QS). The HC is a Bose-Einstein (BE) condensate of the zero spin Higgs bosons. By coupling to the HC, the elementary particles get inertial mass by the Higgs mechanism, that is, get mechanical properties. This will say that the HC rules the inertial motion of matter and the propagation of light and hence is the locally ultimate reference for rest and for motion of matter and light. The present work acknowledges that, likewise the Meissner effect in superconductors develops macroscopic screening currents, forcing magnetic fields out from superconductors, the Higgs mechanism too entails a macroscopic manifestation in the form of the Keplerian velocity field of the QS round each matter body throughout the universe, consistent with the local main astronomical motions. This Keplerian velocity field screens and thrusts the matter fields out from the HC by squeezing them into a minimum of volume. It is shown that this Keplerian velocity field of the QS appropriately induces the observed gravitational dynamics on earth, in the solar system as well as the galactic gravitational d

关键词： Gravity Gravitational Physics Gravitational Fields Gravitational Effects Dark Matter Dark Energy

Holmes-Adie syndrome, autoimmune hepatitis and celiac disease: A case report

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World Journal of Gastroenterology 2006年第9期12卷 1485-1487页

作者： Timea Csak Aniko Folhoffer Andrea Horvath Judit Halász Csaba Diczházi Zsuzsa schaff Ferenc Szalay Department of Medicine Semmelweis University BudapestHungary Department of Pathology Semmelweis University BudapestHungary

A 35-year-old female patient presented with the following symptoms of Holmes-Adie syndrome： photophobia, enlargement of the left pupil unresponsive to light, Achilles areflexia. The pilocarpine test was positive. No tumor or other neurological abnormality was found. She had a 19-year history of autoimmune hepatitis. Flares up were observed following each 3 deliveries. At age of 31 she presented with diarrhea and weight loss. Abdominal tumor was detected by ultrasound. The surgically removed tumor was histologically a benign mesenteric multicystic lymphangioma. Simultaneously, celiac disease was diagnosed. Gluten-free diet resulted in a significant improvement of celiac disease, but not of autoimmune hepatitis. Autonomic neuropathy was proven by standard cardiovascular tests. The patient was a homozygous carrier for HLA DQ2 antigen characteristic for celiac disease and heterozygous for HLA DR3 B8 frequent in autoimmune liver diseases. Our novel observation on association of Holmes-Adie syndrome with autoimmune hepatitis and celiac disease is suggestive for a common immunological background for all three entities present in a patient with mesenteric multicystic lymphangioma.

关键词： Holmes-Adie syndrome Autoimmune hepatitis Celiac disease Mesenteric lymphangioma Autonomic neuropathy

Pressure Slip Casting of Graded Coarse Grained Oxide Ceramics for Refractory Applications

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China's Refractories 2016年第3期25卷 17-24页

作者： Stefan schaffNER Martin THALHEIM Lisa FREITAG Jana HUBLKOV Christos G.ANEZIRIS TU Bergakademie Freiberg

In the present study the fabrication of graded coarse grained ceramic bodies for refractory applications was investigated using a pressure filtration cell,which uses pressurized air as the pressure medium. The pressure filtration cell was used to examine the influence of different ceramic raw materials,two dispersants,and of the particle size distribution on the filtration behavior and on the filter cake surface quality. Pressure slip casting of spinel based slips resulted in crack-free filter cakes,while alumina based slips resulted in filter cakes,which always stuck on the used PMMA filter medium. Furthermore,citric acid as an electrostatic dispersant resulted in a much lower filtration cake resistance and hence shorter filtration times than an electrosteric dispersant. A broader particle size distribution with a higher addition of the finest particle fraction caused an increase in the filter cake resistance but also yielded much better surface qualities. Finally,graded filter cakes with three layers of alumina rich magnesium aluminate spinel with a maximum grain size of 3 mm,1 mm,and 0. 5 mm,respectively,were fabricated. The computed X-ray analyzes indicated a perfect bonding between the three layers,which is a significant improvement to previous studies. However,the graded filter cakes exhibited frequently cracks at the bottom,which was probably caused by tensile stresses from the friction of the filter cakes with the pressure filtration cell. This will be further investigated in subsequent studies. The achieved results demonstrate thefeasibility to produce coarse grained oxide ceramics for refractory applications by pressure slip casting,which eventually allows the production of composites with tailored compositions,microstructure and functionality.

关键词： refractories composites pressure slipcasting X-ray computed tomography spinels

室间隔切除术：治疗梗阻性肥厚型心肌病的金标准

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中华心血管病杂志 2009年第4期37卷 307-311页

作者： Joseph A Dearani Hartzell V schaff Steve R Ommen Minnesota 55905 Division of Cardiovascular Surgery Mayo Clinic and Foundation Division of Cardiovascular Diseases

梗阻性肥厚型心肌病（HCM）间隔切除术的治疗方法几乎与HCM文献报道同时出现。现在越来越清楚的表明，间隔切除术是一种缓解流出道梗阻症状最可靠的治疗方法。间隔切除术在HCM治疗中地位的不断提高，主要是因为：（1）对梗阻的患病率及... 详细信息

梗阻性肥厚型心肌病（HCM）间隔切除术的治疗方法几乎与HCM文献报道同时出现。现在越来越清楚的表明，间隔切除术是一种缓解流出道梗阻症状最可靠的治疗方法。间隔切除术在HCM治疗中地位的不断提高，主要是因为：（1）对梗阻的患病率及其影响认识更加清楚；（2）通过与酒精消融术的比较，使我们对该术式的认识更加清楚。下面我们介绍一下Mayo医院外科治疗HCM的经验。

关键词：梗阻性肥厚型心肌病治疗方法切除术金标准室间隔 HCM 梗阻症状外科治疗

Long Tail Strings: Impact of the Dalkon Shield 40 Years Later

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Open Journal of Obstetrics and Gynecology 2014年第16期4卷 996-1005页

作者： Clare L. Roepke Eric A. schaff Lacusc Medical Center Los Angeles USA Philadelphia Women’s Center Philadelphia USA

Intrauterine devices (IUDs) are the most effective, reversible and longest acting birth control method. They require no effort for compliance and avoid systemic synthetic hormones. Evidence-based effectiveness and safety studies have demonstrated IUDs rival sterilization. IUDs low cost make them the most popular method worldwide. Despite these benefits, IUDs have minimal market penetration in the United States where they are expensive, disparaged by an older generation of physicians, and withheld from teenagers, nulliparous women, and women not in mutually monogamous relationships, i.e., those who would most benefit. This article reviews the nearly forgotten history of the IUD that resulted in broadening the Food and Drug Administration’s oversight of medical devices, brought needed transparency to physicians’ conflicts of interests, uncovered a corporate scandal with a whistleblower that led to a major pharmaceutical bankruptcy, and involved 327,000 women (though only 195,000 met strict criteria for claims) in the largest US personal injury case.

关键词： IUD Dalkon Shield Review Infertility History Scandal Birth Control