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Interdigitated terahertz metamaterial sensors:design with the dielectric perturbation theory

Photonics Research 2024年第6期12卷 1115-1128页

作者： LEI CAO FANQI MENG ESRAÖZDEMIR YANNIK LOTH MERLE RICHTER ANNA KATHARINA WIGGER MAIRA BEATRIZ PÉREZ SOSA ALAA JABBAR JUMAAH SHIHAB AL-DAFFAIE PETER HARING BOLÍVAR hartmut G.ROSKOS State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and TechnologyWuhan 430074China Physikalisches Institut Johann Wolfgang Goethe-UniversitätFrankfurt am MainGermany University of Siegen Institute for High Frequency and Quantum ElectronicsSiegenGermany Department of Electrical Engineering Eindhoven University of Technology5612 AE EindhovenThe Netherlands

Designing terahertz sensors for highly sensitive detection of nanoscale thin films and a few biomolecules poses a substantial challenge but is crucial for unlocking their full potential in scientific research and advanced *** work presents a strategy for optimizing metamaterial sensors in detecting small quantities of dielectric *** amount of frequency shift depends on intrinsic properties(electric field distribution,Q-factor,and mode volume)of the bare cavity as well as the overlap volume of its high-electric-field zone(s)and the *** by the simplified dielectric perturbation theory,interdigitated electric split-ring resonators(ID-eSRRs)are devised to significantly enhance the detection sensitivity compared with eSRRs without interdigitated ***-eSRR’s fin-gers redistribute the electric field,creating strongly localized enhancements,which boost analyte *** periodic change of the inherent antiphase electric field reduces radiation loss,leading to a higher *** with ID-eSRR sensors operating at around 300 GHz demonstrate a remarkable 33.5 GHz frequency shift upon depositing a 150 nm SiO_(2)layer as an analyte simulant,with a figure of merit improvement of over 50 times compared with structures without interdigitated *** rational design offers a promising avenue for highly sensitive detection of thin films and trace biomolecules.

关键词： dielectric perturbation theory

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High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice

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Acta Pharmaceutica Sinica B 2024年第1期14卷 190-206页

作者： Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio hartmut Jaeschke Hong-Min Ni Wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Telethon Institute of Genetics and Medicine TIGEMPozzuoliNaples 80131Italy Medical Genetics Department of Translational MedicineFederico II UniversityNaples 80131Italy Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Department of Internal Medicine Division of GastroenterologyHepatology&MotilityUniversity of Kansas Medical CenterKansas CityKS 66160USA

Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and *** studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein *** lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with *** the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse *** loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,***,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against *** also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB *** these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in *** conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI.

关键词： Autophagy DILI Drug screening Hepatotoxicity Lysosome Mitochondria Mitophagy NRF2

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Convergent Data-Driven Regularizations for CT Reconstruction

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1342-1368页

作者： Samira Kabri Alexander Auras Danilo Riccio Harmut Bauermeister Martin Benning Michael Moeller Martin Burger Helmholtz Imaging Deutsches Elektronen-Synchrotron DESYNotkestr.8522607 HamburgGermany Institute for Vision and Graphics University of SiegenAdolf-Reichwein-StraBe 2a57076 SiegenGermany School of Mathematical Sciences Queen Mary University of LondonMile End RoadLondon E14NSUK The Alan Turing Institute British Library96 Euston RdLondon NW12DBUK Fachbereich Mathematik Universitat HamburgBundesstrasse 5520146 HamburgGermany

The reconstruction of images from their corresponding noisy Radon transform is a typical example of an ill-posed linear inverse problem as arising in the application of computerized tomography(CT).As the(naive)solution does not depend on the measured data continuously,regularization is needed to reestablish a continuous *** this work,we investigate simple,but yet still provably convergent approaches to learning linear regularization methods from *** specifically,we analyze two approaches:one generic linear regularization that learns how to manipulate the singular values of the linear operator in an extension of our previous work,and one tailored approach in the Fourier domain that is specific to *** prove that such approaches become convergent regularization methods as well as the fact that the reconstructions they provide are typically much smoother than the training data they were trained ***,we compare the spectral as well as the Fourier-based approaches for CT-reconstruction numerically,discuss their advantages and disadvantages and investigate the effect of discretization errors at differentresolutions.

关键词： Inverse problems Regularization Computerized tomography(CT) Machine learning

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Quenchants for Induction Hardening for the Automotive Industry, Choice and Maintenance

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材料热处理学报 2004年第5期25卷 514-518页

作者： hartmut Beitz Thorsten Beitz PETROFER CHEMIE Headquarters Hildesheim GermanyPETROFER CHEMIE Department of Heat Treatment Hildesheim Germany

The different types of quenchants for induction hardening - mainly for shower quenching - but also for immersion will be described in regard to their properties, film-formation, remaining residues, how to handle these etc.. Furtheron the maintenance of such quench fluids will be desribed in detail regarding concentration control, control of growth of micro-organism, contamination and maintenance.

关键词：感应淬火淬火剂绝缘薄膜热处理

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Designing a Security Architecture for a P2P Video Conference System

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China Communications 2008年第2期5卷 49-58页

作者： hartmut Koeni Department of Computer Science Brandenburg University of Technology Cottbus

More and more modern group oriented collaborativeapplications use the peer-to-peer(P2P)paradigm tobe independent of expensive infrastructures as theyare,for instance,provided for audio and video conferencesby H.323 *** collaborativeP2P solutions require appropriate mechanismsto protect group privacy and data integrity.A centralizedclient/server based video conference system canbe well shielded in a standard manner,whilst thereare no off-the-shelf approaches to secure a P2P videoconference up to *** paper addresses this issueand presents a flexible security *** BRAVIS system[4]as an example it shows howthe architecture can be embedded into a P2P videoconferencing system.

关键词： Peer-to-peer (P2P) security architecture video conference

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CO_(2)Plume Geothermal(CPG)Systems for Combined Heat and Power Production:an Evaluation of Various Plant Configurations

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Journal of Thermal Science 2022年第5期31卷 1266-1278页

作者： SCHIFFLECHNER Christopher WIELAND Christoph SPLIETHOFF hartmut Chair of Energy Systems TUM School of Engineering and DesignTechnical University of Munich85747 GarchingGermany

CO_(2) Plume Geothermal(CPG)systems are a promising concept for utilising petrothermal resources in the context of a future carbon capture utilisation and sequestration *** geothermal energy has a tremendous worldwide potential for decarbonising both the power and heating *** paper investigates three potential CPG configurations for combined heating and power generation(CHP).The present work examines scenarios with reservoir depths of 4 km and 5 km,as well as required district heating system(DHS)supply temperatures of 70℃ and 90℃.The results reveal that a two-staged serial CHP concept eventuates in the highest achievable net power *** a thermosiphon system,the relative net power reduction by the CHP option compared with a sole power generation system is significantly lower than for a pumped *** net power reduction for pumped systems lies between 62.6%and 22.9%.For a thermosiphon system with a depth of 5 km and a required DHS supply temperature of 70℃,the achievable net power by the most beneficial CHP option is even 9.2%higher than for sole power generation *** second law efficiency for the sole power generation concepts are in a range between 33.0%and 43.0%.The second law efficiency can increase up to 63.0%in the case of a CHP ***,the combined heat and power generation can significantly increase the overall second law efficiency of a CPG *** evaluation of the achievable revenues demonstrates that a CHP application might improve the economic performance of both thermosiphon and pumped CPG ***,the minimum heat revenue required for compensating the power reduction increases with higher electricity *** summary,the results of this work provide valuable insights for the potential development of CPG systems for CHP applications and their economic feasibility.

关键词： deep geothermal energy combined heat and power generation CO_(2)plume geothermal systems petrothermal resources carbon capture utilisation and storage

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A derived grid-based model for simulation of pedestrian flow

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 209-220页

作者： Günter BRWOLFF hartmut SCHWANDT Institut für Mathematik Technische Universitt Berlin

We present a derived grid-based model for the simulation of pedestrian flow. Interactions among pedestrians are considered as the result of forces within a certain neighbourhood. Unlike the social force model,the forces here,as in Newtonian physics,are proportional to the inverse of the square of the distance. Despite the notion of neighbourhood and the underlying grid,this model differs from the existing cellular automaton(CA) models in that the pedestrians are treated as individuals. Bresenham's algorithm for line rastering is applied in the step calculation.

关键词： Bresenham's algorithm Cellular automaton (CA) Pedestrian dynamics Social force model

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Mechanisms of sterile inflammation in acetaminophen hepatotoxicity

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Cellular & Molecular Immunology 2018年第1期15卷 74-75页

作者： hartmut Jaeschke Department of Pharmacology Toxicology&TherapeuticsUniversity of Kansas Medical CenterKansas City66160KSUSA.

Acetaminophen(APAP)hepatotoxicity is the most frequent cause of acute liver failure in many Western *** intracellular signaling mechanisms of APAP-induced cell death have been extensively studied,and the critical roles of key features such as reactive metabolite generation,glutathione depletion,mitochondrial oxidant stress and peroxynitrite formation,mitochondrial dysfunction,and nuclear DNA fragmentation are all well-established.1 Not surprisingly,a substantial number of intracellular molecules,termed damage-associated molecular patterns(DAMPs),are passively released into the circulation during the resulting *** include high mobility group box 1 protein,nuclear DNA fragments and mitochondrial DNA,with most being recognized by pattern recognition receptors such as various Toll-like receptors(TLRs)on macrophages.

关键词： fragmentation nitrite sterile

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Novel insight into mechanisms of cholestatic liver injury

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World Journal of Gastroenterology 2012年第36期18卷 4985-4993页

作者： Benjamin L Woolbright hartmut Jaeschke Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160United States

Cholestasis results in a buildup of bile acids in serum and in *** studies into the mechanisms of cholestatic liver injury strongly implicated bile acidinduced apoptosis as the major cause of hepatocellular *** work has focused both on the role of bile acids in cell signaling as well as the role of sterile inflammation in the *** in modern analytical methodology have allowed for more accurate measuring of bile acid concentrations in serum,liver,and bile to very low levels of ***,toxic bile acid levels are seemingly far lower than previously *** initial hypothesis has been based largely upon the exposure of μmol/L concentrations of toxic bile acids and bile salts to primary hepatocytes in cell culture,the possibility that in vivo bile acid concentrations may be far lower than the observed in vitro toxicity has far reaching implications in the mechanism of *** review will focus on both how different bile acids and different bile acid concentrations can affect hepatocytes during cholestasis,and additionally provide insight into how these data support recent hypotheses that cholestatic liver injury may not occur through direct bile acid-induced apoptosis,but may involve largely inflammatory cell-mediated liver cell necrosis.

关键词： Bile acids Cholestasis Apoptosis Necro-sis Neutrophils Innate immunity Bile duct ligation

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A pilot scale trickling filter with pebble gravel as media and its performance to remove chemical oxygen demand from synthetic brewery wastewater

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第10期14卷 924-933页

作者： Haimanot HABTE LEMJI hartmut ECKST DT Faculty of Agricultural and Environmental Sciences Institute of Hydromechanics and Water Management University of Rostock

Evaluating the performance of a biotrickling filter for the treatment of wastewaters produced by a company manufacturing beer was the aim of this study.A pilot scale trickling filter filled with gravel was used as the experimental *** scale plant experiments were made to evaluate the performance of the trickling filter aerobic and anaerobic biofilm systems for removal of chemical oxygen demand(COD) and nutrients from synthetic brewery *** evaluation data of the trickling filter were generated under different experimental *** trickling filter had an average efficiency of(86.81±6.95)% as the hydraulic loading rate increased from 4.0 to 6.4 m3/(m2·d).Various COD concentrations were used to adjust organic loading rates from 1.5 to 4.5 kg COD/(m3·d).An average COD removal efficiency of(85.10±6.40)% was achieved in all wastewater concentrations at a hydraulic loading of 6.4 m3/(m2·d).The results lead to a design organic load of 1.5 kg COD/(m3·d) to reach an effluent COD in the range of 50–120 mg/*** can be concluded from the results of this study,organic substances in brewery wastewater can be handled in a cost-effective and environmentally friendly manner using the gravel-filled trickling filter.

关键词： Biodegradation Pilot scale trickling filter Aerobic treatment Brewery wastewater Chemical oxygen demand(COD) Trickling filter performance

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