检索结果-南通市图书馆

Drug utilization evaluation of medications used in the management of neurological disorders

Global Health Journal 2023年第3期7卷 153-156页

作者： Meghana Upadhya Nivya Jimmy Jesslyn Maria Jaison Shahal Sidheque harsha sundaramurthy Nemichandra S c Shasthara Paneyala Madhan Ramesh Jehath Syed Nikita Pal Sri harsha Chalasani Department of Pharmacy Practice JSS College of PharmacyJSS Academy of Higher Education&ResearchMysuruKarnataka 570015India Department of Neurology JSS Medical College and HospitalJSS Academyof Higher Education&ResearchMysuruKarnataka570015India

Background and object:The burden of neurological disorders in India is expected to increase due to the rapid demographic and epidemiological transition,with irrational drug use,which is also a global ***,drug utilization evaluation is designed to ensure appropriate medicine use within the healthcare *** aim of the study was to assess the rate and pattern of drug utilization in the management of neurological *** and methods:A hospital-based cross-sectional drug utilization evaluation study on neurological drugs was carried out at the Department of Neurology over a span of six *** legible prescriptions consisting neurological medications irrespective of patient's gender,aged≥18 years were included for the *** World Health Organization(WHO)core drug use indicators were used to assess the drug prescribing and utilization ***:A total of 310 prescriptions were reviewed,where male predominance was found to be 56.45%.Out of 310 prescriptions,drugs belonging to 26 neurological classes were prescribed for the management of various neurological *** majority of patients were diagnosed with epilepsy and the most prescribed drugs per patient were phenytoin(14.8%)and valproic acid(6.45%).By following the WHO core drug prescribing indicators,65.47%of drugs prescribed from the India National List of Essential Medicines,2022,followed by 29.83%of drugs prescribed in generic name and 10.86%of prescriptions including ***:The study findings showed that the prescribing pattern in the Department of Neurology was in accordance with the WHO core prescribing ***,the extent of polypharmacy prescriptions was very ***,interventions are very necessary to promote rational drug prescribing patterns and thus clinical pharmacists can contribute to assess and review the drug utilization pattern to optimize the drug therapy and improvement in patient safety.

关键词： Drug utilization evaluation Neurological disorders Essential medication list Drug-related problems Patient safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integralinput-to-statestability ystemswithsmalldelays Integral input-to-state stability of systems with small delays

引用

Control Theory and Technology 2024年第3期22卷 455-467页

作者： R.H.harsha Nawarathna Yuandan Lin Yuan Wang Department of Mathematical Sciences Florida Atlantic UniversityBoca RatonFL 33431USA

We consider how small delays affect the integral-input-to-state stability(iss)property for a *** result is similar to the input-to-state stability(Iss)result obtained in[1]:the iss property will be preserved in a practical and semi-global manner if the delay interval is small ***,since the iss quantifies the robust stability in terms of a generalized Li norm of the inputs instead of a generalized Loo norm of the inputs for the Iss case,the techniques and proofs for the Iss case do not apply to the iss case *** the proofs in[1]are based on the Lyapunov-Razumikhin approach,our proofs are based on the iss-Lyapunov functions for the zero-delay *** addition to the interest by its own in showing how the iss property is affected by small delays,the result also serves to the study of the iss property for singularly perturbed systems.

关键词： Integral-input-to-state stability Nonlinear systems Small delays Lyapunov method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic plication for diaphragmatic eventration in adults:Unveiling the mystery of eventration

引用

Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 92-96页

作者： Balika Mahesan Prasanna Kumar Reddy K.S.Santhosh Anand Muvva Sri harsha M Vijay N Sudarsan Srikanth Department of Minimal Access Surgery Apollo HospitalsChennaiIndia Department of Surgical Gastroenterology Apollo HospitalsChennaiIndia

Diaphragm eventration is the permanent elevation of a hemidiaphragm and can be due to congenital or acquired *** is a rather uncommon condition in adults and causes a spectrum of symptoms,ranging from asymptomatic incidental findings on imaging to life-threatening respiratory *** patients do not require any treatment,but plication is the conventional,well-known method for treating symptomatic *** varies depending on the *** this article,we discuss two rare cases of diaphragmatic eventration that were treated with minimal access surgery.

关键词： Diaphragmatic eventration Minimal access surgeryLaparoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding:Meta-analysis of randomized controlled trials

引用

World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 214-226页

作者： Gowthami Sai Kogilathota Jagirdhar Jose Andres Perez Akshat Banga Rakhtan K Qasba Ruman K Qasba harsha Pattnaik Muhammad Hussain Yatinder Bains Salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Medicine Saint Francis Health SystemsTulsaOK 74133United States Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Medicine Green Life Medical College and HospitalDhaka 1205Bangladesh Department of Medicine Sher-i-kashmir Institute of Medical ScienceJammuSrinagar 190011India Department of Medicine Lady Hardinge Medical CollegeNew Delhi 110001India Department of Gastroenterology Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine and Pharmacology Texas AM UniversityCollege StationTX 77843United States

BACKGROUND Second-look endoscopy(SLE)to prevent recurrent bleeding in patients with peptic ulcer disease(PUD)and those undergoing endoscopic submucosal dissection(ESD)is routinely being *** evidence exists regarding efficacy,risk,benefit,and *** To identify the role and effectiveness of SLE in ESD and PUD,associated rebleeding and PUD-related outcomes like mortality,hospital length of stay,need for endoscopic or surgical intervention and blood *** A systematic review of literature databases PubMed,Cochrane,and Embase was conducted from inception to January 5,*** controlled trials that compared patients with SLE to those who did not have SLE or evaluated the role of prophylactic hemostasis during SLE compared to other conservative interventions were *** study was conducted per PRISMA guidelines,and the protocol was registered in PROSPERO(ID CRD42023427555:).RevMan was used to perform meta-analysis,and Mantel-Haenszel Odds ratio(OR)were generated using random effect *** A total of twelve studies with 2687 patients were included in our systematic review and meta-analysis,of which 1074 patients underwent SLE after ESD and 1613 patients underwent SLE after PUD-related *** ESD,the rates of rebleeding were 7%in the SLE group compared to 4.4%in the non-SLE group with OR 1.65,95%confidence intervals(CI)of 0.96 to 2.85;P=0.07,whereas it was 11%in the SLE group compared to 13%in the non-SLE group with OR 0.895%CI:0.50 to 1.29;P=*** mean difference in the blood transfusion rates in the SLE and no SLE group in PUD was OR 0.01,95%CI:-0.22 to 0.25;P=*** SLE vs non-SLE groups with PUD,the OR for Endoscopic intervention was 0.29,95%CI:0.08 to 1.00;P=0.05 while it was OR 2.03,95%CI:0.95 to 4.33;P=0.07,for surgical *** mean difference in the hospital length of stay was-3.57 d between the SLE and no SLE groups in PUD with 95%CI:-7.84 to 0.69;P=0.10,denoting an average of

关键词： Endoscopy Endoscopic submucosal dissection Peptic ulcer Gastrointestinal bleeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Film forming systems for topical and transdermal drug delivery

引用

Asian Journal of Pharmaceutical Sciences 2017年第6期12卷 487-497页

作者： Kashmira Kathe harsha Kathpalia Department of Pharmaceutics Vivekanand Education Society’s College of Pharmacy Chembur

Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system’s ability to adhere to skin during the therapy so as to promote drug penetration through the skin *** formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient *** the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient *** the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions) along with their evaluation parameters have also been reviewed.

关键词： Film forming polymers Topical drug delivery Gelling agents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integration of Utility Distributed Energy Resource Management System and Aggregators for Evolving Distribution System Operators

引用

Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 277-285页

作者： Luka Strezoski harsha Padullaparti Fei Ding Murali Baggu the Department for Power Electronicsand TelecommunicationsFaculty of Technical SciencesUniversity of Novi SadNovi SadSerbiaand he is also with Schneider Electric DMS CompanyNovi SadSerbia Energy System Integration National Renewable Energy LaboratoryGoldenUSA

With the rapid integration of distributed energy resources(DERs),distribution utilities are faced with new and unprecedented *** challenges introduced by high penetra-tion of DERs range from poor observability to overload and reverse power flow problems,under-/over-voltages,maloperation of legacy protection systems,and requirements for new planning *** utility personnel are not adequately trained,and legacy control centers are not properly equipped to cope with these ***,distribution energy resource management systems(DERMSs)are emerging software technologies aimed to provide distribution system operators(DSOs)with a specialized set of tools to enable them to overcome the issues caused by DERs and to maximize the benefits of the presence of high penetration of these novel ***,as DERMS technology is still emerging,its definition is vague and can refer to very different levels of software hierarchies,spanning from decentralized virtual power plants to DER aggregators and fully centralized enterprise systems(called utility DERMS).Although they are all frequently simply called DERIMS,these software technologies have different sets of tools and aim to provide different services to different *** paper explores how these different software technologies can complement each other,and how they can provide significant benefits to DSOs in enabling them to successfully manage evolving distribution networks with high penetration of DERs when they are integrated together into the control centers of distribution utilities.

关键词： Distributed generation distributed energy resource(DER) aggregator distributed energy resource management system(DERMS) non-wire alternatives.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Symmetry analysis,closed-form invariant solutions and dynamical wave structures of the generalized (3+1)-dimensional breaking soliton equation using optimal system of Lie subalgebra

引用

Journal of Ocean Engineering and Science 2022年第2期7卷 188-201页

作者： Monika Niwas Sachin Kumar harsha Kharbanda Department of Mathematics Faculty of Mathematical SciencesUniversity of DelhiDelhi110007India

Nonlinear evolution equations(NLEEs)are primarily relevant to nonlinear complex physical systems in a wide range of fields,including ocean physics,plasma physics,chemical physics,optical fibers,fluid dy-namics,biology physics,solid-state physics,and marine *** paper investigates the Lie sym-metry analysis of a generalized(3+1)-dimensional breaking soliton equation depending on five nonzero real *** derive the Lie infinitesimal generators,one-dimensional optimal system,and geo-metric vector fields via the Lie symmetry ***,using the three stages of symmetry reductions,we converted the generalized breaking soliton(GBS)equation into various nonlinear ordinary differential equations(NLODEs),which have the advantage of yielding a large number of exact closed-form *** established closed-form wave solutions include special functional parameter solutions,as well as hyperbolic trigonometric function solutions,trigonometric function solutions,dark-bright solitons,bell-shaped profiles,periodic oscillating wave profiles,combo solitons,singular solitons,wave-wave interac-tion profiles,and various dynamical wave structures,which we present for the first time in this ***,the dynamical analysis of some established solutions is revealed through three-dimensional sketches via numerical *** of the new solutions are often useful and helpful for study-ing the nonlinear wave propagation and wave-wave interactions of shallow water waves in many new high-dimensional nonlinear evolution equations.

关键词： Lie symmetry technique Infinitesimal generators Optimal systems Closed-form wave solutions Solitary waves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anxiolytic property of Lactuca sativa,effect on anxiety behaviour induced by novel food and height

引用

Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 532-536页

作者： SN harsha KR Anilakumar Biochemistry and Applied Nutrition Discipline.Defence Food Research Laboratory Mysore-570011.India

Objective:To study anxiolytic property of hydro alchohol extract and to estimate polyphenols present in the extract by ***:To evaluate anxiolytic properly two animal models were used *** T maze and ***(1 mg/kg body wt.) served as the standard anxiolvtic agent for all the *** dried extract of the plant leaf in doses of 100.200 and 400 mg/kg body weight was administered orally to mice for duration of 1? or 30 days and locomotor and anxiolytic activities were *** was estimated using HPLC. Results:The HPLC analysis of the polyphenols revealed the presence chlorogenic acid,vanillin, epicatechin,caffeic acid,rutin hydrate,sinapic acid,quercetin-3-rhamnoside.p-coumeric acid and *** spent and number of entries into the open arm was improved in 30 days treated animals than that of 15 days treated groups,200 and 400 mg/kg body weight treated group showed significant results when comparing with the control ***:Te hydro alcohol extract rich in Polyphenols and other secondary metabolites is a potent anxiolytic agent.

关键词： Anxiety Lactuca sativa Polyphenols Hyponeophagia Elevated T maze test

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SHOCK AND BOUNDARY STRUCTURE FORMATION BY SPECTRAL-LAGRANGIAN METHODS FOR THE INHOMOGENEOUS BOLTZMANN TRANSPORT EQUATION

引用

Journal of Computational Mathematics 2010年第4期28卷 430-460页

作者： Irene M.Gamba Sri harsha Tharkabhushanam Department of Mathematics & Institute of Computational Engineering and Sciences University of Texas Austin Institute of Computational Engineering and Sciences University of Texas Austin

The numerical approximation of the Spectral-Lagrangian scheme developed by the authors in [30] for a wide range of homogeneous non-linear Boltzmann type equations is extended to the space inhomogeneous case and several shock problems are benchmark. Recognizing that the Boltzmann equation is an important tool in the analysis of formation of shock and boundary layer structures, we present the computational algorithm in Section 3.3 and perform a numerical study case in shock tube geometries well modeled in for ID in x times 3D in v in Section 4. The classic Riemann problem is numerically analyzed for Knudsen numbers close to continuum. The shock tube problem of Aoki et al [2], where the wall temperature is suddenly increased or decreased, is also studied. We consider the problem of heat transfer between two parallel plates with diffusive boundary conditions for a range of Knudsen numbers from close to continuum to a highly rarefied state. Finally, the classical infinite shock tube problem that generates a non-moving shock wave is studied. The point worth noting in this example is that the flow in the final case turns from a supersonic flow to a subsonic flow across the shock.

关键词： Spectral Numerical Methods Lagrangian optimization FFT Boltzmann Trans- port Equation Conservative and non-conservative rarefied gas flows.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

引用

Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.Chan Charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility Memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen(MYC),implicated in stemness and histological *** overexpression of a degradation-resistant MYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：