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Novel succinoylated carboxymethyl guar gum nanocarriers of glimepiride for controlling type-2 diabetes

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Medicine in Novel Technology and Devices 2024年第2期22卷 133-139页

作者： harsh Yadav Biswajit Maji Sabyasachi Maiti Department of Pharmacy Indira Gandhi National Tribal UniversityAmarkantakMadhya PradeshIndia Department of Chemistry Indira Gandhi National Tribal UniversityAmarkantakMadhya PradeshIndia

In this study,guar gum(GG)was chemically modified to its carboxymethyl derivative,which was then esterified with octenyl succinic anhydride(OSA)using a nucleophilic catalyst 4-dimethylaminopyridine(DMAP)to render the derivative amphiphilic *** carboxymethyl guar gum(CMGG)and succinoylated CMGG was characterized using Fourier transform infrared spectroscopy(FTIR)*** amphiphilic CMGG synthesized using DMAP/OSA ratio of 0.5:1(CMGGOSA-I),was found to be *** amphiphilic guar gum self-assembled in water to form nanocarriers with mean diameter of 430 nm and zeta potential of19.0 *** electron microscope(TEM)image showed spherical nature of the developed CMGGOSA-I nano*** presence of amphiphilic CMGG,the aqueous solubility of glimepiride was enhanced by about *** nanocarriers released glimepiride in simulated gastrointestinal fluids for a period of more than 24 h,following Higuchi's ***-Peppas modeling of the drug release data revealed that a combination of swelling and diffusion mechanism was operative in the event of drug *** streptozotocin-induced diabetic rat model,the nanocarriers outperformed pure drug suspensions in terms of anti-diabetic activity,which lasted up to 24 ***;the newly synthesized amphiphilic CMGG nanocarriers demonstrated controlled drug release properties and showed promise for controlling type-2 diabetes.

关键词： Guar gum Glimepiride Octenyl succinic anhydride Anti-diabetic efficacy

Dostarlimab in the treatment of mismatch repair deficient recurrent or advanced endometrial cancer

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Cancer Pathogenesis and Therapy 2024年第3期2卷 135-141页

作者： Siddhant Shukla harsh Patel Shuzhen Chen Rainie Sun Liuya Wei Zhe-Sheng Chen Institute for Biotechnology St.John's UniversityNew YorkNew York 11439United States Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's UniversityNew YorkNew York 11439United States School of Pharmacy Weifang Medical UniversityWeifangShandong 261053China Stuyvesant High School New YorkNew York 10282United States

Dostarlimab,a programmed death receptor-1(PD-1)-blocking IgG4 humanized monoclonal antibody,gained accelerated approval from the US Food and Drug Administration(FDA)in April 2021,and received a full approval in February *** was approved for treating adult patients with mismatch repair deficient(dMMR)recurrent or advanced endometrial cancer(EC)that progressed during or after prior treatment who have no other suitable treatment ***,we review the structure-based mechanism of action of dostarlimab and the results of a clinical study(GARNET;NCT02715284)to comprehensively clarify the efficacy and toxicity of the *** efficacy and safety of dostarlimab as monotherapy was assessed in a non-randomized,multicenter,open-label,multi-cohort trial that included 209 patients with dMMR recurrent or advanced solid tumors after receiving systemic *** received 500 mg of dostarlimab intravenously every three weeks until they were given four ***,patients received 1000 mg dostarlimab intravenously every six weeks until disease progression or unacceptable *** overall response rate,as determined by shrinkage in tumor size,was 41.6%(95%confidence interval[CI];34.9,48.6),with 34.7 months as the median response *** conclusion,dostarlimab is an immunotherapy-based drug that has shown promising results in adult patients with recurrent or advanced dMMR ***,its efficacy in other cancer subtypes,the development of resistance to monotherapy,and efficacy and safety in combination with other immunotherapeutic drugs have not yet been studied.

关键词： Dostarlimab PD-1 Immunotherapy Endometrial cancer Check-point inhibitor

Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis

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Genes & Diseases 2023年第2期10卷 480-494页

作者： harsh Vardhan Charan Durgesh Kumar Dwivedi Sabbir Khan Gopabandhu Jena Facility for Risk Assessment and Intervention Studies Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and ResearchSector-67S.A.S. NagarPunjab 160062India Department of Neuro-Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

The liver injury leads to an inflammatory response, which causes the activation of hepatic stellate cells (HSCs) that further secrete ECM proteins and play an important role in liver fibrosis. Moreover, the inflammatory response is a driving force for fibrogenesis, which is triggered by many types of injuries. Exaggerated inflammatory immune responses are mediated by cytoplasmic protein complexes known as inflammasomes, which are involved in many chronic liver diseases. Inflammasomes are pattern recognition receptors (PRRs) that can sense any microbial motifs known as pathogen-associated molecular patterns (PAMPs), and host- or environmental-derived stress signals known as damage-associated molecular patterns (DAMPs). The inflammasomes cause caspase-mediated proteolytic cleavage of pro-IL-1β and pro-IL-18 into active IL-1β and IL-18. In this review, we provide a comprehensive summary of the important roles of NLRP3 inflammasome in the pathogenesis of liver fibrosis with an emphasis on several direct and indirect pathways responsible for the NLRP3 inflammasome-mediated HSCs activation and fibrogenesis. In addition, we discuss the general pharmacological and genetics strategies for the inhibition of NLRP3 inflammasome activation and its downstream signaling with examples of emerging pharmacotherapeutics, targeting the NLRP3 inflammasome signaling as well as a possible way to develop effective and safer NLRP3 inflammasome inhibitors.

关键词： Hepatic stellate cells Liver fibrosis NLRP3 activation NLRP3 inflammasome NLRP3 inhibitors

State-of-the-art machine learning techniques for melanoma skin cancer detection and classification:a comprehensive review

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Intelligent Medicine 2023年第3期3卷 180-190页

作者： harsh Bhatt Vrunda Shah Krish Shah Ruju Shah Manan Shah Department of Computer Science Institute of TechnologyNirma UniversityAhmedabadGujaratIndia Dhirubhai Ambani Institute of Information and Communication Technology GandhinagarGujaratIndia Department of Chemical Engineering School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagarGujaratIndia

Skin cancer is among the most common and lethal cancer types,with the number of cases increasing dramatically *** not diagnosed in the nascent stages,it can lead to metastases,resulting in high mortality *** cancer can be cured if detected ***,timely and accurate diagnosis of such cancers is currently a key research *** machine learning technologies have been employed in computer-aided diagnosis of skin cancer detection and malignancy *** learning is a subfield of artificial intelligence(AI)involving models and algorithms which can learn from data and generate predictions on previously unseen *** traditional biopsy method is applied to diagnose skin cancer,which is a tedious and expensive ***,machine learning algorithms for cancer diagnosis can aid in its early detection,lowering the workload of specialists while simultaneously enhancing skin lesion *** article presented a critical review of select state-of-the-art machine learning techniques used to detect skin *** studies had been collected,and an analysis of the performance of k-nearest neighbors,support vector machine,and convolutional neural networks algorithms on benchmark datasets was *** shortcomings and disadvantages of each algorithm were briefly *** in detecting skin cancer were highlighted and the scope for future research was proposed.

关键词： Machine learning Skin cancer Classification

GRADE: Deep learning and garlic routing-based secure data sharing framework for IIoT beyond 5G

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Digital Communications and Networks 2023年第2期9卷 422-435页

作者： Nilesh Kumar Jadav Riya Kakkar harsh Mankodiya Rajesh Gupta Sudeep Tanwar Smita Agrawal Ravi Sharma Department of Computer Science and Engineering Institute of TechnologyNirma UniversityAhmedabadGujaratIndia Centre for Inter-Disciplinary Research and Innovation University of Petroleum and Energy StudiesP.O.Bidholi Via-Prem NagarDehradunIndia

The rise of automation with Machine-Type Communication(MTC)holds great potential in developing Industrial Internet of Things(IIoT)-based applications such as smart cities,Intelligent Transportation Systems(ITS),supply chains,and smart industries without any human ***,MTC has to cope with significant security challenges due to heterogeneous data,public network connectivity,and inadequate security *** overcome the aforementioned issues,we have proposed a blockchain and garlic-routing-based secure data exchange framework,i.e.,GRADE,which alleviates the security constraints and maintains the stable connection in ***,the Long-Short-Term Memory(LSTM)-based Nadam optimizer efficiently predicts the class label,i.e.,malicious and non-malicious,and forwards the non-malicious data requests of MTC to the Garlic Routing(GR)*** GR network assigns a unique ElGamal encrypted session tag to each machine partaking in ***,an Advanced Encryption Standard(AES)is applied to encrypt the MTC data ***,the InterPlanetary File System(IPFS)-based blockchain is employed to store the machine's session tags,which increases the scalability of the proposed GRADE ***,the proposed framework has utilized the indispensable benefits of the 6G network to enhance the network performance of ***,the proposed GRADE framework is evaluated against different performance metrics such as scalability,packet loss,accuracy,and compromised rate of the MTC data *** results show that the GRADE framework outperforms the baseline methods in terms of accuracy,i.e.,98.9%,compromised rate,i.e.,18.5%,scalability,i.e.,47.2%,and packet loss ratio,i.e.,24.3%.

关键词： Garlic routing Blockchain I2P LSTM Artificial intelligence Onion routing

De novo design of future rapeseed crops:Challenges and opportunities

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The Crop Journal 2022年第3期10卷 587-596页

作者： Shengyi Liu harsh Raman Yang Xiang Chuanji Zhao Junyan Huang Yuanyuan Zhang Key Laboratory of Biology and Genetic Improvement of Oil Crops the Ministry of Agriculture and Rural AffairsOil Crops Research InstituteChinese Academy of Agricultural SciencesWuhan 430062HubeiChina NSW Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNSW 2650Australia Guizhou Rapeseed Institute Guizhou Academy of Agricultural SciencesGuiyang 550008GuizhouChina

To address the global demand for rapeseed while considering farmers’profit,we face the challenges of making a quantum leap in seed yield and,at the same time,reducing yield loss due to biotic and abiotic *** also face the challenge of efficiently applying new transformative biotechnology tools such as gene editing and breeding by genome design to increase rapeseed productivity and *** this Perspective,we review advances in research on the physiological and genetic bases of both stress factorsaffected yield stability and seed yield potential,focusing on source–sink relationships and allocation of photosynthetic assimilates to vegetative growth and seed *** propose research directions and highlight the role of plant architecture in the relative contributions of the root system,leaves,and pods to seed *** call for de novo design of new rapeseed *** review trait variation in existing germplasm and biotechnologies available for crop ***,we discuss opportunities to apply fundamental knowledge and key germplasm to rapeseed production and propose an ideotype for de novo design of future rapeseed cultivars.

关键词： Oilseed rape Seed yield Stress tolerance Physiological basis Ideotype Gene editing Breeding by genome design

Deep Learning-Based Robust Morphed Face Authentication Framework for Online Systems

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Computers, Materials & Continua 2023年第10期77卷 1123-1142页

作者： harsh Mankodiya Priyal Palkhiwala Rajesh Gupta Nilesh Kumar Jadav Sudeep Tanwar Osama Alfarraj Amr Tolba Maria Simona Raboaca Verdes Marina Department of Computer Science and Engineering Institute of TechnologyNirma UniversityAhmedabad382481India Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Doctoral School University Politehnica of BucharestBucharest060042Romania Department of Hydrogen and Fuel Cell National Research and Development Institute for Cryogenics and Isotopic TechnologiesRamnicu Valcea240050Romania Department of Building Services Faculty of Civil Engineering and Building ServicesTechnical University of Gheorghe AsachiIasi700050Romania

The amalgamation of artificial intelligence(AI)with various areas has been in the picture for the past few *** has enhanced the functioning of several services,such as accomplishing better budgets,automating multiple tasks,and data-driven *** hassle-free polling has been one of ***,at the onset of the coronavirus in 2020,almost all worldly affairs occurred online,and many sectors switched to digital *** allows attackers to find security loopholes in digital systems and exploit them for their lucrative *** paper proposes a three-layered deep learning(DL)-based authentication framework to develop a secure online polling *** provides a novel way to overcome security breaches during the face identity(ID)recognition and verification process for online polling *** verification is done by training a pixel-2-pixel Pix2pix generative adversarial network(GAN)for face image reconstruction to remove facial objects present(if any).Furthermore,image-to-image matching is done by implementing the Siamese network and comparing the result of various metrics executed on feature embeddings to obtain the outcome,thus checking the electorate credentials.

关键词： Artificial intelligence discriminator generator Pix2pix GANs Kullback-Leibler(KL)-divergence online voting system Siamese network

Synthesizing Self-Crosslinking Waterborne Polyurethane-Silanol Dispersion for Waterproofing Application

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Open Journal of Organic Polymer Materials 2022年第1期12卷 1-15页

作者： harsh Pandya Prakash A. Mahanwar Department of Polymer and Surface Engineering Institute of Chemical Technology Mumbai India

Polyurethane dispersions (PUD) have diversified into a myriad of applications over the years. This has led to extensive research on both industrial and laboratory fronts as polyurethane dispersions provide liberty to interplay at the molecular level to diversify the properties of the product which has also led to the development of eco-friendly waterborne dispersions. Yet, waterborne PUDs are limited in their mechanical and physical properties as compared to solvent-based products. The incorporation of crosslinkers in the PUD further bolsters these properties thus improving water and solvent resistance. The incorporation of silanols increases solvent resistance and adhesion of the resultant PUD. In this work, a post crosslinking system based on the ketone-hydrazine mechanism was incorporated into the PUD thus providing the required structural reinforcement for construction application. The targeted application for this work is the use of PUDs for waterproofing.

关键词： Polyurethane Dispersion Waterborne Crosslinking Waterproofing

Wooden foreign body impalement through the right shoulder region–an unusual penetrating injury:A case report

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World Journal of Orthopedics 2022年第12期13卷 1064-1068页

作者： Abhay harsh Kerketta Ritesh Kumar Seelora Sahu Jayanta Kumar Laik Manoj Kumar Rajak Department of Joint Replacement and Orthopaedics Tata Main HospitalSinghbhum 831001JharkhandIndia Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia

BACKGROUND Impalement of the body is a rare injury and comes with varied *** is no set classification or defined protocols for managing this *** case report aims to create awareness among trauma surgeons about unusual presentation and management of such *** SUMMARY A 45-year-old man presented to the emergency department with a sharp penetrating wooden plank at right clavicular region between the neck and shoulder following a road traffic *** vehicle had crashed into a roadside wooden hut,thus causing an impalement *** was meticulously worked up and taken to emergency *** wooden plank was removed and the wound healed ***,he had fairly good shoulder function and was able to return back to work *** Each impalement injury brings in challenges in management as no two cases are the *** varied presentation and risks involved should be known to medical professionals handling the *** multidisciplinary team approach is needed for successful outcome.

关键词： Impaling Wooden Foreign body Sharp object Trunk Case report