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环GMP抑制的环AMP磷酸二酯酶产生的内皮源性NO的基础释放促进前列环素引起的小猪肺动脉舒张(英文)

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Acta Pharmacologica Sinica 2000年第2期21卷 37-44页

作者： thomas M ZELLERS,Jennifer McCORMICK,Paul M VANHOUTTE Department of Pediatrics Division of Cardiology University of Texas Southwestern Medical Center at Dallas 5323 harry Hines Boulevard Dallas TX 75235 Department of Pediatrics Division of Cardiology University of Texas Southwestern Medical Center at Dallas 5323 harry Hines Boulevard Dallas TX 75235 IRIS 6 Place de Pleiades 92415 Courbevoie France

AIM: To study the interactions between prostacyclin and endothelium-derived nitric oxide in porcine pulmonary arteries. METHODS: Rings of 5th order of porcine pulmonary arteries were studied in vitro for the measurement of tension and the content in cyclic nucleotides. RESULTS: Prostacyclin, given exogenously, caused en-dothelium-potentiated relaxations (inhibition of phenyle-phrine contraction) that were inhibited by the inhibitors of the L-arginine nitric oxide pathway, oxyhemoglobin and Nω-nitro-L-arginine. These inhibitors did not affect the tension in rings without endothelium. Cyclic GMP-con-centrations were not increased above basal concentrations in the presence of prostacyclin. Increases were seen with acetylcholine and sodium nitroprusside. Prostacyclin-stimulated cyclic AMP concentrations did not reach statistical significance compared to controls. The addition of 8-bromo-cyclic GMP to prostacyclin, however, increased the cyclic AMP content. The nitric oxide synthase inhibitor, nitro-L-argin

关键词：肺动脉血管内皮硝酸依前列醇环鸟苷一磷酸环腺苷一磷酸磷酸二酯水解酶

The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts

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Signal Transduction and Targeted Therapy 2019年第1期4卷 34-48页

作者： Tianyi Liu Linli Zhou Kun Yang Kentaro Iwasawa Ana Luisa Kadekaro Takanori Takebe thomas Andl Yuhang Zhang Division of Pharmaceutical Sciences College of PharmacyUniversity of CincinnatiCincinnatiOH45267USA Division of Gastroenterology Hepatology&NutritionCincinnati Children’s Hospital Medical Center3333 Burnet AvenueCincinnatiOH45229-3039USA Division of Developmental Biology Cincinnati Children’s Hospital Medical Center3333 Burnet AvenueCincinnatiOH45229-3039USA Department of Dermatology College of MedicineUniversity of CincinnatiCincinnatiOH45267USA Center for Stem Cell and Organoid Medicine(CuSTOM) Cincinnati Children’s Hospital Medical Center3333 Burnet AvenueCincinnatiOH45229-3039USA Department of Pediatrics University of Cincinnati College of Medicine3333 Burnet AvenueCincinnatiOH45229-3039USA Institute of Research Tokyo Medical and Dental University 1-5-45 YushimaBunkyo-kuTokyo113-8510Japan Burnett School of Biological Sciences University of Central FloridaOrlandoFL32816USA

β-catenin is a multifunctional protein that plays crucial roles in embryonic development,physiological homeostasis,and a wide variety of human ***,we showed that in vivo targeted ablation ofβ-catenin in melanoma-associated fibroblasts after melanoma formation significantly suppressed tumor ***,when the expression ofβ-catenin was ablated in melanoma-associated fibroblasts before tumor initiation,melanoma development was surprisingly *** stromalβ-catenin deficiency leads to opposite biological effects in melanoma progression is not completely ***,we report thatβ-catenin is indispensable for the activation of primary human stromal fibroblasts and the mediation of fibroblast-melanoma cell *** coimmunoprecipitation and proximity ligation assays,we identified Yes-associated protein(YAP)as an importantβ-catenin-interacting partner in stromal *** is highly expressed in the nuclei of cancer-associated fibroblasts(CAFs)in both human and murine *** investigation revealed that YAP nuclear translocation is significantly modulated by Wnt/β-catenin activity in *** Wnt/β-catenin signaling in stromal fibroblasts inhibited YAP nuclear *** the absence of YAP,the ability of stromal fibroblasts to remodel the extracellular matrix(ECM)was inhibited,which is consistent with the phenotype observed in cells withβ-catenin *** studies showed that the expression of ECM proteins and enzymes required for remodeling the ECM was suppressed in stromal fibroblasts after YAP ***,our data provide a new paradigm in which theβ-catenin-YAP signaling axis regulates the activation and tumor-promoting function of stromal fibroblasts.

关键词： melanoma inhibited homeostasis

CODE-EHR:临床研究中运用结构化电子医疗记录的最佳实践框架

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英国医学杂志中文版 2022年第12期25卷 721-729页

作者： Dipak Kotecha Folkert W Asselbergs Stephan Achenbach Stefan DAnker Dan Atars Colin Baigent Amitava Banerjee Birgit Beger Cunnar Brobert Barbara Casadei Cinzia Ceccarelli Martin R Cowie Filippo Crea Maureen Cronin Spiros Denaxas Andrea Derix Donna Fitzsimons Martin Fredriksson Chris PGale Georgios V Ckoutos Wim Goettsch harry Hemingway Martin Ingvaris Adrian Jonas's Robert Kazmierski Susanne Logstrup R thomas Lumbers thomas F Lischer Paul McGreavy leana L Pina Lothar Roesiga Carl Steinbeisser Mats Sundgren Benoit Tyl Chislaine van Thiel Kees van Bochove Panos EVardas Tiago Villanueva Marilena Vrana Wim Weber Franz Weidinger Stephan Windecker Angela Wood Diederick E Grobbee 创新药物计划BigData@Heart联盟欧洲心脏病协会 CODE-EHR国际共识小组宋奇繁(译) 汪奕名(译) 不详重庆医药高等专科学校

改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺... 详细信息

改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺陷。证实、核验、数据隐私以及对科学研究社会责任的践行是一项重要挑战。欧洲心脏病协会和BigData@Heart联盟已经收集了包括患者代表、临床医生、科研人员、监管机构、期刊编辑和企业代表在内的多元化国际参与者,提出了CODE-EHR的最低标准框架。为改进研究设计、提高信息透明度提供方法手段,同时为实现医疗保健数据的稳健并能够有效运用制定了技术路线图。

关键词：大数据数据隐私 CODE 技术路线图科研人员信息透明度医疗保健最低标准

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美国全髋置换关节负重面应用的流行情况调研

中华骨科杂志 2010年第3期30卷 I0012-I0017页

作者： Kevin J. Bozic, MD MBA Steven Kurtz, PhD Edmund Lau, MS Kevin Ong, PhD Vanessa Chiu, MPH thomas P. Vail, MD harry E. Rubash, MD Danie J. Berry, MD 田丰德(译) 赵德伟(译) Investigation performed at the Department of Orthopaedic Surgery and Philip R. Lee Institute for Health Policy Studies University of California San Francisco San Francisco California and Exponent Inc. Philadelphia Pennsylcanina 大连大学附属中山医院 116001

背景：硬性对硬性材料的负重面有提高全髋关节置换假体植入物生存的潜力。然而，对于使用这些先进技术的特定适应证仍然存在争议。本研究的日的是从患者、医院、地域和支付人特点几方面对美国全髋关节置换中负重面应用情况进行流行病学... 详细信息

背景：硬性对硬性材料的负重面有提高全髋关节置换假体植入物生存的潜力。然而，对于使用这些先进技术的特定适应证仍然存在争议。本研究的日的是从患者、医院、地域和支付人特点几方面对美国全髋关节置换中负重面应用情况进行流行病学研究。方法：应用全国住院病例数据库资料，对从2005年10月1日至2006年12月31日，在美国进行的112095例初次全髋关节置换病例的负重面类型及其人口统计学特征进行分析。病例按照年龄、性别、普查区域、付款人类别和医院的类型进行分组，计算每种类型髋关节负重面在各组中的使用率。

关键词：关节负重流行情况应用全髋置换美国全髋关节置换病例数据库调研

智能纺织品领域用圆形针织物线圈纵行方向上的添纱集成

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国际纺织导报 2018年第7期46卷 32-33,36,37,38页

作者： E.Hntzsche J.Wendler T.Ruder T.Bhr A.Kluge C.Cherif J.Reichart H.Lucas 徐金贝(译) 赵俐(校) 德累斯顿工业大学纺织机械与高性能材料技术研究所(ITM)(德国) Roma Rolf Mayer针织公司(德国) harry Lucas机械公司(德国) 不详

作为德累斯顿工业大学纺织机械与高性能材料技术研究所(ITM)中小型企业中心创新计划(ZIM)资助项目的一部分,ITM与德国中小型企业Rolf Mayer针织公司(Roma)和harry Lucas机械公司合作,开发了一款具有创新性且成本效益高的针织大圆机(LCKM... 详细信息

作为德累斯顿工业大学纺织机械与高性能材料技术研究所(ITM)中小型企业中心创新计划(ZIM)资助项目的一部分,ITM与德国中小型企业Rolf Mayer针织公司(Roma)和harry Lucas机械公司合作,开发了一款具有创新性且成本效益高的针织大圆机(LCKM)附加装置。通过该附加装置,一组附加的层状纱线可沿线圈纵行方向织入双正面或双罗纹织物。添纱与纬纱一起,同时织入线圈横列方向,这就允许在一个生产步骤中,在织物结构中制备晶格状的、互相关联的面板加热元件,所得织物可用作纺织加热片和传感器元件。以在纬编双针盘针织物中采用弹性纱和导电纱编织加热板元件为例,这种方法显示了其在家纺领域整体化生产功能性纬编针织可加热纺织品的潜力。

关键词：添纱智能纺织品针织大圆机

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院