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推进循环肿瘤细胞和肺癌的发展

国际病理科学与临床杂志 2013年第5期33卷 374-375页

作者： T. Jeroen N.Hiltermann Anthonie J.van der Wekken harry J. M.Groen 王慧娟董艳鹏 Department of pulmonary Diseases University of Groningen University Medical Center GroningenGroningen The Netherlands 河南省职业病防治研究院河南省职业病医院内科郑州450000 河南省南阳市第一人民医院儿三科河南南阳473000

肺癌仍然是世界上最致命的肿瘤。每年有超过100万人因此病丧生[1]。（肺）癌最常见的死因是转移癌。肿瘤细胞在起病部位之外的组织中传播和生长，肿瘤负荷迅速增加[2]。非小细胞肺癌（non—small cell lung carcinoma，NSCLC）约占所有... 详细信息

肺癌仍然是世界上最致命的肿瘤。每年有超过100万人因此病丧生[1]。（肺）癌最常见的死因是转移癌。肿瘤细胞在起病部位之外的组织中传播和生长，肿瘤负荷迅速增加[2]。非小细胞肺癌（non—small cell lung carcinoma，NSCLC）约占所有肺癌病例的85％，并且是全球癌症相关死亡的首要原因。约70％的患者在就诊时已达疾病晚期，

关键词：非小细胞肺癌循环肿瘤细胞 carcinoma 起病部位肿瘤负荷 cell lung 转移癌

Gene editing for corneal disease management

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World Journal of Translational Medicine 2016年第1期5卷 1-13页

作者： Sudhanshu p Raikwar Apoorva S Raikwar Shyam S Chaurasia Rajiv R Mohan Department of Veterinary Medicine and Surgery College of Veterinary MedicineUniversity of Missouri harry S.Truman Memorial Veterans’ Hospital Department of Microbiology Roy J.and Lucille A.Carver College of MedicineUniversity of Iowa Mason Eye Institute School of MedicineUniversity of Missouri Ophthalmology and Molecular Medicine One-health One-Medicine Ophthalmology and Vision ResearchUniversity of Missouri

Gene editing has recently emerged as a promising technology to engineer genetic modifications precisely in the genome to achieve long-term relief from corneal *** advances in the molecular biology leading to the development of clustered regularly interspaced short palindromic repeats(CRISpRs) and CRISpR-associated systems,zinc finger nucleases and transcription activator like effector nucleases have ushered in a new era for high throughput in vitro and in vivo genome *** editing can be successfully used to decipher complex molecular mechanisms underlying disease pathophysiology,develop innovative next generation gene therapy,stem cell-based regenerative therapy,and personalized medicine for corneal and other ocular *** this review we describe latest developments in the field of genome editing,current challenges,and future prospects for the development of personalized genebased medicine for corneal *** gene editing approach is expected to revolutionize current diagnostic and treatment practices for curing blindness.

关键词： Adeno-associated virus Clustered Regularly-Interspaced Short palindromic Repeats associated protein 9 Cornea Clustered regularly interspaced short palindromic repeat Double strand breaks Gene editing sgRNA Gene targeting Homology directed repair Homologous recombination Indels Lentiviral vector protospacer-adjacent motif Transcription activator like effector nucleases Zinc finger nucleases

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持续创新，应用无极限

程序员 2009年第2期 12-12页

作者： harry Storer 本刊记者甲骨文公司

30年以来，市场对于企业的挑战从未如此激烈。几乎每一个企业都在迎接无所不在的变化，这种变化的速度越来越快，而企业为了生存，必须更加适应这些不同的变化，在避免同质化或被同质化的时候，每一家企业都必须有独特的优势。

关键词：创新极限应用同质化企业

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新老板的新压力汇丰面临两大难题

商业周刊（中文版） 2019年第6期 28-28页

作者： harry Wilson 杨熙(译) 不详

2018年,范宁(John Flint)升任汇丰控股有限公司(HSBC Holdings pZc)首席执行官(CEO),他在这家银行工作了一辈子,此时接手的是一个已经历经重组的汇丰。在此前七年里,该行6万个工作岗位被裁撤,21个国家的业务被出售、关闭或缩减。而在依... 详细信息

2018年,范宁(John Flint)升任汇丰控股有限公司(HSBC Holdings pZc)首席执行官(CEO),他在这家银行工作了一辈子,此时接手的是一个已经历经重组的汇丰。在此前七年里,该行6万个工作岗位被裁撤,21个国家的业务被出售、关闭或缩减。而在依然保有业务的67个国家里,成本太高、收入增长不够快这两个核心问题依旧困扰着汇丰。

关键词：汇丰控股有限公司压力老板首席执行官银行工作工作岗位收入增长业务

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国际好邻居节

疯狂英语（口语版） 2014年第3期 28-28页

作者： harry Liebersohn Anny(翻译)

曾几何时，在温馨的大院小巷里，邻里间像老朋友般打着招呼，互敬互爱；孩子们都结为儿时的玩伴，快乐地一起走过了童年；一家有难，多家帮助，大家像兄弟姐妹一样相互扶持……然而，时代变了，社会发展了，人际关系变复杂了，

关键词：邻居国际兄弟姐妹社会发展人际关系朋友

谁主沉浮——GMp后时代我国动保行业发展探讨

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中国畜牧杂志 2007年第18期43卷 5-10页

作者：霄枫（主持人）孙进忠（嘉宾）胡启毅（嘉宾）毕雅礼（harry pICARD）（嘉宾）何谦（嘉宾）周宝贵（嘉宾）不详洛阳普莱柯生物工程有限公司乾元浩生物股份有限公司梅里亚中国区拜耳动物保健业务部中国区北京华都峪口禽业公司

茶,久饮,可以益思、可以养性;茶馆,常往,可品茶论道,道尽天下时事……市场就如此茶,需时刻关注、不断评析,久之,便可把脉市场风云,运筹帷幄。

关键词： GMp 行业沉浮茶馆市场

Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut

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World Journal of Gastrointestinal pharmacology and Therapeutics 2016年第2期7卷 268-273页

作者： Karl M Langberg Neil D parikh Yanhong Deng Maria Ciarlegio Loren Laine harry R Aslanian Section of Digestive Diseases Yale University School of Medicine Department of Biostatistics Yale School of Public Health VA Connecticut Healthcare System

AIM:To use a survey to characterize and identify potential barriers to the use of digital chromoendoscopy(DC)by practicing ***:An anonymous,internet-based survey was sent to gastroenterologists in Connecticut who were members of one of three national gastrointestinal *** survey collected demographic information,frequency of DC use,types of procedures that the respondent performs,setting of practice(academic vs community),years out of training,amount of training in DC,desire to have DC training and perceived barriers to DC *** were collected *** primary endpoint was the proportion of endoscopists utilizing *** between the various data collected were analyzed usingχ2 ***:One hundred and twenty-four gastroenterologists(48%)of 261 who received the online survey ***-eight percent of surveyed gastroenterologists have used DC during the performance of upper endoscopy and 81%with lower *** was used in more than half of procedures by only 14%of gastroenterologists during upper endoscopy and 12%during lower ***-three percent(upper)and 21%(lower)used DC more than one quarter of the *** was used for 10%or less of endoscopies by 60%(upper)and53%(lower)of *** reported lack of training as the leading deterrent to DC use with36%reporting it as their primary ***-nine percent of endoscopists never received formal training in *** of time(30%of respondents),lack of evidence(24%)and lack of reimbursement(10%)were additional *** were no differences in DC use relative to academic vs community practice setting or years out of ***:DC is used infrequently by most endoscopists,primarily due to a lack of *** opportunities should be expanded to meet the interest expressed by the majority of endoscopists.

关键词： Endoscopy Surveys and questionnaires Gastrointestinal diseases Clinical practice patterns Esophageal neoplasms Colonic neoplasms Narrow band imaging Flexible spectral imaging color enhancement I-scan

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“独行侠”须知

中学外语教与学 2003年第6期

作者： By harry Marks 若言

一个人的出游更自由、更有弹性，令人向往，但也往往会出现更多危险和考验。如何才能一个安全而愉快的旅行呢？

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Xp ***:谁是最好的Windows

微电脑世界 2008年第4期 184-184页

作者： harry McCracken pC World

微软认为你的下一台电脑的操作系统应该是Windows Vista,如果你还有选择的自由的话,也许你的选择与微软的期望会不同。

关键词： Windows Vista 操作系统微软电脑