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Gut microbiota in cancer initiation,development and therapy

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Science China Life Sciences 2025年

作者： Ruyi Zhang Xiang Zhang harry Cheuk Hay Lau Jun Yu Institute of Digestive Disease and Department of medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

Cancer has long been associated with genetic and environmental factors,but recent studies reveal the important role of gut microbiota in its initiation and *** 13%of cancers are linked to infectious agents,highlighting the need to identify the specific microorganisms *** microbiota can either promote or inhibit cancer growth by influencing oncogenic signaling pathways and altering immune *** can lead to cancer,while certain probiotics and their metabolites may help reestablish microecological balance and improve anti-tumor immune *** into targeted approaches that enhance therapy with probiotics is ***,the effects of probiotics in humans are complex and not yet fully ***,methods to counteract harmful bacteria are still in *** clinical trials also indicate that modifying gut microbiota may help manage side effects of cancer *** research is crucial to understand better how gut microbiota can be used to improve cancer prevention and treatment outcomes.

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Economic Impact of mutant Cassava （manihot Species） for Agricultural Improvement in Ghana

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Journal of Agricultural Science and Technology(B) 2014年第4期4卷 272-280页

作者： Kwamina Ewur Banson harry amoatey Joe Frederick Cobbinah Department of Technology Transfer Centre (TTC) Biotechnology and Nuclear Agriculture Research Institute (BNARI) Ghana Department of Engineering Takoradi Polytechnic Takoradi Ghana

The importance of agricultural innovations for raising the living standards of farmers has received substantial attention from the economic and political communities. In Ghana, cassava serves as an important source of calorie and cash crop. Production constraints such as the cassava mosaic disease caused by virus have limit farmers access to productivity potentials and marketing. Breeding efforts attempting to address this constraints have had some success such as the mutant Tech Bankye virus resistant variety. This research, therefore, analysed the impact of some production input on mutant cassava productivity growth in Ghana with the use of Cobb-Douglas production function. Results show that farmers cultivate the mutant variety in addition to other traditional varieties to averse risking in marketing and income. The average cost of production of the mutant variety is higher compared to that of the traditional variety. Eighty percent of the farmers complained difficulty in accessing market for the mutant variety because it could not replace the traditional variety in terms of its texture for the local native ＂fufu＂ production and ＂ampesi＂ and also deteriorate quickly in storage. However, for industrial production of ＂gari＂ and starch, the mutant is the best. Both the mutant cassava and the traditional varieties showed increasing returns to scale, however, the returns to scale of the mutant variety were lower compared to that of the traditional variety. Also, the opportunity cost of forgoing the traditional varieties to cultivating the mutant variety was very high making adopted farmers hesitant to continue it cultivation.

关键词： Technology adoption market production cost production function mutant variety opportunity cost returns to scale agricultural productivity.

Sensory sacrifices when we mass-produce mass produce

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Horticulture Research 2016年第1期3卷 167-172页

作者： Kevin m Folta harry J Klee Horticultural Sciences Department Plant Innovation Center and The Graduate Program for Plant Molecular and Cellular BiologyUniversity of FloridaGainesville32606FLUSA

Plant breeders have been extremely successful at driving genetic improvements in ***,‘improvements’are truly a question of *** the last one-hundred years most plant genetic innovations have been driven by industry *** fruits,heavier yields,uniformity,increased resistance to disease and better shipping quality are just a few of the traits that have ensured profits on the farm and affordable food for ***,these milestones have come at the expense of sensory qualities,which have been sacrificed in exchange for practical production *** a base of industry-sufficient genetics,today’s breeders can now turn to the consumer for guidance in defining critical *** approaches to plant breeding start with the analysis of consumer preferences,and then merge them with modern genomics and analytical chemistry *** result is the next generation of crops that meet supply chain demands while presenting improvements in flavor,nutrition,color,aroma and *** review analyzes the approach of consumer-assisted selection as it has been applied to tomato and strawberry,two complementary annual crops that have been intensively bred to meet industry *** breeding efforts start with the consumer,with the objective of reclaiming lost sensory qualities.

关键词： crops breeding driving

Water use efficiencies of maize cultivars grown under rain-fed conditions

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Agricultural Sciences 2011年第2期2卷 125-130页

作者： Daniel Kwasi Asare Justice Okona Frimpong Emmanuel Ofori Ayeh harry mensah amoatey Department of Plant and Soil Sciences Biotechnology and Nuclear Agriculture Research Institute Ghana Atomic Energy Commission Legon-Accra Ghana

Enhancing water use efficiencies of rain-fed maize is a requirement for sustainable maize production, particularly in areas prone to low/drought and erratic rainfall patterns. This study was conducted to assess the relationship between total biomass/grain yield and water use efficiencies of three maize cultivars (Golden Crystal, mamaba and Obatanpa) grown under rain-fed conditions in a coastal savannah agro-ecological environment of Ghana. Results of the study showed that a unified linear model, WUETDm = 0.03TDm with R2 = 0.765 and P ≤ 0.001, described adequately the relation between wa-ter use efficiency and total biomass (dry matter), which is applicable for the three maize cultivars for both the major and minor cropping seasons. A linear model could only, however, describe adequately well the relation between WUEGY and GY for the major (WUEGY = 0.001GY – 0.67;R2 = 0.996;P ≤ 0.001) and minor (WUEGY = 0.002GY + 0.289;R2 = 0.992;P ≤ 0.001) cropping seasons for all the maize cultivars. The linear models developed for the maize cultivars, re-lating WUEGY to GY, are specific to each of the crop growing seasons, indicating that seasonal rainfall impacts significantly on harvest index of the maize cultivars but differently in each of the crop growing seasons as a results of dif-ferences in seasonal rainfall. However, the models could be used to estimate water use efficiencies of each of the three maize cultivars given the appropriate TDm and GY as inputs for the environment under which the study was conducted.

关键词： Water Use Efficiency maize Cultivars Rain-Fed

Significance of using isolated footing technique for resi- dential construction on expansive soils

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 123-129页

作者： harry FAR Deacon FLINT Centre for Built Infrastructure Research School of Civil and Environmental Engineering University of Technology Sydney (UTS)Australia

Expansive soils cause problems with the founding of lightly loaded structures in many parts of the world. Foundation design for expansive soils is one of the most discussed and problematic issues in Australia as expansive soils were responsible for billions of dollars＇ worth of damage to man-made structures such as buildings and roads. Several studies and reports indicate that one of the most common and least recognized problems causing severe structural damage to houses lies in expansive soils. In this study, a critical review has been carried out on the current Australian standards for building on expansive soils and they are compared with some techniques that are not included in the current Australian standards for residential slabs and footings. Based on the results of this review, the most effective and economical method has been proposed for construction of footings on all site classifications without restriction to 75mm of characteristic movement. In addition, it has become apparent that as design procedures for footings resting on sites with extreme characteristic movements are not included in the current Australian standards, there is a strong need for well-developed and simplified standard design procedures for characteristic soil movement of greater than 75mm to be included into the Australian Standards.

关键词： expansive soils residential slabs isolated footings Australian Standards

A review on molten sulfate salts induced hot corrosion

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Journal of materials Science & Technology 2021年第31期90卷 243-254页

作者： Shanshan Hu harry Finkle Xingbo Liu mechanical&Aerospace Engineering Department Benjamin M.Statler College of Engineering&Mineral ResourcesWest Virginia UniversityMorgantownWV 26506-6106USA C.Eugene Bennett Department of Chemistry West Virginia UniversityMorgantownWV 26506USA

Hot corrosion has been extensively observed in various high temperature applications,which might cause large economic *** deepen the insight and understanding of hot corrosion,herein,we provide a detailed discussion on hot corrosion induced by molten sulfate salt,in which Na_(2)SO_(4)is the main chemical *** hot corrosion is triggered and sustained by the negative solubility gradient of protective oxide from the oxide/salt interface to salt/gas *** this work,we reviewed several key factors,including temperature,gas composition,molten salt composition,alloy element and external stress,influencing the hot corrosion of alloy beneath the molten *** application of anti-corrosion coating seems to be the most effective and commercial mothed to mitigate hot ***,the progress of the development of effective coatings,e.g.,Ni-Cr coatings,aluminide coatings,silicide coatings and mCrAlY(X)coatings,has also been summarized.

关键词： Hot corrosion molten sulfate salts Protective oxide layer Dissolution Anti-corrosion coatings

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Synchronization of home departure and arrival times in dual earner households with children:Panel regression model of time gaps

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 504-513页

作者： Bilin Han harry Timmermans Urban Planning Group Eindhoven University of Technology

Organizing schedules and allocating time to different activities is always a challenge in dual-earner households,especially when they have *** may need to link their schedule to those of their children to allow them escorting their children to school or to take care or be with their children at *** paper reports the results of an analysis of the degree of synchronization of home departure and arrival times in dual earner households with children,where the degree of synchronization is defined as the gap between departure and arrival times of a parent and *** activity-travel diary data of different household members,a random parameters regression model is estimated to examine differences in time gaps in home departure and arrival times between parents and children as a function of gender,day of the week,age of the youngest child,and other socio-demographic *** results of the analysis provide insight into factors influencing the degree of synchronization and coordination of double activity-travel scheduling decisions in households with *** indicate that gender,number of children in the household,age of the youngest child,travel within or outside peak hours,day of the week,transport mode used for the work commute and household income level significantly affect time gaps,especially arrival time gaps.

关键词： Home departure and arrival times Synchronization Time gap Dual-earner households Random parameters panel regression model

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Clinical,serological and genetic predictors of inflammatory bowel disease course

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World Journal of Gastroenterology 2012年第29期18卷 3806-3813页

作者： Laurent Beaugerie harry Sokol Department of Gastroenterology AP-HPH pital Saint-Antoine F-75012 and UPMC University Paris 06F-75005 ParisFrance

Patients with extensive or complicated Crohn's disease(CD) at diagnosis should be treated straightaway with immunosuppressive therapy according to the most recent *** patients with localized and uncomplicated CD at diagnosis,early use of immunosuppressive therapy is debated for preventing disease progression and limiting the disabling clinical *** this context,there is a need for predictors of benign or unfavourable subsequent clinical course,in order to avoid over-treating with risky drugs those patients who would have experienced spontaneous mid-term asymptomatic disease without progression towards irreversible intestinal *** diagnosis,an age below 40 years,the presence of perianal lesions and the need for treating the first flare with steroids have been consistently associated with an unfavourable subsequent 5-year or 10-year clinical *** positive predictive value of unfavourable course in patients with 2 or 3 predictors ranges between 0.75 and 0.95 in population-based and referral centre ***,the use of these predictors can be integrated into the elements that influence individual *** the CD postoperative context,keeping smoking and history of prior resection are the stron-gest predictors of disease symptomatic ***,these clinical predictors alone are not as reliable as severity of early postoperative endoscopic recurrence in clinical *** ulcerative colitis(UC),extensive colitis at diagnosis is associated with unfavourable clinical course in the first 5 to 10 years of the disease,and also with long-term colectomy and colorectal inflammation-associated colorectal *** patients with extensive UC at diagnosis,a rapid step-up strategy aiming to achieve sustained deep remission should therefore be *** the moment,no reliable serological or genetic predictor of inflammatory bowel disease clinical course has been identified.

关键词： Crohn's disease Ulcerative colitis Inflammatory bowel diseases Natural history Predictors Clinical practice

Synthesis of Nanostructured Copper-doped Titania and Its Properties

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Nano-micro Letters 2013年第1期5卷 26-33页

作者： Oman Zuas harry Budiman Research Center for Chemistry (RCChem) Indonesian Institute of Sciences (LIPI)Kawasan PUSPIPTEK Serpong

Nanostructured pure-Ti O_2 and Cu3%-Ti O_2 were successfully synthesized via co-precipitation method. The X-ray diffraction(XRD) result proves that the synthesized sample were predominantly in anatase phase with size in the range of 8～16 nm, which are in good agreement with the transmission electron microscopy data. Owing to doping of copper, not only did the thermal stability of the Ti O_2 decrease, but also a significant decrease in its particle size and a shift of the adsorption edge to a higher wavelength region appear. The activity of both pure-Ti O_2 and Cu3%-doped Ti O_2 was tested to study their ability to decolorize congo red(CR) dye in aqueous solution. We observed that the CR dye was decolorized faster by Cu3%-Ti O_2 than pure-Ti O_2. Results of this study demonstrate a potential application of the synthesized sample for decolorizing dye pollutants from aqueous waste.

关键词： Nanostructure Copper Titania Decolorization Congo red

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