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Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International journal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： harry j.carpenter Mergen H.Ghayesh Anthony C.Zander Peter j.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of Cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)*** one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

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Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee j Dufault Katherine M Adler David O carpenter Steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

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Bile acids,gut microbiota,and therapeutic insights in hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第2期21卷 144-162页

作者： Yang Song harry CH Lau Xiang Zhang jun Yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina Department of Gastroenterology Zhongshan Hospital Xiamen UniversityXiamen 361004China

Hepatocellular carcinoma(HCC)is a prevalent and aggressive liver *** interplay between bile acids(BAs)and the gut microbiota has emerged as a critical factor in HCC development and *** normal conditions,BA metabolism is tightly regulated through a bidirectional interplay between gut microorganisms and *** gut microbiota plays a critical role in BA metabolism,and BAs are endogenous signaling molecules that help maintain liver and intestinal *** note,dysbiotic changes in the gut microbiota during pathogenesis and cancer development can disrupt BA homeostasis,thereby leading to liver inflammation and fibrosis,and ultimately contributing to HCC ***,understanding the intricate interplay between BAs and the gut microbiota is crucial for elucidating the mechanisms underlying *** this review,we comprehensively explore the roles and functions of BA metabolism,with a focus on the interactions between BAs and gut microorganisms in ***,therapeutic strategies targeting BA metabolism and the gut microbiota are discussed,including the use of BA agonists/antagonists,probiotic/prebiotic and dietary interventions,fecal microbiota transplantation,and engineered *** summary,understanding the complex BA-microbiota crosstalk can provide valuable insights into HCC development and facilitate the development of innovative therapeutic approaches for liver malignancy.

关键词： Bile acid gut microbiota hepatocellular carcinoma therapeutics microbiota modulation

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Geophysical Surveys over Karst Recharge Features,Illinois,USA

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Acta Geologica Sinica(English Edition) 2001年第3期75卷 249-253页

作者： Philip j.carpenter Shawkat AHMED Department of Geology and Environmental Geosciences 312 Davis Hall Northern Illinois University DeKalb Illinois USADepartment of Geology and Environmental Geosciences 312 Davis Hall Northern Illinois University DeKalb Illinois USA

Karst aquifers supply a significant fraction of the world's drinking water. These types of aquifers are alsohighly susceptible to pollution from the surface with recharge usually occurring through fractures and solution openings at the bedrock surface. Thickness of the protective soil cover, macropores and openings within the soil cover, and the nature of the weathered bedrock surface all influence infiltration. Recharge openings at the bedrock surface, however, are often covered by unconsolidated sediments, resulting in the inadvertent placement of landfills, unregulated dump sites, tailing piles, waste lagoons and septic systems over recharge zones. In these settings surface geophysical surveys, calibrated by a few soil cores, could be employed to identify these recharge openings, and qualitatively assess the protection afforded by the soil cover. In a test of this hypothesis, geophysical measurements accurately predicted the thickness of unconsolidated deposits overlying karstic dolomite at a site about 100 km south of Chicago, Illinois. Zones of elevated electrical conductivity and high ground-penetrating radar (GPR) attenuation within the sediments coincided with subcropping solutionally-enlarged hydraulically active bedrock fractures. These fractures extend to over 12-m depth, as shown by 2-D inverted resistivity sections and soil coring. Anomalous electromagnetic (EM) conductivity and GPR response may be due to higher soil moisture above these enlarged fractures. An epikarstal conduit at 2.5-m depth was directly identified through a GPR survey. These results suggest that surface geophysical surveys are a viable tool for assessing the susceptibility of shallow karst aquifers to contamination.

关键词： karst geophysics epikarst soil pipes recharge infiltration sinkholes

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Disagreement in middle ear volume estimation between tympanometry and three-dimensional volume reconstruction in the context of tympanic membrane perforation

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journal of Otology 2017年第2期12卷 74-79页

作者： David j.carpenter Debara L.Tucci David M.Kaylie Dennis O.Frank-Ito Division of Head and Neck Surgery&Communication Sciences Department of SurgeryDuke University Medical CenterDurhamNCUSA Computational Biology&Bioinformatics PhD Program Duke UniversityDurhamNCUSA Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA

Introduction: Middle ear volume(MEV) is a clinically relevant parameter across middle ear diseases. MEV values between these techniques have never before been tested for agreement in ears with perforated tympanic membranes(TMs).Methods: Middle ears were identified from 36 patients ranging 18-89 years of age with TM perforations who underwent tympanometry and temporal bone computed tomography(CT) between 2005 and 2015. MEVs calculated by both tympanometry and three-dimensional volume reconstruction(3DVR) were analyzed for agreement using Bland Altman plots. The differences between tympanometric and 3DVR MEV values for each given middle ear were characterized across MEV quartiles(1= smallest; 4= largest) and across increasing states of middle ear disease using Kruskale Wallis and Wilcoxon testing with Bonferroni ***: Bland Altman plots demonstrated significant disagreement between MEV measurement techniques. Differences between tympanometric(T) and 3DVR MEV values were significantly greater with increasing average(i.e.(Tt3DVR)/2)) MEV per linear regression(p < 0.0001). Significance was demonstrated between fourth and first average MEV quartiles(p= 0.0024), fourth and second quartiles(p= 0.0024), third and first quartiles(p= 0.0048), and third and second quartiles(p= 0.048). Absolute MEV difference was not significantly different across varying states of middle ear disease(p= 0.44).Conclusion: Statistically and clinically significant disagreement was demonstrated between tympanometric and 3DVR MEV values. Studies that vary in MEV estimation techniques may be expected to demonstrate significantly different results. These preliminary results suggest that clinicians should endeavor to seek further confirmation when interpreting high tympanometric MEV values.

关键词： Middle ear volume Tympanometry Three-dimensional volume reconstruction Tympanic membrane perforation

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The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation

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journal of Otology 2017年第3期12卷 125-131页

作者： David j.carpenter Debara L.Tucci David M.Kaylie Dennis O.Frank-Ito Division of Head and Neck Surgery & Communication Sciences Department of Surgery Duke University Medical Center Durham NC USA Computational Biology & Bioinformatics PhD Program Duke University Durham NC USA Department of Mechanical Engineering and Materials Science Duke University Durham NC USA

Objectives: Recent studies have introduced middle ear volume(MEV) as a novel determinant of perforation-induced conductive hearing loss(CHL) in a mechanism driven by trans-tympanic membrane pressure differences. The primary aims of this preliminary report are to: 1) correlate CHL with perforation size; 2) describe the relationship between CHL and MEV; and 3) compare CHL across a range of cholesteatoma ***: A retrospective pilot study was performed in 31 subjects with audiometry indicative of conductive hearing loss, temporal bone CT scans,and no prior middle ear surgery. Perforation size and MEV were analyzed with respect to CHL in a cohort of 10 perforated ears with no cholesteatoma. CHLs were compared in 3 groups defined by extent of cholesteatoma ***: Ears with large and small perforations showed mean ABG values of 32.0 ± 15.7 dB and 16.0 ± 16.4 dB, respectively. A direct relationship was observed between MEV and CHL for ears with large perforations across all frequencies, whereas this relationship for small perforations was frequency-dependent. Finally, a statistically significant increase in CHL was found across ears with increasing cholesteatoma involvement at 1000 Hz(X^2(2) = 9.786, p = 0.008),2000 Hz(x^2(2) = 8.455, p = 0.015),and 4000 Hz(x^2(2)= 8.253, p = 0.016).Conclusions: These pilot data suggest that greater perforation-induced conductive hearing losses may be associated with larger perforation sizes and cholesteatoma. The correlation between MEV and CHL may require additional study.

关键词： Perforation-induced hearing loss Conductive hearing loss Middle ear volume Three-dimensional volume reconstruction

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Controlled generation of picosecond-pulsed higher-order Poincaré sphere beams from an ytterbium-doped multicore fiber amplifier

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Photonics Research 2023年第2期11卷 181-188页

作者： KUNHAO jI DI LIN IAN A. DAVIDSON SIYI WANG jOEL carpenter YOSHIMICHI AMMA YONGMIN jUNG MASSIMILIANO GUASONI DAVID j. RICHARDSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Photonics Information Technology Guangdong University of TechnologyGuangzhou 510006China School of Information Technology and Electrical Engineering The University of QueenslandBrisbaneQLD 4072Australia Fujikura Ltd. Chiba 285-8550Japan

Higher-order Poincarésphere(HOPS) beams with spatially variable polarization and phase distributions are opening up a host of unique applications in areas ranging from optical communication to ***, the flexible generation of these beams with high peak power from compact laser systems remains a challenge. Here, we demonstrate the controlled generation of HOPS beams based on coherent beam combination from an Yb-doped multicore fiber(MCF) amplifier. Using a spatial light modulator to adaptively adjust the wavefront and polarization of the signals seeded into the individual cores of the MCF various structured beams(including cylindrical vector beams and first-and second-order vortex beams) were generated with peak powers up to 14 k W for ~92 ps pulses.

关键词： amplifier polarization fiber

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One decade(2011–2020)of European agricultural water stress monitoring by MSG-SEVIRI:workflow implementation on the Virtual Earth Laboratory(VLab)platform

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International journal of Digital Earth 2022年第1期15卷 730-747页

作者： Bagher Bayat Carsten Montzka Alexander Graf Gregory Giuliani Mattia Santoro harry Vereecken Institute of Bio-and Geosciences:Agrosphere (IBG-3) Forschungszentrum Jülich GmbHJülichGermany Institute for Environmental Sciences EnviroSPACE labUniversity of GenevaGenevaSwitzerland Institute of Atmospheric Pollution Research National Research Council of Italy (CNR)Sesto FiorentinoItaly

Cloud computing facilities can provide crucial computing support for processing the time series of satellite data and exploiting their spatio-temporal information ***,dedicated efforts are still required to develop workflows,executable on cloud-based platforms,for ingesting the satellite data,performing the targeted processes,and generating the desired *** this study,an operational workflow is proposed,based on monthly Evaporative Stress Index(ESI)anomaly,and implemented in cloud-based online Virtual Earth Laboratory(VLab)platform,as a demonstration,to monitor European agricultural water *** this end,daily time-series of actual and reference evapotranspiration(ETa and ET0),from the Spinning Enhanced Visible and Infrared Imager(SEVIRI)sensor,were used to execute the proposed workflow successfully on *** execution of the workflow resulted in obtaining one decade(2011–2020)of European monthly agricultural water stress maps at 0.04˚spatial resolution and corresponding stress reports for each *** support open science,all the workflow outputs are stored in GeoServer,documented in GeoNetwork,and made available through *** enables creating a dashboard for better visualization of the results for *** results from this study demonstrate the capability of VLab platform for water stress detection from time series of SEVIRI-ET data.

关键词： ET SEVIRI ESI water stress workflow Europe VLab demonstration

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Design and guidance of a multi-active debris removal mission

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Astrodynamics 2023年第4期7卷 383-399页

作者： Minduli C.Wijayatunga(B) Roberto Armellin harry Holt Laura Pirovano Aleksander A.Lidtke Te Pūnaha Atea–Space Institute The University of AucklandAuckland 1010New Zealand Astroscale japan Inc. 1-16-4-16 KinshiSumida-kuTokyoJapan

Space debris have become exceedingly dangerous over the years as the number of objects in orbit continues to *** debris removal(ADR)missions have gained significant interest as effective means of mitigating the risk of collision between objects in *** study focuses on developing a multi-ADR mission that utilizes controlled reentry and *** mission comprises two spacecraft:a Servicer that brings debris to a low altitude and a Shepherd that rendezvous with the debris to later perform a controlled reentry.A preliminary mission design tool(PMDT)was developed to obtain time and fuel optimal trajectories for the proposed mission while considering the effect of j2,drag,eclipses,and duty *** PMDT can perform such trajectory optimizations for multi-debris missions with computational time under a *** guidance schemes are also studied,taking the PMDT solution as a reference to validate the design methodology and provide guidance solutions to this complex mission profile.

关键词： active debris removal(ADR) trajectory design optimization autonomous guidance low-thrust electric propulsion △u-law guidance Q-law guidance

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High-power,electronically controlled source of user-defined vortex and vector light beams based on a few-mode fiber amplifier

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Photonics Research 2021年第5期9卷 856-864页

作者： DI LIN jOEL carpenter YUTONG FENG YONGMIN jUNG SHAIF-UL ALAM DAVID j.RICHARDSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK School of Information Technology and Electrical Engineering The University of QueenslandBrisbaneQLD 4072Australia

Optical angular momentum(OAM)-based structured light beams provide an additional degree of freedom for practical applications ranging from optical communication to laser-based material processing. Many techniques exist for generating such beams within laser sources and these primarily rely upon the use of specially designed optical components that limit laser power scaling and ready tunability of the topological charge and polarization of the output OAM beams. Here we show that some of these limitations can be overcome by employing a computer controlled reflective phase-only spatial light modulator to adaptively tailor the input(and subsequent output) beam wavefront and polarization in a few-mode fiber amplifier. In this way modal-coupling-induced beam distortion within the fiber amplifier can be mitigated and we are able to generate at will any desired supported spatial mode guided in the fiber, including conventional linearly polarized(LP) modes, scalar OAM modes, and cylindrical vector modes, at average powers >10 W and with a peak power of >11 kW. Our results pave the way to the realization of practical high-power structured laser sources with tunable chirality and polarization.

关键词： amplifier fiber power

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